Patents by Inventor Jeff A. Zablocki

Jeff A. Zablocki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted heterocyclic compounds
    Patent number: 7271169
    Abstract: Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: September 18, 2007
    Assignee: CV Therapeutics, Inc.
    Inventors: Jeff Zablocki, Dmitry Koltun
  • Aadenosine receptor agonists
    Patent number: 7271157
    Abstract: Disclosed is a synthesis suitable for large scale manufacture of novel compounds that are partial and full A1 adenosine receptor agonist having the structure of Formula I: wherein R is optionally substituted phenyl, that are useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction.
    Type: Grant
    Filed: June 30, 2005
    Date of Patent: September 18, 2007
    Assignee: CV Therapeutics, Inc.
    Inventors: Elfatih Elzein, Jeff Zablocki
  • C-Pyrazole A2A receptor agonists
    Publication number: 20070207978
    Abstract: 2-adenosine C-pyrazole compounds having formula (a) and methods for using the compounds as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart.
    Type: Application
    Filed: September 15, 2006
    Publication date: September 6, 2007
    Inventors: Jeff Zablocki, Elfatih Elzein, Venkata Palle
  • A2A ADENOSINE RECEPTOR ANTAGONISTS
    Publication number: 20070208040
    Abstract: The present invention relates to novel compounds that are A2A adenosine receptor antagonists, and to their use in treating mammals for various disease states, such as obesity, CNS disorders, including the “movement disorders” (Parkinson's disease, Huntington's Chorea, and catelepsy), and cerebral ischemia, excitotoxicity, cognitive and physiological disorders, depression, ADHD, and drug addiction (alcohol, amphetamine, cannabinoids, cocaine, nicotine, and opioids) and to their use in the enhancement of immune response. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
    Type: Application
    Filed: March 2, 2007
    Publication date: September 6, 2007
    Inventors: Elfatih Elzein, Rao Kalla, Jeff Zablocki, Xiaofen Li, Thao Perry, Tetsuya Kobayashi, Eric Parkhill
  • ABCA1 elevating compounds
    Publication number: 20070203245
    Abstract: The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
    Type: Application
    Filed: December 7, 2006
    Publication date: August 30, 2007
    Inventors: Dmitry Koltun, Melanie Boze, Jeff Zablocki
  • N-pyrazole A2A receptor agonists
    Publication number: 20070203090
    Abstract: 2-adenosine N-pyrazole compounds having the following formula: and methods for using the compounds as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart.
    Type: Application
    Filed: October 27, 2006
    Publication date: August 30, 2007
    Inventors: Jeff Zablocki, Elfatih Elzein, Venkata Palle, Luiz Belardinelli
  • Adenosine A receptor agonists
    Patent number: 7262176
    Abstract: Disclosed are novel compounds that are A3 adenosine receptor agonists, useful for treating various disease states, including cancer, cardiac ischemia, leukopenia, and neutropennia.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: August 28, 2007
    Assignee: CV Therapeutics, Inc.
    Inventors: Elfatih Elzein, Venkata Palle, Vaibhav Varkhedkar, Jeff Zablocki
  • Substituted heterocyclic compounds
    Patent number: 7262198
    Abstract: Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I: The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, diabetes, and myocardial infarction.
    Type: Grant
    Filed: June 13, 2006
    Date of Patent: August 28, 2007
    Assignee: CV Therapeutics, Inc.
    Inventors: Elfatih Elzein, Prabha Ibrahim, Venkata Palle, Kenneth Rehder, Jeff Zablocki
  • ABCA1 elevating compounds
    Publication number: 20070191379
    Abstract: The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
    Type: Application
    Filed: December 27, 2006
    Publication date: August 16, 2007
    Inventors: Matthew Abelman, Robert Jiang, Jeff Zablocki, Dmitry Koltun, Melanie Boze
  • SUBSTITUTED HETEROCYCLIC COMPOUNDS
    Publication number: 20070191390
    Abstract: Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.
