Abstract: Described herein are fusion proteins which include factor H catalytic domains and may include VHH domains, factor H-related protein 5 domains, or integrin binding domains, and the use of such fusion proteins in methods of treatment of diseases mediated by complement alternative pathway activation or dysregulation, for example, kidney diseases.

Abstract: A water pipe bowl cleaning system includes an outer enclosure with a first slot, a nozzle that couples to the bowl in the first slot, an adapter to detachably couple to a fluid source, a valve between the adapter and the nozzle to selectively allow fluid to flow from the fluid source through the nozzle into the bowl, and a catch at the bottom of the first slot to collect material ejected from the bowl by the fluid. The system can utilize various types of valves and fluid sources, including a cartridge of compressed gas. The adapter can be a cartridge charging adapter, cartridge converter, or CO2 adapter which punctures the cartridge as the cartridge is screwed or pushed into the adapter. The first slot can extend to a drawer which supports and houses a removable sponge for additional cleaning. The catch can be a removable drawer for easy disposal of collected material.

Abstract: Temporary access to a digital whiteboard is enabled for conference participants during a conference (e.g., a video conference). Based on a request to share a digital whiteboard with conference participants during a conference, ones of the conference participants to which to grant temporary access permissions for the digital whiteboard are determined. The temporary access permissions are granted to enable the ones of the conference participants to access the digital whiteboard during the conference. Based on an event occurrence, which may, for example, correspond to a termination of the conference or a disconnection of an owner of the digital whiteboard from the conference, the temporary access permissions are revoked to restrict further access to the digital whiteboard by the ones of the conference participants.

Abstract: Whiteboard roles controlling levels of access to functionality of a digital whiteboard shared to a video conference for participants of the video conference are inherited based on conference roles of those participants within the video conference. Based on a request to share a digital whiteboard to a video conference, a whiteboard role is determined for each participant of the video conference based on a conference role of the participant within the video conference. For each participant during the video conference, access to functionality of the digital whiteboard corresponding to the whiteboard role determined for the participant is enabled, in which different functionality of the digital whiteboard is enabled for different whiteboard roles.

Abstract: Inter-party communications, such as telephony communications, virtual meeting communications, or messaging communications, are switched between clients while in progress. An inter-party communication may be detected at a first client. A channel may then be opened between the first client and a second client responsive to an operator initiating switching the inter-party communication from the first client to the second client. The inter-party communication may be switched from the first client to the second client using the channel while the inter-party communication remains in progress. The inter-party communication may then be continued at the second client.

Abstract: An apparatus and method for electrochemically depositing a unitary layer structure using a reactor configured to contain an electrolyte solution with an anode array containing a plurality of independently electrically controllable anodes arranged in a two-dimensional array, a cathode, an addressing circuit configured to receive a signal containing anode address data and configured to output a signal causing an anode array pattern; and, a first controller being a current controller configured to control a flow of current to the anode array; a second controller in communication with the addressing circuit, the current controller and the anode array, the second controller operable to communicate with the current controller to command the flow of current to each anode in the anode array causing an electrochemical reaction at the cathode to deposit a layer corresponding to the anode array pattern signal received from the addressing circuit; and a third controller configured to clear bubbles which have formed on th

Abstract: A request is received. The request identifies a first conference participant of a conference as a follow-along participant for a second conference participant of the conference for which a whiteboard is enabled. A trigger associated with the first conference participant is identified. Responsive to the identified trigger, a second viewport is set for display at a device of the second conference participant. The second viewport is based on a first viewport into the whiteboard where the first viewport is displayed at a device of the first conference participant.

Abstract: A first conference participant of a conference that includes a whiteboard is identified. A first viewport into the whiteboard is identified. The first viewport is displayed at a device of the first conference participant. A second viewport is set based on the first viewport. The second viewport is displayed at a device of a second conference participant. The first conference participant may be identified based on a trigger associated with the first conference participant. The first conference participant may be identified based on speech in an audio stream received from the device of the first conference participant. The first conference participant may be identified based on an edit to the whiteboard received from the device of the first conference participant.

Abstract: An example method of operation may include designating sub-regions which collectively provide a defined reception space, receiving audio signals at a controller from the microphone arrays in the defined reception space, configuring the controller with known locations of each of the microphone arrays, assigning each of the sub-regions to at least one of the microphone arrays based on the known locations, and creating beamform tracking configurations for each of the microphone arrays based on their assigned sub-regions.

