Abstract: A process for manufacturing a ceramic implant with a surface which forms a permanent bonding to bone cell tissues, the surface providing improved osseointegration, the process comprising the step of:—a pretreatment of the ceramic material with the surface wherein said surface of the ceramic material is exposed to a conditioning plasma, which is produced by means of direct current (DC) or alternating current (AC), such as high or radio frequency (HF, RF), or microwaves (MW) at a low pressure, followed by a second step;—a treatment with a reactive plasma in which an organic compound is added to the plasma for the at least partial application of an organic phase to said surface wherein the organic compound is selected from the group consisting of aliphatic amines, cyclic amines, unsaturated and aromatic amines as well as combinations thereof.

Abstract: The present invention generally relates to fusion proteins of antibodies and interleukin-10 (IL-10). More particularly, the invention concerns fusion proteins of antibodies and mutant IL-10 that exhibit improved properties for use as therapeutic agents, e.g. in the treatment of inflammatory diseases. In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the fusion proteins of the invention, and to methods of using them in the treatment of disease.

Abstract: The present invention relates to Bispecific antibodies against human TWEAK and human IL17 (bispecific TWEAK-IL17 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof

Abstract: The invention provides anti-IL-18R1 antibodies and methods of using the same.

Abstract: Among other things, a method is described for the configuration of a communication device (10) as well as a communication device (10). In this method, a communication link (20) is created from the communication device (10) to an external configuration computer unit (30) and identification data (100), which are related to the communication device (10), are transmitted from the communication device (10) to the external configuration computer unit (30) for the purpose of authentication of the communication device (10), with chip card-related identification features (111) being transmitted as identification data (100), with the chip card-related identification features (111) being assigned to a chip card (11) for the identification thereof, and with the chip card (11) being assigned to the communication device (10), and, when authentication is successful, a configuration of the communication device (10) is carried out.

Abstract: Herein is reported a co-cultivation system for co-cultivating a pool of rabbit B-cells or single deposited rabbit B-cells wherein cells CD40L expressing CHO cells are used as feeder in the presence of IL-2 and IL-21.

Abstract: An antibody binding to IL33R characterized in that the heavy chain variable domain comprises a CDR3 region of SEQ ID NO:1, a CDR2 region of SEQ ID NO:2 and a CDR1 region of SEQ ID NO:3 and in that the light chain variable domain comprises a CDR3 region of SEQ ID NO:4, a CDR2 region of SEQ ID NO:5 and a CDR1 region of SEQ ID NO:6 or a a chimeric, humanized or T cell epitope depleted antibody variant thereof has advantageous properties for the treatment of inflammatory diseases.

Abstract: The invention relates to a vehicle headlight having at least one light source arrangement comprising a laser, and having a headlight lens comprising a body composed of a transparent material, wherein the body comprises at least one light tunnel and a light-conducting part having at least one optically active light exit surface, wherein the light tunnel comprises at least one, more particularly optically active, light entrance surface and undergoes transition with a bend into the light-conducting part for the purpose of imaging the bend as a bright-dark boundary by means of light coupled or radiated from the light source arrangement into the light entrance surface.

Abstract: A process for manufacturing a ceramic implant with a surface which forms a permanent bonding to bone cell tissues, the surface providing improved osseointegration, the process comprising the step of:—a pretreatment of the ceramic material with the surface wherein said surface of the ceramic material is exposed to a conditioning plasma, which is produced by means of direct current (DC) or alternating current (AC), such as high or radio frequency (HF, RF), or microwaves (MW) at a low pressure, followed by a second step;—a treatment with a reactive plasma in which an organic compound is added to the plasma for the at least partial application of an organic phase to said surface wherein the organic compound is selected from the group consisting of aliphatic amines, cyclic amines, unsaturated and aromatic amines as well as combinations thereof.

Abstract: An antibody binding to IL33R characterized in that the heavy chain variable domain comprises a CDR3 region of SEQ ID NO:1, a CDR2 region of SEQ ID NO:2 and a CDR1 region of SEQ ID NO:3 and in that the light chain variable domain comprises a CDR3 region of SEQ ID NO:4, a CDR2 region of SEQ ID NO:5 and a CDR1 region of SEQ ID NO:6 or a chimeric, humanized or T cell epitope depleted antibody variant thereof has advantageous properties for the treatment of inflammatory diseases.

