Patents by Inventor Jeffrey J. Seilhamer

Jeffrey J. Seilhamer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030083468
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (ECs) from liver and pituitary gland tissues. The present invention also provides for antisense molecules to the nucleotide sequences which encode ECs, expression vectors for the production of purified ECs, antibodies capable of binding specifically to ECs, hybridization probes or oligonucleotides for the detection of EC-encoding nucleotide sequences, genetically engineered host cells for the expression of ECs, diagnostic tests for inflammation or disease based on EC-encoding nucleic acid molecules or antibodies capable of binding specifically to ECs, pharmaceutical compositions to treat inflammation or disease based on EC-encoding nucleic acid molecules or antibodies capable of binding specifically to ECs.
    Type: Application
    Filed: November 12, 2002
    Publication date: May 1, 2003
    Applicant: Incyte Genomics, Inc.
    Inventors: Craig G. Wilde, Phillip R. Hawkins, Olga Bandman, Jeffrey J. Seilhamer
  • Patent number: 6534275
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: March 18, 2003
    Assignee: Incyte Genomics, Corp.
    Inventors: Susan G. Stuart, Phillip R. Hawkins, Jeffrey J. Seilhamer, Lynn E. Murry
  • Publication number: 20030040615
    Abstract: The present invention provides purified polynucleotides, complements and fragments thereof, identified as encoding or regulating electron transfer molecules. The invention also provides for the use of these polynucleotides in methods to produce polypeptides and in the diagnosis, study, prevention, and treatment of disorders.
    Type: Application
    Filed: March 24, 2000
    Publication date: February 27, 2003
    Inventors: Jeffrey J. Seilhamer, Angelo M. Delegeane, Susan G. Stuart, Laura L. Stuve, Sara J. Mullahy, Rebecca E. Naughton
  • Patent number: 6500938
    Abstract: The present invention relates to a composition comprising a plurality of polynucleotide probes. The composition can be used as array elements in a microarray. The present invention also relates to a method for selecting polynucleotide probes of the composition.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: December 31, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Janice Au-Young, Jeffrey J. Seilhamer
  • Publication number: 20020146712
    Abstract: The invention provides a cDNA which encodes a tumor suppressor. It also provides for the use of the cDNA, protein, and antibody in the diagnosis, prognosis, treatment and evaluation of therapies for cancer. The invention further provides vectors and host cells for the production of the protein and transgenic model systems.
    Type: Application
    Filed: August 7, 2001
    Publication date: October 10, 2002
    Inventors: Richard D. Goold, Ingrid E. Akerblom, Jeffrey J. Seilhamer, Roger Coleman
  • Publication number: 20020142398
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (FSEC) from human fetal spleen cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode FSEC, expression vectors for the production of purified FSEC, antibodies capable of binding specifically to FSEC, hybridization probes or oligonucleotides for the detection of FSEC-encoding nucleotide sequences, genetically engineered host cells for the expression of FSEC, diagnostic tests for chemokine activation based on FSEC-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein.
    Type: Application
    Filed: May 29, 2002
    Publication date: October 3, 2002
    Applicant: Incyte Genomics, Inc.
    Inventors: Roger Coleman, Craig G. Wilde, Jeffrey J. Seilhamer
  • Publication number: 20020128443
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel thrombin receptor homolog (TRH) expressed in human liver. The present invention also provides for antisense molecules to the nucleotide sequences which encode TRH, diagnostic tests based on TRH encoding nucleic acid molecules, expression vectors for the production of purified TRH, antibodies capable of binding specifically to TRH, hybridization probes or oligonucleotides for the detection of TRH-encoding nucleotide sequences, genetically engineered host cells for the expression of TRH, and antagonists, antibodies and inhibitors with specific binding activity for the polypeptide TRH.
    Type: Application
    Filed: November 28, 2001
    Publication date: September 12, 2002
    Applicant: Incyte Pharmaceuticals, Inc.
