Abstract: Oil-in-water nanoemulsions comprising oil globules with an average size of less than 150 nm and comprising at least one oil, at least one amphiphilc lipid, and at least one nonionic polymer comprising at least one hydrophobic block and at least one hydrophilic block. Processes comprising such oil-in-water nanoemulsions.

Abstract: Expression of a messenger RNA which encodes a protein which is expressed by differentiated cells, notably the cells of the skin or appendages thereof, is inhibited by topically administering to said differentiated cells a thus effective amount of at least one double-stranded RNA oligonucleotide, formulated into a topically applicable, physiologically acceptable medium therefor; such regime or regimen is useful for treating a variety of afflictions or conditions, e.g., combating the signs of skin aging, stimulating hair growth or retarding loss thereof, inhibiting cellular proliferation and/or differentiation, etc.

Abstract: The present invention relates to an aqueous dispersion of nanocapsules of core/shell type, in which: the core comprises at least one oil, the shell covering the core is of non-crosslinked polymeric nature and is water-insoluble and insoluble in the oil of the said core, the said nanocapsules having a mean size of less than or equal to 1 ?m and having a degree of encapsulation of at least 8% by weight relative to the total weight of the said dispersion.

Abstract: The present invention relates to individualized porous particles, characterized in that they have a volume-average diameter of less than or equal to 10 ?m and a specific surface area of greater than or equal to 1 m2/g, and in that they comprise at least one cosmetically or pharmaceutically active compound at least present inside said particles.

Abstract: A foundation composition in the form of a water-in-oil emulsion comprising a fatty phase; an aqueous phase; at least one silicone surfacant chosen from C8-C22 alkyl dimethicone copolyols; and at least 5% by weight, relative to the total weight of the composition, of hydrophobic coated pigments; provided that the composition is free of polyglyceryl-4 isostearate or comprises polyglyceryl-4 isostearate in a quantity such that the weight ratio of the C8-C22 alkyl dimethicone copolyol to the polyglyceryl-4 isostearate is greater than or equal to 2:1, wherein the foundation composition can exhibit good stability at room temperature and can be easy to apply to the skin.

Abstract: The present invention relates to a composition comprising: a dispersion, in an outer aqueous phase, of vesicles formed by lipid lamellar phases comprising at least one amphiphilic lipid and encapsulating an inner hydrophilic phase, the said lamellar phases not comprising succinic and/or hemisuccinic derivatives, and at least one DHEA-based compound included in the said lamellar phases. The incorporation of the DHEA-based compound into the lamellar phases of vesicles makes it possible to avoid its recrystallization in the outer aqueous phase and to improve its bioavailability.

Abstract: The invention relates to a composition containing at least one hydrophilic active principle and at least one amphiphilic polyisobutylene polymer. The invention also relates to the use of such a polymer for stabilizing an oxidation-sensitive hydrophilic active principle, in particular in the aqueous phase. The present invention also relates to the uses of this composition.

Abstract: UV-Photoprotective oil-in-water emulsions well suited for photoprotecting the skin, lips and/or hair against the damaging effects of UV-radiation, the oil globules of which having an average size of at most 500 nm and containing particles of at least one ionic polymer and at least one UV-radiation-screening system, such screening system comprising at least one 4,4-diarylbutadiene UV-A-screening agent.

Abstract: A reconstructed epidermis/skin equivalent supplemented with at least one ceramide 7 and/or 5.5 compound, suited for reinforcing the barrier function of normal human epidermis and for improving the barrier function of dry skin and of reconstructed skin or skin equivalents, is prepared by introducing the at least one ceramide 7 and/or 5.5 compound into the culture medium of such reconstructed epidermis/skin equivalent and/or topically applying onto the face surface of such reconstructed epidermis/skin equivalent a composition which comprises lipid lamellar vesicles incorporating at least one ceramide 7 and/or 5.5 compound.

Abstract: Stable, recrystallization-resistant invert emulsions, suited, e.g., for preventing/treating the signs of chronological or actinic skin aging and for preventing/treating atrophy of the skin or mucous membranes, comprise a cosmetically/therapeutically effective amount of DHEA and/or chemical and/or biological precursor or derivative thereof, such invert emulsions also comprising a glycolic or hydroglycolic dispersed hydrophilic phase, a lipophilic continuous phase and an emulsifier having an HLB ranging from 2 to 7.

Abstract: The present invention relates to an aqueous suspension of nanocapsules containing, in an aqueous medium, nanocapsules comprising a polymer shell and a lipid core containing an oily solvent, characterized in that the said lipid core contains at least one steroid chosen from: DHEA, its chemical and biological precursors and its chemical and metabolic derivatives, and in that the said oily solvent comprises at least one compound chosen from certain classes of solvents for DHEA.

