Patents by Inventor Jean Xu

Jean Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Differentiation of human embryonic stem cells
    Patent number: 10076544
    Abstract: The present invention provides a method for lowering blood glucose levels in an animal by transplanting a population of pancreatic endocrine precursor cells into an animal.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: September 18, 2018
    Assignee: Janssen Biotech, Inc.
    Inventor: Jean Xu
  • Solid forms of (1S,4S)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide and methods of their use
    Patent number: 10047090
    Abstract: Provided herein are formulations, solid forms and methods of use relating to (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: August 14, 2018
    Assignee: Signal Pharmaceuticals, LLC
    Inventors: Zheng Chen, Paul F. Fernandez, Tracy L. Gaebele, Lianfeng Huang, Matthew J. Jackson, Matthew M. Kreilein, Xiaoling Lu, Wenju Wu, Jean Xu
  • SALTS AND SOLID FORMS OF (S)-3-(4-((4-(MORPHOLINOMETHYL)BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20180200255
    Abstract: Salts and solid forms of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a stereoisomer thereof, are disclosed. Compositions comprising and methods of using the salts and solid forms are also disclosed.
    Type: Application
    Filed: December 28, 2017
    Publication date: July 19, 2018
    Inventors: Benjamin M. Cohen, John F. Traverse, Jean Xu, Ying Li
  • Forms and compositions of an ERK inhibitor
    Patent number: 10005760
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of one or both of ERK1 and ERK2.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: June 26, 2018
    Assignee: Celgene CAR LLC
    Inventors: Antonio Christian Ferretti, Lianfeng Huang, Ying Li, John Traverse, Jean Xu, Kelvin Hin-Yeong Yong, Daozhong Zou
  • Solid forms of 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses
    Patent number: 9969713
    Abstract: Solid forms comprising 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their uses are disclosed.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: May 15, 2018
    Assignee: Celgene Corporation
    Inventors: George W. Muller, Hon-Wah Man, Benjamin M. Cohen, Ying Li, Jean Xu, William W. Leong
  • PHARMACEUTICAL FORMULATIONS, PROCESSES, SOLID FORMS AND METHODS OF USE RELATING TO 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO[2,3-b]PYRAZIN-2(1H)-ONE
    Publication number: 20180042924
    Abstract: Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2 (1H)-one.
    Type: Application
    Filed: October 23, 2017
    Publication date: February 15, 2018
    Inventors: Anil Menon, Darshan K. Parikh, Dora Visky, Matthew Michael Kreilein, Nathan Boersen, Thomas Lee, Ying Li, Jean Xu, Xiaozhang Liang, William Wei-Hwa Leong, Benjamin Cohen
  • Salts and solid forms of (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and compositions comprising and methods of using the same
    Patent number: 9884062
    Abstract: Salts and solid forms of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a stereoisomer thereof, are disclosed. Compositions comprising and methods of using the salts and solid forms are also disclosed.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: February 6, 2018
    Assignee: Celgene Corporation
    Inventors: Benjamin M. Cohen, John F. Traverse, Jean Xu, Ying Li
  • DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
    Publication number: 20170354690
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
    Type: Application
    Filed: July 26, 2017
    Publication date: December 14, 2017
    Applicant: LifeScan, Inc.
    Inventor: Jean Xu
  • SOLID FORMS OF 3-(5-AMINO-2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE, AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES
    Publication number: 20170342050
    Abstract: Solid forms comprising 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their uses are disclosed
    Type: Application
    Filed: August 7, 2017
    Publication date: November 30, 2017
    Inventors: George W. Muller, Hon-Wah Man, Benjamin M. Cohen, Ying Li, Jean Xu, William W. Leong
  • Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one
    Patent number: 9827243
    Abstract: Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: November 28, 2017
    Assignee: Signal Pharmaceuticals, LLC
    Inventors: Matthew Michael Kreilein, Thomas Lee, Ying Li, Jean Xu, William Wei-Hwa Leong, Benjamin Cohen
  • Differentiation of Human Embryonic Stem Cells
    Publication number: 20170335289
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
    Type: Application
    Filed: July 26, 2017
    Publication date: November 23, 2017
    Applicant: LifeScan, Inc.
