Abstract: The invention discloses diagnostic techniques based on single cell genomics, consisting of obtaining a blood sample, enriching a sub-population of cells present in the blood sample, sequestering individual cells or group of cells from the blood sample, obtaining sequencing data from the sequestered cells or group of cells, using genetic variant information to determine the provenance of the cells, and genetically analyzing the cells of the correct provenance to provide a diagnostic readout. Using the cell-based testing techniques of the invention, the number of false positives is greatly reduced when compared to cell-free DNA (cfDNA) based traditional testing techniques. The invention may be effectively employed for non-invasive prenatal (NIPT) diagnostics, oncological testing and other diagnostic procedures.

Abstract: A suture anchor made of a single length of wire that forms a suture retaining loop having two diverging legs, each having a pointed end. The transverse spacing of the diverging legs is greater than the diameter of the bone tunnel. The suture anchor may be spring loaded and set into the bone tunnel so that the distal points of each diverging leg are below the surface of a bone cortex, the sharp distal points of each diverging leg expand out laterally under pressure and penetrate the bone tunnel wall prohibiting removal of the suture anchor. The diverging legs further penetrate the bone tunnel wall in response to applied withdrawal forces.

Abstract: A mounting structure for adhesively bonding onto a surface includes a base, an outer face of the base and an inner face of the base. An adhesive injection port is provided on the outer face of the base for supplying an adhesive. A primary adhesive flow path is provided on the inner face of the base. The primary adhesive flow path is in fluid communication with the adhesive injection port and allows the adhesive to flow. Further, a plurality of secondary adhesive flow paths originating from the primary adhesive flow path allow the adhesive to distribute on the inner face.

Abstract: A method for making a suspension cable to a desired length is provided. The method includes providing an initial pin hole on a tab of a socket associated with the cable. The method includes stretching the cable to a desired percentage of a rated breaking strength of the cable. The method includes measuring a length of the cable. The method includes determining a position of a final pin hole to be formed on the tab based on the measured length of the cable and a predefined tolerance. The method includes creating the final pin hole at the determined position.

Abstract: A mounting structure for adhesively bonding onto a surface includes a base, an outer face of the base and an inner face of the base. An adhesive injection port is provided on the outer face of the base for supplying an adhesive. A primary adhesive flow path is provided on the inner face of the base. The primary adhesive flow path is in fluid communication with the adhesive injection port and allows the adhesive to flow. Further, a plurality of secondary adhesive flow paths originating from the primary adhesive flow path allow the adhesive to distribute on the inner face.

Abstract: The invention discloses diagnostic techniques based on single cell genomics, consisting of obtaining a blood sample, enriching a sub-population of cells present in the blood sample, sequestering individual cells or group of cells from the blood sample, obtaining sequencing data from the sequestered cells or group of cells, using genetic variant information to determine the provenance of the cells, and genetically analyzing the cells of the correct provenance to provide a diagnostic readout. Using the cell-based testing techniques of the invention, the number of false positives is greatly reduced when compared to cell-free DNA (cfDNA) based traditional testing techniques. The invention may be effectively employed for non-invasive prenatal (NIPT) diagnostics, oncological testing and other diagnostic procedures.

Abstract: A method of making a machine component includes extruding a supply of an aluminum alloy to produce an extrusion. The extrusion is formed under temperature-limited forming conditions of 275° C. or less to produce a blank. The blank is machined to at least one predetermined tolerance to produce the machine component.

Abstract: A method for making a suspension cable to a desired length is provided. The method includes providing an initial pin hole on a tab of a socket associated with the cable. The method includes stretching the cable to a desired percentage of a rated breaking strength of the cable. The method includes measuring a length of the cable. The method includes determining a position of a final pin hole to be formed on the tab based on the measured length of the cable and a predefined tolerance. The method includes creating the final pin hole at the determined position.

Abstract: The invention discloses diagnostic techniques based on single cell genomics, consisting of obtaining a blood sample, enriching a sub-population of cells present in the blood sample, sequestering individual cells or group of cells from the blood sample, obtaining sequencing data from the sequestered cells or group of cells, using genetic variant information to determine the provenance of the cells, and genetically analyzing the cells of the correct provenance to provide a diagnostic readout. Using the cell-based testing techniques of the invention, the number of false positives is greatly reduced when compared to cell-free DNA (cfDNA) based traditional testing techniques. The invention may be effectively employed for non-invasive prenatal (NIPT) diagnostics, oncological testing and other diagnostic procedures.

Abstract: A method of making an engine system component is disclosed. The method may include loading a first metal-based material and a second metal-based material into an extrusion chamber. The first metal-based material may concentrically surround the second metal-based material, and the first metal-based material may have at least one of a thermal property and a wear resistance different than the second metal-based material. The method may additionally include forming an extrudate by simultaneously passing the first metal-based material and the second metal-based material through a die. The first metal-based material of the extrudate may be metallurgically bonded to the second metal-based material of the extrudate. The method may also include forging the extrudate.

