Patents by Inventor Jeffrey A. Silverman

Jeffrey A. Silverman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DOSING AND ADMINISTRATION OF RECOMBINANT L-ASPARAGINASE
    Publication number: 20220323556
    Abstract: The present invention provides compositions and methods for treating a disease treatable by asparagine depletion in a human subject comprising dosing a human subject with L-asparaginase.
    Type: Application
    Filed: March 30, 2022
    Publication date: October 13, 2022
    Inventors: Mi Rim CHOI, Tong LIN, Jeffrey SILVERMAN
  • DOSING OF RECOMBINANT L-ASPARAGINASE
    Publication number: 20220313798
    Abstract: The present invention provides compositions and methods for treating a disease treatable by asparagine depletion in a human subject comprising dosing a human subject with L-asparaginase.
    Type: Application
    Filed: May 14, 2021
    Publication date: October 6, 2022
    Inventors: Mi Rim CHOI, Tong LIN, Jeffrey SILVERMAN
  • RECOMBINANT L-ASPARAGINASE
    Publication number: 20210308237
    Abstract: The present invention provides compositions and methods for treating a disease treatable by asparagine depletion in a human subject comprising administering to a human subject a recombinant L-asparaginase.
    Type: Application
    Filed: October 23, 2020
    Publication date: October 7, 2021
    Inventors: Mi Rim CHOI, Tong LIN, Jeffrey SILVERMAN
  • METHODS OF USING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID FOR TREATMENT OF CANCER
    Publication number: 20180098975
    Abstract: Methods of treating, preventing or managing cancer, including certain leukemias are disclosed. The methods encompass the administration of enantiomerically pure (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.
    Type: Application
    Filed: September 25, 2017
    Publication date: April 12, 2018
    Inventors: Daniel C. Adelman, Jeffrey A. Silverman, Michelle Arkin, Jennifer Hyde, Duncan Walker, Jasmin Wright
  • SNS-595 and methods of using the same
    Patent number: 9757363
    Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: September 12, 2017
    Assignee: Sunesis Pharmaceuticals, Inc.
    Inventors: Daniel C. Adelman, Jeffrey A. Silverman
  • Compounds and compositions for treatment of cancer
    Patent number: 9676774
    Abstract: Compounds and compositions for treating, preventing or managing cancer are disclosed. The compositions provided herein comprise SNS-595 and N-desmethyl-SNS-595. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds and compositions.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: June 13, 2017
    Assignee: Sunesis Pharmaceuticals, Inc.
    Inventors: Daniel C. Adelman, Marc J. Evanchik, Anantha Sudhakar, Jeffrey William Jacobs, Jeffrey A. Silverman
  • METHODS OF USING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID FOR TREATMENT OF CERTAIN HEMATOLOGIC DISORDERS
    Publication number: 20170119745
    Abstract: Methods of treating, preventing or managing hematologic disorders, such as leukemia are disclosed. The methods encompass the administration of SNS-595. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. In certain embodiments, the method of treatment comprise administering SNS-595 in combination with Ara-C. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.
    Type: Application
    Filed: June 3, 2016
    Publication date: May 4, 2017
    Inventors: Daniel C. Adelman, Jeffrey A. Silverman, Glenn Michelson, Caroline Dame Scatena
  • COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF CANCER
    Publication number: 20170101404
    Abstract: Compounds and compositions for treating, preventing or managing cancer are disclosed. The compositions provided herein comprise SNS-595 and N-desmethyl-SNS-595. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds and compositions.
    Type: Application
    Filed: May 16, 2016
    Publication date: April 13, 2017
    Inventors: Daniel C. Adelman, Marc J. Evanchik, Anantha Sudhakar, Jeffrey William Jacobs, Jeffrey A. Silverman
  • SNS-595 AND METHODS OF USING THE SAME
    Publication number: 20160361302
    Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.
    Type: Application
    Filed: January 14, 2016
    Publication date: December 15, 2016
    Inventors: Daniel C. Adelman, Jeffrey A. Silverman
  • METHODS OF USING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID IN COMBINATION THERAPY
    Publication number: 20160317510
    Abstract: Methods of treating, preventing or managing cancers are disclosed. The methods encompass the administration of SNS-595 in combination with a second active agent. In certain embodiments, the method of treatment comprise administering SNS-595 in combination with cisplatin, carboplatin, gemcitabine or a combination thereof.
    Type: Application
    Filed: December 3, 2015
    Publication date: November 3, 2016
    Inventor: Jeffrey A. SILVERMAN
  • METHODS OF USING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID FOR TREATMENT OF CERTAIN HEMATOLOGIC DISORDERS
    Publication number: 20150190380
    Abstract: Methods of treating, preventing or managing hematologic disorders, such as leukemia are disclosed. The methods encompass the administration of SNS-595. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. In certain embodiments, the method of treatment comprise administering SNS-595 in combination with Ara-C. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.
