Patents by Inventor Jefferson Wright Tilley

Jefferson Wright Tilley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATORS
    Publication number: 20090156635
    Abstract: The present invention relates to compounds of formula (I) wherein Ar, Ar2, R2, R3, R4, m, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.
    Type: Application
    Filed: February 16, 2009
    Publication date: June 18, 2009
    Inventors: Paul Gillespie, Robert Alan Goodnow, JR., Jefferson Wright Tilley
  • Biaryloxymethylarenecarboxylic acids as glycogen synthase activators
    Patent number: 7524870
    Abstract: The present invention relates to compounds of formula (I) wherein Ar, Ar2, R2, R3, R4, m, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.
    Type: Grant
    Filed: November 21, 2005
    Date of Patent: April 28, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Paul Gillespie, Robert Alan Goodnow, Jr., Jefferson Wright Tilley
  • PRODRUGS OF THYROID HORMONE ANALOGS
    Publication number: 20090082310
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
    Type: Application
    Filed: September 2, 2008
    Publication date: March 26, 2009
    Inventors: NANCY-ELLEN HAYNES, Nathan R. Scott, Jefferson Wright Tilley
  • THYROID HORMONE ANALOGS
    Publication number: 20090005383
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
    Type: Application
    Filed: August 20, 2008
    Publication date: January 1, 2009
    Inventors: Nancy-Ellen Haynes, Denis J. Kertesz, Sherrie Lynn Pietranico-Cole, Yimin Qian, Nathan Robert Scott, Sung-Sau So, Kshitij Chhabilbhai Thakkar, Jefferson Wright Tilley
  • 3,3-SPIROINDOLINONE DERIVATIVES
    Publication number: 20080287421
    Abstract: There are provided compounds of the general formulas wherein X, Y, R1, R2, R3, R4 and R5 are as described herein. The compounds exhibit anticancer activity.
    Type: Application
    Filed: April 11, 2008
    Publication date: November 20, 2008
    Inventors: Jin-Jun Liu, Jefferson Wright Tilley, Zhuming Zhang
  • Thyroid hormone analogs
    Patent number: 7452882
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: November 18, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nancy-Ellen Haynes, Denis J. Kertesz, Sherrie Lynn Pietranico-Cole, Yimin Qian, Nathan Robert Scott, Sung-Sau So, Kshitij Chhabilbhai Thakkar, Jefferson Wright Tilley
  • BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATOR
    Publication number: 20080255198
    Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, m, n, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.
    Type: Application
    Filed: June 13, 2008
    Publication date: October 16, 2008
    Inventors: Chang An Chu, Paul Gillespie, Jefferson Wright Tilley
  • DIAMINOCYCLOALKANE MCH RECEPTOR ANTAGONISTS
    Publication number: 20080146636
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of obesity, hyperphagia, anxiety, depression and related disorders and diseases.
    Type: Application
    Filed: November 19, 2007
    Publication date: June 19, 2008
    Inventors: Shawn David Erickson, Yimin Qian, Jefferson Wright Tilley
  • Biaryloxymethylarenecarboxylic acids as glycogen synthase activator
    Patent number: 7355049
    Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, m, n, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: April 8, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Chang An Chu, Paul Gillespie, Jefferson Wright Tilley
  • Thiazolo-pyrimidine/pyridine urea derivatives
    Publication number: 20070270433
    Abstract: There are presented compounds of the formula or a pharmaceutically acceptable salt thereof, which are active adenosine A2B receptor antagonists and useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.
    Type: Application
    Filed: May 11, 2007
    Publication date: November 22, 2007
    Inventors: John A. Brinkman, Adrian Wai-Hing Cheung, Fariborz Firooznia, Kevin Richard Guertin, Nicholas Marcopulos, Lida Qi, Jagdish Kumar Racha, Ramakanth Sarabu, Jenny Tan, Jefferson Wright Tilley
  • Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase
    Publication number: 20070225280
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
    Type: Application
    Filed: March 14, 2007
    Publication date: September 27, 2007
    Inventors: Kevin William Anderson, Nader Fotouhi, Paul Gillespie, Robert Alan Goodnow, Kevin Richard Guertin, Nancy-Ellen Haynes, Michael Paul Myers, Sherrie Lynn Pietranico-Cole, Lida Qi, Pamela Loreen Rossman, Nathan Robert Scott, Kshitij Chhabilbhai Thakkar, Jefferson Wright Tilley, Qiang Zhang
  • 4-pyridinyl-n-acyl-l-phenylalanines
    Patent number: 6916933
    Abstract: Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: July 12, 2005
    Assignee: Hoffman-La Roche Inc.
    Inventors: Gerald Lewis Kaplan, Achyutharao Sidduri, Jefferson Wright Tilley
  • Biaryloxymethylarenecarboxylic acids as glycogen synthase activator
    Publication number: 20040266856
    Abstract: The present invention relates to compounds of formula (I) 1
    Type: Application
    Filed: June 17, 2004
    Publication date: December 30, 2004
    Inventors: Chang An Chu, Paul Gillespie, Jefferson Wright Tilley
  • Diaminothiazoles
    Patent number: 6818663
    Abstract: The present invention is directed to novel diaminothiazoles of formula These compounds inhibit cyclin-dependent kinase 4 (Cdk4) and are selective against Cdk2 and Cdk1. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung and colon and prostate tumors.
    Type: Grant
    Filed: May 5, 2003
    Date of Patent: November 16, 2004
    Assignee: Hoffmann-La Roches
    Inventors: Xin-Jie Chu, Qingjie Ding, Nan Jiang, Kyungjin Kim, Allen John Lovey, Warren William McComas, John Guifoyle Mullin, Jr., Jefferson Wright Tilley
  • N-alkanoylphenylalanine derivatives
    Publication number: 20040210051
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: April 21, 2004
    Publication date: October 21, 2004
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achytharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
  • N-alkanoylphenylalamine derivatives
    Patent number: 6806365
    Abstract: Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: October 19, 2004
    Assignee: Hoffmann-La Rocher Inc.
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achytharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
  • 4-Pyridinyl-n-acyl-l-phenylalanines
    Publication number: 20040127706
    Abstract: Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Application
    Filed: September 24, 2003
    Publication date: July 1, 2004
    Inventors: Gerald Lewis Kaplan, Achyutharao Sidduri, Jefferson Wright Tilley
  • DIAMINOTHIAZOLES
    Publication number: 20040006058
    Abstract: The present invention is directed to novel diaminothiazoles of formula 1
    Type: Application
    Filed: May 5, 2003
    Publication date: January 8, 2004
    Inventors: Xin-Jie Chu, Qingjie Ding, Nan Jiang, Kyungjin Kim, Allen John Lovey, Warren William McComas, John Guilfoyle Mullin, Jefferson Wright Tilley
  • N-alkanoylphenylalamine derivatives
    Publication number: 20030109459
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: April 5, 2002
    Publication date: June 12, 2003
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achytharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
  • Phenyl-keto-imidazolidine thioamide derivatives
    Patent number: 6479666
    Abstract: It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (I BD).
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: November 12, 2002
    Assignee: Hoffman-La Roche Inc.
    Inventors: Kenneth Gregory Hull, Achytharao Sidduri, Jefferson Wright Tilley