Abstract: Systems and methods for the distribution of data center power are disclosed. In one embodiment, the method includes supplying power to a critical load using a stored energy device in response to detecting an outage of a utility; transmitting an on bypass request to a reserve power system via an automatic bypass input upon determining that a capacity of the stored energy device has reached a pre-determined threshold, wherein the on bypass request is transmitted from the primary UPS to a switchboard of the reserve power system; transferring the critical load to the reserve power system if the reserve power system is able to support the critical load, the transferring the critical load to the reserve power system comprising coupling the critical load to the switchboard via an automatic bypass input of the primary UPS.

Abstract: A drink container including a liquid container having a neck with an opening and having an internal compartment sized to hold a volume of potable drink liquid and a cap assembly removably coupled to the liquid container, the cap assembly including a base removably coupled to the neck of the liquid container and including a through-passage extending through the base, a first catch structure coupled to the base, a mouthpiece assembly including a rigid collar member, a mouthpiece portion extending from the rigid collar member, and second catch structure adapted to be selectively engaged with the first catch structure, and a user release mechanism adapted to automatically disengage the first and second catch structures upon actuation of the user release mechanism.

Abstract: A closure assembly including a closure base configured to be selectively coupled to a neck of a liquid vessel and a valve assembly operatively coupled to the closure base, the valve assembly comprising a nozzle that extends away from the closure base and defines at least one drink outlet, shower outlets spaced around the at least one drink outlet, and a barrel valve, the barrel valve being configured to be selectively rotated relative to the closure base to transition the valve assembly between a closed configuration, in which a flow of liquid from the liquid vessel through the closure assembly is restricted, a drink configuration, in which liquid is permitted to flow from the liquid vessel through the drink outlet but not the shower outlets, and the shower configuration, in which liquid is permitted to flow from the liquid vessel through the shower outlets but not the drink outlet.

Abstract: Methods of treating patients diagnosed with cancer harboring an IDH-1 mutation are provided, including the therapeutic administration of a certain inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA).

Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.

Abstract: Methods of treating patients diagnosed with AML or MDS harboring mutant IDH-1 include detecting an IDH1 mutation and the therapeutic administration of an inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA) or cytarabine.

Abstract: A drink container including a liquid container having a neck with an opening and having an internal compartment sized to hold a volume of potable drink liquid and a cap assembly removably coupled to the liquid container, the cap assembly including a base removably coupled to the neck of the liquid container and including a through-passage extending through the base, a first catch structure coupled to the base, a mouthpiece assembly including a rigid collar member having second catch structure adapted to be selectively engaged with the first catch structure, and a user release mechanism adapted to automatically disengage the first and second catch structures upon actuation of the user release mechanism.

Abstract: Cap assemblies with magnetic closure retention mechanisms and drink containers including the same. A cap assembly includes a base, a drink spout defining a passage, a closure configured to be selectively transitioned between a closed configuration and a stowed configuration via an open configuration, and a magnetic closure retention mechanism to magnetically retain the closure in the stowed configuration. When the closure is in the closed configuration, the closure is operatively coupled to the drink spout and obstructs the flow of liquid therethrough. When the closure is in the open configuration or the stowed configuration, the drink spout is uncovered and unobstructed by the closure. When the closure is in the stowed configuration, the closure is magnetically retained against the base or a handle of the cap assembly.

Abstract: A fluid container including a fluid vessel having a neck with an opening and having an internal compartment sized to hold a volume of fluid, the internal compartment being at least partially enclosed by an opaque layer, a closure assembly removably coupled to the fluid container to cover the opening, and two or more fluid level indicators defined in the opaque layer, each fluid level indicator comprising a translucent or transparent material configured to permit light to pass through the opaque layer and into the internal compartment, at least two of the two or more fluid level indicators being positioned on circumferentially opposed sides of the fluid vessel.

Abstract: Methods of treating patients diagnosed with AML or MDS harboring mutant IDH-1 include detecting an IDH1 mutation and the therapeutic administration of an inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA) or cytarabine.

