Abstract: A cap and container assembly includes a container having a base and a side wall extending upward from the base. The base and the side wall define an interior, and the side wall defines an opening leading to the interior. A cap moves with respect to the container between an opened position in which the opening is exposed, and a closed position in which the cap covers the opening. A tab projects outward from the cap and has a bottom surface. A spacer projects from the container side wall at a location beneath the tab when the assembly is in the closed position. The spacer bends inward towards the container in response to application of a sufficient force, to move from a locked position that blocks the bottom surface of the tab, to an unlocked position to expose at least a portion of the bottom surface of the tab.

Abstract: Disclosed are plunger assemblies including various convertible plungers and methods of making the same. Each plunger assembly is configured for disposition within a barrel of a medical container, e.g., a syringe, and displaced within the barrel from an engagement position to a release position. The engagement position is configured to provide a compression seal between a storage sealing section of the plunger and an inner wall of the syringe barrel. In the release position, the compression seal is reduced or eliminated. Also disclosed are methods for making convertible plungers and as assembling them into syringes, e.g., pre-filled syringes.

Abstract: A container (20) includes a body (22) defining an interior and an opening (32) that leads to the interior. A cap (24) is removably affixed over the opening and is movable between a closed position and an opened position. The cap includes a front tab (52) having an undersurface (54). A child resistant closure in the form of a guard (56) having a depressible wall (58) is located on the body and is movable between an engaged position and a disengaged position. When in the engaged position the guard covers the undersurface of the front tab to prevent the cap from being moved to the opened position. When in the disengaged position the undersurface of the front tab is exposed, enabling the cap to be moved to the opened position.

Abstract: A pre-filled pharmaceutical package comprising a liquid formulation of a VEGF-antagonist, for example Ranibizumab, inside the package. A nonlimiting example of the package can be a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer. Optionally, the package further comprises a bag, a blister, a pouch or any other vessel. Stability performance of the VEGF-antagonist packaged in the coated COP vessel comparable to or better than glass was obtained. The said pre-filled pharmaceutical package comprising a liquid formulation of a VEGF-antagonist is suitable for sterilization (such as for surface and/or terminal sterilization) with sterilization gas residuals being minimal and/or lower than required by ISO 10993-7.

Abstract: Containers with closures are disclosed. A closure may include at least a polymer orifice reducer configured to be permanently secured to a rim of an opening of a container and a flexible tamper evident seal disposed on the topside of the orifice reducer. The flexible tamper evident seal, optionally foil, covers one or more openings in the orifice reducer. Processes for permanently securing a closure to a container, optionally by forming a heat seal between the orifice reducer and container rim, are also disclosed.

Abstract: A liquid formulation of an ophthalmic drug in a pre-filled pharmaceutical package, for example a syringe, cartridge, vial or any other vessel made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer. A blister, a pouch, a bag, a tray or a tub may encompass as a secondary packaging the syringe, vial, cartridge, tube or any other vessel. The package is suitable for sterilization (e.g., surface and/or terminal sterilization) with sterilization gas residuals being minimal and/or lower than required by ISO 10993-7; and/or the stability of the ophthalmic drug is maintained, during a prolonged time period following the sterilization. The sterilization gas may be EO, propylene oxide, chlorine dioxide, nitrogen dioxide, or vaporized hydrogen peroxide (VHP), among others.

Abstract: An inhaler for facilitating inhalation of dry powder includes a body defining an interior space and a mouth piece. At least one annular member is positioned within the interior space and is rotatable with respect to the mouth piece. The at least one annular member includes a plurality of compartments. Each compartment defines a cavity configured to hold dry powder. Each compartment includes at least one flap and an opening configured to release the dry powder when the at least one flap is reconfigured from a closed position to an open position. The at least one flap covers the opening and inhibits the dry powder from being released from the cavity in the closed position.

Abstract: A process is provided for making a walled structure using an injection molding apparatus. The apparatus has a molding space formed between a mold cavity and an inner core disposed within the mold cavity. The molding space defines a shape of the structure. The process includes injecting molding material into the molding space, moving or retaining a portion of a movable impression member protruding from the inner core within a portion of the molding space so as to create a recess within an inner wall of the structure, and retracting the impression member into the inner core such that the impression member is cleared from the molding space.

Abstract: A dose ring for a dry powder inhaler (DPI) device includes an aluminum foil member covering particulate medication cavities and through holes. The device includes hinged flaps formed by a cut so that one radial side is uncut and forms a hinge. Each flap can cover both a cavity for particulate medication and a through hole located between that cavity and the circular inside edge of the dose ring.

