Patents by Inventor Jean Xu

Jean Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FORMS AND COMPOSITIONS OF A MK2 INHIBITOR
    Publication number: 20210198276
    Abstract: The present invention provides solid forms of an MK2 inhibitor, compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 29, 2020
    Publication date: July 1, 2021
    Inventors: Jianxin Han, Lianfeng Huang, Uday Jain, Ying Li, John Malona, Kevin Molter, Chittari Pabba, Alexander L. Ruchelman, Jean Xu, Daozhong Zou
  • Forms and compositions of a MK2 inhibitor
    Patent number: 10882867
    Abstract: The present invention provides solid forms of an MK2 inhibitor, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: January 5, 2021
    Assignee: Celgene CAR LLC
    Inventors: Jianxin Han, Lianfeng Huang, Uday Jain, Ying Li, John Malona, Kevin Molter, Chittari Pabba, Alexander L. Ruchelman, Jean Xu, Daozhong Zou
  • SALTS AND SOLID FORMS OF (S)-3-(4-((4-(MORPHOLINOMETHYL)BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20200360395
    Abstract: Salts and solid forms of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a stereoisomer thereof, are disclosed. Compositions comprising and methods of using the salts and solid forms are also disclosed.
    Type: Application
    Filed: February 25, 2020
    Publication date: November 19, 2020
    Inventors: Benjamin M. Cohen, John F. Traverse, Jean Xu, Ying Li
  • USE OF NOGGIN, AN ALK5 INHIBITOR AND A PROTEIN KINASE C ACTIVATOR, TO PRODUCE ENDOCRINE CELLS
    Publication number: 20200291360
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.
    Type: Application
    Filed: June 3, 2020
    Publication date: September 17, 2020
    Applicant: Janssen Biotech, Inc.
    Inventor: Jean Xu
  • Use of noggin, an ALK5 inhibitor and a protein kinase c activator to produce endocrine cells
    Patent number: 10704025
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: July 7, 2020
    Assignee: Janssen Biotech, Inc.
    Inventor: Jean Xu
  • FORMS AND COMPOSITIONS OF A MK2 INHIBITOR
    Publication number: 20200148701
    Abstract: The present invention provides solid forms of an MK2 inhibitor, compositions thereof, and methods of using the same.
    Type: Application
    Filed: March 15, 2018
    Publication date: May 14, 2020
    Inventors: Jianxin Han, Lianfeng Huang, Uday Jain, Ying Li, John Malona, Kevin Molter, Chittari Pabba, Alexander L. Ruchelman, Jean Xu, Daozhong Zou
  • Salts and solid forms of (S)-3-(4-((4-(morpholinomethyl)benzyl) oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and compositions comprising and methods of using the same
    Patent number: 10596180
    Abstract: Salts and solid forms of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a stereoisomer thereof, are disclosed. Compositions comprising and methods of using the salts and solid forms are also disclosed.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: March 24, 2020
    Assignee: Celgene Corporation
    Inventors: Benjamin M. Cohen, John F. Traverse, Jean Xu, Ying Li
  • DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
    Publication number: 20200048614
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
    Type: Application
    Filed: October 10, 2019
    Publication date: February 13, 2020
    Applicant: Janssen Biotech, Inc.
    Inventors: Alireza Rezania, Jean Xu
  • PANCREATIC ENDOCRINE CELLS AND METHODS THEREOF
    Publication number: 20200030383
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
    Type: Application
    Filed: September 25, 2019
    Publication date: January 30, 2020
    Applicant: Janssen Biotech, Inc.
    Inventor: Jean Xu
  • METHODS FOR LOWERING BLOOD GLUCOSE
    Publication number: 20200030382
    Abstract: The present invention provides a method for lowering blood glucose levels in an animal by transplanting a population of pancreatic endocrine precursor cells into an animal.
    Type: Application
    Filed: August 13, 2019
    Publication date: January 30, 2020
    Applicant: Janssen Biotech, Inc.
