Abstract: A genetic locus and corresponding family of proteins associated with regulation of immune function and cell survival are provided. These genes encode cell surface molecules with conserved IgV and mucin domains. The locus comprising the TIM family is genetically associated with immune dysfunction, including asthma. Furthermore, the TIM gene family is located within a region of human chromosome 5 that is commonly deleted in malignancies and myelodysplastic syndrome. Polymorphisms in the gene sequences are associated with the development of airway hyperreactivity and allergic inflammation, and T cell production of IL-4 and IL-13. The proteins include the human hepatitis A cellular receptor, hHAVcr-1.

Abstract: A new and improved equestrian board game challenging players to collect points through the simulated care and training of their horse while moving their playing piece from the start area to the finish area. The inventive device includes a game board having a plurality of linear movement paths all leading to another circuitous movement path before finally reaching the finishing lane, two sets of playing cards and a single die provided for determining both movement and scoring. A simplified variation of the game rules is provided for younger players.