Abstract: An implantable medical device configured to monitor fluid in proximity to an implantable medical device for an inadvertent introduction of infusate into a pocket of tissue surrounding the implantable medical device during a refill procedure, the implantable medical device including a refillable infusate delivery system, the refillable infusate delivery system including a reservoir in fluid communication with an access port, and a conductivity sensor configured to monitor fluid in proximity to the conductivity sensor for an introduction of infusate into a pocket of tissue surrounding the implantable medical device, wherein the conductivity sensor comprises a pair of electrodes positioned on an external surface of the implantable medical device.

Abstract: An implantable infusate spread promoting system configured to enable improved dispersion of delivered infusate. The system including an implantable device configured to enable infusate delivery within a body of a patient, and an implantable manually actuatable flushing pump configured to remove and re-inject a quantity of fluid with each actuation to promote improved dispersion of the delivered infusate.

Abstract: Anchors for securing a medical device relative to a body portal, wherein the anchors may accommodate most any implantation trajectory through the portal. Such anchors may further secure the device along any such trajectory without imparting undesirable biasing forces that may shift the device from its intended implanted location. In some embodiments, the anchor is configured as a burr hole anchor including a spherical member contained in a socket of the anchor such that orientation of the spherical member is permitted about three mutually perpendicular axes.

Abstract: A first medical device for obstructive sleep apnea therapy includes therapy delivery circuitry coupled to a first set of electrodes implantable proximate to a first hypoglossal nerve within a tongue of the patient and configured to deliver a first electrical stimulation signal to the first hypoglossal nerve that causes the tongue of the patient to advance and includes information to communicate to a second medical device implantable within the head or neck of the patient and coupled to a second set of electrodes implantable proximate to a second hypoglossal nerve within the tongue of the patient; and sensing circuitry coupled to the first set of electrodes and configured to receive a second electrical stimulation signal, delivered to the second hypoglossal nerve by the second medical device, that includes information that the second medical device communicates to the first medical device.

Abstract: Use of non-contact patient monitoring systems to detect, diagnose, monitor and/or adjust therapy for diseases or conditions that have motion-based symptoms, symptoms such as limb tremors, spasms, etc. that can be correlated to diseases or conditions such as Essential tremor, Parkinson's disease, restless leg syndrome, or a diabetic episode. Information garnered by the non-contact monitoring system, information such as location, frequency, severity, and duration of the motion, can be collected and analyzed so that a diagnosis can be made and/or a treatment plan developed and/or adjusted by the patient's caretaker. The non-contact monitoring can provide real-time feedback regarding effectiveness of therapies or treatments, such as, e.g., neurological stimulation.

Abstract: Systems and methods involve an intrathoracic cardiac stimulation device operable to provide autonomous cardiac sensing and energy delivery. The cardiac stimulation device includes a housing configured for intrathoracic placement relative to a patient's heart. A fixation arrangement of the housing is configured to affix the housing at an implant location within cardiac tissue or cardiac vasculature. An electrode arrangement supported by the housing is configured to sense cardiac activity and deliver stimulation energy to the cardiac tissue or cardiac vasculature. Energy delivery circuitry in the housing is coupled to the electrode arrangement. Detection circuitry is provided in the housing and coupled to the electrode arrangement. Communications circuitry may optionally be supported by the housing. A controller in the housing coordinates delivery of energy to the cardiac tissue or cardiac vasculature in accordance with an energy delivery protocol appropriate for the implant location.

Abstract: A system may generate a waveform signal indicative of a biometric parameter of a target subject based on motion data associated with the target subject. The motion data may be provided by a depth sensing device and be substantially free of image data. The system may set a threshold condition based on one or more characteristics of the waveform signal. The system may output a control signal to a stimulation device based on the waveform signal satisfying the threshold condition.

Abstract: An implantable infusate spread promoting system configured to enable improved dispersion of delivered infusate. The system including an implantable device configured to enable infusate delivery within a body of a patient, and an implantable manually actuatable flushing pump configured to remove and re-inject a quantity of fluid with each actuation to promote improved dispersion of the delivered infusate.

Abstract: A first medical device for obstructive sleep apnea therapy includes therapy delivery circuitry coupled to a first set of electrodes implantable proximate to a first hypoglossal nerve within a tongue of the patient and configured to deliver a first electrical stimulation signal to the first hypoglossal nerve that causes the tongue of the patient to advance and includes information to communicate to a second medical device implantable within the head or neck of the patient and coupled to a second set of electrodes implantable proximate to a second hypoglossal nerve within the tongue of the patient; and sensing circuitry coupled to the first set of electrodes and configured to receive a second electrical stimulation signal, delivered to the second hypoglossal nerve by the second medical device, that includes information that the second medical device communicates to the first medical device.

Abstract: An implantable glymphatic pump configured to flush metabolites from a brain parenchyma of a patient. The implantable glymphatic pump including at least one spinal catheter having a distal end configured to be positioned within an intrathecal space of a spine of a patient, at least one cranial catheter having a distal end configured to be positioned within a brain parenchyma of the patient, and an implantable pump configured to draw cerebrospinal fluid from the intrathecal space of the spine in the patient via the at least one spinal catheter, and reintroduce said cerebrospinal fluid to the brain parenchyma of the patient via the one or more cranial catheters to encourage a flow of the cerebrospinal fluid through the brain parenchyma.