    Inventors: Roger Coleman, Janice Au-Young, Olga Bandman, Jeffrey J. Seilhamer
  • Patent number: 6406679
    Abstract: Pharmaceutical compositions useful in the treatment of autoimmune conditions include as an active ingredient a soluble lectin having a molecular weight of about 14 kilodaltons or a fragment thereof. The lectin or fragment binds &bgr;-galactoside-containing moieties independent of the presence or absence of Ca+2, stimulates hemagglutination of trypsinized rabbit erythrocytes in standard lectin assays wherein the stimulation is inhibited by lactose or thiogalactoside, has an amino acid sequence containing at least one N-glycosylation site and is at least 90% homologous to the amino acid sequence shown in positions 2-135 of FIG. 1 or the relevant portions thereof. The composition is used for treatment of autoimmune conditions such as rheumatoid arthritis, myasthenia gravis, and multiple sclerosis, as well as modulating the immune response in an allergic reactions or to organ or tissue transplant rejection. The inventive composition can be combined with general immunosuppressants.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: June 18, 2002
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jeffrey J. Seilhamer, Glenn Nedwin, Tim Bringman, Pierre-Oliver Couraud
  • Patent number: 6408308
    Abstract: A biomolecular expression information processing system has procedures and tables that store abundance datasets and hybridization data. The tables also store information identifying a microarray technology type for each hybridization and microarray design information for each microarray technology type. The microarray design information includes technology data that specifies global characteristics of each microarray, and array element data that specifies characteristics of array elements in each microarray instance of the microarray technology type. The procedures process the abundance datasets in accordance with the microarray design information associated with each such abundance dataset. The system stores technology data for multiple distinct microarray technology types and stores array element data for multiple microarray designs of a single technology type.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: June 18, 2002
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Timothy J. Maslyn, Srikar D. Rao, Benjamin G. Cocks, Rachel J. Cheng, Timothy M. Engler, James R. Kerr, Steven M. Lassagne, Jeffrey J. Seilhamer
  • Patent number: 6403778
    Abstract: The present invention relates to a composition comprising a plurality of polynucleotide targets. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to methods for screening compounds and therapeutic treatments for toxicological responses.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: June 11, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Mary Jane Cunningham, Gary B. Zweiger, Scott R. Panzer, Jeffrey J. Seilhamer
  • Publication number: 20020064792
    Abstract: The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
    Type: Application
    Filed: September 19, 2001
    Publication date: May 30, 2002
    Inventors: Stephen E. Lincoln, Tod M. Klingler, Janice Au-Young, Y. Tom Tang, Richard D. Goold, Ingrid E. Akerblom, Jeffrey J. Seilhamer, Phillip R. Hawkins, Lynn E. Murry, Angelo M. Delegeane, Wendy B. Levine, Jennifer L. Hillman, Surya K. Goli, Christina M. Altus, Olga Bandman, Samuel T. LaBrie, Purvi Shah
  • Patent number: 6372431
    Abstract: The present invention relates to mammalian nucleic acid and protein molecules comprising a plurality of nucleic acid and protein molecules. The mammalian nucleic acid molecules can be used as hybridizable array elements in a microarray in diagnostic and therapeutic applications including detecting metabolic and toxicological responses, and in monitoring drug mechanism of action. The protein molecules can be used in a pharmaceutical composition. The present invention also relates to methods for screening compounds and therapeutics for metabolic responses indicative of a toxic compound or molecule.
    Type: Grant
    Filed: November 19, 1999
    Date of Patent: April 16, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Mary Jane Cunningham, Gary B. Zweiger, Matthew R. Kaser, Scott R. Panzer, Jeffrey J. Seilhamer, Henry Yue, Mariah R. Baughn, Yalda Azimzai, Preeti Lal
  • Patent number: 6352849
    Abstract: Novel mammalian phospholipase (PLA2) nucleotide sequences and low molecular weight (about 14 KD) amino acid sequences encoded thereby are disclosed. More particularly, a cloned human HPLA2 cDNA expressing HPLA2-10 and its cloned rat RPLA2 cDNA counterpart, expressing RPLA2-10, which are characterized as PLA2 Type IV, are disclosed. A second type of PLA2 cDNA, characterized as PLA2 Type III and exemplified by a rat PLA2 cDNA encoding RPLA2-8 and a partial human PLA2 nucleotide sequence encoding HPLA2-8, is disclosed. Expression of the cDNAs encode the two new types of PLA2 enzymes which have phospholipase activity. The novel PLA2s do not include disulfide bridges between cysteine amino acids 11 and 77 or elapid loops. However, the novel PLA2s may include amino acid COOH-terminal extensions which can vary in length.
