Patents by Inventor Jean-Paul Rene Marie Andre Bosmans
Jean-Paul Rene Marie Andre Bosmans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20030078427Abstract: The present invention of compounds of formula (I) 1Type: ApplicationFiled: June 5, 2002Publication date: April 24, 2003Inventors: Jean-Paul Rene Marie Andre Bosmans, Michel Anna Jozef De Cleyn, Michel Surkyn
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Patent number: 6544997Abstract: The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, —R1—R2— is a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C1-6alkyl or hydroxy; R3 is hydrogen or halo; R4 is hydrogen or C1-6alkyl; R5 is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, oxoC5-6cycloalkyl, C2-6alkenyl, or L is a radical of formula —Alk—R6—, Alk—X—R7, —Alk—Y—C(═O)—R9, or —Alk—Y—C(═O)—NR11R12 wherein each Alk is C1-12alkanediyl; and R6 is hydrogen, amino, cyano, C1-6alkylsulfonylamino, C3-6cycloalkyl, oxoC5-6cycloalkyl, aryl or a heterocyclic ringsystem; R7 is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C3-6cycloalkyl, aryl or a heterocyclic ringsystem; X is O, S, SO2 or NR8; said R8 being hydrogen or C1-6alkyl; R9 is hydrogen, C1-6alkyl, C3-Type: GrantFiled: June 8, 2001Date of Patent: April 8, 2003Assignee: Janssen Pharmaceutica, N.V.Inventors: Jean-Paul René Marie André Bosmans, Ann Louise Gabriëlle Meulemans, Michel Anna Jozef De Cleyn, Henricus Jacobus Maria Gijsen
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Patent number: 6452013Abstract: The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R1 is C1-6alkyloxy, C2-6alkenyloxy or C2-6alkynyl-oxy; R2 is hydrogen, C1-6alkyl C1-6alkyloxy; R3 is hydrogen or halo; R4 is hydrogen or C1-6alkyl; R5 is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone, C2-6alkenyl, or L is a radical of formula —Alk—R6—, Alk—X—R7, -Alk-Y—C(═O)—R9, or -Alk-Y—C(═O)—NR11R12 wherein each Alk is C1-12alkanediyl; and R6 is hydrogen, cyano, C1-6alkylsulfonylamino, C3-6cycloalkyl, C5-6cycloalkanone, or a heterocyclic ringsystem; R7 is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C3-6cycloalkyl, or a heterocyclic ringsystem; X is O, S, SO2 or NR8; said R8 being hydrogen or C1-6alkyl; R9 is hydrogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy or hydroxy; Y is NR10 or a direct bond; said R10 being hydrogen, or C1-6alkyl; R11 anType: GrantFiled: January 5, 2000Date of Patent: September 17, 2002Assignee: Janssen Pharmaceutica N.V.Inventors: Jean-Paul René Marie André Bosmans, Michel Anna Jozef De Cleyn, Michel Surkyn
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Publication number: 20020086879Abstract: The present invention of compounds of formula (I) 1Type: ApplicationFiled: February 22, 2001Publication date: July 4, 2002Inventors: Jean-Paul Rene Marie Andre Bosmans, Michel Anna Jozef De Cleyn, Michel Surkyn
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Patent number: 6395742Abstract: The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein Alk is C1-6alkanediyl or C3-6alkenediyl; R1 is hydrogen or C1-4alkyl; R2 and R3 each independently are hydrogen, C1-6alkyl or C3-7cycloalkyl; or R2 and R3 may also be taken together with the nitrogen atom to which they are attached, thus forming a pyrrolidine, a piperidine or a perhydro azepine ring; R4 is hydrogen or halo; Q is aryl, aryloxy, di(aryl)methyl or heteroaryl; aryl is naphthyl or phenyl, said naphthyl and phenyl may optionally be substituted; and heteroaryl is quinolinyl, isoquinolinyl, pyridinyl, thienyl, indolyl, 2,3-dihydro-1,4-benzodioxinyl, 2,3-dihydro-benzofuranyl or benzodioxolanyl; said heteroaryls may optionally be substituted; it further relates to processes for their preparation, compositions comprising them as well as their use as a medicine; compounds of formula (I) containing a radioactivType: GrantFiled: September 22, 2000Date of Patent: May 28, 2002Assignee: Janssen Pharmaceutica N.V.Inventors: Jean-Paul René Marie André Bosmans, Christopher John Love, Guy Rosalia Eugène Van Lommen
