Abstract: A stent graft delivery system including a tip assembly, a middle member tube, a sheath assembly, and a unitary front grip. The sheath tube is axially slideable within the distal front grip lumen, the threaded assembly distal end is disposed in the proximal front grip lumen and fixed to the unitary front grip, and the first threaded tube portion and the second threaded tube portion are radially compressed together by the unitary front grip. The sheath handle engages the exterior thread of the threaded assembly in a first configuration to move the sheath tube axially relative to the middle member tube and tip tube through rotation of the sheath handle and disengages the exterior thread of the threaded assembly in a second configuration to move the sheath tube axially relative to the middle member tube and tip tube through axial motion of the sheath handle.

Abstract: A suturing device including an elongated body, a distal tip, at least two support arms, and at least two extendable and retractable needles. The distal tip is moveable between an extended position in which the distal tip distally extends from a distal end of the elongated body and a retracted position in which the distal tip is disposed within the elongated body. The support arms are pivotally coupled to the distal tip. When the distal tip is in the extended position, each support arm is in a collapsed position disposed within the elongated body, and when the distal tip is in the retracted position, each support arm is in a deployed position extending radially away from the elongated body. Each needle includes a distal end configured to penetrate through a vessel wall and capture a suture releasably held within a portion of a support arm.

Abstract: A stent or stent-graft delivery system includes a handle having a graft cover retractor having a screw gear and a drive and quick release assembly. The drive and quick release assembly includes a proximal portion and a distal portion that are separable. The proximal portion of the drive and quick release assembly rotates in a first rotational direction about the screw gear to retract the graft cover using the screw gear. The drive and quick release assembly transitions from retraction using the engagement with the screw gear to retraction by sliding by the user grasping the distal portion instead of the proximal portion, and sliding the proximal portion only along the screw gear. In transitioning from using the screw gear to sliding along screw gear, it unnecessary to push any button and unnecessary for the user to remove her/his hand from the assembly.

Abstract: A stent or stent-graft delivery system includes a stent ejection component. The stent ejection component includes a body and an ejection collar. The ejection collar extends from the body in the proximal direction. The ejection collar assists in automatically ejecting a proximal end of a stent when the tapered tip is moved in the distal direction to deploy the stent. A stent or stent-graft delivery system may also include a retain-sleeve landing component. The retaining-sleeve landing component includes a body and a landing collar. The landing collar extends from the body in a distal direction. The landing collar automatically captures a tapered tip of the delivery system when the tapered tip is moved in a distal direction to deploy a stent contained in the delivery system. Upon capture of the tapered tip, the stent ejection component with the tapered tip attached has an atraumatic profile.

Abstract: A stent graft delivery system including a tip assembly, a middle member tube, a sheath assembly, a threaded assembly, and a unitary endoseal. The tip tube is disposed in and longitudinally slideable within the proximal portion of the endoseal lumen, the middle member proximal end of the middle member tube is disposed in the distal portion of the endoseal lumen and fixed to the longitudinal cylindrical endoseal body, the first cylindrical portion of the transverse cylindrical endoseal body is disposed in the first sidewall port of the threaded assembly, the second cylindrical portion of the transverse cylindrical endoseal body is disposed in the second sidewall port of the threaded assembly, and the longitudinal endoseal cylindrical body is disposed in the threaded assembly lumen.

Abstract: A stent or stent-graft delivery system includes a handle having a graft cover retractor having a screw gear and a drive and quick release assembly. The drive and quick release assembly allows a user to retract a graft cover by rotating the assembly in a first rotational direction about the screw gear. When the assembly is being rotated in a particular rotational direction, a partial revolution in the opposite rotational direction disengages the assembly from the screw gear, which is sensed by a change in the force required to rotate the assembly. With the assembly disengaged from the screw gear, the assembly can be slid along the screw so that the graft cover can be positioned more quickly. In transitioning from using the screw gear to sliding along screw gear, it unnecessary to push any button and unnecessary for the user to remove her/his hand from the assembly.

Abstract: A reconfigurable delivery system is disclosed having a multi-lumen delivery catheter configuration that permits the delivery and staged release of a self-expanding main vessel stent-graft and a delivery sheath configuration that permits the introduction of various medical devices for the delivery and implantation of various branch vessel stent-grafts that are to be mated with the main vessel stent-graft. A method is disclosed wherein the delivery system is first used in the multi-lumen delivery catheter configuration to deliver and release a main vessel stent-graft that is configured for placement in the abdominal aorta for treatment of short-neck infrarenal, juxtarenal, and/or suprarenal aneurysms and then used in the delivery sheath configuration to facilitate the delivery of branch vessel stent-grafts that are configured to extend from the main vessel stent-graft into a respective renal artery.

