Patents by Inventor Jennifer Iaci

Jennifer Iaci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods of using chondroitinase ABCI mutants
    Patent number: 9402886
    Abstract: One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: August 2, 2016
    Assignee: Acorda Therapeutics, Inc.
    Inventors: Anthony O. Caggiano, Jennifer Iaci, Andrea Vecchione, Elizabeth Hunter
  • Therapeutic Dosing of a Neuregulin or a Fragment Thereof for Treatment or Prophylaxis of Heart Failure
    Publication number: 20160129084
    Abstract: The invention relates to treatment and prevention of heart failure in a mammal. The invention provides a dosing regimen whereby the therapeutic benefits conferred by administration of peptide comprising an epidermal growth factor-like domain, e.g., a neuregulin such as glial growth factor 2 (GGF2) or a functional fragment thereof, are maintained and/or enhanced, while concomitantly minimizing any potential side effects.
    Type: Application
    Filed: March 6, 2014
    Publication date: May 12, 2016
    Inventors: Anthony O. CAGGIANO, Anindita GANGULY, Jennifer IACI, Tom PARRY
  • Therapeutic Dosing of a Neuregulin or a Subsequence Thereof for Treatment or Prophylaxis of Heart Failure
    Publication number: 20160113999
    Abstract: The invention relates to treatment of heart failure in a mammal. Accordingly, the invention is directed to establishing a dosing regimen whereby the therapeutic benefits conferred by administration of a neuregulin such as glial growth factor 2 (GGF2) or a subsequence thereof are maintained and/or enhanced, while concomitantly minimizing any potential side effects.
    Type: Application
    Filed: October 30, 2015
    Publication date: April 28, 2016
    Inventors: Anthony O. Caggiano, Anindita Ganguly, Jennifer Iaci, Tom Parry
  • Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure
    Patent number: 9198951
    Abstract: The invention relates to treatment of heart failure in a mammal. Accordingly, the invention is directed to establishing a dosing regimen whereby the therapeutic benefits conferred by administration of a neuregulin such as glial growth factor 2 (GGF2) or a subsequence thereof are maintained and/or enhanced, while concomitantly minimizing any potential side effects.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: December 1, 2015
    Assignee: Acorda Therapeutics, Inc.
    Inventors: Anthony O. Caggiano, Anindita Ganguly, Jennifer Iaci, Tom Parry
  • COMPOSITIONS AND METHODS OF USING CHONDROITINASE ABCI MUTANTS
    Publication number: 20150322422
    Abstract: The present disclosure relates to protein and nucleic acid mutants of chondroitinase ABCI. Such nucleic acid mutants encode for chondroitinase ABCI mutant enzymes exhibiting altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using such nucleic acid mutants encoding chondroitinase ABCI mutant enzymes is also provided.
    Type: Application
    Filed: July 2, 2015
    Publication date: November 12, 2015
    Inventors: Anthony O. CAGGIANO, Andrea VECCHIONE, Jennifer IACI
  • FUSION PROTEINS FOR THE TREATMENT OF CNS
    Publication number: 20150299687
    Abstract: This disclosure relates to compositions capable of use in the treatment of spinal cord injuries and related disorders of the central nervous system (CNS), and in particular, compositions including proteoglycan degrading molecules and compositions capable of blocking and/or over coming the activity of neuronal growth inhibitory molecules, as well as fusion proteins which includes a proteoglycan degrading domain and a domain capable of blocking and or over coming the activity of neuronal growth inhibitory molecules.
    Type: Application
    Filed: November 6, 2014
    Publication date: October 22, 2015
    Inventors: Elliott A. GRUSKIN, Anthony O. CAGGIANO, Gargi ROY, Jennifer IACI, Michael P. ZIMBER
  • Compositions and methods of using chondroitinase ABCI mutants
    Patent number: 9102930
    Abstract: The present disclosure relates to protein and nucleic acid mutants of chondroitinase ABCI. Such nucleic acid mutants encode for chondroitinase ABCI mutant enzymes exhibiting altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using such nucleic acid mutants encoding chondroitinase ABCI mutant enzymes is also provided.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: August 11, 2015
    Assignee: Acorda Therapeutics, Inc.
    Inventors: Anthony O. Caggiano, Andrea Vecchione, Jennifer Iaci
  • COMPOSITIONS AND METHODS OF USING CHONDROITINASE ABCI MUTANTS
    Publication number: 20150190483
    Abstract: One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
    Type: Application
    Filed: September 8, 2014
    Publication date: July 9, 2015
    Inventors: Anthony O. CAGGIANO, Jennifer IACI, Andrea VECCHIONE, Elizabeth MARKENSOHN
  • Use of Neuregulin to Treat Peripheral Nerve Injury
    Publication number: 20150094263
    Abstract: The disclosure provides compositions and methods for preventing, ameliorating a sign or symptom of, or treating peripheral nerve injury.
    Type: Application
    Filed: March 29, 2013
    Publication date: April 2, 2015
    Inventors: Anthony O. Caggiano, Anthony J. Bella, Anindita Ganguly, Jennifer Iaci, Thomas Parry, Raymond Warren Colburn
  • Fusion proteins for the treatment of CNS
    Patent number: 8906363
    Abstract: This disclosure relates to compositions capable of use in the treatment of spinal cord injuries and related disorders of the central nervous system (CNS), and in particular, compositions including proteoglycan degrading molecules and compositions capable of blocking and/or over coming the activity of neuronal growth inhibitory molecules, as well as fusion proteins which includes a proteoglycan degrading domain and a domain capable of blocking and or over coming the activity of neuronal growth inhibitory molecules.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: December 9, 2014
    Assignee: Acorda Therapeutics, Inc.
    Inventors: Elliott A. Gruskin, Anthony O. Caggiano, Gargi Roy, Jennifer Iaci, Michael P. Zimber
  • Compositions and methods of using chondroitinase ABCI mutants
    Patent number: 8852583
    Abstract: One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: October 7, 2014
    Assignee: Acorda Therapeutics, Inc.
    Inventors: Anthony O. Caggiano, Jennifer Iaci, Andrea Vecchione, Elizabeth Markensohn
  • Therapeutic Dosing of a Neuregulin or a Subsequence Thereof for Treatment or Prophylaxis of Heart Failure
    Publication number: 20130324466
    Abstract: The invention relates to treatment of heart failure in a mammal. Accordingly, the invention is directed to establishing a dosing regimen whereby the therapeutic benefits conferred by administration of a neuregulin such as glial growth factor 2 (GGF2) or a subsequence thereof are maintained and/or enhanced, while concomitantly minimizing any potential side effects.
    Type: Application
    Filed: May 29, 2013
    Publication date: December 5, 2013
    Inventors: Anthony O. Caggiano, Anindita Ganguly, Jennifer Iaci, Thomas Parry
  • Compositions and methods of using chondroitinase ABCI mutants
    Patent number: 8404232
    Abstract: The present invention relates to protein and nucleic acid mutants of chondroitinase ABCI. Such chondroitinase ABCI mutant enzymes exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: March 26, 2013
    Assignee: Acorda Therapeutics, Inc.
    Inventors: Anthony O. Caggiano, Andrea Vecchione, Jennifer Iaci
  • COMPOSITIONS AND METHODS OF USING CHONDROITINASE ABCI MUTANTS
    Publication number: 20120308547
    Abstract: One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
    Type: Application
    Filed: July 6, 2012
    Publication date: December 6, 2012
    Inventors: Anthony O. CAGGIANO, Jennifer IACI, Andrea VECCHIONE, Elizabeth MARKENSOHN
  • Compositions and methods of using chondroitinase ABCI mutants
    Patent number: 8236302
    Abstract: One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: August 7, 2012
    Assignee: Acorda Therapeutics, Inc.
    Inventors: Anthony O. Caggiano, Jennifer Iaci, Andrea Vecchione, Elizabeth Markensohn
  • Compositions and Methods for Treatment During Non-Acute Periods Following CNS Neurological Injury
    Publication number: 20110269682
    Abstract: This invention relates to treatment of neuroinjury in a post-acute window or in a chronic period following neuroinjury.
    Type: Application
    Filed: August 17, 2009
    Publication date: November 3, 2011
    Applicant: ACORDA THERAPEUTICS, INC.
    Inventors: Anthony Caggiano, Jennifer Iaci
  • Therapeutic Dosing of a Neuregulin or a Subsequence Thereof for Treatment or Pro-phylaxis of Heart Failure
    Publication number: 20110166068
    Abstract: The invention relates to treatment of heart failure in a mammal. Accordingly, the invention is directed to establishing a dosing regimen whereby the therapeutic benefits conferred by administration of a neuregulin such as glial growth factor 2 (GGF2) or a subsequence thereof are maintained and/or enhanced, while concomitantly minimizing any potential side effects.
    Type: Application
    Filed: July 17, 2009
    Publication date: July 7, 2011
    Applicant: ACORDA THERAPEUTICS, INC.
    Inventors: Anthony Caggiano, Anindita Ganguly, Jennifer Iaci, Tom Parry
  • COMPOSITIONS AND METHODS OF USING CHONDROITINASE ABCI MUTANTS
    Publication number: 20110014158
    Abstract: The present invention relates to protein and nucleic acid mutants of chondroitinase ABCI. Such chondroitinase ABCI mutant enzymes exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
    Type: Application
    Filed: May 17, 2010
    Publication date: January 20, 2011
    Inventors: Anthony O. CAGGIANO, Andrea VECCHIONE, Jennifer IACI
  • COMPOSITIONS AND METHODS OF USING CHONDROITINASE ABCI MUTANTS
    Publication number: 20100239557
    Abstract: One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
    Type: Application
    Filed: June 4, 2010
    Publication date: September 23, 2010
    Applicant: ACORDA THERAPEUTICS, INC.
    Inventors: Anthony O. CAGGIANO, Jennifer IACI, Andrea VECCHIONE, Elizabeth MARKENSOHN
  • Compositions and methods of using chondroitinase ABCI mutants
    Patent number: 7731956
    Abstract: One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: June 8, 2010
    Assignee: Acorda Therapeutics, Inc.
    Inventors: Anthony O. Caggiano, Jennifer Iaci, Andrea Vecchione, Elizabeth Markensohn