    Inventors: Alireza Rezania, Jean Xu
  • DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
    Publication number: 20170327793
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells expressing markers characteristic of the pancreatic endoderm lineage, wherein greater than 50% of the cells in the population co-express PDX1 and NKX6.1.
    Type: Application
    Filed: August 4, 2017
    Publication date: November 16, 2017
    Applicant: Janssen Biotech, Inc.
    Inventor: Jean Xu
  • Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
    Patent number: 9814713
    Abstract: Provided herein are formulations, processes, solid forms and methods of use relating to 2 -(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: November 14, 2017
    Assignee: Signal Pharmaceuticals, LLC
    Inventors: Hon-Wah Man, Jean Xu, Marie Georges Beauchamps, Mohit Atul Kothare, Nanfei Zou, Ying Li, Lianfeng Huang, Daozhong Zou
  • SOLID FORMS OF (1S,4S)-4-(2-(((3S,4R)-3-FLUOROTETRAHYDRO-2H-PYRAN-4-YL)AMINO)-8-((2,4,6-TRICHLOROPHENYL)AMINO)-9H-PURIN-9-YL)-1-METHYLCYCLOHEXANE-1-CARBOXAMIDE AND METHODS OF THEIR USE
    Publication number: 20170283418
    Abstract: Provided herein are formulations, solid forms and methods of use relating to (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4, 6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide.
    Type: Application
    Filed: March 31, 2017
    Publication date: October 5, 2017
    Inventors: Zheng Chen, Paul F. Fernandez, Tracy L. Gaebele, Lianfeng Huang, Matthew J. Jackson, Matthew M. Kreilein, Xiaoling Lu, Wenju Wu, Jean Xu
  • SALTS AND SOLID FORMS OF (S)-3-(4-((4-(MORPHOLINOMETHYL)BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
    Publication number: 20170258803
    Abstract: Salts and solid forms of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a stereoisomer thereof, are disclosed. Compositions comprising and methods of using the salts and solid forms are also disclosed.
    Type: Application
    Filed: February 28, 2017
    Publication date: September 14, 2017
    Inventors: Benjamin M. Cohen, John F. Traverse, Jean Xu, Ying Li
  • Differentiation of human embryonic stem cells
    Patent number: 9752125
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells expressing markers characteristic of the pancreatic endoderm lineage, wherein greater than 50% of the cells in the population co-express PDX1 and NKX6.1.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: September 5, 2017
    Assignee: Janssen Biotech, Inc.
    Inventor: Jean Xu
  • Solid forms of 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses
    Patent number: 9751853
    Abstract: Solid forms comprising 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their uses are disclosed.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: September 5, 2017
    Assignee: Celgene Corporation
    Inventors: George W. Muller, Hon-Wah Man, Benjamin M. Cohen, Ying Li, Jean Xu, William W. Leong
  • Differentiation of human embryonic stem cells
    Patent number: 9744195
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: August 29, 2017
    Assignee: LifeScan, Inc.
    Inventor: Jean Xu
  • FORMS AND COMPOSITIONS OF AN ERK INHIBITOR
    Publication number: 20170226083
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of one or both of ERK1 and ERK2.
    Type: Application
    Filed: August 12, 2015
    Publication date: August 10, 2017
    Inventors: Antonio Christian Ferretti, Lianfeng Huang, Ying Li, John Traverse, Jean Xu, Kelvin Hin-Yeong Yong, Daozhong Zou
  • Differentiation of human embryonic stem cells
    Patent number: 9725699
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: August 8, 2017
    Assignee: LifeScan, Inc.
    Inventors: Alireza Rezania, Jean Xu