Abstract: A reconfigurable delivery system is disclosed having a multi-lumen delivery catheter configuration that permits the delivery and staged release of a self-expanding main vessel stent-graft and a delivery sheath configuration that permits the introduction of various medical devices for the delivery and implantation of various branch vessel stent-grafts that are to be mated with the main vessel stent-graft. A method is disclosed wherein the delivery system is first used in the multi-lumen delivery catheter configuration to deliver and release a main vessel stent-graft that is configured for placement in the abdominal aorta for treatment of short-neck infrarenal, juxtarenal, and/or suprarenal aneurysms and then used in the delivery sheath configuration to facilitate the delivery of branch vessel stent-grafts that are configured to extend from the main vessel stent-graft into a respective renal artery.

Abstract: A reconfigurable delivery system is disclosed having a multi-lumen delivery catheter configuration that permits the delivery and staged release of a self-expanding main vessel stent-graft and a delivery sheath configuration that permits the introduction of various medical devices for the delivery and implantation of various branch vessel stent-grafts that are to be mated with the main vessel stent-graft. A method is disclosed wherein the delivery system is first used in the multi-lumen delivery catheter configuration to deliver and release a main vessel stent-graft that is configured for placement in the abdominal aorta for treatment of short-neck infrarenal, juxtarenal, and/or suprarenal aneurysms and then used in the delivery sheath configuration to facilitate the delivery of branch vessel stent-grafts that are configured to extend from the main vessel stent-graft into a respective renal artery.

Abstract: A method includes covering ostai of branch vessels emanating from a main vessel and an aneurysm with a high metal to vessel ratio stent. A metal to vessel ratio of the high metal to vessel ratio stent is sufficiently high to encourage tissue ingrowth around the high metal to vessel ratio stent yet is sufficiently low to ensure perfusion of the branch vessels through the high metal to vessel ratio stent. The ingrowth of tissue provides secure fixation and sealing of the high metal to vessel ratio stent to the main vessel and remodels and essentially eliminates the aneurysm. Further, as the entire high metal to vessel ratio stent is permeably, the high metal to vessel ratio stent is deployed without having to rotationally position the high metal to vessel ratio stent.

Abstract: A variable zone high metal to vessel ratio stent includes a proximal high metal to vessel ratio zone, a central low metal to vessel ratio zone, and a distal high metal to vessel ratio zone. The proximal high metal to vessel ratio zone is deployed with fixation and sealing to healthy tissue of a main vessel superior to branch vessels and an aneurysm. The central low metal to vessel ratio zone is deployed directly on ostai of the branch vessels. However, as the central low metal to vessel ratio zone is highly permeable, blood flows from the main vessel through the central low metal to vessel ratio zone and into branch vessels.

Abstract: A method includes covering ostai of branch vessels emanating from a main vessel and an aneurysm with an integrated mesh high metal to vessel ratio stent. The integrated mesh high metal to vessel ratio stent includes serpentine rings integrated with an integrated mesh having holes formed therein. A metal to vessel ratio of the integrated mesh high metal to vessel ratio stent is sufficiently high to encourage tissue ingrowth around the integrated mesh high metal to vessel ratio stent yet is sufficiently low to ensure perfusion of the branch vessels through the integrated mesh high metal to vessel ratio stent.

Abstract: A stent-graft delivery system includes a stent-graft including a proximal anchor stent ring. The proximal anchor stent ring includes proximal apexes and anchor pin structures extending proximally from each of the proximal apexes. The anchor pin structures include anchor pin connecting arms and anchor pins. The anchor pin structures are tucked together to accommodate small catheter sizes. Further, the anchor pins reduce or eliminate migration of the stent-graft. Further still, the anchor pin connecting arms are long and flexible thus distributing stresses in a way that improves the load carrying capacity of the anchor pins and allows flowering of the graft material of the stent-graft prior to release of the anchor pins structures.

Abstract: A stent or stent-graft delivery system includes a stent ejection component. The stent ejection component includes a body and an ejection collar. The ejection collar extends from the body in the proximal direction. The ejection collar assists in automatically ejecting a proximal end of a stent when the tapered tip is moved in the distal direction to deploy the stent. A stent or stent-graft delivery system may also include a retain-sleeve landing component. The retaining-sleeve landing component includes a body and a landing collar. The landing collar extends from the body in a distal direction. The landing collar automatically captures a tapered tip of the delivery system when the tapered tip is moved in a distal direction to deploy a stent contained in the delivery system. Upon capture of the tapered tip, the stent ejection component with the tapered tip attached has an atraumatic profile.

