Patents by Inventor Jeffrey Friedman

Jeffrey Friedman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220362545
    Abstract: This document describes implantable medical devices and methods of using such devices. The implantable medical devices include a cardiac lead sized for insertion in a cardiac cavity, the cardiac lead having a distal end and a proximal end and a lead body extending therebetween, a heat exchange module disposed at the distal end of the lead body, the heat exchange module comprising an enclosure having a first surface and a second surface, and one or more temperature sensors located within the enclosure.
    Type: Application
    Filed: May 12, 2022
    Publication date: November 17, 2022
    Inventors: Steve Maschino, Samuel J. Asirvatham, Jeffrey Rynbrandt, Charles Ritrivi, Paul A. Friedman, Richard Scott Sanders
  • Publication number: 20210052909
    Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.
    Type: Application
    Filed: August 6, 2020
    Publication date: February 25, 2021
    Inventors: SARAH STANLEY, JEFFREY FRIEDMAN, JONATHAN S. DORDICK, JEREMY SAUER
  • Patent number: 10916082
    Abstract: A system and method for managing a loading dock and access to a facility or group of facilities by providing a web-based application accessible via the Internet having vendors associated with the web-based application based upon specific needs of the facility. Vendors are provided access to a facility by a user of the web-based application by employing specific methods of identification and authorization, and the user is provided with status information regarding the vendor access. Furthermore, vendor access to a facility can be limited by the user based on various parameters. Those parameters can be used to administrate, manage and secure a facility in terms of understanding which vendors are permitted access to the facility or group of facilities. The web-based application is designed to suit the specific needs of a facility.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: February 9, 2021
    Assignee: Building Intelligence, Inc.
    Inventors: Jeffrey Friedman, Travis Sinnott, Max Abramowitz
  • Patent number: 10786570
    Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: September 29, 2020
    Assignee: The Rockefeller University
    Inventors: Jeffrey Friedman, Sarah Stanley
  • Patent number: 10765878
    Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: September 8, 2020
    Assignees: THE ROCKEFELLER UNIVERSITY, RENSSELAER POLYTECHNIC INSTITUTE
    Inventors: Sarah Stanley, Jeffrey Friedman, Jonathan S. Dordick, Jeremy Sauer
  • Publication number: 20200090434
    Abstract: A system and method for managing a loading dock and access to a facility or group of facilities by providing a web-based application accessible via the Internet having vendors associated with the web-based application based upon specific needs of the facility. Vendors are provided access to a facility by a user of the web-based application by employing specific methods of identification and authorization, and the user is provided with status information regarding the vendor access. Furthermore, vendor access to a facility can be limited by the user based on various parameters. Those parameters can be used to administrate, manage and secure a facility in terms of understanding which vendors are permitted access to the facility or group of facilities. The web-based application is designed to suit the specific needs of a facility.
    Type: Application
    Filed: November 15, 2019
    Publication date: March 19, 2020
    Inventors: Jeffrey Friedman, Travis Sinnott, Max Abramowitz
  • Patent number: 10482695
    Abstract: A system and method for managing a loading dock and access to a facility or group of facilities by providing a web-based application accessible via the Internet having vendors associated with the web-based application based upon specific needs of the facility. Vendors are provided access to a facility by a user of the web-based application by employing specific methods of identification and authorization, and the user is provided with status information regarding the vendor access. Furthermore, vendor access to a facility can be limited by the user based on various parameters. Those parameters can be used to administrate, manage and secure a facility in terms of understanding which vendors are permitted access to the facility or group of facilities. The web-based application is designed to suit the specific needs of a facility.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: November 19, 2019
    Assignee: Building Intelligence, Inc.
    Inventors: Jeffrey Friedman, Travis Sinnott, Max Abramowitz
  • Publication number: 20180353605
    Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.
    Type: Application
    Filed: July 30, 2018
    Publication date: December 13, 2018
    Inventors: Jeffrey Friedman, Sarah Stanley
  • Patent number: 10064941
    Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: September 4, 2018
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: Jeffrey Friedman, Sarah Stanley
  • Publication number: 20180200386
    Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.
    Type: Application
    Filed: March 21, 2017
    Publication date: July 19, 2018
    Inventors: Sarah Stanley, Jeffrey Friedman, Jonathan S. Dordick, Jeremy Sauer
  • Publication number: 20160346391
    Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.
    Type: Application
    Filed: May 31, 2016
    Publication date: December 1, 2016
    Inventors: Jeffrey Friedman, Sarah Stanley
  • Patent number: 9399063
    Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: July 26, 2016
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: Jeffrey Friedman, Sarah Stanley
  • Publication number: 20140348825
    Abstract: The present invention provides methods and compositions for the remote control of cell function based on the use of radiofrequency waves to excite nanoparticles targeted to specific cell types. The nanoparticles may be applied to the target cell extracellularly and/or expressed intracellularly. The cell type of interest expresses a temperature sensitive channel wherein excitation of the nanoparticles results in a localized temperature increase that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject. Accordingly, the invention provides a generic approach for treatment of any disease associated with a protein deficiency.
