Patents by Inventor Jean-Baptiste Dumas
Jean-Baptiste Dumas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040204349Abstract: The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptides. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.Type: ApplicationFiled: December 28, 2000Publication date: October 14, 2004Inventors: Frances Yen, Blake Denison, Barbara Bour, Bernard Bihain, Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Lydie Bougueleret, Dana Ebbets-Reed, Luisa Salter-Cid
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Patent number: 6787647Abstract: The invention concerns CCRP-1 polynucleotides and polypeptides. The invention further relates to methods of directing polynucleotides, polypetides, and small molecules to mitochondria. The invention further relates to methods of reducing blood levels of fatty acids in an individual. The invention also concerns methods of identifying individuals who are at increased risk or who have a predisposition for developing, or present state of having, a diseases or disorder, such as obesity or heart disease, by determining the level of a CCRP-1 gene product in an individual.Type: GrantFiled: June 21, 2000Date of Patent: September 7, 2004Assignee: Genset S.A.Inventors: Jean-Baptiste Dumas Milne-Edwards, Aymeric Duclert, Lydie Bougueleret, Catherine Clusel
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Patent number: 6783961Abstract: The sequences of 5′ ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5′ ESTs may be to obtain cDNAs and genomic DNAs corresponding to the 5′ ESTs. The 5′ ESTs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. Upstream regulatory sequences may also be obtained using the 5′ ESTs. The 5′ ESTs may also be used to design expression vectors and secretion vectors.Type: GrantFiled: February 24, 2000Date of Patent: August 31, 2004Assignee: Genset S.A.Inventors: Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Jean-Yves Giordano
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Publication number: 20040110939Abstract: The sequences of cDNAs encoding secreted proteins are disclosed. The cDNAs can be used to express secreted proteins or fragments thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The cDNAs may also be used to design expression vectors and secretion vectors.Type: ApplicationFiled: October 15, 2001Publication date: June 10, 2004Applicant: GENSET, S.A.Inventors: Jean-Baptiste Dumas Milne Edwards, Lydie Bougueleret, Severin Jobert, Catherine Clusel, Aymeric Duclert
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Publication number: 20040023860Abstract: The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptides. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.Type: ApplicationFiled: April 11, 2002Publication date: February 5, 2004Applicant: GENSET, S.A.Inventors: Frances Yen, Blake Denison, Aymeric Duclert, Lydie Bougueleret, Catherine Clusel, Jean-Baptiste Dumas Milne-Edwards, Bernard Bihain, Barbara Bour, Dana Ebbets-Reed, Luisa Salter-Cid
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Publication number: 20030203377Abstract: The sequences of cDNAs encoding secreted proteins are disclosed. The cDNAs can be used to express secreted proteins or fragments thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The cDNAs may also be used to design expression vectors and secretion vectors.Type: ApplicationFiled: December 9, 2002Publication date: October 30, 2003Inventors: Jean-Baptiste Dumas Milne Edwards, Lydie Bougueleret, Severin Jobert
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Patent number: 6639063Abstract: The sequences of 5′ ESTs and consensus contigated 5′ ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5′ ESTs and consensus contigated 5′ ESTs may be used to obtain cDNAs and genomic DNAs corresponding to the 5′ ESTs and consensus contigated 5′ ESTs. The 5′ ESTs and consensus contigated 5′ ESTs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. Upstream regulatory sequences may also be obtained using the 5′ ESTs and consensus contigated ESTs. The 5′ ESTs and consensus contigated 5′ ESTs may also be used to design expression vectors and secretion vectors.Type: GrantFiled: July 21, 2000Date of Patent: October 28, 2003Assignee: Genset S.A.Inventors: Jean-Baptiste Dumas Milne Edwards, Severin Jobert, Jean-Yves Giordano
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Publication number: 20030162176Abstract: The sequences of extended cDNAs encoding secreted proteins are disclosed. The extended cDNAs can be used to express secreted proteins or portions thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The extended cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The extended cDNAs may also be used to design expression vectors and secretion vectors.Type: ApplicationFiled: July 11, 2001Publication date: August 28, 2003Inventors: Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Lydie Bougueleret
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Publication number: 20030152921Abstract: The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers, in the production of expression vectors. In addition, they may be used in screening and diagnosis assays for abnormal GENSET expression and/or biological activity and for screening compounds that may be used in the treatment of GENSET-related disorders.Type: ApplicationFiled: June 8, 2001Publication date: August 14, 2003Inventors: Jean-Baptiste Dumas Milne Edwards, Lydie Bougueleret, Severin Jobert
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Publication number: 20030144490Abstract: The sequences of extended cDNAs encoding secreted proteins are disclosed. The extended cDNAs can be used to express secreted proteins or portions thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The extended cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The extended cDNAs may also be used to design expression vectors and secretion vectors.Type: ApplicationFiled: December 10, 2002Publication date: July 31, 2003Inventors: Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Lydie Bougueleret
