Patents by Inventor Jean-Luc Specklin

Jean-Luc Specklin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OXAZOLIDINONE-QUINOLONE HYBRID ANTIBIOTICS
    Publication number: 20120142635
    Abstract: The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria:
    Type: Application
    Filed: February 8, 2012
    Publication date: June 7, 2012
    Applicant: Morphochem Aktiengesellschaft Fur Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Christine Schmitt, Stefan Müller, Michael W. Cappi
  • USE OF OXAZOLIDINONE-QUINOLINE HYBRID ANTIBIOTICS FOR THE TREATMENT OF ANTHRAX AND OTHER INFECTIONS
    Publication number: 20120135961
    Abstract: The present invention relates to the use of compounds, in which the pharmacophores of quinolone and oxazolidinone are chemically linked together through a linker that is stable under physiological conditions, for the treatment of anthrax and other infections.
    Type: Application
    Filed: January 10, 2011
    Publication date: May 31, 2012
    Applicant: Morphochem Aktiengesellschaft Fur Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Hans Locher, Christine Schmitt
  • Oxazolidinone-quinolone hybrid antibiotics
    Patent number: 8158797
    Abstract: The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: April 17, 2012
    Assignee: Morphochem Aktiengesellschaft fur Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Christine Schmitt, Stefan Müller, Michael W. Cappi
  • 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
    Patent number: 8124623
    Abstract: The invention relates to novel chimeric antibiotics of formula I wherein R1 represents OH, OPO3H2 or OCOR5; R2 represents H, OH or OPO3H2; A represents N or CR6; R3 represents H or fluorine; R4 is H, (C1-C3) alkyl, or cycloalkyl; R5 is the residue of a naturally occurring amino acid, of the enantiomer of a naturally occurring amino acid or of dimethylaminoglycine; R6 represents H, alkoxy or halogen; and n is 0 or 1; and to salts (in particular pharmaceutically acceptable salts) of compounds of formula I. These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections).
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: February 28, 2012
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Christian Hubschwerlen, Hans Locher, Philippe Panchaud, Jean-Luc Specklin
  • Intermediate products for producing oxazolidinone-quinolone hybrids
    Patent number: 8124772
    Abstract: The present invention describes intermediates (ZP) for a novel and efficient synthesis of compounds in which the pharmacophores of quinolone and oxazolidinone are linked to one another by way of a chemically stable linker.
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: February 28, 2012
    Assignee: Morphochem Aktiengesellschaft für Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Jean Phillippe Surivet, Daniel Baeschlin
  • 5-hydroxymethyl-oxazolidin-2-one antibacterials
    Patent number: 8039466
    Abstract: The invention relates to novel chimeric antibiotics of formula I wherein R1 represents OH, OPO3H2 or OCOR5; R2 represents H, OH or OPO3H2; R3 represents H or halogen; R4 is H, (C1-C3)alkyl, or cycloalkyl; R5 represents piperidin-4-yl or R5 is the residue of a naturally occurring amino acid, of the enantiomer of a naturally occurring amino acid or of dimethylaminoglycine; n is 0 or 1; and to salts (in particular pharmaceutically acceptable salts) of compounds of formula I. These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections).
    Type: Grant
    Filed: November 23, 2007
    Date of Patent: October 18, 2011
    Assignee: Actelion Pharmaceutical Ltd.
    Inventors: Christian Hubschwerlen, Philippe Panchaud, Jean-Luc Specklin
  • DUAL ACTION ANTIBIOTICS
    Publication number: 20110059946
    Abstract: The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria:
    Type: Application
    Filed: September 10, 2010
    Publication date: March 10, 2011
    Applicant: Morphochem Aktiengesellschaft fuer Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin
  • Dual action antibiotics
    Patent number: 7820823
    Abstract: The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: October 26, 2010
    Assignee: Morphochem Aktiengesellschaft Fur Kominatorische Chemi
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin
  • Novel Antibacterial Compounds
    Publication number: 20100222302
    Abstract: The invention relates to novel chimeric antibiotics of formula I wherein R1 is CH2NHCOR5, heteroarylmethyl, heteroaryloxymethyl or heteroarylaminomethyl; R2 is H, OH, OSO3H, OPO3H2, OCH2OPO3H2, OCOCH2CH2COOH, OCOR6; R3 is H or halogen; R4 is (C1-C3)alkyl, (C1-C3)haloalkyl or cycloalkyl; R5 is alkyl or haloalkyl; and R6 is the residue of a naturally occurring amino acid or of dimethylaminoglycine. These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections).
    Type: Application
    Filed: August 7, 2006
    Publication date: September 2, 2010
    Inventors: Christian Hubschwerlen, Philippe Panchaud, Christine Sigwalt, Jean-Luc Specklin
  • 5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE ANTIBACTERIALS
    Publication number: 20100069376
    Abstract: The invention relates to novel chimeric antibiotics of formula I wherein R1 represents OH, OPO3H2 or OCOR5; R2 represents H, OH or OPO3H2; R3 represents H or halogen; R4 is H, (C1-C3)alkyl, or cycloalkyl; R5 represents piperidin-4-yl or R5 is the residue of a naturally occurring amino acid, of the enantiomer of a naturally occurring amino acid or of dimethylaminoglycine; n is 0 or 1; and to salts (in particular pharmaceutically acceptable salts) of compounds of formula I. These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections).
    Type: Application
    Filed: November 23, 2007
    Publication date: March 18, 2010
    Applicant: Actelion Pharmaceuticals, Ltd.