    Type: Application
    Filed: August 24, 2012
    Publication date: November 27, 2014
    Applicant: THE ROCKEFELLER UNIVERSITY
    Inventors: Jeffrey Friedman, Sarah Stanley
  • Patent number: 8404639
    Abstract: The present invention is directed to methods of treating Type 1-diabetes by administering a therapeutically effective amount of an Insulin-like Growth Factor-binding protein-2. The present invention is also directed to methods treating Type 2 diabetes by administering a therapeutically effective amount of Insulin-like Growth Factor-binding protein-2. The present invention is further directed to methods treating insulin resistance by administering a therapeutically effective amount of Insulin-like Growth Factor-binding protein-2. The present invention is directed to methods of treating hepatic steatosis by administering a therapeutically effective amount of an Insulin-like Growth Factor-binding protein-2. The present invention is also directed to methods lowering blood glucose and serum insulin in non-diabetic subjects by administering a therapeutically effective amount of Insulin-like Growth Factor-binding protein-2.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: March 26, 2013
    Assignee: The Rockefeller University
    Inventors: Jeffrey Friedman, Kristina Hedbacker
  • Publication number: 20120293301
    Abstract: A system and method for managing a loading dock and access to a facility or group of facilities by providing a web-based application accessible via the Internet having vendors associated with the web-based application based upon specific needs of the facility. Vendors are provided access to a facility by a user of the web-based application by employing specific methods of identification and authorization, and the user is provided with status information regarding the vendor access. Furthermore, vendor access to a facility can be limited by the user based on various parameters. Those parameters can be used to administrate, manage and secure a facility in terms of understanding which vendors are permitted access to the facility or group of facilities. The web-based application is designed to suit the specific needs of a facility.
    Type: Application
    Filed: May 21, 2012
    Publication date: November 22, 2012
    Applicant: BUILDING INTELLIGENCE, INC.
    Inventors: Jeffrey Friedman, Travis Sinnott, Max Abramowitz
  • Patent number: 8230982
    Abstract: New elevator cab construction and reconstruction of old elevator cabs are frequently presented with the problem of increasing the interior size of the elevator cab in an elevator shaft of limited size. This invention relates to an elevator cab design providing a novel way of increasing internal cab size of a standard elevator cab while still retaining decorative design features by having removable decorative panels. The elevator cab is constructed of the normal elements, namely, a platform, a ceiling, cab shell walls, stiffeners and corner stiffener risers. The cab shell walls have a base and transom and shell panels there between designed to overlap one another so as to be readily attached by spot welding or adhesive. The stiffeners are hat-shaped elongated sections typically of stainless steel that are attached to the inside of the shell panels. The stiffeners may also be formed by hat-shaped ribs formed in the shell panels.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: July 31, 2012
    Inventors: Harold S. Friedman, Jeffrey Friedman, Angelo Palmieri
  • Publication number: 20110263495
    Abstract: The present invention is directed to methods of treating Type I diabetes by administering a therapeutically effective amount of an Insulin-like Growth Factor-binding protein-2. The present invention is also directed to methods treating Type 2 diabetes comprising the step of administering a therapeutically effective amount of Insulin-like Growth Factor-binding protein-2. The present invention is further directed to methods treating insulin resistance comprising the step of administering a therapeutically effective amount of Insulin-like Growth Factor-binding protein-2. The present invention is directed to methods of treating hepatic steatosis by administering a therapeutically effective amount of an Insulin-like Growth Factor-binding protein-2. The present invention is also directed to methods lowering blood glucose and serum insulin in non-diabetic subjects comprising the step of administering a therapeutically effective amount of Insulin-like Growth Factor-binding protein-2.
    Type: Application
    Filed: October 29, 2009
    Publication date: October 27, 2011
    Applicant: The Rockefeller University
    Inventors: Jeffrey Friedman, Kristina Hedbacker
  • Patent number: 7991591
    Abstract: A system and method of interior design is provided having an interface for displaying a design report; providing a selection of predetermined architectural designs which can be selected from the design report; wherein each of the predetermined architectural designs includes a plurality of design elements selected from the group of optional elements, non-optional elements, and selectable elements; providing a choice of at least one of the optional and selectable elements for inclusion in a selected predetermined architectural design; and determining design parameters based upon chosen optional elements, non-optional elements, and selectable elements in the selected predetermined architectural design.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: August 2, 2011
    Inventors: Harold S. Friedman, Jeffrey Friedman
  • Publication number: 20080154553
    Abstract: A system and method of interior design is provided having an interface for displaying a design report; providing a selection of predetermined architectural designs which can be selected from the design report; wherein each of the predetermined architectural designs includes a plurality of design elements selected from the group of optional elements, non-optional elements, and selectable elements; providing a choice of at least one of the optional and selectable elements for inclusion in a selected predetermined architectural design; and determining design parameters based upon chosen optional elements, non-optional elements, and selectable elements in the selected predetermined architectural design.
    Type: Application
    Filed: December 3, 2007
    Publication date: June 26, 2008
    Inventors: Harold S. Friedman, Jeffrey Friedman
  • Patent number: 7305329
    Abstract: A lobby or other public space design process for providing an attractive appearance complementary to a building in which the lobby is installed, by (a) Evaluating a building for determination of appropriate lobby interior design architecture and appearance, (b) Selecting a suitable design from a series of previously prepared design proposals, and (c) Selecting material for the decoration of the lobby interior for the design selected from a palette of previously prepared options for available material including selection of material type, color and design.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: December 4, 2007
    Inventors: Jeffrey Friedman, Harold S. Friedman