Patents by Inventor Jean-Paul Rene Marie Andre Bosmans

Jean-Paul Rene Marie Andre Bosmans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5HT-antagonists
    Patent number: 8334304
    Abstract: The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: December 18, 2012
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jean-Paul Rene Marie Andre Bosmans, Henricus Jacobus Maria Gijsen, Laurence Anne Mevellec
  • Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
    Patent number: 8318742
    Abstract: The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impairment of gastric emptying.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: November 27, 2012
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jean-Paul René Marie André Bosmans, Michel Anna Jozef DeCleyn, Michel Surkyn
  • Equilibrative nucleoside transporter ENT1 inhibitors
    Patent number: 8263592
    Abstract: The present invention is related to novel compounds of formula (I) having equilibrative nucleoside transporter ENT1 inhibiting properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of diseases linked to the inhibition of ENT1 receptors in animals, in particular humans.
    Type: Grant
    Filed: November 13, 2008
    Date of Patent: September 11, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Jean-Paul René Marie André Bosmans, Didier Jean-Claude Berthelot, Serge Maria Aloysius Pieters, Bie Maria Pieter Verbist, Michel Anna Jozef De Cleyn
  • Bicyclic Benzamides of 3-Or-4-Substituted 4-(Aminomethyl)-Piperidine Derivatives
    Publication number: 20120028987
    Abstract: The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impairment of gastric emptying.
    Type: Application
    Filed: September 20, 2011
    Publication date: February 2, 2012
    Applicant: JANSSEN PHARMACEUTICA N.V.
    Inventors: Jean-Paul René Marie André Bosmans, Michel Anna Jozef DeCleyn, Michel Surkyn
  • Bicyclic benzamides of 3-or 4-substituted 4-(aminomethyl)-piperidine derivatives
    Patent number: 8063070
    Abstract: The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impairment of gastric emptying.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: November 22, 2011
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jean-Paul René Marie André Bosmans, Michel Anna Jozef De Cleyn, Michel Surkyn
  • Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
    Patent number: 7790750
    Abstract: The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R1 and R2 taken together form a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C1-6alkyl; R3 is hydrogen or halo; R4 is hydrogen or C1-6alkyl; R5 is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone, C2-6alkenyl, or L is a radical of formula -Alk-R6—, Alk-X—R7, -Alk-Y—C(?O)—R9, or -Alk-Y—C(?O)—NR11R12 wherein each Alk is C1-12alkanediyl; and R6 is hydrogen, cyano, C1-6alkylsulfonylamino, C3-6cycloalkyl, C5-6cycloalkanone, or a heterocyclic ringsystem; R7 is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C3-6cycloalkyl, or a heterocyclic ringsystem; X is O, S, SO2 or NR8; said R8 being hydrogen or C1-6alkyl; R9 is hydrogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy or hydroxy; Y is NR10 or a direct bond; said R10 being hydrogen, or C1-6alkyl; R11 and R12 each indepen
    Type: Grant
    Filed: October 20, 2006
    Date of Patent: September 7, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jean-Paul René Marie André Bosmans, Michel Anna Jozef De Cleyn, Michel Surkyn
  • Bicyclic Benzamides of 3-or 4-Substituted 4-(Aminomethyl)-Piperidine Derivatives
    Publication number: 20100210657
    Abstract: The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impairment of gastric emptying.
    Type: Application
    Filed: May 4, 2010
    Publication date: August 19, 2010
    Applicant: JANSSEN PHARMACEUTICA N.V.
    Inventors: Jean-Paul René Marie André Bosmans, Michel Anna Jozef De Cleyn, Michel Surkyn
  • Heterocyclic substituted 4-(aminomethyl)-piperidine benzamides as 5HT-antagonists
    Patent number: 7732464
    Abstract: The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: June 8, 2010
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jean-Paul René Marie André Bosmans, Henricus Jacobus Maria Gijsen, Laurence Anne Mevellec
  • Aminosulfonyl Substituted 4-(Aminomethyl)-Piperidine Benzamides As 5HT 4-Antagonists
    Publication number: 20100087483
    Abstract: The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.
