Abstract: The present invention provides Compound 1, solid forms thereof, compositions thereof, as Aurora kinase inhibitor for use as an oncology agent. The present invention also provides synthetic methods of preparing Compound 1 and intermediates thereto.

Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.

Abstract: Methods of treating, preventing or managing cancers are disclosed. The methods encompass the administration of SNS-595 in combination with a second active agent. In certain embodiments, the method of treatment comprise administering SNS-595 in combination with cisplatin, carboplatin, gemcitabine or a combination thereof.

Abstract: Compounds and compositions for treating, preventing or managing cancer are disclosed. The compositions provided herein comprise SNS-595 and N-desmethyl-SNS-595. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds and compositions.

Abstract: Methods of treating, preventing or managing cancer, including certain leukemias are disclosed. The methods encompass the administration of enantiomerically pure (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.

Abstract: Methods of treating, preventing or managing hematologic disorders, such as leukemia are disclosed. The methods encompass the administration of SNS-595. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. In certain embodiments, the method of treatment comprise administering SNS-595 in combination with Ara-C. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.

Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.

Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.

Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.

Abstract: A pair of educational footwear teaches children all of the skills attendant to wearing footwear, particularly footwear having laces. Indicia on the exterior of the footwear which face one another when the footwear is properly aligned for wearing teach children how to accomplish the task of putting the left item of footwear on the left foot and the right item of footwear on the right foot; a bi-colored lace cooperates with color-coded eyelets to teach children how to properly lace the footwear; and a retaining device holds one end of the lace in a looped configuration to make it much easier for a child to tie the lace with a bowknot. All of these features combine in an inconspicuous manner, and therefore may be incorporated in any type of footwear for daily wear.

Abstract: A split sole shoe has a front outer sole with an outwardly facing recessed section and a heel member with an inwardly facing recessed section, the outwardly facing recessed section being connected to the inwardly facing recessed section in an overlapping configuration so as to form an interior relief groove exposing a portion of the inwardly facing recessed section and an exterior relief groove exposing a portion of the outwardly facing recessed section, thereby increasing the flexibility of the shoe in the region which flexes while taking a heel-to-toe step. A toe cap portion is formed together with the front outer sole so as to provide a smooth and continuous transition from the top of the toe cap to the bottom of the front outer sole, thereby enabling an infant or child to drag the toe portion of the shole without stumbling or tripping on a protuberance in the transition region.

Abstract: Footwear for infants and toddlers which allow the child's foot to relax in a natural, "barefoot" condition, i.e., without exerting substantial pressure on the toes and sides of the foot, and which facilitate the fitting of the shoe onto the foot. The shoe comprises a sole and an upper fastened to the sole for surrounding the sides and heel of the foot. The upper includes a pair of flexible side regions having a respective pair of edge regions which extend rearwardly substantially from a forward end of the toe portion of the sole in mutually spaced relationship for overlying the toe and instep regions of the foot. A tongue is fastened to the upper at its forward end and only to a side region of the upper which itself is fastened to the forward end of the toe portion of the sole so that the side edges of the tongue are unconnected to any part of the upper. The tongue extends rearwardly for covering both the toe and instep regions of the foot.