Patents by Inventor Jean Brochot
Jean Brochot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6726650Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.Type: GrantFiled: December 3, 1998Date of Patent: April 27, 2004Assignee: Bracco Research S.A.Inventors: Michel Schneider, Christophe Golay, Laurent Jakob, Jean Brochot, Feng Yan, Christian Mathieu
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Publication number: 20030195491Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.Type: ApplicationFiled: May 13, 2003Publication date: October 16, 2003Applicant: Bracco Research S.A.Inventors: Michel Schneider, Christophe Golay, Laurent Jacob, Jean Brochot, Feng Yan, Christian Mathieu
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Publication number: 20030129137Abstract: Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarize phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.Type: ApplicationFiled: January 31, 2003Publication date: July 10, 2003Applicant: Bracco International B.V.Inventors: Michel Schneider, Jean Brochot, Jerome Puginier, Feng Yan
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Publication number: 20020077588Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.Type: ApplicationFiled: December 3, 1998Publication date: June 20, 2002Inventors: MICHEL SCHNEIDER, LAURENT JAKOB, CHRISTOPHE GOLAY, JEAN BROCHOT, FENG YAN
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Publication number: 20010024638Abstract: Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed are methods of preparation of the stable suspensions of gas filled microbubbles, as well as dry formulations which, upon reconstitution in an aqueous carrier liquid, will form the injectable suspensions of gas filled microbubbles of the invention and methods of making and using the same The preferred dry formulations are stable when stored over time and at temperatures above ambient temperature and further comprise a lipid acid preserving agent additive.Type: ApplicationFiled: January 29, 2001Publication date: September 27, 2001Inventors: Michel Schneider, Jean Brochot, Jerome Puginier, Feng Yan
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Publication number: 20010001279Abstract: Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.Type: ApplicationFiled: December 15, 2000Publication date: May 17, 2001Applicant: Bracco International BVInventors: Michel Schneider, Jean Brochot, Jerome Puginier, Feng Yan
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Patent number: 6187288Abstract: Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.Type: GrantFiled: September 11, 1998Date of Patent: February 13, 2001Assignee: Bracco International B.V.Inventors: Michel Schneider, Jean Brochot, Jérôme Puginier, Feng Yan
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Patent number: 6042809Abstract: The invention relates to the application of hyperpolarized gases to magnetic resonance imaging (MRI) of living subjects. The invention also concerns administrable compositions, formulations, methods of making the compositions and formulations and contrast agents involving hyperpolarized gases, as well as their use in MRI.Type: GrantFiled: August 12, 1998Date of Patent: March 28, 2000Assignee: Bracco Research S.A.Inventors: Herve Tournier, Michel Schneider, Feng Yan, Jean Brochot
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Patent number: 5961956Abstract: Disclosed are suspensions of gas microbubbles immobilised within a frozen aqueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is a physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by an evanescent envelope or a tangible membrane. The suspensions, when in liquid form, are injectable and useful as a contrast agents in ultrasonic imaging of blood pool and tissue of living beings. The gas microbubbles are immobilised within the carrier by freezing a suspension of microbubbles with average sizes below 50 .mu.m, preferably below 10 .mu.m and more preferably between 2 .mu.m and 8 .mu.m, to a temperature between -1.degree. C. and -76.degree. C. and maintaining this temperature for prolonged periods of time. The microbubbles may be stabilised by a surfactant such as a lamellar phospholipid or may comprise a membrane made of synthetic or natural polymer or protein.Type: GrantFiled: October 6, 1997Date of Patent: October 5, 1999Assignee: Bracco Research S.A.Inventors: Feng Yan, Michel Schneider, Jean Brochot
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Patent number: 5908610Abstract: Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.Type: GrantFiled: June 26, 1997Date of Patent: June 1, 1999Assignee: Bracco International B.V.Inventors: Michel Schneider, Jean Brochot, Jerome Puginier, Feng Yan
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Patent number: 5846518Abstract: The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballoons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usual surfactants, additives and stabilisers provides useful ultrasound contrast agents. At least one of the components (B) in the mixture is a gas whose molecular weight is greater than 80 daltons and whose solubility in water is below 0.0283 ml per ml of water at standard conditions. The presence of the first component (B) in the contrast medium may vary between 0.5 and 41 volume percent. The other component (A) of the ultrasound contrast media is a gas or a mixture of gases whose molecular weight is below 80 daltons. The second component is present in a proportion of between 59-99.5% by vol., and is preferably chosen from oxygen, air, nitrogen, carbon dioxide or mixtures thereof.Type: GrantFiled: May 1, 1997Date of Patent: December 8, 1998Assignee: Bracco Research S.A.Inventors: Feng Yan, Michel Schneider, Jean Brochot
