Patents by Inventor Jeff A. Zablocki

Jeff A. Zablocki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroaryl alkyl piperazine derivatives
    Patent number: 6849632
    Abstract: Novel compounds of the general formula: and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of diabetes, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.
    Type: Grant
    Filed: December 5, 2002
    Date of Patent: February 1, 2005
    Assignee: CV Therapeutics, Inc.
    Inventors: Jeff Zablocki, Prabha Ibrahim, Kevin Shenk, Elfaith Elzein, Venkata Palle
  • Partial and full agonists of A1 adenosine receptors
    Publication number: 20050020532
    Abstract: Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction.
    Type: Application
    Filed: May 27, 2004
    Publication date: January 27, 2005
    Inventors: Elfatih Elzein, Prabha Ibrahim, Venkata Palle, Vaibhav Varkhedkar, Jeff Zablocki
  • A2B adenosine receptor antagonists
    Patent number: 6825349
    Abstract: Disclosed are novel A2B adenosine receptor antagonists compounds having the structure of Formula I or Formula II: The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract disorders, cardiovascular diseases, neurological disorders, and diseases related to undesirable angiogenesis.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: November 30, 2004
    Assignee: CV Therapeutics Inc.
    Inventors: Rao Kalla, Thao Perry, Elfatih Elzein, Vaibhav Varkhedkar, Xiaofen Li, Prabha Ibrahim, Venkata Palle, Dengming Xiao, Jeff Zablocki
  • A2B adenosine receptor antagonists
    Publication number: 20040209899
    Abstract: Disclosed are novel A2B adenosine receptor antagonists of Formula I: 1
    Type: Application
    Filed: April 30, 2004
    Publication date: October 21, 2004
    Inventors: Venkata Palle, Vaibhav Varkhedkar, Jeff Zablocki, Dengming Xiao
  • Partial and full agonists of A1 adenosine receptors
    Publication number: 20040198691
    Abstract: Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction.
    Type: Application
    Filed: February 2, 2004
    Publication date: October 7, 2004
    Inventors: Gloria Cristalli, Venkata Palle, Jeff Zablocki
  • C-pyrazole A2A receptor agonists
    Publication number: 20040198692
    Abstract: 2-adenosine C-pyrazole compounds having formula (a) and methods for using the compounds as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart.
    Type: Application
    Filed: March 30, 2004
    Publication date: October 7, 2004
    Applicant: CV Therapeutics, Inc.
    Inventors: Jeff A. Zablocki, Elfatih O. Elzein, Venkata P. Palle
  • Heteroaryl alkyl piperazine derivatives
    Publication number: 20040192702
    Abstract: Novel compounds of the general formula: 1
    Type: Application
    Filed: March 31, 2004
    Publication date: September 30, 2004
    Inventors: Jeff Zablocki, Prabha Ibrahim, Kevin Shenk, Elfatih Elzein, Venkata Palle
  • Substituted heterocyclic compounds
    Publication number: 20040186109
    Abstract: Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.
    Type: Application
    Filed: January 16, 2004
    Publication date: September 23, 2004
    Inventors: Robert Jiang, Tim Marquart, Jeff Zablocki, Elfatih Elzein, Venkata Palle, Prabha Ibrahim
  • Substituted heterocyclic compounds
    Publication number: 20040176356
    Abstract: Disclosed are novel piperazine derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction.
    Type: Application
    Filed: December 19, 2003
    Publication date: September 9, 2004
    Inventors: Venkata Palle, Jeff Zablocki
  • A2B adenosine receptor antagonists
    Publication number: 20040176399
    Abstract: Disclosed are processes for the synthesis of novel compounds that are A2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.
    Type: Application
    Filed: November 21, 2003
    Publication date: September 9, 2004
    Inventors: Elfatih Elzein, Rao Kalla, Tim Marquart, Jeff Zablocki, Xiaofen Li
  • Substituted heterocyclic compounds
    Publication number: 20040176383
    Abstract: Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes, and for increasing HDL plasma levels in mammals.
