Abstract: An access system adapted for accessing a desired location within a patient's vasculature includes an outer catheter such as a guide extension catheter and an inner catheter such as a dilator. The outer catheter includes an outer catheter push rod, an outer catheter sheath extending distally from the outer catheter push rod, and a first engagement feature disposed within a distal region of the outer catheter sheath. The inner catheter includes an inner catheter push rod, an inner catheter body extending distally from the inner catheter push rod, and a second engagement feature disposed within a proximal region of the inner catheter body, the second engagement feature adapted to releasably engage the first engagement feature.

Abstract: A catheter system (100) for treating a treatment site (106) includes an energy source (124), a balloon (104), an energy guide (122A), and a balloon integrity protection system (142). The energy source (124) generates pulses of energy. The balloon (104) is positionable substantially adjacent to the treatment site (106). The balloon (104) has a balloon wall (130) that defines a balloon interior (146). The balloon (104) is configured to retain a balloon fluid (132) within the balloon interior (146). The energy guide (122A) is configured to receive the energy from the energy source (124) and guide the energy into the balloon interior (146) so that plasma is formed in the balloon fluid (132) within the balloon interior (146). The balloon integrity protection system (142) is operatively coupled to the balloon (104).

Abstract: Intravascular imaging devices as well as methods for making and using intravascular imaging devices are disclosed. An intravascular imaging device may include a catheter shaft including a proximal section and a distal section. The distal section may include a dual lumen region and a distal tip region coupled to the dual lumen region. A bumper tip member may be disposed along the distal tip region. A marker member may be disposed adjacent to the bumper tip member. The marker member may include an inner layer, a tie layer, and an outer layer including a radiopaque material. A sleeve may be disposed over and couple the bumper tip member and the marker member. An imaging core may be disposed within the catheter shaft.

Abstract: Intravascular imaging devices as well as methods for making and using intravascular imaging devices are disclosed. An intravascular imaging device may include a catheter shaft including a proximal section and a distal section. The distal section may include a dual lumen region and a distal tip region coupled to the dual lumen region. The distal tip region may include a bumper tip member, a radiopaque member, and a sleeve disposed over and coupling the bumper tip member and the radiopaque member. An imaging core may be disposed within the catheter shaft.

Abstract: Intravascular imaging devices as well as methods for making and using intravascular imaging devices are disclosed. An intravascular imaging device may include a catheter shaft including a hypotube region, an imaging window region, and a distal end region having a guidewire lumen formed therein. The hypotube region may include a slotted section having a plurality of slots formed therein. The slotted section may include a plurality of discrete zones including a first zone, a second zone disposed proximal of the first zone, a third zone disposed proximal of the second zone, a fourth zone disposed proximal of the third zone, and a fifth zone disposed proximal of the fourth zone. The first zone may have a constant flexural rigidity. One or more of the second zone, the third zone, and the fifth zone may have a flexural rigidity that varies along a length thereof. An imaging core may be within the catheter shaft.

Abstract: Intravascular imaging devices as well as methods for making and using intravascular imaging devices are disclosed. An intravascular imaging device may include a catheter shaft including a hypotube region, an imaging window region, and a distal end region having a guidewire lumen formed therein. The hypotube region may include a first portion free of slots and a second portion having a plurality of slots formed therein. At least a reduced diameter section of the second portion of the hypotube region may have an outer diameter that is less than an outer diameter of the first portion of the hypotube region. The imaging window region may be coupled to the reduced diameter section of the second portion of the hypotube region. An imaging core may be disposed within the catheter shaft.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal member having a proximal end, a distal end, and a proximal diameter. The guide extension catheter may additionally include a collar member attached to an extension portion of the proximal member, where the extension portion may be located at the distal end of the proximal member. The extension portion may allow a delivery device to be inserted through the guide extension catheter to extend along a surface of the extension portion and align with a lumen of a distal sheath of the guide extension catheter.

Abstract: A mount includes a rectangular shaped back surface configured to interface to a surface of a separate object, a first side surface perpendicular to the rectangular back surface and having a first arch-shaped cutout, and a second side surface perpendicular to the rectangular back surface and having a second arch-shaped cutout, wherein each of the first arch-shaped cutout and the second arch-shaped cutout comprises a first arch having a first radius and a second arch having a second radius, different from the first radius, the first radius of the first arch allows the mount to receive a cylindrical-shaped capacitor having a first diameter and the second radius of the second arch allows the mount to receive a cylindrical-shaped capacitor having a second diameter, different from the first diameter, and a channel configured to receive a strap and that extends through the mount, the channel having a closed channel portion, a first open channel portion, and a second open channel portion, wherein the strap extended t

Abstract: A balloon system for balloon aortic valvuloplasty includes a delivery catheter, an outer expandable member coupled to the delivery catheter, and an inner balloon disposed within the outer expandable member. The outer expandable member has a first length, and a preset hourglass shape defined by first and second bulbous portions separated by a waist region. The inner balloon is non-compliant and has a second length shorter than the first length.

