Abstract: Systems and methods involve an intrathoracic cardiac stimulation device operable to provide autonomous cardiac sensing and energy delivery. The cardiac stimulation device includes a housing configured for intrathoracic placement relative to a patient's heart. A fixation arrangement of the housing is configured to affix the housing at an implant location within cardiac tissue or cardiac vasculature. An electrode arrangement supported by the housing is configured to sense cardiac activity and deliver stimulation energy to the cardiac tissue or cardiac vasculature. Energy delivery circuitry in the housing is coupled to the electrode arrangement. Detection circuitry is provided in the housing and coupled to the electrode arrangement. Communications circuitry may optionally be supported by the housing. A controller in the housing coordinates delivery of energy to the cardiac tissue or cardiac vasculature in accordance with an energy delivery protocol appropriate for the implant location.

Abstract: Systems and methods involve an intrathoracic cardiac stimulation device operable to provide autonomous cardiac sensing and energy delivery. The cardiac stimulation device includes a housing configured for intrathoracic placement relative to a patient's heart. A fixation arrangement of the housing is configured to affix the housing at an implant location within cardiac tissue or cardiac vasculature. An electrode arrangement supported by the housing is configured to sense cardiac activity and deliver stimulation energy to the cardiac tissue or cardiac vasculature. Energy delivery circuitry in the housing is coupled to the electrode arrangement. Detection circuitry is provided in the housing and coupled to the electrode arrangement. Communications circuitry may optionally be supported by the housing. A controller in the housing coordinates delivery of energy to the cardiac tissue or cardiac vasculature in accordance with an energy delivery protocol appropriate for the implant location.

Abstract: Systems and methods involve an intrathoracic cardiac stimulation device operable to provide autonomous cardiac sensing and energy delivery. The cardiac stimulation device includes a housing configured for intrathoracic placement relative to a patient's heart. A fixation arrangement of the housing is configured to affix the housing at an implant location within cardiac tissue or cardiac vasculature. An electrode arrangement supported by the housing is configured to sense cardiac activity and deliver stimulation energy to the cardiac tissue or cardiac vasculature. Energy delivery circuitry in the housing is coupled to the electrode arrangement. Detection circuitry is provided in the housing and coupled to the electrode arrangement. Communications circuitry may optionally be supported by the housing. A controller in the housing coordinates delivery of energy to the cardiac tissue or cardiac vasculature in accordance with an energy delivery protocol appropriate for the implant location.

Abstract: Anchors for securing a medical device relative to a burr hole, wherein the anchors may accommodate most any implantation trajectory through the burr hole. Such anchors may further secure the device along any such trajectory without imparting undesirable biasing forces that may shift the device from its intended implanted location. In some embodiments, the anchor is configured with a cup-shaped retention member through which the medical device passes. The retention member may receive a volume of curable material therein to provide strain relief to the medical device.

Abstract: Systems and methods involve an intrathoracic cardiac stimulation device operable to provide autonomous cardiac sensing and energy delivery. The cardiac stimulation device includes a housing configured for intrathoracic placement relative to a patient's heart. A fixation arrangement of the housing is configured to affix the housing at an implant location within cardiac tissue or cardiac vasculature. An electrode arrangement supported by the housing is configured to sense cardiac activity and deliver stimulation energy to the cardiac tissue or cardiac vasculature. Energy delivery circuitry in the housing is coupled to the electrode arrangement. Detection circuitry is provided in the housing and coupled to the electrode arrangement. Communications circuitry may optionally be supported by the housing. A controller in the housing coordinates delivery of energy to the cardiac tissue or cardiac vasculature in accordance with an energy delivery protocol appropriate for the implant location.

Abstract: A system and method for determining, planning, and/or administering a therapy of a selected material from a catheter to a selected specific region of an anatomy is disclosed. The catheter can be used to deliver a drug to the patient to achieve a volume of efficacy (VOE) within a selected target, region, or volume. The drug delivered can be used for treating at least a symptom in the patient.

Abstract: Systems and methods involve an intrathoracic cardiac stimulation device operable to provide autonomous cardiac sensing and energy delivery. The cardiac stimulation device includes a housing configured for intrathoracic placement relative to a patient's heart. A fixation arrangement of the housing is configured to affix the housing at an implant location within cardiac tissue or cardiac vasculature. An electrode arrangement supported by the housing is configured to sense cardiac activity and deliver stimulation energy to the cardiac tissue or cardiac vasculature. Energy delivery circuitry in the housing is coupled to the electrode arrangement. Detection circuitry is provided in the housing and coupled to the electrode arrangement. Communications circuitry may optionally be supported by the housing. A controller in the housing coordinates delivery of energy to the cardiac tissue or cardiac vasculature in accordance with an energy delivery protocol appropriate for the implant location.

Abstract: Anchors for securing a medical device relative to a body portal, wherein the anchors may accommodate most any implantation trajectory through the portal. Such anchors may further secure the device along any such trajectory without imparting undesirable biasing forces that may shift the device from its intended implanted location. In some embodiments, the anchor is configured as a burr hole anchor including a spherical member contained in a socket of the anchor such that orientation of the spherical member is permitted about three mutually perpendicular axes.

Abstract: Anchors for securing a medical device relative to a body portal, wherein the anchors may accommodate most any implantation trajectory through the portal. Such anchors may further secure the device along any such trajectory without imparting undesirable biasing forces that may shift the device from its intended implanted location. In some embodiments, the anchor is configured as a burr hole anchor including a spherical member contained in a socket of the anchor wherein the socket may be collapsed to lock the spherical member along a particular trajectory.

Abstract: Anchors for securing a medical device relative to a burr hole, wherein the anchors may accommodate most any implantation trajectory through the burr hole. Such anchors may further secure the device along any such trajectory without imparting undesirable biasing forces that may shift the device from its intended implanted location. In some embodiments, the anchor is configured with a cup-shaped retention member through which the medical device passes. The retention member may receive a volume of curable material therein to provide strain relief to the medical device.

Abstract: A system and method for determining, planning, and/or administering a therapy of a selected material from a catheter to a selected specific region of an anatomy is disclosed. The catheter can be used to deliver a drug to the patient to achieve a volume of efficacy (VOE) within a selected target, region, or volume. The drug delivered can be used for treating at least a symptom in the patient.

Abstract: An accumulator is employed in an implantable infusion device to provide compliance in the flow path of the device. The accumulator may act to increase the pumping accuracy and repeatability while simultaneously reducing the energy requirements of the device. In one example, the accumulator is arranged at the outlet of a fluid delivery pump of the infusion device. The accumulator includes a cover and a diaphragm biased away from the cover and configured to deflect toward the cover under pressure generated by the therapeutic agent in a flow path of the infusion device. The cover of the accumulator is configured to withstand the pressure generated by the therapeutic agent in the flow path without deforming.

Abstract: An accumulator is employed in an implantable infusion device to provide compliance in the flow path of the device. The accumulator may act to increase the pumping accuracy and repeatability while simultaneously reducing the energy requirements of the device. In one example, the accumulator is arranged at the outlet of a fluid delivery pump of the infusion device. The accumulator includes a cover and a diaphragm biased away from the cover and configured to deflect toward the cover under pressure generated by the therapeutic agent in a flow path of the infusion device. The cover of the accumulator is configured to withstand the pressure generated by the therapeutic agent in the flow path without deforming.

Abstract: An anchoring device for anchoring a medical lead implanted in a patient includes a substantially elongate, hollow, tubular, and elastically compressible body. The body has a longitudinal axis, a groove formed circumferentially about the body for receiving a suture and an inner bore forming a recessed portion. The anchoring device also has a surrounding portion adjacent the recessed portion, where the recessed portion has increased retention characteristics on a medical lead relative to the surrounding portion of the inner bore.

Abstract: This document discusses, among other things, a lead body extending longitudinally along a lead axis, a driver axially displaceable relative to the lead body, and a driven member coupled to the lead body and displaceable away from the lead axis. The driven member at least partially defines an expandable passage having at least one internal dimension. The driver is displaceable into the expandable passage and has at least one outer dimension that is larger than the at least one internal dimension of the expandable passage. An example method includes disposing a first member having a first cross-section in a lead assembly having a lead axis, an expandable passage, and a displaceable member proximate the expandable passage. The method further includes urging the first member into the expandable passage in the lead assembly, and urging the displaceable member away from the lead axis to expand the expandable passage.

Abstract: A lead assembly includes a flexible lead body extending from a proximal end to a distal end, and the lead body includes two or more conductors disposed therein. The second conductor is disposed within the first conductor, and the first conductor has a coating of insulation disposed on a portion thereof. In another option, a sleeve of insulative material is disposed between the first conductor and the second conductor.

Abstract: A lead assembly comprises a lead body extending from a lead proximal end portion to a lead distal end portion with at least one conductor disposed therein. A lead lumen extends within the lead body and is dimensioned and configured to removably and rotatably seat a driver therein. The driver includes a driver body extending from a driver proximal end to a driver distal end and having a stylet or guidewire lumen disposed therein. An extendable and retractable active fixation mechanism is disposed at the lead distal end portion. The active fixation mechanism is actuatable by rotation of the driver. In one example, the at least one conductor includes a first conductor and a second conductor, in which the first conductor is co-radial with the second conductor. In another example, the driver distal end includes a portion extractably engagable with the lead distal end portion.

Abstract: A therapeutic fluid delivery device includes a flexible member configured as an accumulator for flow of a therapeutic fluid through the fluid delivery device to a patient. In one example, the flexible member includes a catheter access port (CAP) septum.

Abstract: An implantable lead assembly includes a lead body extending from a proximal end to a distal end having an intermediate portion therebetween, where the lead body includes an insulating layer. A conductor is disposed within the insulating layer and the insulating layer surrounds the conductor. An electrode is coupled to the lead body, and the electrode is in electrical communication with the conductor. At least one conductive sleeve is disposed within the insulating layer. The at least one conductive sleeve surrounds the conductor and is electrically isolated from the electrode. The at least one conductive sleeve has a first impedance value in a first condition.

Abstract: An implantable lead assembly includes a lead body extending from a proximal end to a distal end having an intermediate portion therebetween, where the lead body includes an insulating layer. A conductor is disposed within the insulating layer and the insulating layer surrounds the conductor. An electrode is coupled to the lead body, and the electrode is in electrical communication with the conductor. At least one conductive sleeve is disposed within the insulating layer. The at least one conductive sleeve surrounds the conductor and is electrically isolated from the electrode. The at least one conductive sleeve has a first impedance value in a first condition.