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Patent number: 6573068Abstract: The sequence of a cDNA encoding Claudin-50 and sequence of Claudin-50 protein are disclosed. The cDNA can be used to express the protein or portions thereof or to obtain antibodies capable of specifically binding to the secreted protein. The cDNA may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The cDNA may also be used to design expression vectors and secretion vectors.Type: GrantFiled: September 15, 2000Date of Patent: June 3, 2003Assignee: Genset, S. A.Inventors: Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Lydie Bougueleret
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Patent number: 6548633Abstract: The sequences of cDNAs encoding secreted proteins are disclosed. The cDNAs can be used to express secreted proteins or fragments thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The cDNAs may also be used to design expression vectors and secretion vectors.Type: GrantFiled: June 21, 2000Date of Patent: April 15, 2003Assignee: Genset, S.A.Inventors: Jean-Baptiste Dumas Milne Edwards, Lydie Bougueleret, Severin Jobert
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Publication number: 20030032783Abstract: The invention provides the genomic sequence of AA4RP, AA4RP cDNAs and AA4RP polypeptides. Further the invention provides polynucleotides including biallelic markers derived from the AA4RP gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also relates to diagnostic methods for determining whether an individual is at risk of developing a lipid metabolism related disorder and/or a liver related disorder, or whether said individual suffers from a lipid metabolism related disorder and/or a liver related disorder as a result of a polymorphism in the AA4RP gene.Type: ApplicationFiled: April 25, 2001Publication date: February 13, 2003Inventors: Frances Yen-Potin, Blake Denison, Jean Baptiste Dumas Milne Edwards, Bernard Bihain, Barbara Bour, Aymeric Duclert, Lydie Bougueleret
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Publication number: 20020142949Abstract: The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptides. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.Type: ApplicationFiled: December 28, 2000Publication date: October 3, 2002Inventors: Frances Yen, Blake Denison, Barbara Bour, Bernard Bihain, Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Lydie Bougueleret, Dana Ebbets-Reed, Luisa Salter-Cid
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Patent number: 6455280Abstract: The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptides. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.Type: GrantFiled: December 28, 2000Date of Patent: September 24, 2002Assignee: Genset S.A.Inventors: Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Lydie Bougueleret, Catherine Clusel
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Publication number: 20020102604Abstract: The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers, in the production of expression vectors. In addition, they may be used in screening and diagnosis assays for abnormal GENSET expression and/or biological activity and for screening compounds that may be used in the treatment of GENSET-related disorders.Type: ApplicationFiled: December 7, 2000Publication date: August 1, 2002Inventors: Jean-Baptiste Dumas Milne Edwards, Lydie Bougueleret, Severin Jobert
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Publication number: 20020035574Abstract: A data management device is provided which comprises a loading module (7) for accessing data from a reference database and a selection module (8) for allowing a user to make a selection from among this data as a function of the categories of reference data to which the data belong. These categories correspond to the categories of data of an information management module (9) of a main data processing terminal (1). The main data processing terminal also comprises a screen (12) and an exporting module (10) for exporting the selected data to the information management module (9). As a result, the selected data are stored with the data of the corresponding categories of the information management module.Type: ApplicationFiled: March 26, 2001Publication date: March 21, 2002Inventor: Jean-Baptiste Dumas
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Patent number: 6312922Abstract: The sequences of extended cDNAs encoding secreted proteins are disclosed. The extended cDNAs can be used to express secreted proteins or portions thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The extended cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The extended cDNAs may also be used to design expression vectors and secretion vectors.Type: GrantFiled: February 9, 1999Date of Patent: November 6, 2001Assignee: GensetInventors: Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Lydie Bougueleret
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Patent number: 6248530Abstract: The invention concerns a method for specifically eliminating at least one type of double strand DNA plasmid from a set of plasmids, characterised in that it consists in: preparing presynaptic filaments by fixing a protein with RecA activity on a single strand DNA whose sequence corresponds to a sequence of the plasmid to be eliminated and which further comprises a recognition sequence for a restriction enzyme sensitive to methylation; mixing the set of plasmid with the presynaptic filaments to form triplexes on the plasmids with the presynaptic filaments to form triplexes on the plasmids to be eliminated; methylating the resulting DNA mixture; releasing the triplexes; digesting the mixture obtained with the restriction methylation sensitive enzyme; if necessary, eliminating or separating the linear double strand DNA's corresponding to the plasmids to be eliminated. The method is useful for preparing DNAc libraries.Type: GrantFiled: July 23, 1999Date of Patent: June 19, 2001Assignee: Genset, S.A.Inventors: Nasri Nahas, Jean-Baptiste Dumas Milne Edwards
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Patent number: 6222029Abstract: The sequences of 5′ ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5′ ESTs may be to obtain cDNAs and genomic DNAs corresponding to the 5′ ESTs. The 5′ ESTs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. Upstream regulatory sequences may also be otained using the 5′ ESTs. The 5′ ESTs may also be used to design expression vectors and secretion vectors.Type: GrantFiled: August 1, 1997Date of Patent: April 24, 2001Assignee: GensetInventors: Jean-Baptiste Dumas Milne Edwards, Aymeric Duclert, Bruno Lacroix