Abstract: A dispenser assembly (2) for solid units (4) includes an outer sleeve (10) having an end (12) and a first sidewall (14) extending from the end of the outer sleeve, the first sidewall having a window (19) proximate to the end of the outer sleeve; and an inner) housing (50) inserted into the outer sleeve, the inner housing including an end (54) with an opening therein leading to a compartment configured for storing the solid units. The dispenser assembly (2) is configured to rotate between a CLOSED position corresponding to the window being blocked by a portion of the inner housing, and an OPEN position corresponding to the window not being blocked by the inner housing in order to allow at least one of the solid units to be dispensed through the window.

Abstract: A child-resistant container including a container body, a lid, and at least one resilient tab is provided. The lid is pivotable about an axis through a hinge joining the lid to the container body to open and close the container. The resilient tab has a proximal portion fixed to the lid, a distal portion projecting from the lid, and at least one abutment on the distal portion. The abutment on the distal portion of the tab is normally biased into engagement with an abutment on the container body when the lid is in its closed position. The distal portion of the tab is displaceable against the bias to disengage the abutment of the tab from the abutment of the container. Displacement of the tab releases the lid so that it can be pivoted about the hinge to open the container.

Abstract: Disclosed are methods for opening containers having child resistant closures. The methods include applying inward radial pressure on a resilient guard of a container to deflect the guard inwardly, followed by applying upward pressure to an exposed front tab of a cap of the container to open the cap.

Abstract: Disclosed are plunger assemblies including various convertible plungers and methods of making the same. Each plunger assembly is configured for disposition within a barrel of a medical container, e.g., a syringe, and displaced within the barrel from an engagement position to a release position. The engagement position is configured to provide a compression seal between a storage sealing section of the plunger and an inner wall of the syringe barrel. In the release position, the compression seal is reduced or eliminated. Also disclosed are methods for making convertible plungers and assembling them into syringes, e.g., pre-filled syringes.

Abstract: A closed and tamper-evident sealed container, including a fluid transport adapter. The adapter provides for sterile fluid communication between a fluid source outside the container and the container interior when adapter is open. The adapter is adjustable to a closed position wherein the fluid communication ceases. An alternative to the adapter utilizes a sampling attachment that fits into tight engagement with the lid which comprises at least one septum. Coupling the sampling attachment to the lid either causes sharps in the attachment to penetrate the at least one septum or to displace the edges of the septum inward to form a fluid communication with the container interior while the lid remains sealed closed. Other variations include a rotatable sampling attachment, a container with a displaceable bottom wall to act as a syringe and a large volume (e.g., 1500 mL) sealed ampoule which also uses a sampling attachment.

Abstract: A child-resistant container including a container body, a lid, and at least one resilient tab is provided. The lid is pivotable about an axis through a hinge joining the lid to the container body to open and close the container. The resilient tab has a proximal portion fixed to the lid, a distal portion projecting from the lid, and at least one abutment on the distal portion. The abutment on the distal portion of the tab is normally biased into engagement with an abutment on the container body when the lid is in its closed position. The distal portion of the tab is displaceable against the bias to disengage the abutment of the tab from the abutment of the container. Displacement of the tab releases the lid so that it can be pivoted about the hinge to open the container.

Abstract: A container (20) includes a body (22) defining an interior and an opening (32) that leads to the interior. A cap (24) is removably affixed over the opening and is movable between a closed position and an opened position. The cap includes a front tab (52) having an undersurface (54). A child resistant closure in the form of a guard (56) having a depressible wall (58) is located on the body and is movable between an engaged position and a disengaged position. When in the engaged position the guard covers the undersurface of the front tab to prevent the cap from being moved to the opened position. When in the disengaged position the undersurface of the front tab is exposed, enabling the cap to be moved to the opened position.

Abstract: A package comprises a latch including first and second legs and an actuating portion. The first and second legs are joined at an angle. The actuator portion of the first leg is positioned to be displaced generally laterally to displace the second leg generally longitudinally to release the latch. In another embodiment the package has base wells on the inside surface. A generally flat marginal sealing surface encircles the first and second base wells. The wells of the base and/or lid are covered with a cover sheet to close them. Still another embodiment is a child-resistant container comprising a shell, two drawers, a stop, and a latch. The drawers are prevented from sliding apart past a limit of travel when one drawer is open sufficiently to provide access to its contents and the other drawer is not.

Abstract: A pre-filled pharmaceutical package comprising a liquid formulation of a VEGF-antagonist, for example Ranibizumab, in a pre-filled pharmaceutical package, for example a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer. Stability performance of the VEGF-antagonist packaged in the coated COP vessel comparable to or better than glass was obtained.

Abstract: A dispenser for dispensing product that includes a dispenser body having first and second interior sections, a lid, and a release mechanism. Product in the first interior section passes through an opening in the second interior portion and into an inner channel for dispensing. The inner channel includes a prong that prevent product from reverting back to the first interior section. The lid includes a lip that, when the dispenser is closed, creates a seal about the inner channel. When the dispenser is to be opened, the user may activate the release mechanism, which includes an upper portion and an activation portion. The user inwardly presses the release activation portion, which deflects or bends a portion of the inner channel away from the lip. The user may also downwardly press on the release mechanism to release the upper portion from engagement with the lip and the sidewall.

Abstract: A liquid formulation of an ophthalmic drug in a pharmaceutical package, for example a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer.

Abstract: A package comprises a latch including first and second legs and an actuating portion. The first and second legs are joined at an angle. The actuator portion of the first leg is positioned to be displaced generally laterally to displace the second leg generally longitudinally to release the latch. In another embodiment the package has base wells on the inside surface. A generally flat marginal sealing surface encircles the first and second base wells. The wells of the base and/or lid are covered with a cover sheet to close them. Still another embodiment is a child-resistant container comprising a shell, two drawers, a stop, and a latch. The drawers are prevented from sliding apart past a limit of travel when one drawer is open sufficiently to provide access to its contents and the other drawer is not.

Abstract: A child resistant container is for containing at least one product, such as medicine. The child resistant container includes a body, a lid, and a directing portion. The body has an end portion defining an opening leading to an interior of the body. The lid is connected to the body via a hinge, and includes a cover portion and a protrusion extending outwardly therefrom. The cover portion is configured to move between a FIRST position corresponding to the cover portion covering the opening, and a SECOND position corresponding to the cover portion not covering the opening. The directing portion extends from one of the body and the cover portion, and at least partially encloses the protrusion when the cover portion is in the FIRST position. When the cover portion moves from the FIRST position to the SECOND position, the protrusion moves away from the directing portion.

Abstract: A process is provided for making a walled structure using an injection molding apparatus. The apparatus has a molding space formed between a mold cavity and an inner core disposed within the mold cavity. The molding space defines a shape of the structure. The process includes injecting molding material into the molding space, moving or retaining a portion of a movable impression member protruding from the inner core within a portion of the molding space so as to create a recess within an inner wall of the structure, and retracting the impression member into the inner core such that the impression member is cleared from the molding space. Precision control in forming the impression member is provided by a closed-loop configuration using a sensor that measures a molding space parameter (e.g., temperature), optionally in combination with a servo drive for activating the impression member.

Abstract: Methods of molding a barrel, such as a syringe barrel having very low draft, are disclosed. Thermoplastic syringes having very low interior draft angels are also disclosed.