Abstract: A drug delivery system uses an electrically sensitive polymer to store a drug and applies an electric field onto the electrically sensitive polymer for quantitatively and temporally controlled drug delivery. In one embodiment, the drug delivery system is part of a cardiac rhythm management (CRM) system that includes an implantable CRM device and an implantable drug delivery device. The implantable CRM device delivers electrical therapies to a heart and controls the implantable drug delivery device by producing the electrical field with controllable amplitude, frequency, and timing.

Abstract: A system delivers combined ventricular assist device (VAD) therapy and chemical and/or biological therapy to modulate myocardial tissue growth in a heart after myocardial infarction (MI). The system includes an agent delivery device to release one or more agents to an MI region to modulate myocardial tissue growth in that region, and a VAD to enhance the effects of the one or more agents by reducing myocardial wall stress and the overall cardiac workload. In one embodiment, the system is an implantable system including an implantable agent delivery device and an implantable VAD for long-term use in a patient.

Abstract: An implantable system which includes a gene/protein delivery device and a pulse generator, as well as method of preparing the gene/protein delivery device and using the system, are provided. In one embodiment, the implantable system detects a predetermined condition or event and, in response, delivers gene(s) and/or protein(s) in conjunction with delivering pacing and/or defibrillation pulses.

Abstract: An apparatus for verifying the functionality of a production line electronics safety tester such as the hipot tester/ground continuity tester. The apparatus simulates a product to be tested by a safety tester and can be configured to simulate a passing or failing product for each of a plurality of separate tests.

Abstract: All or a portion of a surface of an implantable sensor is covered with a biocompatible coating formed at least partially of a biomaterial matrix having properties that promote a substantially even growth of tissue cells over the surface of the coating. Additional materials, such as growth factors, agents that recruit endogenous stem cells, and cell adhesion motif arginine, glycine, aspartic acid may be included in the coating. Autologous cells may be added to the coating prior to implantation. The sensor surface may also be textured, by etching or abrading, in order to promote even tissue growth. Alternatively, the sensor surface may be covered with a coating having properties that inhibit the growth of tissue. These coatings may include a biomaterial, a biomaterial matrix having a drug, such as a sirolimus or a steroid, an active component, or a self assembled monolayer.

Abstract: A system delivers cardiac pacing therapy and chemical and/or biological therapy to modulate myocardial tissue growth in a heart after myocardial infarction (MI). The system includes an agent delivery device to release one or more agents to an MI region to modulate myocardial tissue growth in that region, and a cardiac rhythm management (CRM) device to deliver pacing pulses to enhance the effects of the one or more agents by altering myocardial wall stress and cardiac workload. In one embodiment, the system is an implantable system including an implantable agent delivery device and an implantable CRM device.

Abstract: A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. The pre-excitation pacing in conjunction with counterpulsation therapy serves to either prevent or minimize post-infarct remodeling.

Abstract: Methods for treating or diagnosing cancers of the female reproductive tract and childhood cancers are disclosed. The methods described herein use binding agents, e.g., antibodies, specific for the extracellular domain of human prostate specific membrane antigen (PSMA).

Abstract: A gene regulatory system controls gene therapy by emitting one or more forms of energy that regulate gene expression by triggering promoters. The system includes a sensor to sense a signal indicative of a need for the gene therapy as well as responses to the gene therapy. The regulation of the gene expression is controlled based on the sensed signal and/or a user command. In one embodiment, the system delivers one or more electrical therapies in conjunction with the gene therapy.

Abstract: A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.

Abstract: A system for enabling a mobile phone for wireless communications operation is provided. The system includes identification means for providing enabling identification information to the mobile phone in a wireless manner. The system also includes a mobile phone having a sensor for sensing the enabling identification information, and a transmitter for transmitting registration information to a wireless communications network thereby enabling the phone for wireless communications operation. A method for enabling a mobile phone for wireless communications operation on a wireless communications network is also provided. The method includes bringing identification means within the proximity of a mobile phone initially in standby mode to transfer enabling identification information to the phone in a wireless manner. The mobile phone registers with the network using the enabling information which enables the mobile phone for wireless communications operation.

Abstract: A method of diagnosing the presence or absence of cancer in a human patient is disclosed. In one embodiment, this method comprises the steps of examining patient tissue for the CRD-BP expression levels and comparing that expression level with control levels. The present invention is also a method of inhibiting cancer cell growth comprising the step of eliminating or lowering the level of functional CRD-BP in the cancerous tissues.