    Inventor: Jean Xu
  • Solid forms of (1S,4S)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide and methods of their use
    Patent number: 10513519
    Abstract: Provided herein are formulations, solid forms and methods of use relating to (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: December 24, 2019
    Assignee: Signal Pharmaceuticals, LLC
    Inventors: Zheng Chen, Paul F. Fernandez, Tracy L. Gaebele, Lianfeng Huang, Matthew J. Jackson, Matthew M. Kreilein, Xiaoling Lu, Wenju Wu, Jean Xu
  • SALTS AND SOLID FORMS OF (S)-3-(4-((4-(MORPHOLINOMETHYL)BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20190365772
    Abstract: Salts and solid forms of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a stereoisomer thereof, are disclosed. Compositions comprising and methods of using the salts and solid forms are also disclosed.
    Type: Application
    Filed: June 17, 2019
    Publication date: December 5, 2019
    Inventors: Benjamin M. Cohen, John F. Traverse, Jean Xu, Ying Li
  • Lowering blood glucose
    Patent number: 10471104
    Abstract: The present invention provides a method for lowering blood glucose levels in an animal by transplanting a population of pancreatic endocrine precursor cells into an animal.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: November 12, 2019
    Assignee: Janssen Biotech, Inc.
    Inventor: Jean Xu
  • Salts and solid forms of (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and compositions comprising and methods of using the same
    Patent number: 10463672
    Abstract: Salts and solid forms of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a stereoisomer thereof, are disclosed. Compositions comprising and methods of using the salts and solid forms are also disclosed.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: November 5, 2019
    Assignee: Celgene Corporation
    Inventors: Benjamin M. Cohen, John F. Traverse, Jean Xu, Ying Li
  • Pancreatic endocrine cells and methods thereof
    Patent number: 10456424
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: October 29, 2019
    Assignee: Janssen Biotech, Inc.
    Inventor: Jean Xu
  • Forms and compositions of an ERK inhibitor
    Patent number: 10202364
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of one or both of ERK1 and ERK2.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: February 12, 2019
    Assignee: CELGENE CAR LLC
    Inventors: Antonio Christian Ferretti, Lianfeng Huang, Ying Li, John Traverse, Jean Xu, Kelvin Hin-Yeong Yong, Daozhong Zou
  • DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
    Publication number: 20190030086
    Abstract: The present invention provides a method for lowering blood glucose levels in an animal by transplanting a population of pancreatic endocrine precursor cells into an animal.
    Type: Application
    Filed: September 18, 2018
    Publication date: January 31, 2019
    Applicant: Janssen Biotech, Inc.
    Inventor: Jean Xu
  • FORMS AND COMPOSITIONS OF AN ERK INHIBITOR
    Publication number: 20180362498
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of one or both of ERK1 and ERK2.
    Type: Application
    Filed: June 14, 2018
    Publication date: December 20, 2018
    Inventors: Antonio Christian Ferretti, Lianfeng Huang, Ying Li, John Traverse, Jean Xu, Kelvin Hin-Yeong Yong, Daozhong Zou
  • SOLID FORMS OF (1S,4S)-4-(2-(((3S,4R)-3-FLUOROTETRAHYDRO-2H-PYRAN-4-YL)AMINO)-8-((2,4,6-TRICHLOROPHENYL)AMINO)-9H-PURIN-9-YL)-1-METHYLCYCLOHEXANE-1-CARBOXAMIDE AND METHODS OF THEIR USE
    Publication number: 20180362529
    Abstract: Provided herein are formulations, solid forms and methods of use relating to (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide.
    Type: Application
    Filed: July 5, 2018
    Publication date: December 20, 2018
    Inventors: Zheng Chen, Paul F. Fernandez, Tracy L. Gaebele, Lianfeng Huang, Matthew J. Jackson, Matthew M. Kreilein, Xiaoling Lu, Wenju Wu, Jean Xu
  • SOLID FORMS OF 3-(5-AMINO-2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE, AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES
    Publication number: 20180305333
    Abstract: Solid forms comprising 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their uses are disclosed.
    Type: Application
    Filed: April 18, 2018
    Publication date: October 25, 2018
    Inventors: George W. Muller, Hon-Wah Man, Benjamin M. Cohen, Ying Li, Jean Xu, William W. Leong