Abstract: A method of making a machine component includes extruding a supply of an aluminum alloy to produce an extrusion. The extrusion is formed under temperature-limited forming conditions of 275° C. or less to produce a blank. The blank is machined to at least one predetermined tolerance to produce the machine component.

Abstract: The invention discloses diagnostic techniques based on single cell genomics, consisting of obtaining a blood sample, enriching a sub-population of cells present in the blood sample, sequestering individual cells or group of cells from the blood sample, obtaining sequencing data from the sequestered cells or group of cells, using genetic variant information to determine the provenance of the cells, and genetically analyzing the cells of the correct provenance to provide a diagnostic readout. Using the cell-based testing techniques of the invention, the number of false positives is greatly reduced when compared to cell-free DNA (cfDNA) based traditional testing techniques. The invention may be effectively employed for non-invasive prenatal (NIPT) diagnostics, oncological testing and other diagnostic procedures.

Abstract: A method of fusing an edge member to a peripheral portion of the metallic component is disclosed. The method initiates with providing an edge forming apparatus, which includes a manipulator, a heating unit, and at least one set of rollers. The manipulator is capable of receiving the edge member and the metallic component. Thereafter, edge member and the metallic component are positioned on the manipulator. After positioning, the heating unit heats a first portion of the edge member and a first section of the peripheral portion. Thereafter, the manipulator is manipulated to facilitate an engagement between the first portion and the first section, by passing the first portion and the first section through the set of rollers. Afterwards, the first portion of the edge member is fused with the first section of the peripheral portion of the metallic component.

Abstract: A cooling fan shroud comprises multiple, functionally identical sections that form a ring-like structure that completely surrounds the fan when the shroud is installed onto an aperture plate or other structure. The shroud makes the cooling system more efficient by improving air flow at a given fan speed by reducing fan tip clearance, and increasing air flow due through the fan. An alternative, single piece shroud is also provided which can be retrofitted to an existing cooling system.

Abstract: A turbocharger includes a turbine section, a compressor section and a bearing section. A turbine wheel and a compressor wheel are mounted on a shaft and the shaft is rotatably mounted in a bore of a housing. A lubrication system circulates lubricant through the bearing section. First and second spaced apart seals are positioned along the shaft. A recess is positioned between the first seal and the second seal to define an air buffer chamber. The air buffer chamber is provided with pressurized air to discourage lubricant leakage past the first seal.

Abstract: An ignition system and method of igniting the ignition system includes a main catalyst section in a staged relationship with a pilot-catalyst section to stage a decomposition though the pilot-catalyst section which preheats the main catalyst section.

Abstract: A frictional welding process for joining a titanium aluminide turbine to a titanium alloy shaft is disclosed. The disclosed process includes preheating the turbine to a designated temperature, providing a specially-designed joining interface geometry at the distal end of the shaft and optimizing the frictional welding parameters. The frictional welding is carried out in multiple steps but, while the shaft is being spun by a rotating chuck, two different pressures and two different time periods are used until the narrower portions of the distal end of the shaft have been fused onto the welding surface of the turbine. Then, an additional forging step with yet another engagement pressure between the shaft and the turbine is carried out without rotation of the shaft.

Abstract: Systems and a method for printing and applying labels on packages. The system includes a conveyor configured to transport a plurality of packages, one or more scanners configured to scan the plurality of packages, and one or more print and apply stations. The one or more print and apply stations includes a printer configured to print labels, and an applier configured to apply the labels on the plurality of packages. The system further includes a management controller configured to retrieve promotion data for the plurality of packages, transmit the promotion data and spooling instructions associated with the promotion data to a print controller, and control operation of the conveyor in synchronization with the spooling instructions, and the print controller. The print controller is configured to manage and spool the promotion data to the one or more print and apply stations.

Abstract: A laminate structure is provided. The laminate structure includes a plurality of laminate layers. The laminate structure also includes a joint interface. The joint interface includes a retention member at least partially disposed between any two of the plurality of laminate layers. Further, the retention member has an opening for receiving a pin retaining member. The retention member is configured to provide a surface for transitioning the pin retaining member to the laminate structure.

Abstract: A cooling fan shroud comprises multiple, functionally identical sections that form a ring-like structure that completely surrounds the fan when the shroud is installed onto an aperture plate or other structure. The shroud makes the cooling system more efficient by improving air flow at a given fan speed by reducing fan tip clearance, and increasing air flow due through the fan. An alternative, single piece shroud is also provided which can be retrofitted to an existing cooling system.