Abstract: The invention relates mainly to an apparatus comprising a chamber for physically and/or chemically treating one or more samples or products, said apparatus comprising a door for introducing samples inside the apparatus chamber or bringing samples outside the apparatus, said apparatus comprising a membrane or film defining a chamber wall inside said apparatus when the door is closed.

Abstract: The present invention relates to a disposable bioreactor including a flexible pouch made of a polymer material and in addition a single-use stirring system placed entirely within said pouch; said stirring system comprising a drive means and at least one stirring means driven in rotation by said drive means via magnetic coupling. The invention also relates to a single-use stirring system.

Abstract: The invention relates mainly to a disposable working place or chamber and in particular to a disposable isolator. The invention relates to a disposable isolator (1) defining a top portion (10) and a bottom portion (20), said top and bottom portions being linked together by one or more side walls (30) forming all together an inside portion (40), wherein said bottom portion (20) comprises at least one support area (21) for positioning at least one container (80), wherein said disposable isolator (1) comprises at least one filling means (12), wherein said filling means (12) and said support area (21) cooperating, independently or not, to position at least one container substantially in front of said filling means to fill said container by a product.

Abstract: The invention relates mainly to a packaging which may be sterilized and/or depyroged. The invention relates in particular to a packaging for the sterilization or pyrogen free packaging for one or more packaged devices, said packaging comprising a valve or outlet tube.

Abstract: In one embodiment, there is provided a method for producing a sterilized and pyrogen-free bag for storing fluids. The method includes providing a bag comprised of polymeric film and heating the bag to at least approximately 253 degrees Celsius for at least approximately 30 minutes for sterilization and pyrogen removal. The polymeric film is a polymer selected from the group of poly(oxy-1,4-phenylene-oxy -1,4-phenylene-carbonyl-1,4-phenylene) (PEEK); polytetrafluoroethylene (PTFE); a perfluoroalkoxy (PFA) polymer; poly(tetrafluoroethylene-co-perfluoromethyl vinyl ether) (MFA); polyperfluoro(ethylene-co-propylene)(FEP); poly(ethylene-alt-chlorotrifluoroethylene) (ECTFE); poly(ethylene-co-tetrafluoroethylene) (ETFE); poly(vinylidene fluoride) (PDVF); tetrafluoroethylene-co-hexafluoropropylene-co-vinylidene fluoride terpolymer (THV); poly(bisphenol A-co-4-nitrophthalic anhydride-co-1,3-phenylenediamine) (PEI); poly(4-methyl-1-pentene) (PMP); and suitable mixtures thereof.

Abstract: A disposable material processing apparatus, useable as a bioreactor or fermenter, includes a hollow tank (101) and a mixing paddle (110) disposed within the interior of the tank and adapted to mix contents therein. The paddle may be isolated within a flexible sleeve (140). Various functional elements, such as a sparger, sensor, material extraction conduit, material addition conduit, and/or heat exchange element may be provided, and optionally arranged to travel with the paddle within the tank interior. Baffles may protrude into a mixing tank to enhance mixing. A tank and/or sleeve may comprise polymeric film materials.

Abstract: A mixing apparatus including a kinetic energy source, a mixing tank, a pivot guide, and transfer shaft is used to drive a mixing paddle through a circular path within a tank without substantial shaft rotation. Sleeved and sleeveless mixing paddles are provided in combination with sealable mixing tanks. A volumetric compensation system responsive to tank wall deflection is used to maintain the internal volume of a mixing tank within predetermined limits. One mixing apparatus includes multiple mixing shafts and paddles coupled to at least one kinetic energy source. Methods for fabricating sleeved paddle-containing mixing apparatuses are further provided.

Abstract: In an embodiment, an apparatus includes a disposable and flexible mixing tank, configurable as a bag, having a sealed sleeve therein for arrangement of a mixing device. The volume of the mixing tank is defined by an inner wall of the mixing tank and an inner wall of the sleeve. The mixing tank may be used to mix, store, reconstitute and/or dispense materials therein. Draining of a mixture may be aided with pressurized gas. Heating or cooling of the contents of a mixing tank may be accomplished with a thermal exchange fluid disposed within a thermal exchange vessel and in thermal communication with the tank.

Abstract: In one embodiment, a method includes puncturing, with a piercing element of a hollow connector, an opening of a membrane that encloses the hollow connector in a gas that is essentially sterile. The puncturing of the opening of the membrane generates a laminar flow of the gas along sides of the opening. The method also includes transferring the fluids, through the opening with the piercing element of the hollow connector.

Abstract: In an embodiment, an apparatus includes a disposable and flexible mixing tank, configurable as a bag, having a sealed sleeve therein for arrangement of a mixing device. The volume of the mixing tank is defined by an inner wall of the mixing tank and an inner wall of the sleeve. The mixing tank may be used to mix, store, reconstitute and/or dispense materials therein. Draining of a mixture may be aided with pressurized gas. Heating or cooling of the contents of a mixing tank may be accomplished with a thermal exchange fluid disposed within a thermal exchange vessel and in thermal communication with the tank.

Abstract: In an embodiment, an apparatus includes a disposable and flexible mixing tank having a sealed sleeve therein for arrangement of a mixing device. The volume of the mixing tank is defined by an inner wall of the mixing tank and an inner wall of the sleeve. The mixing tank may be used to mix, store, reconstitute and/or dispense materials therein.