Abstract: Containers with closures are disclosed. A closure may include at least a polymer orifice reducer configured to be permanently secured to a rim of an opening of a container and a flexible tamper evident seal disposed on the topside of the orifice reducer. The flexible tamper evident seal, optionally foil, covers one or more openings in the orifice reducer. Processes for permanently securing a closure to a container, optionally by forming a heat seal between the orifice reducer and container rim, are also disclosed.

Abstract: A convertible plunger is provided comprising an internal portion and a generally cylindrical exterior surface. At least a portion of the exterior surface is maintained in an initial expanded state by a property of the internal portion. The expanded state is reducible to a constricted state by an operation that is applied to the internal portion of the plunger to alter the property. A film coating may also be applied to a sidewall of the sleeve to reduce a sliding friction between the sleeve and barrel. A film coating may also be applied to a nose cone of the plunger to provide a barrier between the plunger and product in the barrel.

Abstract: Containers with closures are disclosed. A closure may include at least a polymer orifice reducer configured to be permanently secured to a rim of an opening of a container and a flexible tamper evident seal disposed on the topside of the orifice reducer. The flexible tamper evident seal, optionally foil, covers one or more openings in the orifice reducer. Processes for permanently securing a closure to a container, optionally by forming a heat seal between the orifice reducer and container rim, are also disclosed.

Abstract: A needle includes a hollow needle body. The needle body includes a sharp and a proximal end portion located opposite the sharp and defining an opening. The needle body has at least one thru hole and a lumen. The thru hole is located at or proximate the sharp. The lumen is provided between the thru hole and the opening of the end portion. The needle body is constructed of a blend of a polymeric base material for providing flexibility, and a fiber material for providing rigidity.

Abstract: A dosage dispensing cap and container assembly and method of use are disclosed. The assembly includes a container defining an opening that leads to an interior space. A cap is removably affixed over the opening and defines a channel that leads to the interior space. The cap includes a puncturing structure positioned at a bottom region of the channel. A plunger is slidably disposed within the channel and includes a sleeve portion and a dosage product housed within the sleeve portion. The plunger slides within the channel between a first position in which the plunger is located in an upper region of the channel, and a second position in which the plunger is located in a lower region of the channel and the dosage product contacts the puncturing structure.

Abstract: A fluid receiver fitting (FRF) for supporting aseptic fluid transfer between enclosures, as well as methods for forming the fluid receiver, is disclosed. The FRF includes a unitized seal section (226) and channel section (228) formed together by 2-shot injection molding, thereby eliminating or minimizing modes of fluid contamination where the seal section and channel section are separate members. The channel section may comprise one or more channels (286) for insertion of a needle (N) therein and a respective penetration zone (266) in a corresponding section of the seal section for the needle to a penetrate and thereby extract a fluid sample from a liquid stream against which a portion of the seal section is exposed. An angled interface (288) between each channel and its corresponding penetration zone provides a liquid stream pressure concentration zone which applies pressure to close a core (C) in the seal section formed by removal of the needle.

Abstract: A container includes container body (120) defining an interior (122) and an opening (124) leading to the interior. A lid (140) is movable with respect to the container body to move the container between a closed position in which the lid covers the opening and an opened position in which the opening is exposed. A housing (180) is affixed to an upper portion of the container body, adjacent to the opening. A release (160) is movably housed within the housing. The release is configured to move between a locked position in which the release retains the lid in the closed position, and an unlocked position, in which the release permits the lid to move into the opened position. The release moves from the locked position to the unlocked position by a first movement in a radially inward direction of the container, followed by a second movement in an axially upward direction of the container.

Abstract: A fluid receiver fitting (FRF) for supporting aseptic fluid transfer between enclosures, as well as methods for forming the fluid receiver, is disclosed. The FRF includes a unitized seal section (226) and channel section (228) formed together by 2-shot injection molding, thereby eliminating or minimizing modes of fluid contamination where the seal section and channel section are separate members. The channel section may comprise one or more channels (286) for insertion of a needle (N) therein and a respective penetration zone (266) in a corresponding section of the seal section for the needle to penetrate and thereby extract a fluid sample from a liquid stream against which a portion of the seal section is exposed. An angled interface (288) between each channel and its corresponding penetration zone provides a liquid stream pressure concentration zone which applies pressure to close a core (C) in the seal section formed by removal of the needle.