    Type: Application
    Filed: August 15, 2014
    Publication date: July 9, 2015
    Inventors: Daniel C. Adelman, Jeffrey A. Silverman, Glenn Michelson, Caroline Dame Scatena
  • COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF CANCER
    Publication number: 20150150858
    Abstract: Compounds and compositions for treating, preventing or managing cancer are disclosed. The compositions provided herein comprise SNS-595 and N-desmethyl-SNS-595. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds and compositions.
    Type: Application
    Filed: June 30, 2014
    Publication date: June 4, 2015
    Inventors: Daniel C. ADELMAN, Marc J. EVANCHIK, Anantha SUDHAKAR, Jeffrey William JACOBS, Jeffrey A. SILVERMAN
  • SNS-595 AND METHODS OF USING THE SAME
    Publication number: 20140378505
    Abstract: The present invention relates to SNS-595 and of treating cancer using the same.
    Type: Application
    Filed: February 3, 2014
    Publication date: December 25, 2014
    Applicant: SUNESIS PHARMACEUTICALS, INC.
    Inventors: Daniel C. ADELMAN, Jeffrey A. Silverman
  • METHODS OF USING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID FOR TREATMENT OF CANCER
    Publication number: 20140205680
    Abstract: Methods of treating, preventing or managing cancer, including certain leukemias are disclosed. The methods encompass the administration of enantiomerically pure (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.
    Type: Application
    Filed: October 17, 2013
    Publication date: July 24, 2014
    Applicant: SUNESIS PHARMACEUTICALS, INC.
    Inventors: Daniel C. Adelman, Jeffrey A. Silverman, Michelle Arkin, Jennifer Hyde, Duncan Walker, Jasmin Wright
  • METHODS OF USING (+)-1,4-DIHYDRO-7-[(3S,4S)-3-METHOXY-4-(METHYLAMINO)-1-PYRROLIDINYL]-4-OXO-1-(2-THIAZOLYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID IN COMBINATION THERAPY
    Publication number: 20140205679
    Abstract: Methods of treating, preventing or managing cancers are disclosed. The methods encompass the administration of SNS-595 in combination with a second active agent. In certain embodiments, the method of treatment comprise administering SNS-595 in combination with cisplatin, carboplatin, gemcitabine or a combination thereof.
    Type: Application
    Filed: August 21, 2013
    Publication date: July 24, 2014
    Applicant: SUNESIS PHARMACEUTICALS, INC.
    Inventor: Jeffrey A. Silverman
  • 1,8-naphthyridine compounds for the treatment of cancer
    Patent number: 8765954
    Abstract: Compounds and compositions for treating, preventing or managing cancer are disclosed. The compositions provided herein comprise SNS-595 and N-desmethyl-SNS-595. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds and compositions.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: July 1, 2014
    Assignee: Sunesis Pharmaceuticals, Inc.
    Inventors: Daniel C. Adelman, Marc J. Evanchik, Anantha Sudhakar, Jeffrey William Jacobs, Jeffrey A. Silverman
  • Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
    Patent number: 8580814
    Abstract: Methods of treating, preventing or managing cancer, including certain leukemias are disclosed. The methods encompass the administration of enantiomerically pure (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.
    Type: Grant
    Filed: September 5, 2006
    Date of Patent: November 12, 2013
    Assignee: Sunesis Pharmaceuticals, Inc.
    Inventors: Daniel C. Adelman, Jeffrey A. Silverman
  • Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-OXO-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination therapy
    Patent number: 8518872
    Abstract: Methods of treating, preventing or managing cancers are disclosed. The methods encompass the administration of SNS-595 in combination with a second active agent. In certain embodiments, the method of treatment comprise administering SNS-595 in combination with cisplatin, carboplatin, gemcitabine or a combination thereof.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: August 27, 2013
    Assignee: Sunesis Pharmaceuticals, Inc.
    Inventor: Jeffrey A. Silverman
  • COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF CANCER
    Publication number: 20120245198
    Abstract: Compounds and compositions for treating, preventing or managing cancer are disclosed. The compositions provided herein comprise SNS-595 and N-desmethyl-SNS-595. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds and compositions.
    Type: Application
    Filed: January 27, 2012
    Publication date: September 27, 2012
    Inventors: Daniel C. Adelman, Marc J. Evanchik, Anantha Sudhakar, Jeffrey William Jacobs, Jeffrey A. Silverman
  • 1,8-naphthyridine compounds for the treatment of cancer
    Patent number: 8124773
    Abstract: Compounds and compositions for treating, preventing or managing cancer are disclosed. The compositions provided herein comprise SNS-595 and N-desmethyl-SNS-595. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds and compositions.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: February 28, 2012
    Assignee: Sunesis Pharmaceuticals, Inc.
    Inventors: Daniel C. Adelman, Marc J. Evanchik, Anantha Sudhakar, Jeffrey William Jacobs, Jeffrey A. Silverman