Abstract: An occlusion bypassing apparatus for re-entering the true lumen of a vessel after subintimally bypassing an occlusion in a vessel. The apparatus includes an outer shaft component, a needle component, and an inflatable balloon. The outer shaft component has a side port proximal to a distal end thereof and a needle lumen there-through that includes a curved distal portion that terminates at the side port of the outer shaft component. The needle component is configured to be slidably disposed within the needle lumen of the outer shaft component. The inflatable balloon includes a body portion that is disposed distal to the side port of the outer shaft component, and the body portion of the balloon has a flattened profile in an inflated state with first and second chambers that laterally extend from opposing sides of the outer shaft component for stabilizing the apparatus within a subintimal space.

Abstract: A delivery system for delivering a prosthesis includes a sheath, a slide shaft having a threaded outer surface, and a handle. The handle includes an internal spring assembly for selectively engaging and disengaging the handle with the threaded outer surface of the slide shaft. The internal spring assembly includes at least one spring arm, a head coupled to the spring arm and having a circumferentially rounded threaded inner surface, and a ring slidably disposed over the spring arm. When the ring is in a first longitudinal position, the threaded inner surface of the head is spaced apart from the threaded outer surface of the slide shaft. When the ring is in a second longitudinal position, the threaded inner surface of the head is threadedly engaged with the threaded outer surface of the slide shaft. The handle may include a resilient cover to provide the internal spring assembly with a biased or nominal operational position.

Abstract: A scaffolded stent-graft includes a graft material comprising an inner surface and an outer surface. The inner surface defines a lumen within the graft material. The scaffolded stent-graft further includes a scaffold comprising a mesh coupled to the graft material at the outer surface. The scaffold is configured to promote tissue ingrowth therein. In this manner, the scaffold enhances tissue integration into the scaffolded stent-graft. The tissue integration enhances biological fixation of the scaffolded stent-graft in vessels minimizing the possibility of endoleaks and migration.

Abstract: A venous valve prosthesis includes a frame and a prosthetic valve coupled to the frame. With the venous valve prosthesis implanted in a vein, the prosthetic valve includes a closed configuration wherein an outer surface of the prosthetic valve is in contact with a wall of the vein around a circumference of the prosthetic valve to prevent blood from flowing past the prosthetic valve between the wall of the vein and the outer surface of the prosthetic valve. The prosthetic valve is configured to move to an open configuration such that at least a portion of an outer wall of the prosthetic valve partially collapses away from the wall of the vein in response to antegrade blood flow through the vein to enable blood flow between the outer surface of the prosthetic valve and the wall of the vein.

Abstract: A delivery system for delivering a prosthesis includes a sheath, a slide shaft having a threaded outer surface, and a handle. The handle includes an internal spring assembly for selectively engaging and disengaging the handle with the threaded outer surface of the slide shaft. The internal spring assembly includes at least one spring arm, a head coupled to the spring arm and having a circumferentially rounded threaded inner surface, and a ring slidably disposed over the spring arm. When the ring is in a first longitudinal position, the threaded inner surface of the head is spaced apart from the threaded outer surface of the slide shaft. When the ring is in a second longitudinal position, the threaded inner surface of the head is threadedly engaged with the threaded outer surface of the slide shaft. The handle may include a resilient cover to provide the internal spring assembly with a biased or nominal operational position.

Abstract: A scaffolded stent-graft includes a graft material comprising an inner surface and an outer surface. The inner surface defines a lumen within the graft material. The scaffolded stent-graft further includes a scaffold comprising a mesh coupled to the graft material at the outer surface. The scaffold is configured to promote tissue ingrowth therein. In this manner, the scaffold enhances tissue integration into the scaffolded stent-graft. The tissue integration enhances biological fixation of the scaffolded stent-graft in vessels minimizing the possibility of endoleaks and migration.

