Patents by Inventor Jeffrey A. Jeddeloh

Jeffrey A. Jeddeloh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glanders/meliodosis vaccines
    Patent number: 7666404
    Abstract: The present invention relates to nucleic acids encoding B. mallei and B. pseudomallei AHL synthases and LuxR transcriptional regulators, and methods for use, as well as describes the construction, characterization and use of avirulent strains of B. mallei and methods of use.
    Type: Grant
    Filed: July 15, 2003
    Date of Patent: February 23, 2010
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Ricky Ulrich, Jeffrey Jeddeloh, Petra Oyston
  • METHODS AND SYSTEMS FOR UNIFORM ENRICHMENT OF GENOMIC REGIONS
    Publication number: 20090221438
    Abstract: The present invention provides methods and compositions for the enrichment of target nucleic acids in a microarray system. In particular, the present invention provides methods and compositions for uniform enrichment of target nucleic acid molecules in a microarray format. The present invention also provides for intentionally non-uniform enrichment among target nucleic acid molecules.
    Type: Application
    Filed: February 23, 2009
    Publication date: September 3, 2009
    Applicant: ROCHE NIMBLEGEN, INC.
    Inventors: Jacob Kitzman, Todd Richmond, Mark D'Ascenzo, Thomas Albert, Matthew Rodesch, Jeffrey Jeddeloh, Christina Middle
  • Methods and Systems for Quality Control Metrics in Hybridization Assays
    Publication number: 20090203540
    Abstract: The present invention provides methods and systems for performing quality control metrics in hybridization assays. In particular, the present invention provides for quality control metrics for nucleic acid enrichment on hybridization assay formats, such as microarray assays.
    Type: Application
    Filed: February 2, 2009
    Publication date: August 13, 2009
    Applicant: ROCHE NIMBLEGEN, INC.
    Inventors: CHRISTINA MIDDLE, JACOB KITZMAN, TODD RICHMOND, THOMAS ALBERT, JEFFREY JEDDELOH
  • GENE METHYLATION IN PROSTATE CANCER DIAGNOSIS
    Publication number: 20090176215
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with prostate cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of prostate cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: July 9, 2009
    Applicant: ORION GENOMICS LLC
    Inventors: MUHAMMAD A. BUDIMAN, JEFFREY A. JEDDELOH, REBECCA MALONEY, YULIA KORSHUNOVA
  • GENE METHYLATION IN BREAST CANCER
    Publication number: 20090170084
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with breast cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of breast cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: July 2, 2009
    Applicant: Orion Genomics LLC
    Inventors: Muhammad A. Budiman, Jeffrey A. Jeddeloh, Rebecca Maloney, Yulia Korshunova
  • Gene Methylation in Cervical Cancer Diagnosis
    Publication number: 20090170087
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with cervical cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of cervical cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: July 2, 2009
    Applicant: ORION GENOMICS LLC
    Inventors: MUHAMMAD A. BUDIMAN, JEFFREY A. JEDDELOH, REBECCA MALONEY, YULIA KORSHUNOVA
  • GENE METHYLATION IN BLADDER CANCER DIAGNOSIS
    Publication number: 20090170081
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with bladder cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of bladder cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: July 2, 2009
    Applicant: Orion Genomics LLC
    Inventors: Muhammad A. Budiman, Jeffrey A. Jeddeloh, Rebecca Maloney, Yulia Korshunova
  • Gene Methylation in Head and Neck Cancer Diagnosis
    Publication number: 20090170085
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with head and neck cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of head and neck cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: July 2, 2009
    Applicant: ORION GENOMICS LLC
    Inventors: MUHAMMAD A. BUDIMAN, JEFFREY A. JEDDELOH, REBECCA MALONEY, YULIA KORSHUNOVA
  • GENE METHYLATION IN RENAL CANCER DIAGNOSIS
    Publication number: 20090170082
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with renal cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of renal cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: July 2, 2009
    Applicant: Orion Genomics LLC
    Inventors: Muhammad A. Budiman, Jeffrey A. Jeddeloh, Rebecca Maloney, Yulia Korshunova
  • Gene Methylation In Esophageal Cancer Diagnosis
    Publication number: 20090170086
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with esophageal cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of esophageal cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: July 2, 2009
    Applicant: ORION GENOMICS LLC
    Inventors: MUHAMMAD A. BUDIMAN, JEFFREY A. JEDDELOH, REBECCA MALONEY, YULIA KORSHUNOVA
  • GENE METHYLATION IN CANCER DIAGNOSIS
    Publication number: 20090170088
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: July 2, 2009
    Applicant: ORION GENOMICS LLC
    Inventors: MUHAMMAD A. BUDIMAN, JEFFREY A. JEDDELOH, REBECCA MALONEY, YULIA KORSHUNOVA
  • GENE METHYLATION IN DIAGNOSIS OF MELANOMA
    Publication number: 20090170083
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with melanoma. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of melanoma.
