Abstract: The invention relates to an ex vivo method for detecting or monitoring the progression of a chronic proliferative disease, in a sample of human or animal serum or plasma, by immunoassay for the presence of antibodies in the sample, including at least one or several antibodies directed against benzo(a)pyrene. The invention also relates to a kit for implementing such a method.

Abstract: The invention relates to an ex vivo method for detecting or monitoring the progression of a chronic autoimmune disease, in a sample of human or animal biological fluid, by immunoassay for the presence of antibodies in the sample, including at least: one or more antibodies directed against at least one enterobacterium, and one or more antibodies directed against a product at the origin of or resulting from lipoperoxidation and/or one or more antibodies directed against a nitrated or nitrosylated product. The invention also relates to a kit for implementing such a method.

Abstract: The invention relates to an ex vivo method for detecting or monitoring the progression of a chronic degenerative disease, in a sample of human or animal biological fluid, by immunoassay for the presence of antibodies in the sample, including at least: one or more antibodies directed against at least one endobacterium, and one or more antibodies directed against a tryptophan oxidation product. The invention also relates to a kit for implementing such a method.

Abstract: An apparatus for processing one or more products in need of closure. The apparatus comprises a vessel including an inlet for receiving the one or more products and an outlet for discharging the one or more products under sterile and/or pyrogen free conditions. A device is also adapted for applying the closure to the one or more products in the vessel, along with the optional filling and/or weighing of the products before or after applying the closure. Related apparatuses, systems, and methods are disclosed.

Abstract: The present invention provides a method and kit which can be used to prevent or reduce contaminants in a clean production environment. The method involves providing a processing apparatus having a chamber, and providing a liner within the chamber, wherein a negative pressure is applied to the interior of the chamber to retain the liner against the interior wall of the chamber.

Abstract: A disposable material processing apparatus, useable as a bioreactor or fermenter, includes a hollow tank (101) and a mixing paddle (110) disposed within the interior of the tank and adapted to mix contents therein. The paddle may be isolated within a flexible sleeve (140). Various functional elements, such as a sparger, sensor, material extraction conduit, material addition conduit, and/or heat exchange element may be provided, and optionally arranged to travel with the paddle within the tank interior. Baffles may protrude into a mixing tank to enhance mixing. A tank and/or sleeve may comprise polymeric film materials.

Abstract: The invention relates mainly to an apparatus comprising a chamber for physically and/or chemically treating one or more samples or products, said apparatus comprising a door for introducing samples inside the apparatus chamber or bringing samples outside the apparatus, said apparatus comprising a membrane or film defining a chamber wall inside said apparatus when the door is closed.

Abstract: Disclosed is a method of sealing a container with a liquid, the container including a body with an opening at at least one end and including at least one sealing plug, designed to seal the opening after filling, the filling defining a free surface S for filling, the filling having allowed a head space to remain in the container. The method includes: introduction of at least one rod parallel to an inside wall of the body of the container; mechanical insertion of the plug in the body, along the at least one insertion rod, generating at least one channel C, the air of the head space being evacuated between the plug and the rod; and withdrawal of the at least one rod while leaving the plug in place at the level of insertion of the preceding step. Also disclosed are the associated device and the industrial production line.

Abstract: A mixing apparatus including a kinetic energy source, a mixing tank, a pivot guide, and transfer shaft is used to drive a mixing paddle through a circular path within a tank without substantial shaft rotation. Sleeved and sleeveless mixing paddles are provided in combination with sealable mixing tanks. A volumetric compensation system responsive to tank wall deflection is used to maintain the internal volume of a mixing tank within predetermined limits. One mixing apparatus includes multiple mixing shafts and paddles coupled to at least one kinetic energy source. Methods for fabricating sleeved paddle-containing mixing apparatuses are further provided.