Abstract: A stent-graft includes a graft material having a main body, a first leg, a second leg, and a transition region where the first leg and the second leg meet the main body. A main body transition stent is coupled to the main body. A transition stent support including a gusset is coupled to the graft material such that a transition apex of the main body transition stent is interposed between the gusset and the graft material, the transition apex being aligned with the transition region. The transition apex, which is susceptible to failure, is stabilized by the gusset in combination with a supporting ligament. The gusset and supporting ligament prevent flexing of the transition apex and the associated failure thereof.

Abstract: A prosthetic assembly for repairing a target tissue defect within a target vessel region configured includes an exclusion structure sized to substantially bypass target tissue defect, and includes a branch assembly. The branch assembly can include a self-expanding outer branch prosthesis having an inflow region configured to deform to a non-circular cross-sectional-shape when deployed, and a support structure at least partially disposed within the inflow region. The support structure preserves blood flow to the branch vessel while the deformed inflow region inhibits blood leakage between and/or around the prosthetic assembly.

Abstract: A venous valve prosthesis includes a frame and a prosthetic valve coupled to the frame. With the venous valve prosthesis implanted in a vein, the prosthetic valve includes a closed configuration wherein an outer surface of the prosthetic valve is in contact with a wall of the vein around a circumference of the prosthetic valve to prevent blood from flowing past the prosthetic valve between the wall of the vein and the outer surface of the prosthetic valve. The prosthetic valve is configured to move to an open configuration such that at least a portion of an outer wall of the prosthetic valve partially collapses away from the wall of the vein in response to antegrade blood flow through the vein to enable blood flow between the outer surface of the prosthetic valve and the wall of the vein.

Abstract: A delivery system for delivering a prosthesis includes a housing, a sheath extending from within the housing, a first rotatable knob, a first pulley coupled to the first rotatable knob so as to be rotatable therewith, a second rotatable knob, a second pulley coupled to the second rotatable knob so as to be rotatable therewith, and a cable coupled to the first pulley and to the second pulley. The cable is coupled to a proximal portion of the sheath. Rotation of the first rotatable knob causes the first pulley to rotate while the second pulley remains stationary thereby causing the first pulley to wind up a portion of the cable and retract the sheath at a first speed. Rotation of the second rotatable knob causes both the first and second pulleys to rotate, thereby causing both the first and second pulleys to wind up a portion of the cable and retract the sheath at a second speed being faster than the first speed.

Abstract: A delivery system for delivering a prosthesis includes a housing, a sheath extending from within the housing, a first motor housed within the housing, a first battery coupled to the first motor, a second motor housed within the housing, a second battery coupled to the second motor, and an actuator accessible from an exterior of the housing. The actuator is coupled to the first and second batteries to selectively activate the first and second batteries to power the first and second motors, respectively. A first pulley is coupled to the first motor such that the first pulley rotates during operation of the first motor and a second pulley is coupled to the second motor such that the second pulley rotates during operation of the second motor. Actuation of the actuator causes at least one of the first and second motors to rotate, thereby causing at least one of the first and second pulleys to wind up a portion of a single continuous cable and retract the sheath.

Abstract: A stent-graft includes a graft material having a main body, a first leg, a second leg, and a transition region where the first leg and the second leg meet the main body. A main body transition stent is coupled to the main body. A transition stent support including a gusset is coupled to the graft material such that a transition apex of the main body transition stent is interposed between the gusset and the graft material, the transition apex being aligned with the transition region. The transition apex, which is susceptible to failure, is stabilized by the gusset in combination with a supporting ligament. The gusset and supporting ligament prevent flexing of the transition apex and the associated failure thereof.

Abstract: A reconfigurable delivery system is disclosed having a multi-lumen delivery catheter configuration that permits the delivery and staged release of a self-expanding main vessel stent-graft and a delivery sheath configuration that permits the introduction of various medical devices for the delivery and implantation of various branch vessel stent-grafts that are to be mated with the main vessel stent-graft. A method is disclosed wherein the delivery system is first used in the multi-lumen delivery catheter configuration to deliver and release a main vessel stent-graft that is configured for placement in the abdominal aorta for treatment of short-neck infrarenal, juxtarenal, and/or suprarenal aneurysms and then used in the delivery sheath configuration to facilitate the delivery of branch vessel stent-grafts that are configured to extend from the main vessel stent-graft into a respective renal artery.

Abstract: A handle component of a medical device is disclosed for delivering a material to an enclosed cavity or space. The handle component includes a self-contained mechanism for holding the material and for providing or releasing the material to the enclosed cavity. The handle component also includes a pressure relief valve in fluid communication with the mechanism and the enclosed cavity. The pressure relief valve is configured to indicate when delivery of the material to the enclosed cavity reaches a preselected or set pressure and to thereby assure precise filling of the enclosed cavity with the material.

Abstract: A prosthetic assembly for repairing a target tissue defect within a target vessel region configured includes an exclusion structure sized to substantially bypass target tissue defect, and includes a branch assembly. The branch assembly can include a self-expanding outer branch prosthesis having an inflow region configured to deform to a non-circular cross-sectional-shape when deployed, and a support structure at least partially disposed within the inflow region. The support structure preserves blood flow to the branch vessel while the deformed inflow region inhibits blood leakage between and/or around the prosthetic assembly.

Abstract: An iliac branch device includes an iliac septum limb configured to be deployed in the common iliac artery. The iliac septum limb includes a graft material, a proximal end, and a septum. The graft material defines a common iliac lumen extending between the proximal end and the septum, the graft material and the septum defining an internal iliac lumen and an external iliac lumen. The iliac branch device including the iliac septum limb has several modes of adjustability. In addition, the iliac branch device has a relatively small cross-sectional area allowing the iliac branch device to treat relatively small iliac aneurysms in short common iliac arteries. This allows the iliac aneurysms to be treated at very early stages of the disease.

Abstract: A stent-graft includes a graft material having a main body, a first leg, a second leg, and a transition region where the first leg and the second leg meet the main body. A main body transition stent is coupled to the main body. A transition stent support including a gusset is coupled to the graft material such that a transition apex of the main body transition stent is interposed between the gusset and the graft material, the transition apex being aligned with the transition region. The transition apex, which is susceptible to failure, is stabilized by the gusset in combination with a supporting ligament. The gusset and supporting ligament prevent flexing of the transition apex and the associated failure thereof.

Abstract: The present technology relates generally to endovascular prostheses. More particularly, the disclosure relates to endovascular prostheses having an outer surface of a graft material thereof associated with a hydrogel composition, which may swell upon implantation within a blood vessel, thereby mediating various complications associated with endovascular procedures. The hydrogel compositions can also include various stabilizing polymers and active agents to further aid their use in the body.

Abstract: A dissection prosthesis system for implantation within a blood vessel includes a first prosthesis and a second prosthesis. The first prosthesis includes a first stent ring, a second stent ring, a first graft material band coupling the first stent ring to the second stent ring, a third stent ring, and a second graft material band coupling the second stent ring to the third stent ring. The second stent ring includes a plurality of openings that enable fluid flow from a lumen of the first prosthesis through the plurality of openings. The graft material bands may include band openings disposed therethrough to enable fluid flow from the lumen through the band openings. The second prosthesis includes a stent coupled to a graft material. The second prosthesis is configured to be disposed within the lumen of the first prosthesis.

Abstract: An iliac branch device includes an iliac septum limb configured to be deployed in the common iliac artery. The iliac septum limb includes a graft material, a proximal end, and a septum. The graft material defines a common iliac lumen extending between the proximal end and the septum, the graft material and the septum defining an internal iliac lumen and an external iliac lumen. The iliac branch device including the iliac septum limb has several modes of adjustability. In addition, the iliac branch device has a relatively small cross-sectional area allowing the iliac branch device to treat relatively small iliac aneurysms in short common iliac arteries. This allows the iliac aneurysms to be treated at very early stages of the disease.