Abstract: Intravascular imaging catheters and methods for making and using intravascular imaging catheters are disclosed. An example intravascular imaging catheter may include an elongate catheter shaft having a distal end region and a proximal region. The distal end region may include a side port. An imaging core may be disposed within the elongate catheter shaft. The imaging core may include an imaging device configured to be slidable within the elongate catheter shaft and through the side port.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal member having a proximal end, a distal end, and a proximal diameter. The guide extension catheter may additionally include a collar member attached to the distal end of the proximal member, the collar member comprising a base portion and one or more ribs connected to the base portion and extending distally away from the base portion. In still some additional embodiments, the guide extension catheter may further include a distal sheath member attached to the collar member, the distal sheath member having a distal diameter larger than the proximal diameter.

Abstract: An apparatus for treating a total occlusion in a blood vessel may include a self-orienting device including an elongate shaft and an inflatable orienting element. The shaft includes an inflation lumen having a first noncircular shape and a working lumen having a second noncircular shape. The inflatable orienting element includes first and second inflatable members extending laterally from the shaft. An outer diameter of the shaft is 0.045 inches or less, a cross-sectional area of the first noncircular cross-sectional shape is at least 0.00013 square inches, and a cross-sectional area of the second noncircular cross-sectional shape is at least 0.00056 square inches. The shaft may include a distal tail extending distally from the inflatable orienting element, the distal tail being at least 15 millimeters long. The shaft may include a plurality of first apertures communicating with the working lumen and disposed in the distal tail.

Abstract: The present invention relates to compounds of Formula (I) or an agronomically acceptable salt of said compounds wherein Q, R1, R2, n and m are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I) and to the use of compounds of Formula (I) for controlling weeds, in particular in crops of useful plants.

Abstract: A modified Regular Slotted Container (RSC) style carton is configured to be easily shipped in electronic commerce while allowing a consumer to use the carton as a storage container for bagged pet food. The packaging carton is a modified regular slotted container (RSC) featuring a full or partial die cut perforation design forming a lid that facilitates converting the carton into a re-usable storage carton for a bag of pet food. The perforation design allows for the consumer to separate portions of the lid from the carton along the perforations. Once the carton is opened, the die cut or partial die cut flap created along the perforations is preferably used as a lid for the pet food. The carton provides many advantages, such as establishing protective packaging, accommodating dedicated e-commerce identifiers, and providing additional ways to use and store a bagged pet food product without having to purchase alternative containers.

Abstract: A wearable physical rehabilitation device configured to separate the thighs of a subject to promote proper posture of the pelvis while walking is provided. The device comprises a supporting belt fitted around the subject's waist, a 3D wedge-like PU-foam structure arranged between the subject's thighs, a saddle-shaped structure for receiving the subject's buttocks, and a hollow control handle arranged anteriorly relative to the subject's body. The 3D wedge-like structure has a hole and is attached to the belt by a pair of ascending straps each passing through the hole. Each of a pair of lateral straps passes through the hole and attaches the 3D wedge-like structure to and around one of the thighs. The handle has one pair of descending straps extending therefrom and attaching to the saddle-shaped structure and another pair of ascending straps extending therefrom and attached to each other behind the subject's neck.

Abstract: A power system includes an external-battery-power terminal configured to receive an external-battery-power connector, an external battery emergency power off (EPO) terminal, and an EPO switch coupled to the EPO terminal. The EPO switch is configured to be triggered by decoupling a mechanical latch associated with the external-battery-power connector. An EPO signal is manipulated when the EPO switch is triggered to decouple a battery from the external-battery-power terminal.

Abstract: The present invention relates to a compound of Formula (I), wherein Q, R1 and R3, X and n are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I) and to the use of compounds of Formula (I) for controlling weeds, in particular in crops of useful plants.

Abstract: A portable electrical drilling assembly includes an electric motor rotating a gear contained within a gear box housing, a connector reversibly coupling the gear to a splined shaft with the splined shaft extending within and engaging an internal surface of a cutter or reamer with the shaft and cutter/reamer defining a cutter-spline drive, a pivoting power feed mechanism coupled to the gear box housing, and a spindle coupled to the feed mechanism for receiving the cutter or reamer. The gear rotation rotates the splined shaft and reamer/cutter to drill/ream a hole, with the pivoting of the power feed mechanism controlling the depth of the drilled or reamed hole. The separate coupling of the splined shaft and cutter/reamer and interchangeability of cutters/reamers allows the assembly to be used in a confined space while still achieving deep drilling of holes in workpieces. The cutter-spline drive can be used in other drilling assemblies.

Abstract: An improved method, system, and apparatus is provided to implement a general architecture for robot systems. A mode execution module is provided to universally execute execution modes on different robotic system. A system includes an execution module that receives software instructions in a normalized programming language. The system also includes an interface having a translation layer that converts the software instructions from the normalized language into robot-specific instructions that operate in a particular robotic system. The system further includes a controller that is communicatively coupled to the interface, wherein the controller receives the robot-specific instructions. Moreover, the system includes a robotic device that is operatively controlled by the controller by execution of the robot-specific instructions.

Abstract: Provided herein are methods of manipulating ARID5B expression in immune cells such NK cells, T cells, and T cell and NK cell progenitors to enhance their persistence and function in vivo. Also provided herein are modified immune cells and compositions comprising such modified cells for anti-cancer, anti-viral, and other immunotherapies. In some embodiments, immune cells are genetically modified to increase ARID5B expression and, thus, improve persistence, increase in vivo anti-tumor efficacy, and increase viability and functionality of the modified cells after freezing and thawing.