Patents by Inventor Jeffrey H. Price

Jeffrey H. Price has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180307005
    Abstract: Multifunction autofocus for automated microscopy includes automatic coarse focusing of an automated microscope by reflective positioning, followed by automatic image-based autofocusing of the automated microscope performed in reference to a coarse focus position. In some aspects, the image-based autofocusing utilizes astigmatism in microscope optics for multi-planar image acquisition along a Z axis direction of a microscope. In some other aspects, the image-based autofocusing utilizes astigmatism in microscope optics in combination with chromatic aberration for multi-planar image acquisition along the Z axis direction.
    Type: Application
    Filed: June 18, 2018
    Publication date: October 25, 2018
    Applicants: Sanford-Burnham Medical Research Institute, Vala Sciences, Inc.
    Inventors: Jeffrey H. Price, Derek N. Fuller, Albert L. Kellner, Behrad Azimi
  • Publication number: 20180299371
    Abstract: Video recordings from two or more optical channels are produced, processed, and analyzed simultaneously in order to provide quantitative analysis of action potentials, calcium transients and ionic flux in excitable cells loaded with voltage or ion sensitive dyes with distinct excitation and emission wavelengths. The specific wavelengths of fluorescent light emitted from each dye are separated and recorded. The recordings are mutually registered and cytometric analysis is performed to provide a quantitative analysis of the action potentials, calcium transient, and/or ionic flux on a cell-by-cell and well-by-well basis in microtiter plates. The cells are then fixed, labeled for other biomarkers, and scanned again. The resulting fixed cell images are registered with the live cell recordings and analyzed; missing cells that were washed off are detected relative to the live recordings, and cytometry data from live and fixed cell scans is collated cell-by-cell.
    Type: Application
    Filed: April 6, 2018
    Publication date: October 18, 2018
    Applicant: Vala Sciences, Inc.
    Inventors: Fabio Cerignoli, Piyush Gehalot, Patrick M. McDonough, Jeffrey H. Price, Ross J. Whittaker
  • Patent number: 10001622
    Abstract: Multifunction autofocus for automated microscopy includes automatic coarse focusing of an automated microscope by reflective positioning, followed by automatic image-based autofocusing of the automated microscope performed in reference to a coarse focus position. In some aspects, the image-based autofocusing utilizes astigmatism in microscope optics for multi-planar image acquisition along a Z axis direction of a microscope. In some other aspects, the image-based autofocusing utilizes astigmatism in microscope optics in combination with chromatic aberration for multi-planar image acquisition along the Z axis direction.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: June 19, 2018
    Assignees: Sanford Burnham Medical Research Institute, Vala Sciences, Inc.
    Inventors: Jeffrey H. Price, Derek N. Fuller, Albert L. Kellner, Behrad Azimi
  • Publication number: 20180100856
    Abstract: An analytical reference for digital histochemistry is constituted of an on-slide standard used to calibrate biomarker expression in biopsy material and tissue sections. The standard consists of one or more calibration standards, which are derived from cell lines that express biomarkers, and are arranged into a calibration array. Expression of the desired biomarkers is validated by Western blotting, flow cytometry, or other methods. The calibration array is applied to a microscopy slide in such a manner that test samples from biopsies or tissue sections, or other cellular material, can also be mounted on the same slide, adjacent to the calibration array. Data obtained from the calibration array can be used to quantify expression of biomarkers in the biopsy, material, tissue sections, tissue microarrays, and cellular material, via digital histochemistry.
    Type: Application
    Filed: December 13, 2017
    Publication date: April 12, 2018
    Applicant: Vala Sciences, Inc.
    Inventors: Patrick M. McDonough, Jeffrey H. Price, Claire R. Weston
  • Patent number: 9939372
    Abstract: Video recordings from two or more optical channels are produced, processed, and analyzed simultaneously in order to provide quantitative analysis of action potentials, calcium transients and ionic flux in excitable cells loaded with voltage or ion sensitive dyes with distinct excitation and emission wavelengths, The specific wavelengths of fluorescent light emitted from each dye are separated and recorded. The recordings are mutually registered and cytometric analysis is performed to provide a quantitative analysis of the action potentials calcium transient, and/or ionic flux on a cell-by-cell and well-by-well basis in microtiter plates. The cells are then fixed, labeled for other biomarkers, and scanned again. The resulting fixed cell images are registered with the live cell recordings and analyzed; missing cells that were washed off are detected relative to the live recordings, and cytometry data from live and fixed cell scans is collated cell-by-cell.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: April 10, 2018
    Assignee: Vala Science, Inc.