    Type: Application
    Filed: March 13, 2007
    Publication date: August 16, 2007
    Inventors: Jeff Zablocki, Elfatih Elzein, Tim Marquart
  • Partial and full agonists of A1 adenosine receptors
    Publication number: 20070185051
    Abstract: Disclosed are novel compounds a compound of Formula I that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular dyslipidemia, diabetes, decreased insulin sensitivity, Polycystic Ovarian Syndrome, Stein-Leventhal syndrome, and obesity.
    Type: Application
    Filed: December 18, 2006
    Publication date: August 9, 2007
    Inventors: Arvinder Dhalla, Elfatih Elzein, Prabha Ibrahim, Venkata Palle, Vaibhav Varkhedkar, Jeff Zablocki
  • Substituted Heterocyclic Compounds
    Publication number: 20070155728
    Abstract: Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.
    Type: Application
    Filed: March 8, 2007
    Publication date: July 5, 2007
    Inventors: Venkata Palle, Jeff Zablocki
  • Aadenosine receptor antagonists
    Patent number: 7238700
    Abstract: Disclosed are novel A2B adenosine receptor antagonists of Formula I: A compound of the formula: wherein: R1 is optionally substituted alkyl or a group —Y-Z, in which Y is a covalent bond or optionally substituted alkylene, and Z is optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkenyl or optionally substituted alkynyl, with the proviso that when Y is a covalent bond Z cannot be alkenyl or alkynyl; and X is oxygen, sulfur, or NH—, or a pharmaceutically acceptable salt, ester, or prodrug thereof. The compounds are particularly useful for treating asthma and diabetic retinopathy.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: July 3, 2007
    Assignee: CV Therapeutics, Inc.
    Inventors: Venkata Palle, Vaibhav Varkhedkar, Jeff Zablocki, Dengming Xiao
  • Substituted heterocyclic compounds
    Patent number: 7208496
    Abstract: Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.
    Type: Grant
    Filed: June 7, 2004
    Date of Patent: April 24, 2007
    Assignee: CV Therapeutics, Inc.
    Inventors: Jeff Zablocki, Elfatih Elzein, Tim Marquart
  • A1 adenosine receptor agonists
    Publication number: 20070087994
    Abstract: Disclosed are novel compounds that are A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, diseases related to release of nonesterified fatty acids, and myocardial infarction.
    Type: Application
    Filed: October 11, 2006
    Publication date: April 19, 2007
    Inventors: Elfatih Elzein, Xiaofen Li, Jeff Zablocki
  • Substituted heterocyclic compounds
    Patent number: 7205303
    Abstract: Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, m particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: April 17, 2007
    Assignee: CV Therapeutics, Inc.
    Inventors: Venkata Palle, Jeff Zablocki
  • Partial and full agonists of A1 adenosine receptors
    Publication number: 20070066560
    Abstract: Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction.
    Type: Application
    Filed: November 15, 2006
    Publication date: March 22, 2007
    Inventors: Elfatih Elzein, Prabha Ibrahim, Venkata Palle, Vaibhav Varkhedkar, Jeff Zablocki
  • N-pyrazole A2A receptor agonists
    Patent number: 7183264
    Abstract: 2-adenosine N-pyrazole compounds having the following formula: and methods for using the compounds as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart are disclosed.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: February 27, 2007
    Assignee: CV Therapeutics, Inc.
    Inventors: Jeff Zablocki, Elfatih O. Elzein, Venkata P. Palle, Luiz Belardinelli
  • Partial and full agonists of Aadenosine receptors
    Patent number: 7163928
    Abstract: Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction.
    Type: Grant
    Filed: February 2, 2004
    Date of Patent: January 16, 2007
    Assignee: CV Therapeutics, Inc.
    Inventors: Gloria Cristalli, Venkata Palle, Jeff Zablocki
  • ABCA1 elevating compounds
    Publication number: 20070010544
    Abstract: The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
    Type: Application
    Filed: June 28, 2006
    Publication date: January 11, 2007
    Inventors: Matthew Abelman, Robert Jiang, Jeff Zablocki, Dmitry Koltun