Patents by Inventor Jefferson Wright Tilley

Jefferson Wright Tilley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diphenyl carbocyclic thioamide derivatives
    Patent number: 6458844
    Abstract: It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (I BD).
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: October 1, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Kenneth Gregory Hull, Achytharao Sidduri, Jefferson Wright Tilley
  • N-alkanoylphenylalanine derivatives
    Patent number: 6455550
    Abstract: Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: September 24, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achytharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
  • 4-pyridinyl-N-acyl-L-phenylalanines
    Publication number: 20020133015
    Abstract: Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Application
    Filed: January 29, 2002
    Publication date: September 19, 2002
    Inventors: Gerald Lewis Kaplan, Achyutharao Sidduri, Jefferson Wright Tilley
  • Diphenyl heterocyclic thioamide derivatives
    Patent number: 6426348
    Abstract: It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (I BD).
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: July 30, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Kenneth Gregory Hull, Achytharao Sidduri, Jefferson Wright Tilley
  • Heterocyclic thioamide derivatives
    Patent number: 6423728
    Abstract: It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are usefull in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (IBD).
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: July 23, 2002
    Assignee: Hoffman-La Roche Inc.
    Inventors: Kenneth Gregory Hull, Achytharao Sidduri, Jefferson Wright Tilley
  • Phenylalaninol derivatives
    Patent number: 6420600
    Abstract: It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, are more readily absorbed and more bioavailable than the corresponding carboxylic acids from which they are derived, both of which are effective inhibitors of the binding of VCAM-1 to VLA-4 in vivo and are useful in treating inflammation in inflammatory diseases in which such binding acts to bring on the inflammation.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: July 16, 2002
    Assignee: Hoffman-La Roche Inc.
    Inventors: Achytharao Sidduri, Jefferson Wright Tilley
  • 4-pyridinyl-n-acyl-l-phenylalanines
    Patent number: 6388084
    Abstract: Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: May 14, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gerald Lewis Kaplan, Achyutharao Sidduri, Jefferson Wright Tilley
  • 4-Pyrimidinyl-n-acyl-l phenylalanines
    Patent number: 6380387
    Abstract: Compounds of Formula I are disclosed, having activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4, and accordingly useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: April 30, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Achyutharao Sidduri, Jefferson Wright Tilley
  • Thioamide derivatives
    Patent number: 6288267
    Abstract: It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis, (MS), asthma, and inflammatory bowel disease (I BD).
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: September 11, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Kenneth Gregory Hull, Achytharao Sidduri, Jefferson Wright Tilley
  • Pyrrolidincarbonylamino cyclic disulfide anti-inflammatory agents
    Patent number: 6265572
    Abstract: Compounds of the formula: are described which have activity as anti-inflammatory agents. Cyclic disulfide compounds are provided which inhibit of binding of cells to endothelium. Such compounds are useful for treating inflammatory diseases, such as asthma, whose symptoms and/or damage are related to the binding of cell adhesion molecules to integrin expressing cells.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: July 24, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Nader Fotouhi, David Young Jackson, Jefferson Wright Tilley
  • N-aroylphenylalanine derivative VCAM-1 inhibitors
    Patent number: 6229011
    Abstract: Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: May 8, 2001
    Assignee: Hoffman-La Roche Inc.
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achyutharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
  • 1-(2-Aminoethyl)-3-(2,6-dihalophenyl)guanidines
    Patent number: 4113776
    Abstract: Antihypertensively active thiourea derivatives of the formulas ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and X are as hereinafter described, as well as a method of using a compound of the formula ##STR2## wherein R.sub.1 ', R.sub.2 ', R.sub.3 and X are as previously described, or a compound of formula II as an anti-hypertensive agent, is described.
    Type: Grant
    Filed: October 25, 1977
    Date of Patent: September 12, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael Robert Cohen, Richard Wightman Kierstead, Jefferson Wright Tilley
  • Thiourea derivatives for treating hypertension
    Patent number: 4096276
    Abstract: Antihypertensively active thiourea derivatives of the formulas ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and X are as hereinafter described,As well as a method of using a compound of the formula ##STR2## wherein R.sub.1 ', R.sub.2 ', R.sub.3 and X are as previously described,Or a compound of formula II as an anti-hypertensive agent, is described.
    Type: Grant
    Filed: January 27, 1977
    Date of Patent: June 20, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael Robert Cohen, Richard Wightman Kierstead, Jefferson Wright Tilley
  • Thiourea derivatives
    Patent number: 4066695
    Abstract: Antihypertensively active thiourea derivatives of the formulas ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and X are as hereinafter described, as well as a method of using a compound of the formula ##STR2## wherein R.sub.1 ', R.sub.2 ', R.sub.3 and X are as previously described, or a compound of formula II as an anti-hypertensive agent, is described.
    Type: Grant
    Filed: January 27, 1977
    Date of Patent: January 3, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael Robert Cohen, Richard Wightman Kierstead, Jefferson Wright Tilley