Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.

Abstract: A system and method for managing a loading dock and access to a facility or group of facilities by providing a web-based application accessible via the Internet having vendors associated with the web-based application based upon specific needs of the facility. Vendors are provided access to a facility by a user of the web-based application by employing specific methods of identification and authorization, and the user is provided with status information regarding the vendor access. Furthermore, vendor access to a facility can be limited by the user based on various parameters. Those parameters can be used to administrate, manage and secure a facility in terms of understanding which vendors are permitted access to the facility or group of facilities. The web-based application is designed to suit the specific needs of a facility.

Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.

Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.

Abstract: A system and method for managing a loading dock and access to a facility or group of facilities by providing a web-based application accessible via the Internet having vendors associated with the web-based application based upon specific needs of the facility. Vendors are provided access to a facility by a user of the web-based application by employing specific methods of identification and authorization, and the user is provided with status information regarding the vendor access. Furthermore, vendor access to a facility can be limited by the user based on various parameters. Those parameters can be used to administrate, manage and secure a facility in terms of understanding which vendors are permitted access to the facility or group of facilities. The web-based application is designed to suit the specific needs of a facility.

Abstract: A system and method for managing a loading dock and access to a facility or group of facilities by providing a web-based application accessible via the Internet having vendors associated with the web-based application based upon specific needs of the facility. Vendors are provided access to a facility by a user of the web-based application by employing specific methods of identification and authorization, and the user is provided with status information regarding the vendor access. Furthermore, vendor access to a facility can be limited by the user based on various parameters. Those parameters can be used to administrate, manage and secure a facility in terms of understanding which vendors are permitted access to the facility or group of facilities. The web-based application is designed to suit the specific needs of a facility.

Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.

Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.

Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.

Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.

Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.

Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.

Abstract: The present invention is directed to methods of treating Type 1-diabetes by administering a therapeutically effective amount of an Insulin-like Growth Factor-binding protein-2. The present invention is also directed to methods treating Type 2 diabetes by administering a therapeutically effective amount of Insulin-like Growth Factor-binding protein-2. The present invention is further directed to methods treating insulin resistance by administering a therapeutically effective amount of Insulin-like Growth Factor-binding protein-2. The present invention is directed to methods of treating hepatic steatosis by administering a therapeutically effective amount of an Insulin-like Growth Factor-binding protein-2. The present invention is also directed to methods lowering blood glucose and serum insulin in non-diabetic subjects by administering a therapeutically effective amount of Insulin-like Growth Factor-binding protein-2.

Abstract: A system and method for managing a loading dock and access to a facility or group of facilities by providing a web-based application accessible via the Internet having vendors associated with the web-based application based upon specific needs of the facility. Vendors are provided access to a facility by a user of the web-based application by employing specific methods of identification and authorization, and the user is provided with status information regarding the vendor access. Furthermore, vendor access to a facility can be limited by the user based on various parameters. Those parameters can be used to administrate, manage and secure a facility in terms of understanding which vendors are permitted access to the facility or group of facilities. The web-based application is designed to suit the specific needs of a facility.

Abstract: New elevator cab construction and reconstruction of old elevator cabs are frequently presented with the problem of increasing the interior size of the elevator cab in an elevator shaft of limited size. This invention relates to an elevator cab design providing a novel way of increasing internal cab size of a standard elevator cab while still retaining decorative design features by having removable decorative panels. The elevator cab is constructed of the normal elements, namely, a platform, a ceiling, cab shell walls, stiffeners and corner stiffener risers. The cab shell walls have a base and transom and shell panels there between designed to overlap one another so as to be readily attached by spot welding or adhesive. The stiffeners are hat-shaped elongated sections typically of stainless steel that are attached to the inside of the shell panels. The stiffeners may also be formed by hat-shaped ribs formed in the shell panels.

Abstract: The present invention is directed to methods of treating Type I diabetes by administering a therapeutically effective amount of an Insulin-like Growth Factor-binding protein-2. The present invention is also directed to methods treating Type 2 diabetes comprising the step of administering a therapeutically effective amount of Insulin-like Growth Factor-binding protein-2. The present invention is further directed to methods treating insulin resistance comprising the step of administering a therapeutically effective amount of Insulin-like Growth Factor-binding protein-2. The present invention is directed to methods of treating hepatic steatosis by administering a therapeutically effective amount of an Insulin-like Growth Factor-binding protein-2. The present invention is also directed to methods lowering blood glucose and serum insulin in non-diabetic subjects comprising the step of administering a therapeutically effective amount of Insulin-like Growth Factor-binding protein-2.

Abstract: A system and method of interior design is provided having an interface for displaying a design report; providing a selection of predetermined architectural designs which can be selected from the design report; wherein each of the predetermined architectural designs includes a plurality of design elements selected from the group of optional elements, non-optional elements, and selectable elements; providing a choice of at least one of the optional and selectable elements for inclusion in a selected predetermined architectural design; and determining design parameters based upon chosen optional elements, non-optional elements, and selectable elements in the selected predetermined architectural design.

Abstract: A system and method of interior design is provided having an interface for displaying a design report; providing a selection of predetermined architectural designs which can be selected from the design report; wherein each of the predetermined architectural designs includes a plurality of design elements selected from the group of optional elements, non-optional elements, and selectable elements; providing a choice of at least one of the optional and selectable elements for inclusion in a selected predetermined architectural design; and determining design parameters based upon chosen optional elements, non-optional elements, and selectable elements in the selected predetermined architectural design.

Abstract: A lobby or other public space design process for providing an attractive appearance complementary to a building in which the lobby is installed, by (a) Evaluating a building for determination of appropriate lobby interior design architecture and appearance, (b) Selecting a suitable design from a series of previously prepared design proposals, and (c) Selecting material for the decoration of the lobby interior for the design selected from a palette of previously prepared options for available material including selection of material type, color and design.