    Inventors: Fabio Cerignoli, Piyush Gehalot, Patrick M. McDonough, Jeffrey H. Price, Ross J. Whittaker
  • Patent number: 9315847
    Abstract: A method, system, and instrument for automatically measuring transient activity in cells uses image time sequences to identify transients in cells. Preferably, the transient activity is stimulated or provoked in synchronism with acquisition of the image time sequences. A cell mask is applied to each image of an image time sequence in order to localize the transient activity with respect to each cell. Localization enables cell-by-cell analysis of properties of the transient activity.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: April 19, 2016
    Inventors: David J. Charlot, Randall S. Ingermanson, Patrick M. McDonough, Jeffrey H. Price
  • Publication number: 20150330892
    Abstract: Video recordings from two or more optical channels are produced, processed, and analyzed simultaneously in order to provide quantitative analysis of action potentials, calcium transients and ionic flux in excitable cells loaded with voltage or ion sensitive dyes with distinct excitation and emission wavelengths, The specific wavelengths of fluorescent light emitted from each dye are separated and recorded. The recordings are mutually registered and cytometric analysis is performed to provide a quantitative analysis of the action potentials calcium transient, and/or ionic flux on a cell-by-cell and well-by-well basis in microtiter plates. The cells are then fixed, labeled for other biomarkers, and scanned again. The resulting fixed cell images are registered with the live cell recordings and analyzed; missing cells that were washed off are detected relative to the live recordings, and cytometry data from live and fixed cell scans is collated cell-by-cell.
    Type: Application
    Filed: December 16, 2013
    Publication date: November 19, 2015
    Applicant: VALA SCIENCES, INC.
    Inventors: Fabio Cerignoli, Piyush Gehalot, Patrick M. McDonwough, Jeffrey H. Price, Ross L. Whittaker
  • Patent number: 8760756
    Abstract: In an automated scanning cytometry system, chromatic aberration is used for multiplanar image acquisition.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: June 24, 2014
    Assignee: Burnham Institute for Medical Research
    Inventors: Jeffrey H. Price, Martin Weinigel, Derek N. Fuller, Albert L. Kellner
  • Publication number: 20130244318
    Abstract: A method, system, and instrument for automatically measuring transient activity in cells uses image time sequences to identify transients in cells. Preferably, the transient activity is stimulated or provoked in synchronism with acquisition of the image time sequences. A cell mask is applied to each image of an image time sequence in order to localize the transient activity with respect to each cell. Localization enables cell-by-cell analysis of properties of the transient activity.
    Type: Application
    Filed: February 22, 2013
    Publication date: September 19, 2013
    Inventors: David J. Charlot, Randall S. Ingermanson, Patrick M. McDonough, Jeffrey H. Price
  • Publication number: 20130100272
    Abstract: Multifunction autofocus for automated microscopy includes automatic coarse focusing of an automated microscope by reflective positioning, followed by automatic image-based autofocusing of the automated microscope performed in reference to a coarse focus position. In some aspects, the image-based autofocusing utilizes astigmatism in microscope optics for multi-planar image acquisition along a Z axis direction of a microscope. In some other aspects, the image-based autofocusing utilizes astigmatism in microscope optics in combination with chromatic aberration for multi-planar image acquisition along the Z axis direction.
    Type: Application
    Filed: October 25, 2011
    Publication date: April 25, 2013
    Inventors: Jeffrey H. Price, Derek N. Fuller, Albert L. Kellner, Behrad Azimi
  • Patent number: 8385624
    Abstract: A method, system, and instrument for automatically measuring transient activity in cells uses image time sequences to identify transients in cells. Preferably, the transient activity is stimulated or provoked in synchronism with acquisition of the image time sequences. A cell mask is applied to each image of an image time sequence in order to localize the transient activity with respect to each cell. Localization enables cell-by-cell analysis of properties of the transient activity.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: February 26, 2013
    Inventors: David J. Charlot, Randall S. Ingermanson, Patrick M. McDonough, Jeffrey H. Price
  • Publication number: 20110274337
    Abstract: A system, method and kit for processing an original image of biological material to identify certain components of a biological object by locating the biological object in the image, enhancing the image by sharpening components of interest in the object, and applying a contour-finding function to the enhanced image to create a contour mask. The contour mask may be processed to yield a segmented image divided by structural units of the biological material.
    Type: Application
    Filed: April 21, 2011
    Publication date: November 10, 2011
    Applicant: Vala Sciences, Inc.