Abstract: A submarine is designed for combating oil when submerged. The submarine includes a snout (14, 36) which is conduit-connected to a conduit leading into the submarine. The snout (14, 36) is part of an oil suction device and/or part of a device for bringing out an oil decomposition substance. The snout (14) may be designed in a rigid manner and be pivotable from a position between a pressure hull (6) of the submarine and an outer hull (10) forming an upper deck (12) of the submarine, into a position outside the outer hull (10). The snout (36) may also be designed in a flexible manner, wherein the snout (36) is fastened in a section adjacent to a free end, on an ROV (40).

Abstract: The present invention generally relates to fusion proteins of antibodies and interleukin-10 (IL-10). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the fusion proteins of the invention, and to methods of using them in the treatment of disease.

Abstract: The invention relates to a method for producing a headlamp lens (2) for a vehicle headlamp, in particular for a motor-vehicle headlamp (1), wherein the headlamp lens (2) comprises a transparent body (3) with an optically effective surface (5), which is in particular substantially planar and can be turned towards a light source (10), and an optically effective surface (4), which is in particular convex and can be turned away from the light source (10), wherein the gradient of a light-dark boundary (25) projected by the headlamp lens (2) or a further headlamp lens is measured, and wherein a light diffusing structure (35) is produced in the transparent body (3) in accordance with the measured gradient.

Abstract: A vehicle headlamp includes a first light source, at least one second light source and an integrally designed, transparent shaped part. The shaped part includes a first optical structure for orienting light radiated by the first light source and at least one second optical structure for orienting light radiated by the second light source. The first optical structure and the second optical structure each have a continuously curved surface or a continuous, curved surface with an extent of at least in each case half a centimeter, in particular one centimeter, in two orthogonal directions.

Abstract: An antibody binding to IL33R characterized in that the heavy chain variable domain comprises a CDR3 region of SEQ ID NO:1, a CDR2 region of SEQ ID NO:2 and a CDR1 region of SEQ ID NO:3 and in that the light chain variable domain comprises a CDR3 region of SEQ ID NO:4, a CDR2 region of SEQ ID NO:5 and a CDR1 region of SEQ ID NO:6 or a chimeric, humanized or T cell epitope depleted antibody variant thereof has advantageous properties for the treatment of inflammatory diseases.

Abstract: Among other things, a method is described for the configuration of a communication device (10) as well as a communication device (10). In this method, a communication link (20) is created from the communication device (10) to an external configuration computer unit (30) and identification data (100), which are related to the communication device (10), are transmitted from the communication device (10) to the external configuration computer unit (30) for the purpose of authentication of the communication device (10), with chip card-related identification features (111) being transmitted as identification data (100), with the chip card-related identification features (111) being assigned to a chip card (11) for the identification thereof, and with the chip card (11) being assigned to the communication device (10), and, when authentication is successful, a configuration of the communication device (10) is carried out.

Abstract: The invention provides anti-IL-18R1 antibodies and methods of using the same.

Abstract: The invention relates to a vehicle headlamp (1), in particular motor vehicle headlamp (1), with a first light source (10), with at least one second light source (24) and with an integrally designed, transparent shaped part (2), wherein the shaped part (2) comprises a first optical structure (3) for orienting light radiated by the first light source (10) and at least one second optical structure (4) for orienting light radiated by the second light source (24), and wherein the first optical structure (3) and the second optical structure (4) each have a continuously curved surface or a continuous, curved surface with an extent of at least in each case half a centimetre, in particular one centimetre, in two orthogonal directions.

Abstract: The invention relates to a method for producing a headlamp lens (2) for a vehicle headlamp, in particular for a motor-vehicle headlamp (1), wherein the headlamp lens (2) comprises a transparent body (3) with an optically effective surface (5), which is in particular substantially planar and can be turned towards a light source (10), and an optically effective surface (4), which is in particular convex and can be turned away from the light source (10), wherein the gradient of a light-dark boundary (25) projected by the headlamp lens (2) or a further headlamp lens is measured, and wherein a light diffusing structure (35) is produced in the transparent body (3) in accordance with the measured gradient.