Patents by Inventor Jeffrey J. Seilhamer

Jeffrey J. Seilhamer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of screening for compounds that modulate the activity of ADEC, a chemokine expressed in inflamed adenoid
    Patent number: 8008027
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
    Type: Grant
    Filed: March 24, 2010
    Date of Patent: August 30, 2011
    Assignee: Incyte Corporation
    Inventors: Karl J. Guegler, Phillip R. Hawkins, Craig G. Wilde, Jeffrey J. Seilhamer
  • METHODS OF TREATMENT WITH ANTIBODIES TO A CHEMOKINE EXPRESSED IN INFLAMED ADENOID
    Publication number: 20100279333
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
    Type: Application
    Filed: March 24, 2010
    Publication date: November 4, 2010
    Inventors: KARL J. GUEGLER, PHILLIP R. HAWKINS, CRAIG G. WILDE, JEFFREY J. SEILHAMER
  • Methods of treatment with anitbodies to a chemokine expressed in inflamed adenoid
    Patent number: 7708984
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: May 4, 2010
    Assignee: Incyte Corporation
    Inventors: Karl J. Guegler, Phillip R. Hawkins, Craig G. Wilde, Jeffrey J. Seilhamer
  • Antibodies to a chemokine expressed in inflamed adenoid
    Publication number: 20080138346
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
    Type: Application
    Filed: June 4, 2007
    Publication date: June 12, 2008
    Inventors: Karl J. Guegler, Phillip R. Hawkins, Craig G. Wilde, Jeffrey J. Seilhamer
  • Antibodies to a chemokine expressed in inflamed adenoid
    Patent number: 7235239
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
    Type: Grant
    Filed: October 28, 2003
    Date of Patent: June 26, 2007
    Assignee: Incyte Incorporation
    Inventors: Karl J Guegler, Phillip R Hawkins, Craig G Wilde, deceased, Jeffrey J Seilhamer, deceased
  • Antibodies to a cathepsin C homolog
    Patent number: 7195926
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a new cathepsin C homolog (RCP) expressed in THP-1 cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode RCP, expression vectors for the production of purified RCP, antibodies capable of binding specifically to RCP, hybridization probes or oligonucleotides for the detection of RCP-encoding nucleotide sequences, genetically engineered host cells for the expression of RCP, diagnostic tests for activation of monocyte/macrophages based on RCP-encoding nucleic acid molecules, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: March 27, 2007
    Assignee: Incyte Corporation
    Inventors: Roger Coleman, Scott Michael Braxton, Jeffrey J. Seilhamer
  • Human myeloid terminal differentiation response gene
    Patent number: 6913891
    Abstract: The present invention provides polynucleotide and amino acid sequences which encode and identify a novel human myeloid terminal differentiation response gene designated MYD118. The present invention also provides for myd118 antisense molecules. The invention further provides genetically engineered expression vectors and host cells for the production of purified MYD118 polypeptide; antibodies, antagonists and inhibitors of MYD118 polypeptide; and pharmaceutical compositions and methods of treatment based on polynucleotide sequences encoding MYD118 and MYD118 polypeptide. The invention specifically provides for use of the myd118 polynucleotide sequences as a diagnostic composition for the detection of myeloproliferative diseases and leukemias. The invention also relates to therapeutic methods and compositions based upon the nucleotide sequences for myd118. The invention further provides antibodies which specifically bind to MYD118.
    Type: Grant
    Filed: December 9, 1998
    Date of Patent: July 5, 2005
    Assignee: Incyte Corporation
    Inventors: Benjamin Graeme Cocks, Janice Au-Young, Jeffrey J. Seilhamer
  • Transporters and ion channels
    Publication number: 20040224911
    Abstract: The invention provides human transporters and ion channels (TRICH) and polynucleotides which identify and encode TRICH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRICH.