    Type: Application
    Filed: December 8, 2009
    Publication date: April 8, 2010
    Inventors: Jean-Paul René Marie André BOSMANS, Henricus Jacobus Maria GIJSEN, Laurence Anne MEVELLEC
  • Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5HT-antagonists
    Patent number: 7652040
    Abstract: The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: January 26, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jean-Paul René Marie André Bosmans, Henricus Jacobus Maria Gijsen, Laurence Anne Mevellec
  • 4-(aminomethyl)-piperidine benzamides as 5HT-antagonists
    Patent number: 7638535
    Abstract: The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: December 29, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jean-Paul René Marie André Bosmans, Henricus Jacobus Maria Gijsen, Laurence Anne Mevellec
  • 5HT-antagonistic 4-(aminomethyl)-piperidine benzamides
    Patent number: 7635706
    Abstract: The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.
    Type: Grant
    Filed: August 10, 2004
    Date of Patent: December 22, 2009
    Assignee: Janssen Pharmaceutica NV
    Inventors: Jean-Paul René Marie André Bosmans, Henricus Jacobus Maria Gijsen, Laurence Anne Mevellec
  • Hydroxycarbonylphenyl substituted 4-(aminomethyl)-piperidine benzamides as 5HTantagonists
    Patent number: 7498347
    Abstract: The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: March 3, 2009
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jean-Paul René Marie André Bosmans, Henricus Jacobus Maria Gijsen, Laurence Anne Mevellec
  • 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
    Patent number: 7205410
    Abstract: The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, —R1—R2— is a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C1-6alkyl or hydroxy; R3 is hydrogen or halo; R4 is hydrogen or C1-6alkyl; R5 is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, oxoC5-6cycloalkyl, C2-6alkenyl, or L is a radical of formula -Alk-R6—, Alk-X—R7, -Alk-Y—C(?O)—R9, or -Alk-Y—C(?O)—NR11R12 wherein each Alk is C1-12alkanediyl; and R6 is hydrogen, amino, cyano, C1-6alkylsulfonylamino, C3-6cycloalkyl, oxoC5-6cycloalkyl, aryl or a heterocyclic ringsystem; R7 is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C3-6cycloalkyl, aryl or a heterocyclic ringsystem; X is O, S, SO2 or NR8; said R8 being hydrogen or C1-6alkyl; R9 is hydrogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy, hydroxy or aryl; Y is a direct bond or NR10; said R10 being hydrogen, or C1-6alkyl; R11 and R
    Type: Grant
    Filed: January 29, 2003
    Date of Patent: April 17, 2007
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jean-Paul René Marie André Bosmans, Ann Louise Gabriëlle Meulemans, Michel Anna Jozef De Cleyn, Henricus Jacobus Maria Gijsen
  • (+)-Norcisapride
    Publication number: 20040176414
    Abstract: The present invention concerns (+)-norcisapride, and its pharmaceutically acceptable acid additions salts, a process for preparing said compound, and its use for the manufacture of a medicament for treating gastro-intestinal disorders while avoiding central nervous system effects. Also provided are method of treating gastro-intestinal disorders.
