Patents by Inventor Jens Nagel

Jens Nagel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carboxylic acid aromatic amides as antagonists of bradykinin B1 receptor
    Patent number: 11905270
    Abstract: The present invention relates to carboxylic acid aromatic amides compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a diseaseas a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: February 20, 2024
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Stefan Baeurle, Adam James Davenport, Christopher Stimson, Jens Nagel, Nicole Schmidt, Andrea Rotgeri, Ina Groeticke, Alexandra Rausch, Juergen Klar, Thomas Dyrks
  • CARBOXYLIC ACID AROMATIC AMIDES AS ANTAGONISTS OF BRADYKININ B1 RECEPTOR
    Publication number: 20230271931
    Abstract: The present invention relates to carboxylic acid aromatic amides compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a diseases a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: April 7, 2023
    Publication date: August 31, 2023
    Inventors: Stefan BAEURLE, Adam DAVENPORT, Christopher STIMSON, Jens NAGEL, Nicole SCHMIDT, Andrea ROTGERI, Ina GROETICKE, Alexandra RAUSCH, Juergen KLAR, Thomas DYRKS
  • USE OF N-PHENYLACETAMIDES HAVING P2X4 RECEPTOR ANTAGONISTIC ACTIVITY FOR TREATING CERTIAN OCULAR DISORDERS
    Publication number: 20230270729
    Abstract: The use of P2X4 antagonists for the treatment of dry eye syndrome, more in particular substituted N-phenylacetamide compounds of general formula (I), pharmaceutical compositions and combinations comprising said compounds for use in the treatment or prophylaxis of dry eye syndrome and in particular dry eye, ocular neuropathic pain, ocular trauma and post-operative ocular pain.
    Type: Application
    Filed: June 28, 2021
    Publication date: August 31, 2023
    Applicants: Bayer Aktiengesellschaft, The Johns Hopkins University
    Inventors: Stefan BÄURLE, William SCHUBERT, Jens NAGEL, Carsten TERJUNG, David FINIS, Samuel YIU, Hui LIN, Minjie CHEN, Stefanie SEO
  • SUBSTITUTED N-PHENYLACETAMIDES HAVING P2X4 RECEPTOR ANTAGONISTIC ACTIVITY
    Publication number: 20230257351
    Abstract: Substituted N-phenylacetamide compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases.
    Type: Application
    Filed: June 28, 2021
    Publication date: August 17, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Stefan BÄURLE, Sven RING, Jens NAGEL, Alexis LAUX-BIEHLMANN, Reinhard NUBBEMEYER, Elisabeth POOK, Sven WITTROCK, Daryl Simon WALTER, Robert John SCOTT
  • CARBOXYLIC ACID AROMATIC AMIDES
    Publication number: 20230086179
    Abstract: The present invention relates to carboxylic acid aromatic amides compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: December 18, 2017
    Publication date: March 23, 2023
    Inventors: Stefan BAEURLE, Adam James DAVENPORT, Christopher STIMSON, Jens NAGEL, Nicole SCHMIDT, Andrea ROTGERI, Ina GROETICKE, Alexandra RAUSCH, Juergen KLAR, Thomas DYRKS
  • 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
    Publication number: 20230053411
    Abstract: The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: September 9, 2021
    Publication date: February 23, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Adam James DAVENPORT, Nico BRÄUER, Oliver Martin FISCHER, Andrea ROTGERI, Antje ROTTMANN, Ioana NEAGOE, Jens NAGEL, Anne-Marie GODINHO-COELHO, Jürgen KLAR
  • CARBOXYLIC ACID AROMATIC AMIDES
    Publication number: 20230043209
    Abstract: The present invention relates to carboxylic acid aromatic amides compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: September 17, 2021
    Publication date: February 9, 2023
    Inventors: Stefan BAEURLE, Adam James DAVENPORT, Christopher STIMSON, Jens NAGEL, Nicole SCHMIDT, Andrea ROTGERI, Ina GROETICKE, Alexandra RAUSCH, Juergen KLAR, Thomas DYRKS
  • Pyrazolo-pyrrolo-pyrimidine-dione derivatives as P2X3 inhibitors
    Patent number: 11319324
    Abstract: The present invention covers substituted. Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: May 3, 2022
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft
    Inventors: Marcus Koppitz, Holger Siebeneicher, Nico Bräuer, Elisabeth Pook, Andrea Rotgeri, Roland Neuhaus, Oliver Martin Fischer, Jens Nagel, Adam James Davenport, James Lindsay Carr, Robert James Townsend, Nina Connelly Ursinyova, Shelley Anne Parrott
  • Substituted N-arylethyl-2-aminoquinoline-4-carboxamides and use thereof
    Patent number: 11149018
    Abstract: The present application relates to novel substituted N-arylethyl-2-aminoquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and inflammatory disorders.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: October 19, 2021
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft
    Inventors: Hartmut Beck, Raimund Kast, Mark Meininghaus, Chantal Fuerstner, Timo Stellfeld, Clemens-Jeremias Von Buehler, Lisa Dietz, Michaela Bairlein, Johanna Anlahr, Hannah Joerissen, Peter Hauff, Joerg Mueller, Karoline Droebner, Jens Nagel
  • NOVEL PYRAZOLO-PYRROLO-PYRIMIDINE-DIONE DERIVATIVES AS P2X3 INHIBITORS
    Publication number: 20210317128
    Abstract: The present invention covers substituted. Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: October 18, 2018
    Publication date: October 14, 2021
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft
    Inventors: Marcus KOPPITZ, Holger SIEBENEICHER, Nico BRÄUER, Elisabeth POOK, Andrea ROTGERI, Roland NEUHAUS, Oliver Martin FISCHER, Jens NAGEL, Adam James DAVENPORT, James Lindsay CARR, Robert James TOWNSEND, Nina CONNELLY URSINYOVA, Shelley Anne PARROTT
  • TETRAZOLE CONTAINING COMPOUNDS
    Publication number: 20210317092
    Abstract: The present invention relates to tetrazole containing compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease syndrome, condition, or symptoms, in particular related to chronic pain and inflammation, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: December 18, 2017
    Publication date: October 14, 2021
    Inventors: Stefan BÄEURLE, Adam James DAVENPORT, Christopher STIMSON, James Lindsay CARR, Christian Abingdon BUBERT, Frédéric Jacques MARLIN, Jens NAGEL, Nicole SCHMIDT, Andrea ROTGERI, Horst IRLBACHER
  • 1,3-thiazol-2-yl substituted benzamides
    Patent number: 11142523
    Abstract: The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: October 12, 2021
    Assignee: Bayer Aktiengesellschaft
    Inventors: Adam James Davenport, Nico Bräuer, Oliver Martin Fischer, Andrea Rotgeri, Antje Rottmann, Ioana Neagoe, Jens Nagel, Anne-Marie Godinho-Coelho, Jürgen Klar
  • Substituted -arylethyl-2-arylquinoline-4-carboxamides and use thereof
    Patent number: 11136296
    Abstract: The present application relates to novel substituted N-arylethyl-2-arylquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and inflammatory disorders.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: October 5, 2021
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft
    Inventors: Hartmut Beck, Raimund Kast, Mark Meininghaus, Lisa Dietz, Chantal Fuerstner, Timo Stellfeld, Sonja Anlauf, Clemens-Jeremias Von Buehler, Michaela Bairlein, Johanna Anlahr, Uwe Muenster, Carsten Terjung, Hannah Joerissen, Peter Hauff, Joerg Mueller, Karoline Droebner, Jens Nagel
  • Benzimidazole derivatives as EP4 ligands
    Patent number: 10730856
    Abstract: The present invention relates to novel benzimidazole derivatives of the general formula (I), to processes for their preparation and to their use for preparing pharmaceutical compositions for the treatment of disorders and indications associated with the EP4 receptor.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: August 4, 2020
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Olaf Peters, Nico Bräuer, Ulrich Bothe, Marcus Koppitz, Jens Nagel, Gernot Langer
  • SUBSTITUTED N-ARYLETHYL-2-AMINOQUINOLINE-4-CARBOXAMIDES AND USE THEREOF
    Publication number: 20200157073
    Abstract: The present application relates to novel substituted N-arylethyl-2-aminoquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and inflammatory disorders.
    Type: Application
    Filed: April 4, 2018
    Publication date: May 21, 2020
    Inventors: Hartmut BECK, Raimund KAST, Mark MEININGHAUS, Chantal FUERSTNER, Timo STELLFELD, Clemens-Jeremias VON BUEHLER, Lisa DIETZ, Michaela BAIRLEIN, Johanna ANLAHR, Hannah JOERISSEN, Peter HAUFF, Joerg MUELLER, Karoline DROEBNER, Jens NAGEL
  • 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
    Publication number: 20200131169
    Abstract: The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: October 1, 2019
    Publication date: April 30, 2020
    Applicant: Bayer Aktiengesellschaft
    Inventors: Adam James DAVENPORT, Nico BRÄUER, Oliver Martin FISCHER, Andrea ROTGERI, Antje ROTTMANN, Ioana NEAGOE, Jens NAGEL, Anne-Marie GODINHO-COELHO, Jürgen KLAR
  • Assigning textures to graphical keyboards based on thematic textures of applications
    Patent number: 10614595
    Abstract: A computing device is described that determines, by executing a first application, a thematic texture of a second application separate from the first application. Additionally, the computing device determines, by executing the first application and based at least in part on the thematic texture of the second application, a texture. The computing device assigns, by executing the first application, the determined texture to a region of a graphical keyboard.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: April 7, 2020
    Assignee: Google LLC
    Inventors: Jens Nagel, Song Fu
  • SUBSTITUTED N-ARYLETHYL-2-ARYLQUINOLINE-4-CARBOXAMIDES AND USE THEREOF
    Publication number: 20200031775
    Abstract: The present application relates to novel substituted N-arylethyl-2-arylquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and inflammatory disorders.
    Type: Application
    Filed: April 4, 2018
    Publication date: January 30, 2020
    Inventors: Hartmut BECK, Raimund KAST, Mark MEININGHAUS, Lisa DIETZ, Chantal FUERSTNER, Timo STELLFELD, Sonja ANLAUF, Clemens-Jeremias VON BUEHLER, Michaela BAIRLEIN, Johanna ANLAHR, Uwe MUENSTER, Carsten TERJUNG, Hannah JOERISSEN, Peter HAUFF, Joerg MUELLER, Karoline DROEBNER, Jens NAGEL
  • 1,3-thiazol-2-yl substituted benzamides
    Patent number: 10472354
    Abstract: The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: November 12, 2019
    Assignee: Bayer Aktiengesellschaft
    Inventors: Adam James Davenport, Nico Bräuer, Oliver Martin Fischer, Andrea Rotgeri, Antje Rottmann, Ioana Neagoe, Jens Nagel, Anne-Marie Godinho-Coelho, Jürgen Klar
  • Display screen for graphical user interface
    Patent number: D859424
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: September 10, 2019
    Assignee: Google LLC
    Inventors: Min-sang Choi, Jens Nagel, Jing Cao, Yanchao Su, Christian Paul Charsagua, Heather Luipold