Abstract: Cap assemblies with magnetic closure retention mechanisms and drink containers including the same. A cap assembly includes a base, a drink spout defining a passage, a closure configured to be selectively transitioned between a closed configuration and a stowed configuration via an open configuration, and a magnetic closure retention mechanism to magnetically retain the closure in the stowed configuration. When the closure is in the closed configuration, the closure is operatively coupled to the drink spout and obstructs the flow of liquid therethrough. When the closure is in the open configuration or the stowed configuration, the drink spout is uncovered and unobstructed by the closure. When the closure is in the stowed configuration, the closure is magnetically retained against the base or a handle of the cap assembly.

Abstract: A drink container including a liquid container having a neck with an opening and having an internal compartment sized to hold a volume of potable drink liquid and a cap assembly removably coupled to the liquid container, the cap assembly including a base removably coupled to the neck of the liquid container and including a through-passage extending through the base, a first catch structure coupled to the base, a mouthpiece assembly including a rigid collar member having second catch structure adapted to be selectively engaged with the first catch structure, and a user release mechanism adapted to automatically disengage the first and second catch structures upon actuation of the user release mechanism.

Abstract: A fluid container including a fluid vessel having a neck with an opening and having an internal compartment sized to hold a volume of fluid, the internal compartment being at least partially enclosed by an opaque layer, a closure assembly removably coupled to the fluid container to cover the opening, and two or more fluid level indicators defined in the opaque layer, each fluid level indicator comprising a translucent or transparent material configured to permit light to pass through the opaque layer and into the internal compartment, at least two of the two or more fluid level indicators being positioned on circumferentially opposed sides of the fluid vessel.

Abstract: Methods of treating patients diagnosed with cancer harboring an IDH-1 mutation are provided, including the therapeutic administration of a certain inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA).

Abstract: Cap assemblies with magnetic closure retention mechanisms and drink containers including the same. A cap assembly includes a base, a drink spout defining a passage, a closure configured to be selectively transitioned between a closed configuration and a stowed configuration via an open configuration, and a magnetic closure retention mechanism to magnetically retain the closure in the stowed configuration. When the closure is in the closed configuration, the closure is operatively coupled to the drink spout and obstructs the flow of liquid therethrough. When the closure is in the open configuration or the stowed configuration, the drink spout is uncovered and unobstructed by the closure. When the closure is in the stowed configuration, the closure is magnetically retained against the base or a handle of the cap assembly.

Abstract: Drink containers with mouthpiece assemblies having a dispensing configuration and a stowed configuration. A mouthpiece assembly defines a liquid passage through which drink liquid may be dispensed when the mouthpiece assembly is in the dispensing configuration and includes means for selectively restricting the flow of drink liquid through the liquid passage when the mouthpiece assembly is in the stowed configuration. In some examples, the means for selectively restricting the flow of drink liquid include a tube that at least partially defines the liquid passage and which includes a crimping region. The crimping region may be constructed of a resiliently and reversibly deformable material that is adapted to restrict the flow of drink liquid through the liquid passage when the mouthpiece assembly is in the stowed configuration. In some embodiments, the mouthpiece assembly includes a means for automatically releasing the mouthpiece assembly from its stowed configuration to a dispensing configuration.

Abstract: Closure assemblies with distinct dispensing modes and drink containers including the same. A closure assembly includes a closure base and a valve assembly. The valve assembly includes at least one drink outlet, at least one shower outlet, and a barrel valve. The valve assembly is configured to be selectively transitioned between a closed configuration, a drink configuration, and a shower configuration. The barrel valve is configured to be selectively rotated relative to the closure base about a rotational axis of the closure assembly to transition the valve assembly between the closed configuration, the drink configuration, and the shower configuration.

Abstract: Closure assemblies with distinct dispensing modes and drink containers including the same. A closure assembly includes a closure base and a valve assembly. The valve assembly includes at least one drink outlet, at least one shower outlet, and a barrel valve. The valve assembly is configured to be selectively transitioned between a closed configuration, a drink configuration, and a shower configuration. The barrel valve is configured to be selectively rotated relative to the closure base about a rotational axis of the closure assembly to transition the valve assembly between the closed configuration, the drink configuration, and the shower configuration.

Abstract: Methods of treating patients diagnosed with AML or MDS harboring mutant IDH-1 include detecting an IDH1 mutation and the therapeutic administration of an inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA) or cytarabine.

Abstract: Methods of treating patients diagnosed with cancer harboring an IDH-1 mutation are provided, including the therapeutic administration of a certain inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA).