Patents by Inventor Jeffrey R. Millman

Jeffrey R. Millman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
    Publication number: 20220162562
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: October 29, 2021
    Publication date: May 26, 2022
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler
  • SC-beta cells and compositions and methods for generating the same
    Patent number: 11162078
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: November 2, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler
  • CELL-EMBEDDED VASCULAR GRAFT FOR TRANSPLANTATION
    Publication number: 20210290821
    Abstract: Disclosed herein is a transplantation graft for transplanting cells into a patient. In an aspect, the graft may include a first graft layer having a generally cylindrical configuration defining a lumen therethrough, a coating layer surrounding the first graft layer, and a plurality of cells or vectors implanted in either the first graft layer or the coating layer. Further disclosed herein is a method for transplanting cells into a patient and a method of treating a patient in need thereof. The transplantation graft may be implanted in the patient in an arteriovenous configuration and the coating layer protects the implanted cells from the patient's immune system. The plurality of cells in the transplantation graft may release a biologically active agent in response to a biological factor in blood flowing through the lumen of the transplantation graft.
    Type: Application
    Filed: July 29, 2019
    Publication date: September 23, 2021
    Applicant: Washington University
    Inventors: Mohamed A. Zayed, Jeffrey R. Millman
  • SC-beta cells and compositions and methods for generating the same
    Patent number: 11104883
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: August 31, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler
  • SC-beta cells and compositions and methods for generating the same
    Patent number: 11078463
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: August 3, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler
  • METHODS AND COMPOSITIONS FOR GENERATING CELLS OF ENDODERMAL LINEAGE AND BETA CELLS AND USES THEREOF
    Publication number: 20210207099
    Abstract: Among the various aspects of the present disclosure is the provision of methods and compositions for the generation of cells of endodermal lineage and beta cells and uses thereof.
    Type: Application
    Filed: May 16, 2019
    Publication date: July 8, 2021
    Inventors: Jeffrey R. Millman, Nathaniel Hogrebe, Jiwon Song, Leonardo Velazco-Cruz
  • SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
    Publication number: 20210079355
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: July 21, 2020
    Publication date: March 18, 2021
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler
  • METHODS FOR GENERATING STEM CELL-DERIVED BETA CELLS AND USES THEREOF
    Publication number: 20210060083
    Abstract: Disclosed herein are methods for generating SC-? cells, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: July 9, 2020
    Publication date: March 4, 2021
    Inventors: Douglas A. Melton, Jeffrey R. Millman
  • Methods for generating stem cell-derived beta cells and uses thereof
    Patent number: 10927350
    Abstract: Disclosed herein are methods for generating SC-? cells, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: February 23, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Douglas A. Melton, Jeffrey R. Millman
  • SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
    Publication number: 20200385681
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: July 21, 2020
    Publication date: December 10, 2020
    Applicant: President and Fellows of Harvard College
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler
  • SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
    Publication number: 20200347358
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: July 21, 2020
    Publication date: November 5, 2020
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler
  • SC-beta cells and compositions and methods for generating the same
    Patent number: 10655106
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: May 19, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler
  • METHODS FOR GENERATING STEM CELL-DERIVED BETA CELLS AND USES THEREOF
    Publication number: 20190185817
    Abstract: Disclosed herein are methods for generating SC-? cells, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: December 7, 2018
    Publication date: June 20, 2019
    Inventors: Douglas A. Melton, Jeffrey R. Millman
  • SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
    Publication number: 20190169575
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: February 11, 2019
    Publication date: June 6, 2019
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler, Alireza Rezania, Benjamin Fryer
  • METHODS FOR GENERATING AUGMENTED STEM CELL-DERIVED BETA CELLS AND USES THEREOF
    Publication number: 20190119649
    Abstract: Disclosed herein are methods for generating augmented SC-? cells, and isolated populations of augmented SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: May 17, 2018
    Publication date: April 25, 2019
    Inventors: Douglas A. Melton, Jeffrey R. Millman, Mads Gürtler
  • SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
    Publication number: 20190040362
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: July 23, 2018
    Publication date: February 7, 2019
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler
  • Methods for generating stem cell-derived ? cells and uses thereof
    Patent number: 10190096
    Abstract: Disclosed herein are methods for generating SC-? cells, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: January 29, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Douglas A. Melton, Jeffrey R. Millman
  • SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
    Publication number: 20190017031
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: July 23, 2018
    Publication date: January 17, 2019
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler
  • Methods and compositions for increased safety of stem cell-derived populations
    Patent number: 10179901
    Abstract: The invention provides methods and compositions relating to differentiated cell populations that derive from pluripotent stem cells. The methods relate to reducing the number of residual stem cells present in such populations. The compositions include differentiated cell populations that contain reduced number of stem cells or that contain no stem cells. Pluripotent stem cells may be reduced in number and/or function through exposure to low oxygen levels.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: January 15, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Jeffrey R. Millman
  • SC-? cells and compositions and methods for generating the same
    Patent number: 10030229
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: July 24, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler