Patents by Inventor Jean Brochot

Jean Brochot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10335502
    Abstract: A freeze-dried powder composition comprising a phospholipid and a polyethylene glycol, said polyethylene glycol having a percentage of folded polymeric chains of 40% or higher. The composition is suitable for preparing gas-filled microvesicles.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: July 2, 2019
    Assignee: Bracco Suisse SA
    Inventors: Anne Lassus, St├ęphane Gorgerat, Feng Yan, Christian Guillot, Jean Brochot
  • Patent number: 10232061
    Abstract: A freeze-dried powder composition comprising a phospholipid and a polyethylene glycol, said polyethylene glycol having a percentage of folded polymeric chains of 40% or higher. The composition is suitable for preparing gas-filled microvesicles.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: March 19, 2019
    Assignee: Bracco Suisse SA
    Inventors: Anne Lassus, St├ęphane Gorgerat, Feng Yan, Christian Guillot, Jean Brochot
  • Publication number: 20140163366
    Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
    Type: Application
    Filed: December 12, 2013
    Publication date: June 12, 2014
    Applicant: BRACCO SUISSE SA
    Inventors: Michel SCHNEIDER, Christophe GOLAY, Laurent JAKOB, Jean BROCHOT, Feng YAN, Christian MATHIEU
  • Publication number: 20130101520
    Abstract: The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents.
    Type: Application
    Filed: September 12, 2012
    Publication date: April 25, 2013
    Applicant: Bracco Suisse S.A.
    Inventors: Michel SCHNEIDER, Feng Yan, David Lazarus, Jean Brochot, Jerome Puginier
  • Publication number: 20120265065
    Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
    Type: Application
    Filed: May 9, 2012
    Publication date: October 18, 2012
    Applicant: BRACCO RESEARCH S.A.
    Inventors: Michel Schneider, Christophe Golay, Laurent Jakob, Jean Brochot, Feng Yan, Christian Mathieu
  • Publication number: 20120093732
    Abstract: The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents.
    Type: Application
    Filed: September 1, 2011
    Publication date: April 19, 2012
    Applicant: Bracco Suisse S.A.
    Inventors: Michel Schneider, Feng Yan, David Lazarus, Jean Brochot, Jerome Puginier
  • Publication number: 20110245663
    Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
    Type: Application
    Filed: January 20, 2011
    Publication date: October 6, 2011
    Applicant: BRACCO RESEARCH S.A.
    Inventors: Michel Schneider, Christophe Golay, Laurent Jakob, Jean Brochot, Feng Yan, Christian Mathieu
  • Patent number: 7534239
    Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
    Type: Grant
    Filed: May 22, 2000
    Date of Patent: May 19, 2009
    Assignee: Bracco Research S.A.
    Inventors: Michel Schneider, Laurent Jakob, Christophe Golay, Jean Brochot, Feng Yan
  • Publication number: 20090076477
    Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
    Type: Application
    Filed: September 11, 2008
    Publication date: March 19, 2009
    Inventors: Michel Schneider, Christophe Golay, Laurent Jakob, Jean Brochot, Feng Yan, Christian Mathieu
  • Publication number: 20080063603
    Abstract: The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents.
    Type: Application
    Filed: September 7, 2007
    Publication date: March 13, 2008
    Applicant: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, David Lazarus, Jean Brochot, Jerome Puginier
  • Publication number: 20050025710
    Abstract: The invention relates to a formulation comprising a dry material (e.g. lyophilised or spray dried) comprising at least one film forming surfactant and a gas or a gas mixture usable in diagnostic imaging, to a process for the preparation thereof and to a suspension obtainable by reconstituting said formulation with an aqueous carrier for use in contrast imaging. The invention also relates to a container comprising the dry material in contact with a gas. The gas associated with the dry material is at a pressure lower than the atmospheric pressure.