    Type: Application
    Filed: February 3, 2003
    Publication date: November 11, 2004
    Inventors: Henry Yue, Michael B. Thornton, Jayalxmi Ramkumar, Y.Tom Tang, Yalda Azimzai, Mariah R. Baughn, Junming Yang, Monique G. Yao, Preeti G. Lal, Narinder K. Chawla, Ameena R. Gandhi, April J. A. Hafalia, Danniel B. Nguyen, Chandra S. Arvizu, Vicki S. Elliott, Catherine M. Tribouley, Dyung Aina M. Lu, Yuming Xu, Roopa M. Reddy, Roberto Hernandez, Mark L. Borowsky, Terence P. Lo, Yan Lu, Jennifer L. Policky, Barrie D. Greene, Madhusudan M. Sanjanwala, Brigitte E. Raumann, Neil Burford, Craig H. Ison, Ernestine A. Lee, Li Ding, Debopriya Das, Deborah A. Kallick, Farrah A. Khan, Jeffrey J. Seilhamer
  • Chemokine expressed in inflamed adenoid
    Publication number: 20040086975
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
    Type: Application
    Filed: October 28, 2003
    Publication date: May 6, 2004
    Applicant: Incyte Corporation
    Inventors: Karl J. Guegler, Phillip R. Hawkins, Craig G. Wilde, Jeffrey J. Seilhamer
  • Composition for the detection of blood cell and immunological response gene expression
    Publication number: 20040077003
    Abstract: The present invention relates to a composition comprising a plurality of polynucleotide probes. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to a method for selecting polynucleotide probes for the composition.
    Type: Application
    Filed: August 14, 2003
    Publication date: April 22, 2004
    Applicant: Incyte Corporation
    Inventors: Benjamin G. Cocks, Susan G. Stuart, Jeffrey J. Seilhamer
  • Transporters and ion channels
    Publication number: 20040053258
    Abstract: The invention provides human transporters and ion channels (TRICH) and polynucleotides which identify and encode TRICH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRICH.
    Type: Application
    Filed: September 22, 2003
    Publication date: March 18, 2004
    Inventors: Brigitte E. Raumann, Michael B. Thornton, Li Ding, Henry Yue, Y Tom Tang, Lee Harland, Neil Burford, Barrie D. Greene, Madhusudan M. Sanjanwala, Mariah R. Baughn, Monique G. Yao, Junming Yang, Chandra S. Arvizu, Ameena R. Gandhi, April J.A. Hafalia, Catherine M. Tribouley, Narinder K. Chawla, Janice K. Au-Young, Roderick T. Walsh, Jayalaxmi Ramkumar, Yan Lu, Dyung Aina M. Lu, Yalda Azimzai, Preeti G Lal, Vicki S. Elliott, Danniel B. Nguyen, Yuming Xu, Jeffrey J. Seilhamer, Mark L. Borowsky, Farrah A. Khan, Liam Kearney, Kavitha Thangavelu, Debopriya Das, Jennifer L. Policky
  • Antibodies to a chemokine expressed in inflamed adenoid
    Patent number: 6692920
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
    Type: Grant
    Filed: June 5, 2000
    Date of Patent: February 17, 2004
    Assignee: Incyte Corporation
    Inventors: Karl J. Guegler, Phillip R. Hawkins, Craig G. Wilde, Jeffrey J. Seilhamer
  • Cyclic nucleotide phosphodiesterase
    Publication number: 20040018605
    Abstract: 99 The invention provides human cyclic nucleotide phosphodiesterases (PDE8) and polynucleotides which identify and encode PDE8. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of PDE8.
    Type: Application
    Filed: July 25, 2003
    Publication date: January 29, 2004
    Applicant: Incyte Corporation
    Inventors: Janice Au-Young, Benjamin G. Cocks, Roger Coleman, Jeffrey J. Seilhamer, Douglas A. Fisher
  • Composition for the detection of signaling pathway gene expression
    Publication number: 20040010136
    Abstract: The present invention relates to a composition comprising a plurality of polynucleotide probes. The composition can be used as array elements in a microarray. The present invention also relates to a method for selecting polynucleotide probes of the composition.
    Type: Application
    Filed: November 26, 2002
    Publication date: January 15, 2004
    Applicant: Incyte Genomics, Inc.