Abstract: Methods and systems described in this disclosure describe an integration of video sessions across platforms, transforming the user experience. In some embodiments, a user can participate in an interaction via a channel. Next, the system can determine whether the interaction is eligible for a video session with a representative. When the interaction is eligible for the video session, an option for the video session can be displayed on a user interface of the device. After receiving a request for the video session, the video session can be routed to a uniquely skilled representative, where the uniquely skilled representative is determined based, at least in part, on the interaction.

Abstract: One example method includes determining, by a computing device, a user present in a room is associated with a virtual space hosted at a video conference provider, wherein the room includes one or more peripheral devices; connecting, by the computing device, to the virtual space; receiving, by the computing device, data from at least one of the one or more peripheral devices or one or more user devices while connected to the virtual space, the one or more user devices associated with the user or one or more other users within the room; transmitting, by the computing device, at least a portion of the data to the virtual space; determining, by the computing device, a state change associated with the room based on the data received from the one or more peripheral devices or one or more user devices; generating, by the computing device, a change detection signal; and transmitting, by the computing device, the change detection signal to the video conference provider to cause the video conference provider to store d

Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.

Abstract: The present disclosure relates to modified IL-2 polypeptides, compositions comprising modified IL-2 polypeptides, methods of making the same, and methods of using the modified IL-2 polypeptides for treatment of diseases. In one aspect, the disclosure relates to the treatment of cancer using the modified IL-2 polypeptides. In some embodiments, the disclosed IL-2 polypeptides exhibit preferential binding characteristics to IL-2 receptor ?? complex (IL-2R?) over IL-2 receptor ??? complex (IL-2R?). In some embodiments, the molecular weight distribution of the modified IL-2 polypeptides is monodispersed.

Abstract: Methods and systems described in this disclosure receive a request for assistance from a device associated with a user, launch a conversational virtual assistant on the device, determine at least one potential subject of the request based on information associated with the user and a tab or webpage from which the conversational virtual assistant is launched, receive a verification of the subject of the request, create a contact menu with options for receiving the assistance, and receive a selection of one of the options.

Abstract: A catheter for use in a patient's heart, especially for mapping a tubular region of the heart, has a catheter body, a deflectable intermediate section and a distal a mapping assembly that has a generally circular portion adapted to sit on or in a tubular region of the heart. A control handle of the catheter allows for single-handed manipulation of various control mechanisms that can deflect the intermediate section and contract the mapping assembly by means of a deflection control assembly and a linear control assembly. The deflection control assembly has a deflection arm and a rocker member. The linear control assembly has a linear control member, an inner rotational member and a cam. A pair of puller members are responsive to the deflection control assembly to bi-directionally deflect the intermediate section. A third puller member is responsive to the linear control assembly to contract the generally circular portion of the mapping assembly.

Abstract: A vehicle determines the value of at least one predefined variable related to predefined contexts for discontinuous reception (DRX) cycle control during an engine-off state of the vehicle. The vehicle determines how a current DRX cycle should be changed responsive to the value of the at least one predefined variable in accordance with a control strategy associated with the at least one variable and, responsive to the determining how the cycle should be changed, automatically changes the current DRX cycle in accordance with the control strategy while the vehicle remains powered down.

Abstract: A system may connect user devices to a virtual whiteboard configured to output visual content to displays of the user devices. The system may invoke a video conference from the whiteboard to transmit, to the user devices, a message configured to connect the user devices to the video conference, and instantiate the whiteboard including the visual content output to the displays of the user devices within the video conference. In some implementations, the message may include context information (e.g., a title associated with the whiteboard, participants of the video conference, or an elapsed time of the video conference). In some implementations, the system may configure a graphical user interface (GUI) indicating users of the whiteboard. The GUI may be configured to receive selections of users to invite to the video conference.

Abstract: The present application provides materials and methods for treating a patient with Alpha-1 antitrypsin deficiency (AATD) both ex vivo and in vivo. In addition, the present application provides materials and methods for editing the SERPINA1 gene in a cell by genome editing.

Abstract: A method for assembling a liner system including disposing from an uphole end of the liner a first slip subsystem, disposing from the uphole end of the liner a seal, and disposing from the uphole end of the liner a second slip subsystem.