Abstract: A method and system for pairing a remote control transmitter and receiver includes associating an identification (ID) code with the transmitter. The transmitter includes a light generator for generating a light signal in order to perform a primary function which is visually detectable by a human operator. The light generator may be a laser pointer or a status indicator LED. The light generator is modulated to encode the identification code onto the light signal while the light generator is performing the primary function. The receiver includes a light signal detector such as an LED for receiving the light signal from the light generator. The receiver associates itself with the ID code contained in the light signal in order to pair the receiver with the transmitter. By being paired with the transmitter, the receiver acts upon transmitted command signals received from the transmitter.

Abstract: A sound discriminator (107, 207) in accordance with the invention distinguishes or emphasis a specific audio signal or class or audio signals. The sound discriminator is employed in a digital audio encoding and/or decoding process. A comparator (110, 210) within the sound discriminator compares a received representation of an audio signal with a stored representation (112, 212) of a desired signal. An error between the two signals is determined and if the error is within an acceptable range, the stored representation of the desired signal replaces the actual received representation of the audio signal in an encoded or decoded stream of data. In this manner, a desired signal within an encoded or decoded signal is discriminated.

Abstract: Apparatus and a method for establishing a cellular mobile call. If no radio traffic (voice or data) channels are available for a calling or called mobile station (MS), then a test is made to determine the expected wait time before a channel becomes available. If the expected wait time is less than a first threshold, then the call or the call request is queued. If a channel for an incoming call to an MS does not become available before a second time threshold, then the caller is notified by an announcement that the call has been queued and is expected to be established in a short time. If the caller of an incoming call to the MS does not disconnect, then the MSC waits for an available channel and establishes a connection to the MS over that available channel. For an outgoing call from an MS, a control message is sent to the MS to trigger an indication of the queued status to the user. The indication may be one or more tones, a data display, or the playing of a pre-recorded announcement.

Abstract: The present invention allows NIC resources to be accessed through auxiliary power and an ASIC clock while the PC is powered down and while PCI power and the PCI clock are not available. The present invention also provides an alternate path for accessing the NIC registers, downloading keep-alive and alert-on-LAN packets to the transmit packet buffer (TPB), as well as uploading received packets from the receive packet buffer (RPB). The present invention also allows monitoring PCI activity and seamlessly servicing the PCI configuration cycle (when PCI power and the PCI clock are restored) in conjunction with responding to the access through the alternate path (while PCI power and the PCI clock are not available).

Abstract: Apparatus and a method for establishing a cellular mobile call. If no radio traffic (voice or data) channels are available for a calling Mobile Station (MS), then a test is made to determine the expected wait time before a channel becomes available. If the expected wait time is less than a first threshold, then the call request is queued. If a channel does not become available before a second time threshold, then the caller is notified that the call has been queued and is expected to be established in a short time. A control message is sent to the MS to trigger an indication of the queued status to the user. The indication may be one or more tones, a data display, or the playing of a pre-recorded announcement. If the expected wait time is more than the first threshold, the caller is given the opportunity to be called back when a radio channel becomes available. Advantageously, the number of failed calls because of unavailable traffic channels is reduced, and the caller's annoyance level is reduced.

Abstract: A method and apparatus for establishing a wireless telephone connection when a call cannot be made immediately. The caller and the wireless system negotiate for a later time when another attempt will be made to establish the call. Shortly before that time arrives, the wireless system reserves a radio channel and retains that channel for the deferred call. Then, the system calls the customer back, or waits for the customer to attempt the call. A reserved channel is then used for the call if the system has been successful in reserving such a channel. Advantageously, there is a high probability that the deferred call will have a radio channel available.

Abstract: A method and apparatus for permitting a wireless telecommunications caller to use an alternate service provider if the primary service provider has no available bearer channels. If the primary service provider has no available bearer channels for a call, that service provider sends a message to the caller's mobile station to switch its control channel to one of the control channels of an alternate service provider. The caller then attempts to complete the call over the facilities of the alternate service provider. Advantageously, spare facilities of the alternate service provider can be employed to good use; advantageously, the caller's service is improved because the call is not finally blocked when no bearer channels are available for the call.

Abstract: In a cellular mobile telecommunications system, apparatus and a method for altering the charge for a call if the occupancy of radio channels is above or below an appropriate threshold. For one proposed service, the users are charged less if they make calls during the time when the occupancy of radio channels is less than a threshold. For users having another proposed service, the charge is greater when the occupancy of the radio channels is above another threshold. Advantageously, users are encouraged to use the mobile telecommunications service when the occupancy of regular channels is low, and to use the service less when the occupancy of the radio channels is high.