Abstract: Disclosed are a method and a device for measuring a biometric signal by using a radar. The disclosed method measures a plurality of biometric signals by using a radar by: (a) receiving the plurality of biometric signals from the radar; (b) calculating distance information of the received plurality of biometric signals and classifying the same on the basis of a distance; (c) selecting a signal having a largest variance according to a time; (d) further selecting a number of signals among signals having a distance with the signal selected in the step (c) smaller than an arbitrary distance from the distance-based classified signals; (e) converting all signals selected from a time domain to a frequency domain; (f) calculating a reliability of each biometric signal from the converted distance-based signals; and (g) detecting a corresponding biometric signal by selecting the distance-based signal where the calculated reliability is highest.

Abstract: Disclosed are a method and a device for adaptively configuring a threshold for object detection by means of radar, the device including: a position-specific maximum signal value extraction unit extracting a maximum value of a signal for each position by obtaining the signal when there is no moving object; a position-specific signal magnitude sorting unit obtaining signals caused by a moving object, and sorting magnitudes of the obtained signals for each position in descending order for a time index; a candidate signal index selection unit selecting a candidate signal index; a signal index determination unit setting weighting factors for the respective signals up to the candidate signal index, and determining a sum of the weighting factors as a signal index; and a position-specific threshold configuring unit configuring the threshold for each position by using a signal of the determined signal index and a scaling factor.

Abstract: The present disclosure provides a basal ganglia-on-a-chip for screening therapeutic agents for brain and nervous system diseases and a method for fabricating the same. The present invention provides a method for screening therapeutic agents for dopamine-dependent brain and nervous system diseases by using a basal ganglia-on-a-chip. When the basal ganglia-on-a-chip of the present invention is used in the effect evaluation of therapeutic agents for brain and nervous system diseases, the effect evaluation of therapeutic candidate substances can be economically and promptly carried out compared with an existing technique.

Abstract: A bioelectronic device for regulating stem cell differentiation, a method for differentiating stem cells using the same, and a method for manufacturing the bioelectronic device. According to the present invention, it is possible to effectively control the differentiation of stem cells at a single-cell level, and to simultaneously perform a free radical inhibition function.

Abstract: The present invention provides a method and a kit for half coating nanoparticles. According to the present invention, nanoparticles can be half coated in a relatively simple and economical process that can replace complicated processes, such as chemical synthesis, of a conventional Janus nanoparticle-preparing method.

Abstract: A method and device for measuring biometric data using a UWB radar are disclosed. The disclosed method includes: (a) determining a respiratory rate by using reflection signals reflected off a target patient; (b) extracting respiration signals from the reflection signals, removing the extracted respiration signals from the reflection signals and converting into signals of a frequency domain; and (c) determining a heartbeat rate by detecting peak values from the frequency-domain signals converted in said step (b).

Abstract: A method for measuring cell cycles includes immobilizing a capture specifically binding to a cell membrane protein to a substrate, wherein the cell membrane protein is a counterpartner binding to the capture, binding a cell having the cell membrane protein as the counterpartner to the capture, and measuring a redox potential of the cell. A method for screening a substance affecting cell cycles includes immobilizing a capture specifically binding to a cell membrane protein to a substrate; wherein the cell membrane protein is a counterpartner binding to the capture, binding a cell having the cell membrane protein as the counterpartner to the capture, treating a test substance of interest for analysis to a cell, and measuring a redox potential of the cell.

Abstract: The present invention relates to a method for detecting an undifferentiated pluripotent stem cell, and a cell-chip using the same. Since the cell chip-based quantitative analysis method of the present invention does not use antibodies, unlike flow cytometry or real-time PCR which has been conventionally used for the quantitative analysis of pluripotent stem cells, there is an advantage in that it is possible to conveniently and rapidly perform quantitative analysis, and since the function of cells is not affected even after analysis, it is possible to recover and use the cells used in the analysis.

Abstract: The present invention relates to a biomemory device, comprising (a) a substrate; and (b) a heterolayer comprising a protein having a redox potential and an inorganic particle; wherein the heterolayer is immobilized on the substrate. By applying inorganic particles, the present invention provides a biomemory device capable of enhancing low current signals detected electron transfer between biomolecules and substrates up to at least five (5) times greater signals. The present invention is capable of controlling the redox states with help of redox potentials of proteins depending on applied potential. The present invention provides a new-concept biomemory device as an information storage device based on the principle of electron transfer of a naturally occurring biomolecule.