Abstract: Systems and methods involve an intrathoracic cardiac stimulation device operable to provide autonomous cardiac sensing and energy delivery. The cardiac stimulation device includes a housing configured for intrathoracic placement relative to a patient's heart. A fixation arrangement of the housing is configured to affix the housing at an implant location within cardiac tissue or cardiac vasculature. An electrode arrangement supported by the housing is configured to sense cardiac activity and deliver stimulation energy to the cardiac tissue or cardiac vasculature. Energy delivery circuitry in the housing is coupled to the electrode arrangement. Detection circuitry is provided in the housing and coupled to the electrode arrangement. Communications circuitry may optionally be supported by the housing. A controller in the housing coordinates delivery of energy to the cardiac tissue or cardiac vasculature in accordance with an energy delivery protocol appropriate for the implant location.

Abstract: A drug delivery system including an implantable reservoir containing drug microspheres, with an innocuous fluid flushed through the implantable microsphere reservoir to form a drug containing solution for delivery within a body of a patient.

Abstract: An implantable medical device configured to monitor fluid in proximity to an implantable medical device for an inadvertent introduction of infusate into a pocket of tissue surrounding the implantable medical device during a refill procedure, the implantable medical device including a refillable infusate delivery system, the refillable infusate delivery system including a reservoir in fluid communication with an access port, and a conductivity sensor configured to monitor fluid in proximity to the conductivity sensor for an introduction of infusate into a pocket of tissue surrounding the implantable medical device, wherein the conductivity sensor comprises a pair of electrodes positioned on an external surface of the implantable medical device.

Abstract: This disclosure describes devices, systems, and techniques for recharging power sources using RF energy received by one or more antennae. In one example, an implantable medical device includes a rechargeable power supply and an antenna configured to receive radio frequency (RF) energy having one or more frequencies within at least one of a first range from 1 MHz to 20 MHz or a second range from 100 MHz to 700 MHz. The implantable medical device may also include charging circuitry configured to convert the RF energy to a direct current (DC) power and charge the rechargeable power supply with the DC power.

Abstract: An implantable glymphatic pump configured to flush metabolites from a brain parenchyma of a patient. The implantable glymphatic pump including at least one spinal catheter having a distal end configured to be positioned within an intrathecal space of a spine of a patient, at least one cranial catheter having a distal end configured to be positioned within a brain parenchyma of the patient, and an implantable pump configured to draw cerebrospinal fluid from the intrathecal space of the spine in the patient via the at least one spinal catheter, and reintroduce said cerebrospinal fluid to the brain parenchyma of the patient via the one or more cranial catheters to encourage a flow of the cerebrospinal fluid through the brain parenchyma.

Abstract: Anchors for securing a medical device relative to a body portal, wherein the anchors may accommodate most any implantation trajectory through the portal. Such anchors may further secure the device along any such trajectory without imparting undesirable biasing forces that may shift the device from its intended implanted location. In some embodiments, the anchor is configured as a burr hole anchor including a spherical member contained in a socket of the anchor such that orientation of the spherical member is permitted about three mutually perpendicular axes.

Abstract: Systems and methods involve an intrathoracic cardiac stimulation device operable to provide autonomous cardiac sensing and energy delivery. The cardiac stimulation device includes a housing configured for intrathoracic placement relative to a patient's heart. A fixation arrangement of the housing is configured to affix the housing at an implant location within cardiac tissue or cardiac vasculature. An electrode arrangement supported by the housing is configured to sense cardiac activity and deliver stimulation energy to the cardiac tissue or cardiac vasculature. Energy delivery circuitry in the housing is coupled to the electrode arrangement. Detection circuitry is provided in the housing and coupled to the electrode arrangement. Communications circuitry may optionally be supported by the housing. A controller in the housing coordinates delivery of energy to the cardiac tissue or cardiac vasculature in accordance with an energy delivery protocol appropriate for the implant location.

Abstract: Anchors for securing a medical device relative to a body portal, wherein the anchors may accommodate most any implantation trajectory through the portal. Such anchors may further secure the device along any such trajectory without imparting undesirable biasing forces that may shift the device from its intended implanted location. In some embodiments, the anchor is configured as a burr hole anchor including a spherical member contained in a socket of the anchor such that orientation of the spherical member is permitted about three mutually perpendicular axes.

Abstract: Systems and methods involve an intrathoracic cardiac stimulation device operable to provide autonomous cardiac sensing and energy delivery. The cardiac stimulation device includes a housing configured for intrathoracic placement relative to a patient's heart. A fixation arrangement of the housing is configured to affix the housing at an implant location within cardiac tissue or cardiac vasculature. An electrode arrangement supported by the housing is configured to sense cardiac activity and deliver stimulation energy to the cardiac tissue or cardiac vasculature. Energy delivery circuitry in the housing is coupled to the electrode arrangement. Detection circuitry is provided in the housing and coupled to the electrode arrangement. Communications circuitry may optionally be supported by the housing. A controller in the housing coordinates delivery of energy to the cardiac tissue or cardiac vasculature in accordance with an energy delivery protocol appropriate for the implant location.

Abstract: Systems and methods involve an intrathoracic cardiac stimulation device operable to provide autonomous cardiac sensing and energy delivery. The cardiac stimulation device includes a housing configured for intrathoracic placement relative to a patient's heart. A fixation arrangement of the housing is configured to affix the housing at an implant location within cardiac tissue or cardiac vasculature. An electrode arrangement supported by the housing is configured to sense cardiac activity and deliver stimulation energy to the cardiac tissue or cardiac vasculature. Energy delivery circuitry in the housing is coupled to the electrode arrangement. Detection circuitry is provided in the housing and coupled to the electrode arrangement. Communications circuitry may optionally be supported by the housing. A controller in the housing coordinates delivery of energy to the cardiac tissue or cardiac vasculature in accordance with an energy delivery protocol appropriate for the implant location.