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Patent number: 6310077Abstract: The present invention is concerned with a novel benzamide of formula (I). Pharmaceutical compositions comprising said novel compounds, process for preparing compounds and compositions, and the use thereof as a medicine, in particular in the treatment of conditions involving a decreased motility of the intestine are described.Type: GrantFiled: June 4, 1999Date of Patent: October 30, 2001Assignee: Janssen Pharmaceutica N.V.Inventors: Georges H. P. Van Daele, Jean-Paul René Marie André Bosmans, Joannes Adrianus Jacobus Schuurkes
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Patent number: 6159982Abstract: The present invention concerns the compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, wherein Alk is C.sub.1-6 alkanediyl or C.sub.3-6 alkenediyl; R.sup.1 is hydrogen or C.sub.1-4 alkyl; R.sup.2 and R.sup.3 each independently are hydrogen, C.sub.1-6 alkyl or C.sub.3-7 cycloalkyl; or R.sup.2 and R.sup.3 may also be taken together with the nitrogen atom to which they are attached, thus forming a pyrrolidine, a piperidine or a perhydro azepine ring; R.sup.Type: GrantFiled: November 9, 1998Date of Patent: December 12, 2000Assignee: Janssen Pharmaceutica N. V.Inventors: Jean-Paul Rene Marie Andre Bosmans, Christopher John Love, Guy Rosalia Eugene Van Lommen
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Patent number: 5990159Abstract: The present invention concerns the use of receptor antagonists of the 5HT4 receptor for avoiding, alleviating, suppressing or overcoming the gastrointestinal side-effects of serotonin reuptake inhibitors. The present invention also concerns pharmaceutical formulations comprising 5HT4-receptor antagonists for alleviating, suppressing or overcoming the gastrointestinal side-effects of serotonin reuptake inhibitors, as well as pharmaceutical compositions comprising 5HT4 receptor antagonists and serotonin reuptake inhibitors.Type: GrantFiled: August 11, 1998Date of Patent: November 23, 1999Assignee: Janssen Pharmaceutica, N.V.Inventors: Ann Louise Gabrielle Meulemans, Jean-Paul Rene Marie Andre Bosmans
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Patent number: 5948794Abstract: The present invention is concerned with a novel benzamide derivative for formula (I). ##STR1## Pharmaceutical compositions comprising said novel compounds, processes for preparing compounds and compositions, and the use thereof as a medicine, in particular in the treatment of conditions involving a decreased motility of the intestine are described.Type: GrantFiled: September 24, 1998Date of Patent: September 7, 1999Assignee: Janssen Pharmaceutica, N.V.Inventors: Georges H. P. Van Daele, deceased, Marie-Louise Hendrickx, heir, Kurt Godfried Cornelius Emile Van Daele, heir, Peter Jules Victor Van Daele, heir, Glenn Kurt Ludo Van Daele, heir, Jean-Paul Rene Marie Andre Bosmans, Joannes Adrianus Jacobus Schuurkes
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Patent number: 5872131Abstract: The present invention is concerned with novel benzoate derivatives having the formula ##STR1## the N-oxide forms, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R.sup.1 is halo or C.sub.1-6 alkylsulfonylamino; either R.sup.2 is hydrogen and R.sup.3 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.2-6 alkynyl; or R.sup.2 and R.sup.3 taken together form a bivalent radical of formula --CH.dbd.CH-- (a), --(CH.sub.2).sub.2 -- (b), or --(CH.sub.2).sub.3 -- (c); in the bivalent radicals of formula (a), (b) or (c) one or two hydrogen atoms may be replaced by C.sub.1-6 alkyl; Alk is C.sub.1-6 alkanediyl; R.sup.4 is hydrogen or C.sub.1-6 alkyloxy; R.sup.5, R.sup.6 and R.sup.7 each independently are hydrogen, halo, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy; or R.sup.5 and R.sup.6 taken together may also form a bivalent radical of formula: --NR.sup.8 C(O)NR.sup.9 --, --NH--C(NHR.sup.10).dbd.N--, --O--(CH.sub.2).sub.m --O--; R.sup.8 and R.sup.Type: GrantFiled: March 24, 1997Date of Patent: February 16, 1999Assignee: Janssen Pharmaceutica, N.V.Inventors: Marie-Louise Hendrickx, Kurt Godfried Cornelius Emile Van Daele, Peter Jules Victor Van Daele, Glenn Kurt Ludo Van Daele, Jean-Paul Rene Marie Andre Bosmans, Marc Gustaaf Celine Verdonck
