Patents by Inventor Jeffrey R. Millman

Jeffrey R. Millman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR GENERATING STEM CELL-DERIVED BETA CELLS AND USES THEREOF
    Publication number: 20180153941
    Abstract: Disclosed herein are methods for generating SC-? cells, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: August 1, 2017
    Publication date: June 7, 2018
    Inventors: Douglas A. Melton, Jeffrey R. Millman
  • METHODS AND COMPOSITIONS FOR INCREASED SAFETY OF STEM CELL-DERIVED POPULATIONS
    Publication number: 20170121677
    Abstract: The invention provides methods and compositions relating to differentiated cell populations that derive from pluripotent stem cells. The methods relate to reducing the number of residual stem cells present in such populations. The compositions include differentiated cell populations that contain reduced number of stem cells or that contain no stem cells. Pluripotent stem cells may be reduced in number and/or function through exposure to low oxygen levels.
    Type: Application
    Filed: June 10, 2016
    Publication date: May 4, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Jeffrey R. Millman
  • SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
    Publication number: 20170029778
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: June 11, 2014
    Publication date: February 2, 2017
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gürtler, Alireza Rezania, Benjamin Fryer
  • Method for differentiating human embryonic stem cells into ?-cells for the treatment of type I diabetes
    Patent number: 9447378
    Abstract: The invention provides inter alia methods for differentiating embryonic stem cells into insulin producing cells, as well as compositions comprising such cells, and therapeutic uses of such compositions.
    Type: Grant
    Filed: April 29, 2013
    Date of Patent: September 20, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Amanda Dilenno, Jeffrey R. Millman
  • Methods and compositions for increased safety of stem cell-derived populations
    Patent number: 9388381
    Abstract: The invention provides methods and compositions relating to differentiated cell populations that derive from pluripotent stem cells. The methods relate to reducing the number of residual stem cells present in such populations. The compositions include differentiated cell populations that contain reduced number of stem cells or that contain no stem cells. Pluripotent stem cells may be reduced in number and/or function through exposure to low oxygen levels.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: July 12, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Jeffrey R. Millman
  • METHODS FOR GENERATING STEM CELL-DERIVED BETA CELLS AND USES THEREOF
    Publication number: 20160186143
    Abstract: Disclosed herein are methods for generating SC-? cells, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: December 18, 2015
    Publication date: June 30, 2016
    Inventors: Douglas A. Melton, Jeffrey R. Millman
  • METHODS FOR GENERATING STEM CELL-DERIVED BETA CELLS AND USES THEREOF
    Publication number: 20160175363
    Abstract: Disclosed herein are methods for generating SC-? cells, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: December 18, 2015
    Publication date: June 23, 2016
    Inventors: Douglas A. Melton, Jeffrey R. Millman
  • METHODS FOR GENERATING AUGMENTED STEM CELL-DERIVED BETA CELLS AND USES THEREOF
    Publication number: 20160177268
    Abstract: Disclosed herein are methods for generating augmented SC-? cells, and isolated populations of augmented SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: December 18, 2015
    Publication date: June 23, 2016
    Inventors: Douglas A. Melton, Jeffrey R. Millman, Mads Gürtler
  • SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
    Publication number: 20150240212
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: April 10, 2015
    Publication date: August 27, 2015
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler
  • SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
    Publication number: 20150218522
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Application
    Filed: April 10, 2015
    Publication date: August 6, 2015
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler
  • Methods and compositions for enhanced differentiation from embryonic stem cells
    Patent number: 9029147
    Abstract: The invention provides methods for differentiating pluripotent stem cells such as ES cells with improved progenitor and differentiated cell yield using low oxygen conditions and optionally in the absence of exogenously added differentiation factors.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: May 12, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Daryl E. Powers, Jeffrey R. Millman
  • METHOD FOR DIFFERENTIATING HUMAN EMBRYONIC STEM CELLS INTO ß-CELLS FOR THE TREATMENT OF TYPE I DIABETES
    Publication number: 20130287743
    Abstract: The invention provides inter alia methods for differentiating embryonic stem cells into insulin producing cells, as well as compositions comprising such cells, and therapeutic uses of such compositions.
    Type: Application
    Filed: April 29, 2013
    Publication date: October 31, 2013
    Applicant: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Amanda Dilenno, Jeffrey R. Millman
  • METHODS AND COMPOSITIONS FOR INCREASED SAFETY OF STEM CELL-DERIVED POPULATIONS
    Publication number: 20120219532
    Abstract: The invention provides methods and compositions relating to differentiated cell populations that derive from pluripotent stem cells. The methods relate to reducing the number of residual stem cells present in such populations. The compositions include differentiated cell populations that contain reduced number of stem cells or that contain no stem cells. Pluripotent stem cells may be reduced in number and/or function through exposure to low oxygen levels.
    Type: Application
    Filed: July 9, 2010
    Publication date: August 30, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: Clark K. Colton, Jeffrey R. Millman
  • METHODS AND COMPOSITIONS FOR ENHANCED DIFFERENTIATION FROM EMBRYONIC STEM CELLS
    Publication number: 20100261277
    Abstract: The invention provides methods for differentiating pluripotent stem cells such as ES cells with improved progenitor and differentiated cell yield using low oxygen conditions and optionally in the absence of exogenously added differentiation factors.
    Type: Application
    Filed: June 13, 2008
    Publication date: October 14, 2010
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Clark K. Colton, Daryl Powers, Jeffrey R. Millman