    Inventors: Edward Hunter, Patrick M. Donough, Ivana Mikic, Jeffrey H. Price
  • Patent number: 7933435
    Abstract: A system, method and kit for processing an original image of biological material to identify certain components of a biological object by locating the biological object in the image, enhancing the image by sharpening components of interest in the object, and applying a contour-finding function to the enhanced image to create a contour mask. The contour mask may be processed to yield a segmented image divided by structural units of the biological material.
    Type: Grant
    Filed: November 21, 2005
    Date of Patent: April 26, 2011
    Assignee: VALA Sciences, Inc.
    Inventors: Edward Hunter, Patrick M. Mc Donough, Ivana Mikic, Jeffrey H. Price
  • Publication number: 20100289887
    Abstract: A method, system, and instrument for automatically measuring transient activity in cells uses image time sequences to identify transients in cells. Preferably, the transient activity is stimulated or provoked in synchronism with acquisition of the image time sequences. A cell mask is applied to each image of an image time sequence in order to localize the transient activity with respect to each cell. Localization enables cell-by-cell analysis of properties of the transient activity.
    Type: Application
    Filed: May 13, 2009
    Publication date: November 18, 2010
    Applicant: Vala Sciences, Inc.
    Inventors: David J. Charlot, Randall S. Ingermanson, Patrick M. McDonough, Jeffrey H. Price
  • Patent number: 7756305
    Abstract: Methods and apparatus are described for enhancing operator independent image cytometry. Aspects of the invention include enhanced tissue surface tracking which can detect both tissue surfaces. The surface detection can aid cytometry, such as by reducing the amount of image data to be stored. Segmentation is described for 3D images in which 3D least squares filtering is applied to increase contrast for simplifying the delineation of objects from backgrounds. A method of creating 3D FIR image filters based on ideal objects is also described. A data structure is defined by which 3D object data may be organized for image representations if samples. Methods of performing remote segmentation processing are also described toward centralizing the necessary processor power and applications and reducing the burden on researchers and clinicians.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: July 13, 2010
    Assignee: The Regents of the University of California
    Inventor: Jeffrey H. Price
  • Publication number: 20100172020
    Abstract: In an automated scanning cytometry system, chromatic aberration is used for multiplanar image acquisition.
    Type: Application
    Filed: October 14, 2009
    Publication date: July 8, 2010
    Applicant: Burnham Institute for Medical Research
    Inventors: Jeffrey H. Price, Martin Weinigel, Derek N. Fuller, Albert L. Kellner
  • Publication number: 20080144895
    Abstract: A system, method and kit for processing an original image of biological material to identify certain components of a biological object by locating the biological object in the image, enhancing the image by sharpening components of interest in the object, and applying a contour-finding function to the enhanced image to create a contour mask. The contour mask may be processed to yield a segmented image divided by structural units of the biological material.
    Type: Application
    Filed: November 21, 2005
    Publication date: June 19, 2008
    Inventors: Edward Hunter, Patrick M. Mc Donough, Ivana Mikic, Jeffrey H. Price
  • Patent number: 7358478
    Abstract: A system for imaging of a sample is disclosed. The system includes a plurality of detectors which are each focussed at a respective focal plane in a sample volume. The system also includes light selection optics positioned between the plurality of detectors and the sample volume. The light selection optics transmit to the detectors a portion of light originating at the respective focal planes while screening out light which originates from outside of the respective focal planes.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: April 15, 2008
    Assignee: The Regents of the University of California
    Inventor: Jeffrey H. Price
  • Patent number: 6839469
    Abstract: Volume imaging is supported in an optical apparatus that simultaneously acquires multiple images from multiple focal planes in an image object. A plurality of image detectors is arranged with respect to an objective lense. A plurality of reflective devices are disposed between the objective lense and the plurality of detectors to divide the light travelling through the objective lense to the detectors into channels such that each channel is registered with a respective detector.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: January 4, 2005
    Inventors: Lam K. Nguyen, Miguel Bravo-Zanoquera, Albert L. Kellner, Jeffrey H. Price
  • Patent number: RE40674
    Abstract: An analog circuit for an autofocus microscope system measures a degree of focus of an object directly from the video signal of a microscope CCD camera. The circuit then returns an index to a host computer for the purpose of adjusting the position of the microscope's objective lens to bring the object in focus. Best focus is found by comparing indices at several different vertical positions. The criterion adopted for determining the degree of focus is derived from the energy distribution of the video signal spectrum. The high frequency energy of the video spectrum is a maximum at best focus and as the optics defocus, the distribution shifts to lower frequencies. Low cost, real time autofocus is achieved with the analog circuitry of this invention, replacing more expensive dedicated, real time image processing hardware.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: March 24, 2009
    Assignee: Q3DM, LLC
    Inventors: Jeffrey H. Price, Miguel Bravo-Zanoguera