    Inventors: Janice Au-Young, Jeffrey J. Seilhamer
  • Transporters and ion channels
    Publication number: 20030216310
    Abstract: The invention provides human transporters and ion channels (TRICH) and polynucleotides which identify and encode TRICH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRICH.
    Type: Application
    Filed: May 8, 2003
    Publication date: November 20, 2003
    Inventors: Michael B. Thornton, Narinder K. Chawla, Henry Yue, Danniel B. Nguyen, Preeti G. Lal, Ameena R. Gandhi, Catherine M. Tribouley, Monique G. Yao, Jayalaxmi Ramkumar, Janice K. Au-Young, Yan Lu, Y. Tom Tang, Yalda Azimzai, Christopher M. Bruns, Jennifer A. Griffin, Junming Yang, Mariah R. Baughn, Madhusudan M. Sanjanwala, Brigitte E. Raumann, Ernestine A. Lee, April J.A. Hafalia, Barrie D. Greene, Farrah A. Khan, Liam Kearney, Vicki S. Elliott, Jeffrey J. Seilhamer, Jennifer L. Policky, Mark L. Borowsky, Li Ding, Dyung Aina M. Lu, Jennifer L. Jackson
  • Transporters and ion channels
    Publication number: 20030211499
    Abstract: The invention provides human transporters and ion channels (TRICH) and polynucleotides which identify and encode TRICH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRICH.
    Type: Application
    Filed: October 4, 2002
    Publication date: November 13, 2003
    Inventors: Roppa Reddy, Michael Thornton, Mark L. Borowsky, Y. Tom Tang, Farrah A. Khan, Catherine M. Tribouley, Ameena R. Gandhi, Monique G. Yao, Madhu M. Sanjanwala, Mariah R. Baughn, Danniel B. Nguyen, Jennifer L. Policky, Henry Yue, Jeffrey J. Seilhamer, Narinder K. Walia, Preeti Lal, Liam Kearney, Roderick T. Walsh, Dyung Aina M. Lu, Yan Lu, Barrie D. Greene, Brigitte E. Raumann, Chandra Arvizu
  • Cellubrevin homologs
    Publication number: 20030180931
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.
    Type: Application
    Filed: January 29, 2003
    Publication date: September 25, 2003
    Applicant: Incyte Genomics, Inc.
    Inventors: Susan G. Stuart, Phillip R. Hawkins, Jeffrey J. Seilhamer, Lynn E. Murry
  • Genes expressed in foam cell differentiation
    Publication number: 20030165924
    Abstract: The present invention relates to purified polynucleotides and compositions comprising pluralities of polynucleotides that are differentially expressed during foam cell development and are associated with atherosclerosis. The present invention presents the use of the compositions as elements on a substrate, and provides methods for using the compositions and polynucleotides.
    Type: Application
    Filed: October 4, 2002
    Publication date: September 4, 2003
    Inventors: Dov Shiffman, Roland Somogyi, Richard Lawn, Jeffrey J. Seilhamer, J. Gordon Porter, Thomas Mikita, Julie Tai
  • Compositions for the detection of blood cell and immunological response gene expression
    Patent number: 6607879
    Abstract: The present invention relates to a composition comprising a plurality of polynucleotide probes. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to a method for selecting polynucleotide probes for the composition.
    Type: Grant
    Filed: February 9, 1998
    Date of Patent: August 19, 2003
    Assignee: Incyte Corporation
    Inventors: Benjamin G. Cocks, Susan G. Stuart, Jeffrey J. Seilhamer
  • Antibodies specifically binding PDE8A and PDE8B
    Publication number: 20030139578
    Abstract: The invention provides a antibody that specifically binds human PDE8s and is used to diagnose, stage and treat prostate cancer.
    Type: Application
    Filed: October 15, 2002
    Publication date: July 24, 2003
    Applicant: Incyte Genomics, Inc.
    Inventors: Janice K. Au-Young, Benjamin G. Cocks, Roger T. Coleman, Jeffrey J. Seilhamer, Douglas A. Fisher