Abstract: The present invention relates to a composition comprising in a physiologically acceptable medium at least one steroid selected from DHEA and a metabolic or chemical derivative thereof, characterized in that the said composition further comprises dipropylene glycol.

Abstract: A nanoemulsion, the oily globules of which have a number-average size of less than 100 nm, comprising a surfactant which is solid at a temperature of less than or equal to 45° C., which surfactant is chosen from esters of a fatty acid and of a sugar and ethers of a fatty alcohol and of a sugar, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The nanoemulsion may be used for cosmetics and dermatological applications, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.

Abstract: A foundation composition in the form of a water-in-oil emulsion comprising a fatty phase; an aqueous phase; at least one silicone surfacant chosen from C8-C22 alkyl dimethicone copolyols; and at least 5% by weight, relative to the total weight of the composition, of hydrophobic coated pigments; provided that the composition is free of polyglyceryl-4 isostearate or comprises polyglyceryl-4 isostearate in a quantity such that the weight ratio of the C8-C22 alkyl dimethicone copolyol to the polyglyceryl-4 isostearate is greater than or equal to 2:1, wherein the foundation composition can exhibit good stability at room temperature and can be easy to apply to the skin.

Abstract: The present invention relates generally to nanocapsules having a core-envelope structure where the core contains a lipophilic active agent and the envelope contains at least one polyester polyol obtained by polycondensation of an aliphatic dicarboxylic acid with at least two alkanediols or with at least one alkanediol and at least one hydroxyalkyl alkanediol. These nanocapsules make it possible to stabilize lipophilic active agents that are difficult to stabilize, especially retinol esters such as retinyl propionate.

Abstract: The present application relates to an oil-in-water nanoemulsions which comprising an oily phase dispersed in an aqueous phase, the oil globules of which have a mean size of less than 100 nm, characterized in that it comprises at least one amphiphilic lipid chosen from nonionic amphiphilic lipids, anionic amphiphilic lipids and their mixtures and at least one anionic polymer which contains at least one hydrophobic chain and in which the weight ratio of the amount of oily phase to the amount of amphiphilic lipid ranges from 1.2 to 10. The anionic polymer can in particular be an acrylic or methacrylic acid copolymer or a 2-acrylamido-2-methylpropanesulphonic acid copolymer, in particular an acrylic or methacrylic acid terpolymer. The nanoemulsion obtained is transparent and stable on storage. It can constitute a composition for topical use and in particular for cosmetic or dermatological use, a pharmaceutical composition, or an ophthalmological composition.

Abstract: Oil-in-water nanoemulsions comprising oil globules with an average size of less than 150 nm and comprising at least one oil, at least one amphiphilc lipid, and at least one nonionic polymer comprising at least one hydrophobic block and at least one hydrophilic block. Processes comprising such oil-in-water nanoemulsions.

Abstract: The invention relates to a composition in the form of a water-in-oil emulsion containing at least 80% of aqueous phase and at least one glycoglyceride. The glycoglyceride may be obtained by synthesis or by extraction, and it may be, in particular, a galactolipid such as, for example, digalactosyl diglyceride or monogalactosyl diglyceride. The composition according to the invention provides a great sensation of freshness when applied to the skin, and may be used in particular in cosmetics and/or dermatology.

Abstract: The present invention relates to nanocapsules consisting of a lipid centre forming or containing a lipophilic active principle, and of a water-insoluble continuous envelope comprising at least one polyester of poly(alkylene adipate) type as well as to cosmetic and/or dermatological compositions containing the said nanocapsules based on poly(alkylene adipate).

Abstract: Oil-in-water nanoemulsions comprising oil globules with an average size of less than 150 nm and comprising at least one oil, at least one amphiphilc lipid, and at least one polyethylene glycol (PEG) derivative chosen from PEG esters and PEG ethers chosen from compounds of formula (I): R1—(O—CH2—CH2)n—OR2  (I) in which: R1 is chosen from linear and branched, saturated and unsaturated alkyl groups comprising from 8 to 30 carbon atoms and linear and branched, saturated and unsaturated acyl groups comprising from 8 to 30 carbon atoms, R2 is chosen from a hydrogen atom, linear and branched, saturated and unsaturated alkyl groups comprising from 1 to 30 carbon atoms, and linear and branched, saturated and unsaturated acyl groups comprising from 1 to 30 carbon atoms, and n is a number ranging from 80 to 350. Processes comprising such oil-in-water nanoemulsions.