Patents by Inventor Jeffrey Borenstein

Jeffrey Borenstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210162416
    Abstract: A microfluidic device for modeling a tumor-immune microenvironment can include a multiwell plate defining a plurality of microenvironment units fluidically coupled with a plurality of wells. Each microenvironment unit of the plurality of microenvironment units can include one or more compartments. Each microenvironment unit can include a trapping feature positioned within the one or more compartments. The trapping feature can be defined by a portion of at least one of a sidewall or a floor of the one or more compartments. The trapping feature can restrict movement of a tissue sample introduced into the one or more compartments and to allow fluid to flow past the tissue sample. The microfluidic device can include a plurality of micropumps each coupled with a respective well and configured to control movement of a respective fluid sample through each respective well.
    Type: Application
    Filed: December 1, 2020
    Publication date: June 3, 2021
    Inventors: Jeffrey Borenstein, Nathan Moore, Daniel Doty, Timothy Haggerty, Joseph Charest, Alla Gimbel, Vienna Mott, Brett Isenberg, Hesham Azizgolshani, Brian Cain, Mark Mescher
  • Patent number: 11022603
    Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: June 1, 2021
    Assignees: THE CHARLES STARK DRAPER LABORATORY, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Ashley Lynne Beckwith, Jeffrey Borenstein, Nathan Moore, Daniel Doty, Luis Velasquez-Garcia
  • Publication number: 20210155889
    Abstract: A system for cell bioprocessing and cell therapy manufacturing can include a series of microfluidic modules to enable continuous-flow end-to-end cell bioprocessing. Each module can implement a different technology, and the modules can be coupled to one another to perform various unit operations in the cell bioprocessing or cell-therapy manufacturing chain to enable direct processing of a blood or blood product sample. The system can automatically and continuously process the sample into genetically-modified lymphocytes or T cells for cellular therapy. The technologies implemented by each module in the system can include any combination of microfluidic acoustophoresis, microfluidic acoustophoretic media exchange or cell washing, and continuous-flow microfluidic electrotransfection. Modules implementing these microfluidic technologies can be interconnected with plastic tubing or with a custom manifold.
    Type: Application
    Filed: November 20, 2020
    Publication date: May 27, 2021
    Inventors: Vishal Tandon, Jeffrey Borenstein, Jason Fiering, Jenna Balestrini, Heena Mutha, Jonathan Robert Coppeta, Mark Mescher
  • Publication number: 20210154452
    Abstract: The present solution provides systems and methods for trans-round window membrane drug delivery. As an overview, a system can include a micropump that is connected to a flexible cannula. The cannula can be threaded through a handpiece that can be used to pierce the round window membrane of a patient. Using the handpiece, the cannula can be inserted through the round window membrane to improve the distribution of the delivered drug throughout the inner ear. The present solution can function as a small implantable or wearable device that can be used for both chronic and acute trans-round window membrane drug delivery. With this configuration, the micropump can constantly or intermittently deliver, over a period of days to months, small volumes of drugs from an internal reservoir.
    Type: Application
    Filed: November 20, 2020
    Publication date: May 27, 2021
    Inventors: Vishal Tandon, Ernest Kim, Jeffrey Borenstein
  • Publication number: 20210154379
    Abstract: The present disclosure provides a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can be integrated with a micropump and a fluid reservoir. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. The micropump can include a self-contained fluid reservoir that can provide predetermined volumes of fluid to precise areas of the patient.
    Type: Application
    Filed: November 20, 2020
    Publication date: May 27, 2021
    Inventors: Vishal Tandon, Ernest Kim, Jeffrey Borenstein
  • Publication number: 20190329250
    Abstract: This disclosure describes techniques for fabricating a high-resolution, non-cytotoxic and transparent microfluidic device. A material can be selected based on having an optical property with a predetermined degree of transparency to provide viewability of a biological sample through the microfluidic device and a level of cytotoxicity within a predetermined threshold to provide viability of the biological sample within the microfluidic device. An additive manufacturing technique can be selected from a plurality of additive manufacturing techniques for fabricating the microfluidic device based on the selected material to provide a resolution of dimensions of one or more channels of the microfluidic device higher than a predetermined resolution threshold.