    Type: Application
    Filed: January 16, 2004
    Publication date: September 9, 2004
    Inventors: Prabha Ibrahim, Kevin Shenk, Elfatih Elzein, Venkata Palle, Jeff Zablocki, Kenneth S. Rehder
  • Substituted heterocyclic compounds
    Publication number: 20040152890
    Abstract: Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.
    Type: Application
    Filed: December 5, 2003
    Publication date: August 5, 2004
    Inventors: Elfatih Elzein, Dmitry Koltun, Jeff Zablocki
  • A2B adenosine receptor antagonists
    Patent number: 6770651
    Abstract: Disclosed are novel A2B adenosine receptor antagonists of Formula I: A compound of the formula: wherein: R1 is optionally substituted alkyl or a group —Y—Z, in which Y is a covalent bond or optionally substituted alkylene, and Z is optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkenyl or optionally substituted alkynyl, with the proviso that when Y is a covalent bond Z cannot be alkenyl or alkynyl; and X is oxygen, sulfur, or NH—, or a pharmaceutically acceptable salt, ester, or prodrug thereof. The compounds are particularly useful for treating asthma and diabetic retinopathy.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: August 3, 2004
    Inventors: Venkata Palle, Vaibhav Varkhedkar, Jeff Zablocki, Dengming Xiao
  • C-pyrazole a2a receptor agonists
    Patent number: 6770634
    Abstract: 2-adenosine C-pyrazole compounds having formula (a) and methods for using the compounds as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: August 3, 2004
    Assignee: CV Therapeutics, Inc.
    Inventors: Jeff A. Zablocki, Elfatih O. Elzein, Venkata P. Palle
  • Adenosine A3 receptor agonists
    Publication number: 20040116376
    Abstract: Disclosed are novel compounds that are A3 adenosine receptor agonists, useful for treating various disease states, including cancer, cardiac ischemia, leukopenia, and neutropennia.
    Type: Application
    Filed: November 25, 2003
    Publication date: June 17, 2004
    Inventors: Elfatih Elzein, Venkata Palle, Vaibhav Varkhedkar, Jeff Zablocki
  • ABCA-1 elevating compounds
    Patent number: 6713650
    Abstract: The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: March 30, 2004
    Inventors: Prabha N. Ibrahim, Robert Jiang, Christopher Morrison, Kevin Shenk, Jeff A. Zablocki, Richard Lawn
  • Partial and full agonists of A1 adenosine receptors
    Publication number: 20040043960
    Abstract: Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular the supraventricular tachycardias, emesis, angina, myocardial infarction and hyperlipidemia.
    Type: Application
    Filed: August 15, 2003
    Publication date: March 4, 2004
    Inventors: Jeff Zablocki, Venkata Palle, Elfatih Elzein, Xiaofen Li
  • N-pyrazole A2A receptor agonists
    Publication number: 20040038928
    Abstract: 2-adenosine N-pyrazole compounds having the following formula: 1
    Type: Application
    Filed: August 29, 2003
    Publication date: February 26, 2004
    Applicant: CV Therapeutics, Inc.
    Inventors: Jeff A. Zablocki, Elfatih O. Elzein, Venkata P. Palle
  • Heteroaryl alkyl piperazine derivatives as fatty acid oxidation inhibitors
    Publication number: 20040029889
    Abstract: Novel compounds of the general formula (I): and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.
    Type: Application
    Filed: July 14, 2003
    Publication date: February 12, 2004
    Inventors: Jeff A Zablocki, Prabha N Ibrahim, Kevin Shunk, Elfatih Elzein, Venkata P Palle
  • Substituted piperazine compounds
    Patent number: 6677336
    Abstract: Novel compounds of the general formula: and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: January 13, 2004
    Assignee: CV Therapeutics, Inc.
    Inventors: Jeff Zablocki, Elfatih Elzein, Grigory Nudelman, Tim Marquart, Brent K. Blackburn, Venkata P. Palle