    Type: Application
    Filed: March 23, 2004
    Publication date: September 9, 2004
    Inventors: Jozef Jan Pieter Heykants, Antonius Adrianus Hendrikus Petrus Megens, Willem Emiel Gustaaf Meuldermans, Joannes Adrianus Jacobus Schuurkes, Jean-Paul Rene Marie Andre Bosmans
  • Gastrokinetic monocyclic benzamides of 3-or 4-substituted 4-(aminoethyl)-piperidine derivatives
    Patent number: 6750349
    Abstract: The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R1 is C1-6alkyloxy, C2-6alkenyloxy or C2-6alkynyl-oxy; R2 is hydrogen, C1-6alkyl C1-6alkyloxy; R3 is hydrogen or halo; R4 is hydrogen or C1-6alkyl; R5 is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone, C2-6alkenyl, or L is a radical of formula —Alk—R6—, Alk-X—R7, —Alk—Y—C(═O)—R9, or —Alk—Y—C(═O)—NR11R12 wherein each Alk is C1-12alkanediyl; and R6 is hydrogen, cyano, C1-6alkylsulfonylamino, C3-6cycloalkyl, C5-6cycloalkanone, or a heterocyclic ringsystem; R7 is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C3-6cycloalkyl, or a heterocyclic ringsystem; X is O, S, SO2 or NR8; said R8 being hydrogen or C1-6alkyl; R9 is hydrogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy or hydroxy; Y is NR10 or a direct bond; said R10 being hydrogen, or
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: June 15, 2004
    Assignee: Janssen Pharmaceutics, N.V.
    Inventors: Jean-Paul René Marie André Bosmans, Michel Anna Jozef De Cleyn, Michel Surkyn
  • Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
    Publication number: 20040058958
    Abstract: The present invention of compounds of formula (I) 1
    Type: Application
    Filed: August 19, 2003
    Publication date: March 25, 2004
    Inventors: Jean-Paul Rene Marie Andre Bosmans, Michel Anna Jozef De Cleyn, Michel Surkyn
  • Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
    Patent number: 6635643
    Abstract: The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R1 and R2 taken together form a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C1-6alkyl; R3 is hydrogen or halo; R4 is hydrogen or C1-6alkyl; R5 is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone, C2-6alkenyl, or L is a radical of formula —Alk—R6—, Alk—X—R7, —Alk—Y—C(═O)—R9, or —Alk—Y—C(═O)— NR11R12 wherein each Alk is C1-12alkanediyl; and R6 is hydrogen, cyano, C1-6alkylsulfonylamino, C3-6cycloalkyl, C5-6cycloalkanone, or a heterocyclic ringsystem; R7 is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C3-6cycloalkyl, or a heterocyclic ringsystem; X is O, SO2 or NR8; said R8 being hydrogen or C1-6alkyl; R9 is hydrogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy or
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: October 21, 2003
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jean-Paul René Marie André Bosmans, Michel Anna Jozef De Cleyn, Michel Surkyn
  • 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
    Publication number: 20030181456
    Abstract: The present invention of compounds of formula (I) 1
    Type: Application
    Filed: January 29, 2003
    Publication date: September 25, 2003
    Inventors: Jean-Paul Rene Marie Andre Bosmans, Ann Louise Gabrielle Meulemans, Michel Anna Jozef De Cleyn, Henricus Jacobus Maria Gijsen
  • Bicyclic benzamides of 3-or 4-substituted 4-(aminomethyl)-piperidine derivatives
    Patent number: RE40793
    Abstract: The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R1 and R2 taken together form a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C1-6alkyl; R3 is hydrogen or halo; R4 is hydrogen or C1-6alkyl; R5 is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone, C2-6alkenyl, or L is a radical of formula —Alk—R6—, Alk—X—R7, —Alk—Y—C(?O)—R9, or —Alk—Y—C (?O)—NR11R12 wherein each Alk is C1-12alkanediyl; and R6 is hydrogen, cyano, C1-6alkylsulfonylamino, C3-6cycloalkyl, C5-6cycloalkanone, or a heterocyclic ring-system; R7 is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C3-6cycloalkyl, or a heterocyclic ringsystem; X is O, SO2 or NR8; said R8 being hydrogen or C1-6alkyl; R9 is hydrogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy or hydroxy; Y is NR10 or a direct bond; said R10 being hydrogen, or C1-6alkyl; R11 and R12 each independ
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: June 23, 2009
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jean-Paul Renë Marie Andrë Bosmans, Michel Anna Jozef DeCleyn, Michel Surkyn