    Type: Application
    Filed: August 29, 2018
    Publication date: October 31, 2019
    Inventors: Ashley Lynne Beckwith, Jeffrey Borenstein, Nathan Moore, Daniel Doty, Luis Velasquez-Gracia
  • Publication number: 20190064148
    Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.
    Type: Application
    Filed: August 29, 2018
    Publication date: February 28, 2019
    Inventors: Ashley Lynne Beckwith, Jeffrey Borenstein, Nathan Moore, Daniel Doty, Luis Velasquez-Garcia
  • Publication number: 20170117235
    Abstract: A destroy on-demand electrical device includes a substrate layer formed using a soluble material (e.g., a Germanium oxide), a semi-conductor layer formed from a material that can become soluble upon further processing (e.g., Germanium) and conductive elements, formed from a metallic material such as Copper. The device is coupled with one or more disintegration sources that contain disintegration agents (e.g., Hydrogen Peroxide) that can promote disintegration of the device. The device can be destroyed in response to actuation of the disintegration sources, for example by actuation of a source that produces Hydrogen Peroxide for use in oxidizing the semi-conductor layer. Water can be used to dissolve dissolvable substrate layers. The semi-conductor layer can be destroyed by first processing this layer to form a dissolvable material and dissolving the processed layer with water. The remaining Copper components disintegrate once their underlying layer have been dissolved and/or by use of a salt.
    Type: Application
    Filed: October 21, 2016
    Publication date: April 27, 2017
    Applicant: The Charles Stark Draper Laboratory Inc.
    Inventors: Jeffrey Borenstein, Gregory M. Fritz, Jonathan R. Coppeta, Brett C. Isenberg
  • Patent number: 9421315
    Abstract: An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: August 23, 2016
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Christopher DiBiasio, Joseph Charest, Jeffrey Borenstein, Ernest Kim, Daniel Harjes
  • Patent number: 9060842
    Abstract: An adhesive article includes a biocompatible and at least partially biodegradable substrate having a surface; and a plurality of protrusions extending from the surface. The protrusions include a biocompatible and at least partially biodegradable material, and have an average height of less than approximately 1,000 micrometers.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: June 23, 2015
    Assignees: Massachusettes Institute of Technology, The Charles Stark Draper Laboratory, Inc.
    Inventors: Jeffrey Karp, Mahdavi Alborz, Lino Ferreira, David Carter, Andreas Zumbuehl, Jeffrey Borenstein, Edwin Chan, Christopher Bettinger, Robert Langer
  • Patent number: 8529724
    Abstract: MEMS and microelectronic devices and fabrication methods feature providing a first material including a glass, providing a second material having an elastic modulus greater than the elastic modulus of silicon, causing the second material to have a surface with a RMS surface roughness of greater than 0.001 ?m and less than approximately 0.15 ?m, contacting the surface of the second material to a surface of the first material, and applying a voltage between the first and second materials to cause an anodic bond to form.
    Type: Grant
    Filed: October 1, 2003
    Date of Patent: September 10, 2013
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Carissa Tudryn, Jeffrey Borenstein, Ralph Hopkins
  • Patent number: 8147562
    Abstract: The present invention relates to methods for the design and fabrication of biological constructs, such as organ simulants or organ replacements, which contain complex microfluidic architecture. Designs of the present invention provide increased space in the lateral dimension, enabling a large number of small channels for small vessels.
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: April 3, 2012
    Assignee: The General Hospital Corporation
    Inventors: Joseph P. Vacanti, Jeffrey Borenstein, Mohammad R. Kaazempur-Mofrad, Eli Weinberg
  • Publication number: 20110021965
    Abstract: An adhesive article includes a biocompatible and at least partially biodegradable substrate having a surface; and a plurality of protrusions extending from the surface. The protrusions include a biocompatible and at least partially biodegradable material, and have an average height of less than approximately 1,000 micrometers.
    Type: Application
    Filed: November 19, 2008
    Publication date: January 27, 2011
    Applicant: Massachusetts Institute of Technology
    Inventors: Jeffrey Karp, Mahdavi Alborz, Lino Ferreira, David Carter, Andreas Zumbuehl, Jeffrey Borenstein, Edwin Chan, Christopher Bettinger, Robert Langer
  • Patent number: 7402425
    Abstract: Electrostatic capacitance measurements are used to detect chemical or biological analytes, or chemical interactions, with great sensitivity. A diaphragm is coated with a material capable of selectively interacting with an analyte of interest, and interaction of the analyte with the coating exerts stresses tangential to the diaphragm's surface. These stresses cause diaphragm displacements that are sensed as varying capacitance.
