Abstract: Disclosed are devices, systems and methods for integrating a media device with a network. A media device may be connected to a cradle device to receive updates of digital content. The cradle device may be coupled to a wireless link to receive content data and/or signals.

Abstract: This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds.

Abstract: Disclosed are a system and method of processing image data for presentation of an image on a display. In particular, image data may be transformed and/or mapped for presentation on a display based, at least in part, on a user preference.

Abstract: A control module for a multi-nozzle shower has a body, a control panel and a controlling assembly. The body is mounted securely in the shower and defines at least one chamber having valve seats, at least one inlet and multiple outlets respectively communicating with the nozzles. The control panel is mounted securely on the body and seals the at least one chamber. The controlling assembly is mounted in the control panel and has multiple valve disks and buttons. The valve disks selectively block the valve seats to stop water flow. The buttons connected to the valve disks and are arranged on the control panel and selectively actuate the valve disks to block the valve seats. Thereby, people can conveniently control water discharged from different nozzles or showerheads of the shower.

Abstract: A fastening assembly for a shower apparatus has a locating pipe, a fastening element and an interconnecting element. The locating pipe has a through hole and an outer thread. The fastening element is mounted around the locating pipe and has a mounting tube, a head and a mounting hole. The mounting tube is mounted around the locating pipe. The head is formed with the mounting tube. The mounting hole is formed in the fastening element and is screwed with the outer thread. The interconnecting element is mounted in the locating pipe, is connected to the fastening element and has an inserting tube and a connecting panel. The inserting tube is inserted into the locating pipe. The connecting panel is formed with the inserting tube and abuts the head. Therefore, the fastening assembly is mounted on the outlet pipe quickly and efficiently to aid shower installation.

Abstract: This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: Systems and methods are disclosed herein to provide improved jitter tolerant delay-locked loop circuitry. For example, in accordance with an embodiment of the present invention, an integrated circuit includes a plurality of delay cells each having a plurality of programmable delay taps. Each delay cell is adapted to provide a delayed clock signal delayed by a selected number of the delay taps. A phase detector is adapted to compare a first clock signal with a selected one of the delayed clock signals to obtain a comparison result and provide a plurality of control signals in response to the comparison result. An arithmetic logic unit (ALU) is adapted to vary the selected number of delay taps in response to the control signals provided by the phase detector.

Abstract: A door lock has an outside doorknob assembly having an outside doorknob and a lock core, an inside doorknob assembly having an inside doorknob and a latch button, an arresting assembly and a latch assembly. The arresting assembly has a retaining blade connecting the lock core and the latch button, a driving tube mounted rotatably around the retaining blade, a recessed arrestor slidably and non-rotatably mounted on the retaining blade and a protruding arrestor slidably mounted rotatably on the retaining blade and selectively engaging with the recessed arrestor. The latch assembly has a driving element interacting with the driving tube and a latch bolt connected to the driving element. A person can turn the latch button to rotate the retaining blade to drive the recessed arrestor to smoothly engage with or detach from the protruding arrestor to selectively lock or unlock the door lock.

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Abstract: In one embodiment, a programmable logic device includes: a multiplexer adapted to select a compressed configuration bitstream from a plurality of external serial interface memories; a serial interface processor adapted to command the bitstream selection by the multiplexer; and a bitstream decompressor adapted to decompress the selected configuration bitstream into a decompressed configuration bitstream.

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Abstract: The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.

Abstract: A door lock has an outside doorknob assembly having an outside doorknob and a lock core, an inside doorknob assembly having an inside doorknob and a latch button, an arresting assembly and a latch assembly. The arresting assembly has a retaining blade connecting the lock core and the latch button, a driving tube mounted rotatably around the retaining blade, a recessed arrestor slidably and non-rotatably mounted on the retaining blade and a protruding arrestor slidably mounted rotatably on the retaining blade and selectively engaging with the recessed arrestor. The latch assembly has a driving element interacting with the driving tube and a latch bolt connected to the driving element. A person can turn the latch button to rotate the retaining blade to drive the recessed arrestor to smoothly engage with or detach from the protruding arrestor to selectively lock or unlock the door lock.

Abstract: The invention provides compounds and methods for inhibition of kinases, more specifically IGF 1 R kinases. The invention also provides compounds and methods for inhibition of wildtype Abl. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, wherein, V is NR1R1a, or O—R1, wherein X is H, halo, C1-C6 alkyl, NO2, mono-, di-, or tri-halo substituted methyl, NR13R,14.

Abstract: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Abstract: Described embodiments relate to improved methods and systems for computationally efficient optimization of radiation dose delivery. The optimization involves determining an improved form of objective function to be used for mapping radiotherapy beams to a patient body volume having at least one target volume and at least one non-target volume. The objective function has a first term related to the at least one target volume and a second term related to the at least one non-target volume.

Abstract: Disclosed is a power LED light source that can be employed with different reflectors and other additional parts to form various power LED light units. Compared with the power LED light unit utilizing Luxeon LED packages and the like, the disclosed invention has the advantages of higher power, lower costs, better heat dissipation design and simpler optical design. The power LED light unit comprises of a base metal ring with multiple power LED dies mounted on it, one or more reflectors connected to the base metal ring, one or more extend metal rings connected to the base metal ring, a light unit base connected to the last extended metal ring, and a control circuit inside the metal rings. Such designed power LED light unit can emit light patterns such as parallel light pattern, non-parallel light pattern, and ring light pattern.

Abstract: Systems and methods are disclosed herein to provide improved jitter tolerant delay-locked loop circuitry. For example, in accordance with an embodiment of the present invention, an integrated circuit includes a plurality of delay cells each having a plurality of programmable delay taps. Each delay cell is adapted to provide a delayed clock signal delayed by a selected number of the delay taps. A phase detector is adapted to compare a first clock signal with a selected one of the delayed clock signals to obtain a comparison result and provide a plurality of control signals in response to the comparison result. An arithmetic logic unit (ALU) is adapted to vary the selected number of delay taps in response to the control signals provided by the phase detector.