Abstract: A method includes covering an ostium of a branch vessel emanating from a main vessel with a proximal landing zone of a high metal to vessel ratio landing zone stent-graft, wherein a metal to vessel ratio of the proximal landing zone when deployed is sufficiently high to encourage tissue ingrowth around the proximal landing zone yet is sufficiently low to ensure perfusion of the branch vessel through the proximal landing zone. The method further includes covering an aneurysm of the main vessel with an exclusion zone of the high metal to vessel ratio landing zone stent-graft, the exclusion zone being formed of graft material. By forming the exclusion zone of graft material, excellent exclusion of the aneurysm is achieved.

Abstract: An introducer sheath includes a elongated sheath configured to be inserted into a blood vessel. The elongated sheath includes a central lumen configured to allow a surgical implement or medical device to pass therethrough. The introducer sheath also includes a hemostatic valve operatively connected to the sheath. The hemostatic valve is configured to prevent blood in the blood vessel from exiting the introducer sheath assembly when the elongated sheath is located in the blood vessel. The hemostatic valve includes a plurality of seals supported by a housing, including a front seal configured to provide a hemostatic seal with a guide wire, and a rear seal configured to provide a hemostatic seal with a range of sizes of implements and devices. The housing is configured to provide strain recovery for strain induced by displacement forces generated during movement of the implement or medical device through the plurality of seals.

Abstract: An introducer sheath includes a elongated sheath configured to be inserted into a blood vessel. The elongated sheath includes a central lumen configured to allow a surgical implement or medical device to pass therethrough. The introducer sheath also includes a hemostatic valve operatively connected to the sheath. The hemostatic valve is configured to prevent blood in the blood vessel from exiting the introducer sheath assembly when the elongated sheath is located in the blood vessel. The hemostatic valve includes a plurality of seals supported by a housing, including a front seal configured to provide a hemostatic seal with a guide wire, and a rear seal configured to provide a hemostatic seal with a range of sizes of implements and devices. The housing is configured to provide strain recovery for strain induced by displacement forces generated during movement of the implement or medical device through the plurality of seals.

Abstract: A stent graft delivery system including a tip assembly, a middle member tube, a sheath assembly, and a unitary front grip. The sheath tube is axially slideable within the distal front grip lumen, the threaded assembly distal end is disposed in the proximal front grip lumen and fixed to the unitary front grip, and the first threaded tube portion and the second threaded tube portion are radially compressed together by the unitary front grip. The sheath handle engages the exterior thread of the threaded assembly in a first configuration to move the sheath tube axially relative to the middle member tube and tip tube through rotation of the sheath handle and disengages the exterior thread of the threaded assembly in a second configuration to move the sheath tube axially relative to the middle member tube and tip tube through axial motion of the sheath handle.

Abstract: A stent graft delivery system including a tip assembly, a middle member tube, a sheath assembly, a threaded assembly, and a unitary endoseal. The tip tube is disposed in and longitudinally slideable within the proximal portion of the endoseal lumen, the middle member proximal end of the middle member tube is disposed in the distal portion of the endoseal lumen and fixed to the longitudinal cylindrical endoseal body, the first cylindrical portion of the transverse cylindrical endoseal body is disposed in the first sidewall port of the threaded assembly, the second cylindrical portion of the transverse cylindrical endoseal body is disposed in the second sidewall port of the threaded assembly, and the longitudinal endoseal cylindrical body is disposed in the threaded assembly lumen.

Abstract: A delivery system for percutaneously delivering and deploying a stented prosthetic heart valve. The delivery device includes a delivery sheath slidably disposed over an inner shaft, and a capture assembly. The capture assembly includes a spindle and a biasing member. The spindle is attached to the inner shaft and defines slot. The biasing member is disposed within the slot and self-transitions from a deflected condition to a normal condition. In a delivery state, the delivery sheath retains the prosthesis over the inner shaft and coupled to the spindle via the capture slot, including a portion of the prosthetic valve being engaged within the slot and the biasing member forced to the deflected condition. In a deployment state, the delivery sheath is proximally withdrawn and the biasing member self-transitions toward the normal condition to eject the prosthetic valve from the capture slot.