    Type: Application
    Filed: February 1, 2008
    Publication date: July 2, 2009
    Applicant: Orion Genomics LLC
    Inventors: Muhammad A. Budiman, Jeffrey A. Jeddeloh, Rebecca Maloney, Yulia Korshunova
  • Gene Methylation in Colon Cancer Diagnosis
    Publication number: 20090098542
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with colon cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of colon cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: April 16, 2009
    Applicant: Orion Genomics LLC
    Inventors: Muhammad A. Budiman, Jeffrey A. Jeddeloh, Rebecca Maloney, Yulia Korshunova
  • GENE METHYLATION IN LUNG CANCER DIAGNOSIS
    Publication number: 20090098543
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with lung cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of lung cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: April 16, 2009
    Applicant: ORION GENOMICS LLC
    Inventors: MUHAMMAD A. BUDIMAN, JEFFREY A. JEDDELOH, REBECCA MALONEY, YULIA KORSHUNOVA
  • GENE METHYLATION IN LIVER CANCER DIAGNOSIS
    Publication number: 20090075264
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with liver cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of liver cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: March 19, 2009
    Applicant: Orion Genomics LLC
    Inventors: Muhammad A. Budiman, Jeffrey A. Jeddeloh, Rebecca Maloney, Yulia Korshunova
  • GENE METHYLATION IN OVARIAN CANCER DIAGNOSIS
    Publication number: 20090075263
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with ovarian cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of ovarian cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: March 19, 2009
    Applicant: Orion Genomics LLC
    Inventors: Muhammad A. Budiman, Jeffrey A. Jeddeloh, Rebecca Maloney, Yulia Korshunova
  • GENE METHYLATION IN THYROID CANCER DIAGNOSIS
    Publication number: 20090075265
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with thyroid cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of thyroid cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: March 19, 2009
    Applicant: Orion Genomics LLC
    Inventors: MUHAMMAD A. BUDIMAN, JEFFREY A. JEDDELOH, REBECCA MALONEY, YULIA KORSHUNOVA
  • Gene Methylation In Endometrial Cancer Diagnosis
    Publication number: 20090075262
    Abstract: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with endometrial cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of endometrial cancer.
    Type: Application
    Filed: February 1, 2008
    Publication date: March 19, 2009
    Applicant: Orion Genomics LLC
    Inventors: Muhammad A. Budiman, Jeffrey A. Jeddeloh, Rebecca Maloney, Yulia Korshunova
  • Differential enzymatic fragmentation by whole genome amplification
    Patent number: 7459274
    Abstract: The present invention provides methods for detecting the presence of methylation at a locus within a population of nucleic acids.
    Type: Grant
    Filed: March 2, 2005
    Date of Patent: December 2, 2008
    Assignee: Orion Genomics LLC
    Inventors: Nathan D. Lakey, Jeffrey A. Jeddeloh, Yulia Korshunova
  • ENRICHMENT AND SEQUENCE ANALYSIS OF GENOMIC REGIONS
    Publication number: 20080194414
    Abstract: The present invention provides novel methods for reducing the complexity of preferably a genomic sample for further analysis such as direct DNA sequencing, resequencing or SNP calling. The methods use pre-selected immobilized oligonucleotide probes to capture target nucleic acid molecules from a sample containing denatured, fragmented (genomic) nucleic acids for reducing the genetic complexity of the original population of nucleic acid molecules.
    Type: Application
    Filed: January 8, 2008
    Publication date: August 14, 2008
    Inventors: Thomas J. Albert, Roland Green, Todd Richmond, Michael Molla, Jeffrey Jeddeloh, Jason Patrick Affourtit, Mathreyan Srinivasan, Brian Christopher Godwin, Matthew Rodesch