Abstract: A connector is provided for forming a substance transfer pathway between two or more volumes without exposing the interior contents of the volumes to an exterior environment. A removable cover is provided over a flap-defining membrane or boundary element, wit h the flap including an adhesive. Two receptacles and/or conduits may be connected to one another with corresponding connectors by removing the covers, registering the flaps, joining the receptacles and/or conduits, and then freeing the flaps from the surrounding membranes.

Abstract: The invention relates to a plastic needle. The plastic needle of the invention is made of a polyarylethercetone polymer. The invention finds industrial applicability in particular in medical and analysis fields.

Abstract: In one embodiment, there is provided a method for producing a sterilized and pyrogen-free bag for storing fluids. The method includes providing a bag comprised of polymeric film and heating the bag to at least approximately 253 degrees Celsius for at least approximately 30 minutes for sterilization and pyrogen removal. The polymeric film is a polymer selected from the group of poly(oxy-1,4-phenylene-oxy-1,4-phenylene-carbonyl-1,4-phenylene) (PEEK); polytetrafluoroethylene (PTFE); a perfluoroalkoxy (PFA) polymer; poly(tetrafluoroethylene-co-perfluoromethyl vinyl ether) (MFA); polyperfluoro(ethylene-co-propylene)(FEP); poly(ethylene-alt-chlorotrifluoroethylene) (ECTFE); poly(ethylene-co-tetrafluoroethylene) (ETFE); poly(vinylidene fluoride) (PDVF); tetrafluoroethylene-co-hexafluoropropylene-co-vinylidene fluoride terpolymer (THV); poly(bisphenol A-co-4-nitrophthalic anhydride-co-1,3-phenylenediamine) (PEI); poly(4-methyl-1-pentene) (PMP); and suitable mixtures thereof.

Abstract: In an embodiment, an apparatus includes a conduit. The apparatus also includes two or more flexible compartments. Each of the two or more flexible compartments has an interior wall defining a storage area configured to house a substance. Each of the two or more flexible compartments includes a distal end and a proximal end. The proximal ends of the two or more flexible compartments are coupled to the conduit such that the conduit defines a passageway between the two or more flexible compartments. A diameter of the storage area at the proximal end is less than a diameter of the storage area at the distal end.

Abstract: In an embodiment, an apparatus includes a disposable and flexible mixing tank having a sealed sleeve therein for arrangement of a mixing device. The volume of the mixing tank is defined by an inner wall of the mixing tank and an inner wall of the sleeve. The mixing tank may be used to mix, store, reconstitute and/or dispense materials therein.

Abstract: In one embodiment, a method includes puncturing, with a piercing element of a hollow connector, an opening of a membrane that encloses the hollow connector in a gas that is essentially sterile. The puncturing of the opening of the membrane generates a laminar flow of the gas along sides of the opening. The method also includes transferring the fluids, through the opening with the piercing element of the hollow connector.

Abstract: In one embodiment, there is a method for storing fluids in a bag that has an inner lining that is essentially sterilized and essentially free of pyrogen. The method comprises heating the bag that is comprised of a polymeric film to at least approximately 253° Celsius. The polymeric film includes a polymer selected from the group of poly(oxy-1,4-phenylene-oxy-1,4-phenylene-carbonyl-1,4-phenylene) (PEEK); polytetrafluoroethylene (PTFE); a perfluoroalkoxy (PFA) polymer; poly(tetrafluoroethylene-co-perfluoromethyl vinyl ether) (MFA); polyperfluoro(ethylene-co-propylene) (FEP); poly(ethylene-alt-chlorotrifluoroethylene) (ECTFE); poly(ethylene-co-tetrafluoroethylene) (ETFE); poly(vinylidene fluoride) (PDVF); tetrafluoroethylene-co-hexafluoropropylene-co-vinylidene fluoride terpolymer (THV); ultra-high molecular weight polyethylene (UHMW PE); (poly(bisphenol A-co-4-nitrophthalic anhydride-co-1,3-phenylenediamine) (PEI); poly(4-methyl-1-pentene) (PMP); and suitable mixtures thereof.

Abstract: In an embodiment, an apparatus includes a conduit. The apparatus also includes two or more flexible compartments. Each of the two or more flexible compartments has an interior wall defining a storage area configured to house a substance. Each of the two or more flexible compartments includes a distal end and a proximal end. The proximal ends of the two or more flexible compartments are coupled to the conduit such that the conduit defines a passageway between the two or more flexible compartments. A diameter of the storage area at the proximal end is less than a diameter of the storage area at the distal end.

Abstract: In an embodiment, an apparatus includes a disposable and flexible mixing tank, configurable as a bag, having a sealed sleeve therein for arrangement of a mixing device. The volume of the mixing tank is defined by an inner wall of the mixing tank and an inner wall of the sleeve. The mixing tank may be used to mix, store, reconstitute and/or dispense materials therein. Draining of a mixture may be aided with pressurized gas. Heating or cooling of the contents of a mixing tank may be accomplished with a thermal exchange fluid disposed within a thermal exchange vessel and in thermal communication with the tank.