    Type: Grant
    Filed: March 2, 2004
    Date of Patent: July 22, 2008
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Marc S. Weinberg, Jeffrey Borenstein, Christopher E. Dubé, Ralph Hopkins, Edwin Carlen
  • Publication number: 20070281353
    Abstract: The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type.
    Type: Application
    Filed: May 21, 2004
    Publication date: December 6, 2007
    Inventors: Joseph Vacanti, Jeffrey Borenstein, Eli Weinberg
  • Publication number: 20070266801
    Abstract: Channel arrays are reversibly disposed over an array of microwells to deliver materials, for example, cells, to the microwells.
    Type: Application
    Filed: December 18, 2006
    Publication date: November 22, 2007
    Inventors: Alireza Khademhosseini, Jeffrey Borenstein, George Eng, Judy Yeh, Robert Langer
  • Publication number: 20070148139
    Abstract: A method and materials to create complex vascularized living tissue in three dimensions from a two-dimension microfabricated mold has been developed. The method involved creating a two dimensional surface having a branching structure etched into the surface. The pattern begins with one or more large channels which serially branch into a large array of channels as small as individual capillaries, then converge to one or more large channels. The etched surface serves a template within a mold formed with the etched surface for the circulation of an individual tissue or organ. Living vascular cells are then seeded onto the mold, where they form living vascular channels based on the pattern etched in the mold. Once formed and sustained by their own matrix, the top of the mold is removed. The organ or tissue specific cells are then added to the etched surface, where they attach and proliferate to form a thin, vascularized sheet of tissue.
    Type: Application
    Filed: November 2, 2006
    Publication date: June 28, 2007
    Applicants: The General Hospital Corporation, The Charles Stark Draper Laboratory
    Inventors: Joseph Vacanti, Jeffrey Borenstein, Homer Pien, Brian Cunningham
  • Publication number: 20070062283
    Abstract: A method for reducing errors in a tuning fork gyroscope includes determining a first distance, gt, between an upper sense plate and a proof mass and a second distance, gb, between a lower sense plate and the proof mass. The method further includes applying a first voltage, Vt, to the upper sense plate and a second voltage, Vb, to the lower sense plate, wherein the ratio of the first voltage and the second voltage is a function of the first distance and the second distance.
    Type: Application
    Filed: October 21, 2004
    Publication date: March 22, 2007
    Inventors: Marc Weinberg, Anthony Kourepenis, William Sawyer, Jeffrey Borenstein, James Connelly, Amy Duwel, Christopher Lento, James Cousens
  • Publication number: 20060283246
    Abstract: A tuning fork gyroscope design where at least one proof mass is supported above a substrate. At least one drive electrode is also supported above the substrate adjacent the proof mass. Typically, the proof mass and the drive electrode include interleaved electrode fingers. A sense plate or shield electrode on the substrate beneath the proof mass extends completely under the extent of the electrode fingers of proof mass.
    Type: Application
    Filed: June 15, 2005
    Publication date: December 21, 2006
    Inventors: Marc Weinberg, Jonathan Bernstein, Jeffrey Borenstein, Richard Elliott, Gregory Kirkos, Anthony Kourepenis
  • Publication number: 20060167435
    Abstract: The invention provides a low-profile, dome-shaped body for attachment to a scleral surface of an eye and defining an internal cavity for receiving a drug or other pharmaceutically active agent. The device has an opening for controllably delivering the drug into the eye at therapeutically effective concentrations over a prolonged period of time. When attached, the device does not affect or otherwise restrict movement of the eye. Features of the invention include an optional drug inlet port and puncture guard, both designed for refilling the device while preventing a needle inserted through the inlet port from contacting the sclera.
    Type: Application
    Filed: February 17, 2004
    Publication date: July 27, 2006
    Inventors: Anthony Adamis, Joan Miller, Mark Mescher, Evangelos Gragoudas, Jeffrey Borenstein