Publication number: 20130259858
Abstract: A method of predicting outcome in a subject with for example Her2+ (ER??) breast cancer comprising: a. determining a HTICs expression signature comprising determining an expression level of 2 or more HTICS biomarkers selected from Aurkb, Ccna2, Scrn1, Npy, Atp7b, Chaf1b, Ccnb1 Cldn8, Nrp1, Ccr2, C1qb, Cd74, Vcam1, Cd180, Itgb2, Cd72, St8sia4 Kif11, Plk1, Chek1, Mphosph6, Coro1a, Ccl5, Cd3e Hcls1, Vav1, Plek, Arhgdib, Il2rg, Sash3, Lck, Il2rb, Cybb, Cd79b, Sell, Ccnd2, Tnfrsf1b, Rftn1, Rac2 and Ly86; and b. calculating a signature score, the signature score comprising a sum of HTICs biomarker expression parameters; wherein a signature score greater than a selected cut-off or control signature score is indicative of a poor outcome (HTICS+) and a signature score less than a selected cut-off is indicative of a good outcome (HTICS?). The methods can be used to prognose outcome and/or select suitable treatment. Arrays and kits for use with the methods are also provided.
Type:
Application
Filed:
March 14, 2013
Publication date:
October 3, 2013
Applicant:
UNIVERSITY HEALTH NETWORK
Inventors:
Eldad Zacksenhaus, Jeff Liu