Abstract: Embodiments herein relate to devices and methods for assessing deep tissue temperature using optical sensing. In an embodiment an optical temperature monitoring device is included having an optical emitter, wherein the optical emitter is configured to emit light at a first wavelength from 100 nm to 2000 nm. The optical temperature monitoring device also includes an optical detector configured to detect incident light. The optical temperature monitoring device can be configured so that the light from the optical emitter propagates at a depth of at least 1 cm through tissue as measured from a surface of the optical temperature monitoring device and back to the optical detector and the incident light detected by the optical detector is used to determine a temperature of the tissue at depths of at least 1 cm as measured from a surface of the optical temperature monitoring device. Other embodiments are also included herein.

Abstract: Embodiments herein relate to devices and methods for assessing pulmonary status using optical oxygenation sensing. In an embodiment, an oxygenation monitoring device can be included having a first optical emitter, wherein the first optical emitter can be configured to emit light at a first wavelength from 100 nanometers (nm) to 2000 nm. The oxygenation monitoring device and further include a first optical detector, wherein the first optical detector can be configured to detect incident light. The device can be configured so that emitted light from the first optical emitter propagates through a lung tissue and detected incident light can be used to determine an oxygenation status of the lung tissue. Other embodiments are also included herein.

Abstract: Embodiments herein relate to devices and methods for assessing pulmonary congestion using optical sensing techniques. In an embodiment, a pulmonary congestion monitoring device can be included having a first optical emitter, wherein the first optical emitter can be configured to emit light at a first wavelength, such as at a near-infrared wavelength or an ultraviolet wavelength. The monitoring device can also include a first optical detector configured to detect incident light. The first optical emitter and the first optical detector can be separated by a distance of 1 centimeters (cm) to 10 cm. The monitoring device can be configured so that the light from the first optical emitter propagates through at least one of a lung tissue and an airway tissue. The monitoring device can also be configured to use detected incident light to determine a congestion status of the lung tissue. Other embodiments are also included herein.

Abstract: Systems and methods for managing communication strategies between implanted medical devices. Methods include temporal optimization relative to one or more identified conditions in the body. A selected characteristic, such as a signal representative or linked to a biological function, is assessed to determine its likely impact on communication capabilities, and one or more communication strategies may be developed to optimize intra-body communication.

Abstract: Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.

Abstract: Embodiments herein relate to systems and methods for combining data from different types of sensors. In an embodiment, a medical system is included. The medical system can include a first sensor configured to produce a first value for an analyte and a second sensor different than the first sensor, the second sensor configured to produce a second value for the analyte. The medical system can also include a controller configured to receive the first and second values. The controller can create a blended analyte value from the first value and second value. Other embodiments are included herein.

Abstract: An example of a system for monitoring and treating a medical condition of a patient may include signal inputs to receive patient condition signals indicative of a state of inflammatory bowel disease (IBD), a signal processing circuit configured to process the patient condition signals and generate patient condition parameters indicative of the state of IBD using the processed patient condition signals, and a medical condition analyzer configured to analyze the patient condition parameters and determine the medical condition including the state of IBD using an outcome of the analysis. The patient condition parameters may include one or more physiological marker parameters each representative of a physiological marker of IBD and one or more quality of life parameters each being measure of quality of life of the patient.

Abstract: A medical system for monitoring a left atrial pressure in a heart of a patient may include an implantable device including an expandable framework and a first sensor secured to the expandable framework and an external component configured to communicate wirelessly with the implantable device. The first sensor may be configured to detect a first measurement. The first sensor may be a pressure sensor and the first measurement may be the left atrial pressure. The implantable device or the external component may include a processor configured to create a first trend for the first measurement. The processor may be configured to use the first trend to modify the first measurement prior to outputting a corrected result.

Abstract: Systems and methods for monitoring patients with a chronic disease such as heart failure are disclosed. The system may include a physiological sensor circuit to sense physiological signals and generate signal metrics from the physiological signals. The system may include a health status analyzer circuit to use the signal metrics to generate one or more stability indicators of patient health status, such as stability of heart failure status. The system may additionally generate one or more health status indicators indicating patient health status such as heart failure progression. A patient disposition decision may be generated using the health status indicators and the stability indicators to provide an indication of readiness for patient discharge from or a risk of admission to a hospital.

Abstract: Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.

