Patents by Inventor Jeffrey I. Cohen

Jeffrey I. Cohen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolated epstein-barr virus BZLF2 proteins that bind MHC class II beta chains
    Patent number: 5726286
    Abstract: Isolated viral proteins, and pharmaceutical compositions made therefrom, are disclosed which are capable of binding to a .beta. chain of a Class II Major Histocompatibility Complex antigen, thereby functioning to inhibit an antigen-specific response. The viral proteins also have superantigen-like activity, and inhibit EBV infection.
    Type: Grant
    Filed: April 28, 1995
    Date of Patent: March 10, 1998
    Assignee: Immunex Corporation
    Inventors: Mark Alderson, Richard J. Armitage, Jeffrey I. Cohen, Michael R. Comeau, Theresa M. Farrah, Lindsey M. Hutt-Fletcher, Melanie K. Spriggs
  • cDNA encoding attenuated cell culture adapted hepatitis A virus genome
    Patent number: 5478746
    Abstract: A full-length cDNA copy of an attenuated, cell culture-adapted hepatitis-A virus genome has been constructed. The HAV cDNA when inserted, without the oligo (dG) oligo (dC) tails, into an RNA transcription vector yielded a plasmid designated pHAV/7. Transfection of monkey kidney cells with pHAV/7 DNA yielded HAV. Transfection with RNA transcripts produced in vitro from pHAV/7 yielded about 10-fold more HAV than transfection with pHAV/7 DNA. HAV thus produced are useful as a vaccine.
    Type: Grant
    Filed: September 13, 1993
    Date of Patent: December 26, 1995
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jeffrey I. Cohen, Robert H. Purcell, Stphen M. Feinstone, John R. Ticehurst
  • Vaccine against hepatitis A virus
    Patent number: 4894228
    Abstract: The present invention provides an attenuated hepatitis A virus useful as a vaccine.
    Type: Grant
    Filed: July 12, 1988
    Date of Patent: January 16, 1990
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Robert H. Purcell, John R. Ticehurst, Jeffrey I. Cohen, Suzanne U. Emerson, Stephan M. Feinstone, Richard J. Daemer, Ian D. Gust