    Type: Application
    Filed: July 29, 2003
    Publication date: February 3, 2005
    Inventors: Michel Schneider, Yan Feng, Jean Brochot, David Lazurus
  • Publication number: 20040197269
    Abstract: The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballoons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usual surfactants, additives and stabilisers provides useful ultrasound contrast agents. At least one of the components (B) in the mixture is a gas whose molecular weight is greater than 80 daltons and whose solubility in water is below 0.0283 ml per ml of water at standard conditions. The presence of the first component (B) in the contrast medium may vary between 0.5 and 41 volume percent. The other component (A) of the ultrasound contrast media is a gas or a mixture of gases whose molecular weight is below 80 daltons. The second component is present in a proportion of between 59-99.5% by vol., and is preferably chosen from oxygen, air, nitrogen, carbon dioxide or mixtures thereof.
    Type: Application
    Filed: April 26, 2004
    Publication date: October 7, 2004
    Applicant: Bracco Research S.A.
    Inventors: Feng Yan, Michel Schneider, Jean Brochot
  • Publication number: 20040186425
    Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
    Type: Application
    Filed: January 30, 2004
    Publication date: September 23, 2004
    Inventors: Michel Schneider, Christophe Golay, Laurent Jacob, Jean Brochot, Feng Yan, Christian Mathieu
  • Publication number: 20040180004
    Abstract: Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed are methods of preparation of the stable suspensions of gas filled microbubbles, as well as dry formulations which, upon reconstitution in an aqueous carrier liquid, will form the injectable suspensions of gas filled microbubbles of the invention and methods of making and using the same The preferred dry formulations are stable when stored over time and at temperatures above ambient temperature and further comprise a lipid acid preserving agent additive.
    Type: Application
    Filed: February 20, 2004
    Publication date: September 16, 2004
    Applicant: Bracco International B.V.
    Inventors: Michel Schneider, Jean Brochot, Jerome Puginier, Feng Yan
  • Patent number: 6726650
    Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
    Type: Grant
    Filed: December 3, 1998
    Date of Patent: April 27, 2004
    Assignee: Bracco Research S.A.
    Inventors: Michel Schneider, Christophe Golay, Laurent Jakob, Jean Brochot, Feng Yan, Christian Mathieu
  • Publication number: 20030195491
    Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
    Type: Application
    Filed: May 13, 2003
    Publication date: October 16, 2003
    Applicant: Bracco Research S.A.
    Inventors: Michel Schneider, Christophe Golay, Laurent Jacob, Jean Brochot, Feng Yan, Christian Mathieu
  • Publication number: 20030129137
    Abstract: Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarize phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.
    Type: Application
    Filed: January 31, 2003
    Publication date: July 10, 2003
    Applicant: Bracco International B.V.
    Inventors: Michel Schneider, Jean Brochot, Jerome Puginier, Feng Yan
  • Publication number: 20020077588
    Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
    Type: Application
    Filed: December 3, 1998
    Publication date: June 20, 2002
    Inventors: MICHEL SCHNEIDER, LAURENT JAKOB, CHRISTOPHE GOLAY, JEAN BROCHOT, FENG YAN
  • Publication number: 20010024638
    Abstract: Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed are methods of preparation of the stable suspensions of gas filled microbubbles, as well as dry formulations which, upon reconstitution in an aqueous carrier liquid, will form the injectable suspensions of gas filled microbubbles of the invention and methods of making and using the same The preferred dry formulations are stable when stored over time and at temperatures above ambient temperature and further comprise a lipid acid preserving agent additive.
    Type: Application
    Filed: January 29, 2001
    Publication date: September 27, 2001
    Inventors: Michel Schneider, Jean Brochot, Jerome Puginier, Feng Yan
  • Publication number: 20010001279
    Abstract: Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.
    Type: Application
    Filed: December 15, 2000
    Publication date: May 17, 2001
    Applicant: Bracco International BV
    Inventors: Michel Schneider, Jean Brochot, Jerome Puginier, Feng Yan