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Patent number: 5863923Abstract: Method of treating 5-HT.sub.3 -mediated disorders, which comprises systemic administration of an effective amount of a compound of formula (I) ##STR1## the pharmaceutically acceptable acid addition salt forms and the stereochemically isomeric forms thereof, wherein R.sup.1 and R.sup.2 represent hydrogen, or R.sup.1 and R.sup.2 taken together form a bivalent radical of formula --CH.dbd.CH--CH.dbd.CH-- (a), --CH.dbd.C(Cl)--CH.dbd.CH--(b) or --CH.dbd.CH--C(Cl)=CH-- (c); n represents 2, 3 or 4; R.sup.3 represents hydrogen or methoxy; m represents 1 or 2; R.sup.4 represents hydrogen, amino or C.sub.1-3 -alkylcarbonylamino; and R.sup.5 represents hydrogen or halo; novel compounds; compositions; processes for preparing novel compounds and intermediates.Type: GrantFiled: May 1, 1997Date of Patent: January 26, 1999Assignee: Janssen Pharmaceutica N.V.Inventors: Georges Henri Paul Van Daele, Jean-Paul Rene Marie Andre Bosmans, Willy Joannes Carolus Van Laerhoven
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Patent number: 5854261Abstract: The present invention concerns novel oxadiazole derivatives of formula (I) ##STR1## the N-oxide forms, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R.sup.1 is hydrogen or halo; R.sup.2 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.2-6 alkynyl; R.sup.3 is hydrogen; or R.sup.2 and R.sup.3 taken together may form a C.sub.2-3 alkanediyl radical wherein one or two hydrogen atoms may be replaced by C.sub.1-4 alkyl; R.sup.4 is hydrogen or C.sub.1-6 alkyloxy; X is a bivalent radical of the formula ##STR2## L is a radical of formula -Alk-R.sup.5 or -Alk--O--R.sup.6, Alk is C.sub.1-12 alkanediyl; R.sup.5 is hydrogen, cyano, C.sub.1-6 alkylcarbonyl, C.sub.1-6 alkylsulfinyl, C.sub.1-6 alkylsulfonyl, aryl, arylcarbonyl, tetrahydrofuran, dioxolane, dioxolane substituted with C.sub.1-6 alkyl, dioxane, dioxane substituted with C.sub.1-6 alkyl; R.sup.6 is hydrogen, aryl, C.sub.1-6 alkyl, hydroxyC.sub.1-6 alkyl, C.sub.Type: GrantFiled: August 15, 1997Date of Patent: December 29, 1998Assignee: Janssen Pharmaceutica N.V.Inventor: Jean-Paul Rene Marie Andre Bosmans
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Patent number: 5854260Abstract: The present invention is concerned with a novel benzamide derivative of formula (I). ##STR1## Pharmaceutical compositions comprising said novel compounds, processes for preparing compounds and compositions, and the use thereof as a medicine, in particular in the treatment of conditions involving a decreased motility of the intestine are described.Type: GrantFiled: April 30, 1997Date of Patent: December 29, 1998Assignee: Janssen Pharmaceutica, N.V.Inventors: Georges H. P. Van Daele, deceased, Jean-Paul Rene Marie Andre Bosmans, Joannes Adrianus Jacobus Schuurkes
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Patent number: 5674868Abstract: Method of treating 5-HT.sub.3 -mediated disorders, which comprises systemic administration of an effective amount of a compound of formula (I) ##STR1## the pharmaceutically acceptable acid addition salt forms and the stereochemically isomeric forms thereof, wherein R.sup.1 and R.sup.2 represent hydrogen, or R.sup.1 and R.sup.2 taken together form a bivalent radical of formula --CH.dbd.CH--CH.dbd.CH-- (a), --CH.dbd.C(Cl)--CH.dbd.CH-- (b) or --CH.dbd.CH--C(Cl).dbd.CH-- (c); n represents 2, 3 or 4; R.sup.3 represents hydrogen or methoxy; m represents 1 or 2; R.sup.4 represents hydrogen, amino or C.sub.1-3 -alkylcarbonylamino; and R.sup.5 represents hydrogen or halo; novel compounds; compositions; processes for preparing novel compounds and intermediates.Type: GrantFiled: June 16, 1995Date of Patent: October 7, 1997Assignee: Janssen Pharmaceutica N.V.Inventors: Georges Henri Paul Van Daele, Jean-Paul Rene Marie Andre Bosmans, Willy Joannes Carolus Van Laerhoven