Abstract: The present invention relates to novel pyrazoloazepin-8-ones with phosphodiesterase inhibitory activity, as well as to their use as therapeutic agents in the treatment of inflammatory diseases and conditions.

Abstract: Method for producing shaped bodies from reaction-bonded, silicon-infiltrated silicon carbide and/or boron carbide, characterized in that a monolithic preliminary body is built up in layers using a formless granulation to which a physical or chemical hardening or melt process is applied, wherein the granulation has a weight fraction of at least 95% silicon carbide and/or boron carbide with an average grain size of 70 to 200 ?m, the so-created preliminary body is impregnated at least once by the introduction of a carbon black suspension or via a gas-phase separation and secondary silicon carbide is created in contact with liquid or gaseous silicon by a subsequent reaction firing that solidifies an engagement composite produced.

Abstract: Method for producing shaped bodies from reaction-bonded, silicon-infiltrated silicon carbide and/or boron carbide, characterised in that a monolithic preliminary body is built up in layers using a formless granulation to which a physical or chemical hardening or melt process is applied, wherein the granulation has a weight fraction of at least 95% silicon carbide and/or boron carbide with an average grain size of 70 to 200 pm, the so-created preliminary body is impregnated at least once by the introduction of a carbon black suspension or via a gas-phase separation and secondary silicon carbide is created in contact with liquid or gaseous silicon by a subsequent reaction firing that solidifies an engagement composite produced.

Abstract: Methods and uses for the treatment and prevention of cardiac and cardiovascular diseases comprising administration of a GLP-1 agonist.

Abstract: Methods and uses for the treatment and prevention of cardiac and cardiovascular diseases comprising administration of a GLP-1 agonist.

Abstract: Methods and uses for the treatment and prevention of cardiac and cardiovascular diseases comprising administration of a GLP-1 agonist.

Abstract: Methods and uses for the treatment and prevention of cardiac and cardiovascular diseases comprising administration of a GLP-1 agonist.

Abstract: Methods and uses for the treatment and prevention of cardiac and cardiovascular diseases comprising administration of a GLP-1 agonist.

Abstract: Methods and uses for the treatment and prevention of cardiac and cardiovascular diseases comprising administration of a GLP-1 agonist.

Abstract: Methods and uses for the treatment and prevention of cardiac and cardiovascular diseases comprising administration of a GLP-1 agonist.

Abstract: An endless filter chain for filtering a liquid, such as sewage, which flows along a drainage duct is provided. The filter chain comprises strainer elements and connecting links interconnected to allow the strainer elements to pivot about respective axes of the connecting links while maintaining a small clearance between the leading edge of each strainer element and the trailing edge of the respective adjacent preceding element while the filter chain is trained about an upper and a lower turning roller. the filter chain does not comprise conveyor chains and the strainer elements can be sized to a width where they cover practically the entire width of the drainage duct. A method and an apparatus for filtering liquid as well as a strainer element and a connecting link are provided.