    Type: Grant
    Filed: July 28, 1999
    Date of Patent: March 5, 2002
    Assignees: Incyte Pharmaceuticals, Inc.
    Inventors: Jay A. Tischfield, Jeffrey J. Seilhamer
  • Patent number: 6303297
    Abstract: The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: October 16, 2001
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Steve E. Lincoln, Tod M. Klingler, Janice Au-Young, Y. Tom Tang, Richard D. Goold, Ingrid E. Akerblom, Jeffrey J. Seilhamer, Phillip R. Hawkins, Lynn E. Murry, Angelo M. Delegeane, Wendy B. Levine, Jennifer L. Hillman, Surya K. Goli, Christina M. Altus, Olga Bandman, Samuel T. LaBrie, Purvi Shah
  • Patent number: 6160104
    Abstract: The present invention relates to a composition comprising a plurality of polynucleotide targets. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to methods for screening compounds and therapeutic treatments for toxicological responses.
    Type: Grant
    Filed: October 13, 1998
    Date of Patent: December 12, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Mary Jane Cunningham, Gary B. Zweiger, Scott R. Panzer, Jeffrey J. Seilhamer
  • Patent number: 6160105
    Abstract: The present invention relates to a composition comprising a plurality of polynucleotide targets. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to methods for screening compounds and therapeutic treatments for toxicological responses.
    Type: Grant
    Filed: October 13, 1998
    Date of Patent: December 12, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Mary Jane Cunningham, Gary B. Zweiger, Scott R. Panzer, Jeffrey J. Seilhamer
  • Patent number: 6143870
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel thrombin receptor homolog (TRH) expressed in human liver. The present invention also provides for antisense molecules to the nucleotide sequences which encode TRH, diagnostic tests based on TRH encoding nucleic acid molecules, expression vectors for the production of purified TRH, antibodies capable of binding specifically to TRH, hybridization probes or oligonucleotides for the detection of TRH-encoding nucleotide sequences, genetically engineered host cells for the expression of TRH, and antagonists, antibodies and inhibitors with specific binding activity for the polypeptide TRH.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: November 7, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Roger Coleman, Janice Au-Young, Olga Bandman, Jeffrey J. Seilhamer
  • Patent number: 6114114
    Abstract: A method and system for quantifying the relative abundance of gene transcripts in a biological sample. One embodiment of the method generates high-throughput sequence-specific analysis of multiple RNAs or their corresponding cDNAs (gene transcript imaging analysis). Another embodiment of the method produces a gene transcript imaging analysis by the use of high-throughput CDNA sequence analysis. In addition, the gene transcript imaging can be used to detect or diagnose a particular biological state, disease, or condition which is correlated to the relative abundance of gene transcripts in a given cell or population of cells. The invention provides a method for comparing the gene transcript image analysis from two or more different biological samples in order to distinguish between the two samples and identify one or more genes which are differentially expressed between the two samples.
    Type: Grant
    Filed: July 29, 1994
    Date of Patent: September 5, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jeffrey J. Seilhamer, Randal W. Scott
  • Patent number: 6080548
    Abstract: The invention provides human cyclic nucleotide phosphodiesterases (PDE8) and polynucleotides which identify and encode PDE8. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of PDE8.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: June 27, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Janice Au-Young, Benjamin G. Cocks, Roger Coleman, Jeffrey J. Seilhamer, Douglas A. Fisher
  • Patent number: 6071701
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization robes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
    Type: Grant
    Filed: December 1, 1998
    Date of Patent: June 6, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Karl J. Guegler, Phillip R. Hawkins, Craig G. Wilde, Jeffrey J. Seilhamer