    Inventors: Christian Hubschwerlen, Philippe Panchaud, Jean-Luc Specklin
  • Intermediate products for producing oxazolidinone-quinolone hybrids
    Publication number: 20090306389
    Abstract: The present invention describes intermediates (ZP) for a novel and efficient synthesis of compounds in which the pharmacophores of quinolone and oxazolidinone are linked to one another by way of a chemically stable linker.
    Type: Application
    Filed: June 5, 2009
    Publication date: December 10, 2009
    Applicant: Morphochem Aktiengesellschaft fur Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Jean Phillippe Surivet, Daniel Baeschlin
  • 5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE-DERIVATIVES AND THEIR USES AS ANTIBACTERIALS
    Publication number: 20090247578
    Abstract: The invention relates to novel chimeric antibiotics of formula I wherein R1 represents OH, OPO3H2 or OCOR5; R2 represents H, OH or OPO3H2; A represents N or CR6; R3 represents H or fluorine; R4 is H, (C1-C3) alkyl, or cycloalkyl; R5 is the residue of a naturally occurring amino acid, of the enantiomer of a naturally occurring amino acid or of dimethylaminoglycine; R6 represents H, alkoxy or halogen; and n is 0 or 1; and to salts (in particular pharmaceutically acceptable salts) of compounds of formula I. These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections).
    Type: Application
    Filed: May 8, 2009
    Publication date: October 1, 2009
    Applicant: Actelion Pharmaceuticals Ltd.
    Inventors: Christian HUBSCHWERLEN, Hans Locher, Philippe Panchaud, Jean-Luc Specklin
  • Intermediate products for producing oxazolidinone-quinolone hybrids
    Patent number: 7557214
    Abstract: The present invention describes intermediates (ZP) for a novel and efficient synthesis of compounds in which the pharmacophores of quinolone and oxazolidinone are linked to one another by way of a chemically stable linker.
    Type: Grant
    Filed: September 3, 2004
    Date of Patent: July 7, 2009
    Assignee: Morphochem Aktiengesellschaft für Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Jean Phillippe Surivet, Daniel Baeschlin
  • Oxazolidinone-Quinolone Hybrid Antibiotics
    Publication number: 20080027040
    Abstract: The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria:
    Type: Application
    Filed: December 20, 2004
    Publication date: January 31, 2008
    Applicant: Morphochem Aktiengesellschaft Fur Kombinatorische
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Christine Schmitt, Stefan Muller, Michael W. Cappi
  • Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
    Publication number: 20070155714
    Abstract: The present invention relates to the use of compounds, in which the pharmacophores of quinolone and oxazolidinone are chemically linked together through a linker that is stable under physiological conditions, for the treatment of anthrax and other infections.
    Type: Application
    Filed: April 6, 2004
    Publication date: July 5, 2007
    Applicant: Morphochem Aktiengesellschaft Fur Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Daniel Baeschlin, Hans Locher, Christine Schmitt
  • Intermediate products for producing oxazolidinone-quinolone hybrids
    Publication number: 20070004769
    Abstract: The present invention describes intermediates (ZP) for a novel and efficient synthesis of compounds in which the pharmacophores of quinolone and oxazolidinone are linked to one another by way of a chemically stable linker.
    Type: Application
    Filed: September 3, 2004
    Publication date: January 4, 2007
    Applicant: Morphochem Aktiegesellschaft Fur Kombinatorische Chemie
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin, Jean Surivet, Daniel Baeschlin
  • Piperazine derivatives
    Patent number: 7022707
    Abstract: The present invention is a chemical compound of formula (I) or a pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R4, A1, A2 m and n are as described in the specification.
    Type: Grant
    Filed: June 23, 2004
    Date of Patent: April 4, 2006
    Assignees: Hoffman-La Roche Inc., Vernalis Research Limited
    Inventors: David Reginald Adams, Jonathan Mark Bentley, James Edward Paul Davidson, Claire Elizabeth Dawson, Ashley Roger George, Howard Langham Mansell, Patrizio Mattei, Jacques Mizrahi, Matthias Heinrich Nettekoven, Robert Mark Pratt, Stephan Roever, Jonathan Richard Anthony Roffey, Jean-Luc Specklin, Henri Stalder, Kerry Wilkinson
  • Dual action antibiotics
    Publication number: 20050096343
    Abstract: The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria.
    Type: Application
    Filed: October 4, 2002
    Publication date: May 5, 2005
    Inventors: Christian Hubschwerlen, Jean-Luc Specklin
  • Novel piperazine derivatives
    Publication number: 20040235859
    Abstract: The present invention is a chemical compound of formula (I) 1
    Type: Application
    Filed: June 23, 2004
    Publication date: November 25, 2004
    Inventors: David Reginald Adams, Jonathan Mark Bentley, James Edward Paul Davidson, Claire Elizabeth Dawson, Ashley Roger George, Howard Langham Mansell, Patrizio Mattei, Jacques Mizrahi, Matthias Heinrich Nettekoven, Robert Mark Pratt, Stephan Roever, Jonathan Richard Anthony Roffey, Jean-Luc Specklin, Henri Stalder, Kerry Wilkinson
  • Novel piperazine derivatives
    Publication number: 20020143020
    Abstract: The present invention is a chemical compound of formula (I) 1
    Type: Application
    Filed: December 7, 2001
    Publication date: October 3, 2002
    Inventors: David Reginald Adams, Jonathan Mark Bentley, James Edward Paul Davidson, Claire Elizabeth Dawson, Ashley Roger George, Howard Langham Mansell, Patrizio Mattei, Jacques Mizrahi, Matthias Heinrich Nettekoven, Robert Mark Pratt, Stephan Roever, Jonathan Richard Anthony Roffey, Jean-Luc Specklin, Henri Stalder, Kerry Wilkinson