Abstract: This document discusses, among other things, systems and methods to determine an indication of contractility of a heart of a patient using received physiologic information, and to determine blood pressure information of the patient using the heart sound information and the determined indication of contractility of the heart. The system can include an assessment circuit configured to determine an indication of contractility of a heart of the patient using first heart sound (S1) information of the patient, and to determine blood pressure information of the patient using second heart sound (S2) information of the patient and the determined indication of contractility of the heart.

Abstract: An implantable pressure sensor includes a housing and a sensing component that is housed by the housing and exposed to an external pressure that is exterior to the housing. In response to the external pressure, the sensing component is configured to undergo a physical transformation that is representative of a mean pressure of the external pressure over a period of time of at least one minute. The pressure sensor includes circuitry that is operatively coupled to the sensing component and that is responsive to the physical transformation of the sensing component to produce a mean pressure signal that is representative of the mean pressure of the external pressure over the period of time.

Abstract: An implantable medical device (IMD) that includes a housing, a first electrode secured relative to the housing, a second electrode secured relative to the housing, and a gyroscope secured relative to the housing. The IMD may include circuitry in the housing in communication with the first electrode, the second electrode, and the gyroscope. The circuitry may be configured to determine and store a plurality of torsion data measurements, from which a representation of a twist profile may be determined.

Abstract: Systems and methods for monitoring patients with a chronic disease such as heart failure are disclosed. The system may include a physiological sensor circuit to sense physiological signals and generate signal metrics from the physiological signals. The system may include a health status analyzer circuit to use the signal metrics to generate one or more stability indicators of patient health status, such as stability of heart failure status. The system may additionally generate one or more health status indicators indicating patient health status such as heart failure progression. A patient disposition decision may be generated using the health status indicators and the stability indicators to provide an indication of readiness for patient discharge from or a risk of admission to a hospital.

Abstract: Systems and methods to determine a composite respiratory vibration of a patient are disclosed, including a signal receiver circuit configured to receive physiologic information cyclic with patient respiration and vibration information indicative of patient respiratory vibrations for a plurality of respiratory cycles of a patient, and an assessment circuit configured to identify a first set of respiratory cycles of the plurality of respiratory cycles having a duration within a threshold, align segments of the vibration information corresponding to the first set of respiratory cycles, the segments associated with a desired portion of the respiratory cycle using a feature of the respiratory cycle, and determine the composite respiratory vibration using the aligned segments.

Abstract: This document discusses, among other things, systems and methods to determine an indication of contractility of a heart of a patient using received physiologic information, and to determine blood pressure information of the patient using the heart sound information and the determined indication of contractility of the heart. The system can include an assessment circuit configured to determine an indication of contractility of a heart of the patient using first heart sound (S1) information of the patient, and to determine blood pressure information of the patient using second heart sound (S2) information of the patient and the determined indication of contractility of the heart.

Abstract: A ventricularly implantable medical device that includes a sensing module that is configured to detect an artifact during ventricular filling and to identify an atrial event based at least on part on the detected artifact. Control circuitry of the implantable medical device is configured to deliver a ventricular pacing therapy to a patient's heart, wherein the ventricular pacing therapy is time dependent, at least in part, on the identified atrial event.

Abstract: A leadless cardiac pacemaker (LCP) is configured to sense cardiac activity and to pace a patient's heart and is disposable within a ventricle of the patient's heart. The LCP may include a housing, a first electrode and a second electrode that are secured relative to the housing and are spaced apart. A controller is disposed within the housing and is operably coupled to the first electrode and the second electrode such that the controller is capable of receiving, via the first electrode and the second electrode, electrical cardiac signals of the heart. The LCP may include a pressure sensor and/or an accelerometer. The controller may determine a pace time for a cardiac cycle based at least in part upon a signal from the pressure sensor.

Abstract: Systems and methods to determine a composite respiration phase of a patient are disclosed, including a signal receiver circuit to receive first and second physiologic information of a patient, and an assessment circuit to determine first respiration phase information of the first physiologic information and to determine the composite respiration phase of the patient using the determined first respiration phase information and the second physiologic information.

Abstract: A medical system may include a left atrial appendage closure device including an expandable framework and a proximal hub centered on a central longitudinal axis of the framework. An insert may be disposed within the proximal hub and include a collar configured to engage the proximal hub, a recess extending into the insert from a proximal end, and a post member disposed within the recess. The post member may be radially spaced apart from the collar and may extend proximally from a distal end of the recess to a proximal surface. The insert may include a first connection structure disposed distal of the proximal surface. The medical system may include a delivery catheter having a second connection structure configured to engage the first connection structure in a delivery configuration. The distal end of the delivery catheter includes a hollow portion configured to receive the post member in the delivery configuration.