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Patent number: 5830435Abstract: Disclosed are suspensions of gas microbubbles immobilised within a frozen aqueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is a physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by an evanescent envelope or a tangible membrane. The suspensions, when in liquid form, are injectable and useful as a contrast agents in ultrasonic imaging of blood pool and tissue of living beings. The gas microbubbles are immobilised within the carrier by freezing a suspension of microbubbles with average sizes below 50 .mu.m, preferably below 10 .mu.m and more preferably between 2 .mu.m and 8 .mu.m, to a temperature between -1.degree. C. and -76.degree. C. and maintaining this temperature for prolonged periods of time. The microbubbles may be stabilised by a surfactant such as a lamellar phospholipid or may comprise a membrane made of synthetic or natural polymer or protein.Type: GrantFiled: August 12, 1997Date of Patent: November 3, 1998Assignee: Bracco Research S.A.Inventors: Feng Yan, Michel Schneider, Jean Brochot
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Patent number: 5827504Abstract: Disclosed are suspensions of gas microbubbles immobilised within a frozen aqueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is a physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by an evanescent envelope or a tangible membrane. The suspensions, when in liquid form, are injectable and useful as a contrast agents in ultrasonic imaging of blood pool and tissue of living beings. The gas microbubbles are immobilised within the carrier by freezing a suspension of microbubbles with average sizes below 50 .mu.m, preferably below 10 .mu.m and more preferably between 2 .mu.m and 8 .mu.m, to a temperature between -1.degree. C. and -76.degree. C. and maintaining this temperature for prolonged periods of time. The microbubbles may be stabilised by a surfactant such as a lamellar phospholipid or may comprise a membrane made of synthetic or natural polymer or protein.Type: GrantFiled: August 12, 1997Date of Patent: October 27, 1998Assignee: Bracco Research S.A.Inventors: Feng Yan, Michel Schneider, Jean Brochot
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Patent number: 5686060Abstract: Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.Type: GrantFiled: April 12, 1995Date of Patent: November 11, 1997Assignee: Bracco International BVInventors: Michel Schneider, Jean Brochot, Jerome Puginier, Feng Yan
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Patent number: 5597549Abstract: Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.Type: GrantFiled: March 31, 1995Date of Patent: January 28, 1997Assignee: Bracco International B.V.Inventors: Michel Schneider, Jean Brochot, Jerome Puginier, Feng Yan
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Patent number: 5556610Abstract: The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballoons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usual surfactants, additives and stabilisers provides useful ultrasound contrast agents. At least one of the components (B) in the mixture is a gas whose molecular weight is greater than 80 daltons and whose solubility in water is below 0.0283 ml per ml of water at standard conditions. The presence of the first component (B) in the contrast medium may vary between 0.15 and 41 volume percent. The other component (A) of the ultrasound contrast media is a gas or a mixture of gases whose molecular weight is below 80 daltons. The second component is present in a proportion of between 59-99.5% by vol., and is preferably chosen from oxygen, air, nitrogen, carbon dioxide or mixtures thereof.Type: GrantFiled: November 30, 1994Date of Patent: September 17, 1996Assignee: Bracco Research S.A.Inventors: Feng Yan, Michel Schneider, Jean Brochot
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Patent number: 5445813Abstract: Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.Type: GrantFiled: October 12, 1993Date of Patent: August 29, 1995Assignee: Bracco International B.V.Inventors: Michel Schneider, Jean Brochot, Jerome Puginier, Feng Yan
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Patent number: 5110746Abstract: Serum is reacted with a dinitrohalobenzene compound and the rate of halogen formation is measured. This rate is in proportion to the amount of albumin in the sample. Other proteins like the globulins, as well as free aminoacids and urea, do not interfere with this reaction.Type: GrantFiled: December 22, 1988Date of Patent: May 5, 1992Assignee: Pharmacia Diagnostics Inc.Inventors: Howard Grey, Ciaran Mangan, Jean Brochot, Iqbal Siddiqi
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Patent number: 5081014Abstract: The method makes use of the action of the co-enzyme in the production of H.sub.2 O.sub.2 associated with the reaction of a hydroxylase with a decoupling agent in the presence of air or oxygen, the H.sub.2 O.sub.2 being subsequently determined by quantitative breaking of the C--F bond of a fluorinated compound in the presence of peroxidase, followed by electrometric titration of the resulting ions.Type: GrantFiled: September 19, 1990Date of Patent: January 14, 1992Assignee: Hoffmann-La Roche Inc.Inventors: Jean Brochot, Iqbal Siddiqi
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Patent number: 4956276Abstract: The sample for analysis containing the co-enzyme to be detemined, inter alia NADH or NADPH, is placed in the presence of a fluorinated aromatic compound. In the presence of oxygen and peroxidase, the fluorinated compound releases fluoride ions at a rate proportional to the quantity of co-enzyme to be determined. The thus-formed F.sup.- ions are determined, thus obtaining the desired result.Type: GrantFiled: November 13, 1986Date of Patent: September 11, 1990Assignee: Battelle Memorial InstituteInventors: Igbal Siddiqi, Jean Brochot