Abstract: The invention relates mainly to a disposable working place or chamber and in particular to a disposable isolator. The invention relates to a disposable isolator (1) defining a top portion (10) and a bottom portion (20), said top and bottom portions being linked together by one or more side walls (30) forming all together an inside portion (40), wherein said bottom portion (20) comprises at least one support area (21) for positioning at least one container (80), wherein said disposable isolator (1) comprises at least one filling means (12), wherein said filling means (12) and said support area (21) cooperating, independently or not, to position at least one container substantially in front of said filling means to fill said container by a product.

Abstract: The invention relates mainly to an apparatus comprising a chamber for physically and/or chemically treating one or more samples or products, said apparatus comprising a door for introducing samples inside the apparatus chamber or bringing samples outside the apparatus, said apparatus comprising a membrane or film defining a chamber wall inside said apparatus when the door is closed.

Abstract: The invention relates to a disposable production line. The invention relates notably to a process for manipulating, manufacturing or packaging products or devices under inert atmosphere, and/or sterile conditions and/or pyrogen free environment.

Abstract: An apparatus for processing one or more products in need of closure. The apparatus comprises a vessel including an inlet for receiving the one or more products and an outlet for discharging the one or more products under sterile and/or pyrogen free conditions. A device is also adapted for applying the closure to the one or more products in the vessel, along with the optional filling and/or weighing of the products before or after applying the closure. Related apparatuses, systems, and methods are disclosed.

Abstract: The invention relates mainly to an apparatus comprising a chamber for physically and/or chemically treating one or more samples or products, said apparatus comprising a door for introducing samples inside the apparatus chamber or bringing samples outside the apparatus, said apparatus comprising a membrane or film defining a chamber wall inside said apparatus when the door is closed.

Abstract: The invention relates mainly to a packaging which may be sterilized and/or depyroged. The invention relates in particular to a packaging for the sterilization or pyrogen free packaging for one or more packaged devices, said packaging comprising a valve or outlet tube.

Abstract: The invention relates to a disposable packaging item capable of being sterilised and/or depyrogenated. The invention in particular relates to the packaging of products and/or devices in the fields of medicine, pharmaceutics, chemistry, biology, food or electronics. The invention in particular relates to a disposable packaging item (1) at least partially produced with at least one thermoplastic film (10) that can withstand sterilisation and/or depyrogenation, said disposable packaging item (1) defining at least one inner enclosure (5) for receiving one or more elements (50) to be packaged, said inner enclosure (5) being under vacuum (40) and preferably sterile and/or depyrogenated, said packaging item (1) including one or more packaged elements (50).

Abstract: A mixing apparatus including a kinetic energy source, a mixing tank, a pivot guide, and transfer shaft is used to drive a mixing paddle through a circular path within a tank without substantial shaft rotation. Sleeved and sleeveless mixing paddles are provided in combination with sealable mixing tanks. A volumetric compensation system responsive to tank wall deflection is used to maintain the internal volume of a mixing tank within predetermined limits. One mixing apparatus includes multiple mixing shafts and paddles coupled to at least one kinetic energy source. Methods for fabricating sleeved paddle-containing mixing apparatuses are further provided.

Abstract: In an embodiment, an apparatus includes a disposable and flexible mixing tank, configurable as a bag, having a sealed sleeve therein for arrangement of a mixing device. The volume of the mixing tank is defined by an inner wall of the mixing tank and an inner wall of the sleeve. The mixing tank may be used to mix, store, reconstitute and/or dispense materials therein. Draining of a mixture may be aided with pressurized gas. Heating or cooling of the contents of a mixing tank may be accomplished with a thermal exchange fluid disposed within a thermal exchange vessel and in thermal communication with the tank.

Abstract: The invention relates to a disposable production line. The invention relates notably to a process for manipulating, manufacturing or packaging products or devices under inert atmosphere, and/or sterile conditions and/or pyrogen free environment.

Abstract: The invention relates to a plastic needle. The plastic needle of the invention is made of a polyarylethercetone polymer. The invention finds industrial applicability in particular in medical and analysis fields.