Abstract: Provided is a bioprocessing device including a hybrid of (1) a protein having a redox potential; and (b) a single strand DNA (ssDNA) conjugated to the protein. The bioprocessing device of the present invention has a function of information reinforcement, information regulation, or information amplification. This bioprocessing device of the present invention presents a new concept of biocomputing system enabling various functions.

Abstract: This invention relates to a sensor for detecting a stem cell differentiation, including (a) an electrode; and (b) a substrate of an alkaline phosphatase. The phosphorylation or dephosphorylation of the substrate for an alkaline phosphatase as a stem cell undifferentiation marker which dephosphorylates its substrate may be measured using an electrical signal in the present sensor. Therefore, the sensor of the present invention enables to electrically detect a stem cell status in a high-throughput manner and to determine the stem cell differentiation.

Abstract: A method and device for measuring biometric data using a UWB radar are disclosed. The disclosed method includes: (a) determining a respiratory rate by using reflection signals reflected off a target patient; (b) extracting respiration signals from the reflection signals, removing the extracted respiration signals from the reflection signals and converting into signals of a frequency domain; and (c) determining a heartbeat rate by detecting peak values from the frequency-domain signals converted in said step (b).

Abstract: Provided is a bioprocessing device including a hybrid of (1) a protein having a redox potential; and (b) a single strand DNA (ssDNA) conjugated to the protein. The bioprocessing device of the present invention has a function of information reinforcement, information regulation, or information amplification. This bioprocessing device of the present invention presents a new concept of biocomputing system enabling various functions.

Abstract: The present invention relates to a sensor for detecting hydrogen peroxide, comprising: (a) a gold (Au) nanoparticle conjugated with a conducting oxide substrate comprising a conduction oxide; (b) a cytochrome c immobilized on the gold nanoparticle. In the performance of the present sensor, current values are increased in parallel with increased hydrogen peroxide concentration. Such performance enables to easily analyze the presence or concentration of hydrogen peroxide.

Abstract: A device, system, and method for detecting or separating target molecules allowing efficient detection even when only a small amount of target molecules or target cells are included in a sample involving the use of a target molecule linkage portion, a signal production portion, and first and second separation portions.

Abstract: This invention relates to a sensor for detecting a stem cell differentiation, including (a) an electrode; and (b) a substrate of an alkaline phosphatase. The phosphorylation or dephosphorylation of the substrate for an alkaline phosphatase as a stem cell undifferentiation marker which dephosphorylates its substrate may be measured using an electrical signal in the present sensor. Therefore, the sensor of the present invention enables to electrically detect a stem cell status in a high-throughput manner and to determine the stem cell differentiation.

Abstract: The present invention relates to a biomolecule-based electronic device in which the biomolecule with redox potential is directly immobilized on the substrate. The present invention enables to excellently exhibit the capability of a protein-based bio-memory device in which it is preferable to use the substrate on which cysteine-introduced recombinant proteins are effectively immobilized and a self-assembled layer (SAM) is fabricated. It becomes realized that a redox potential is regulated using intrinsic redox potential of the protein dependent on applied voltage. The present invention provides a novel operating method in which three potentials are applied throughout four steps. The present invention has some advantages of fabricating a protein layer in a convenient manner and inducing electron transfer by fundamental electrochemical or electronic operation.

Abstract: A method for measuring cell cycles includes immobilizing a capture specifically binding to a cell membrane protein to a substrate, wherein the cell membrane protein is a counterpartner binding to the capture, binding a cell having the cell membrane protein as the counterpartner to the capture, and measuring a redox potential of the cell. A method for screening a substance affecting cell cycles includes immobilizing a capture specifically binding to a cell membrane protein to a substrate; wherein the cell membrane protein is a counterpartner binding to the capture, binding a cell having the cell membrane protein as the counterpartner to the capture, treating a test substance of interest for analysis to a cell, and measuring a redox potential of the cell.

Abstract: The present disclosure relates to a multifunctional biomemory device in which a protein having a redox potential substituted with a metal ion is directly immobilized on a substrate. The present disclosure provides an operating method in which the redox state of the protein is controlled by applying three different potentials. The present disclosure provides a biomemory device in which the metal ion of a metalloprotein is substituted to allow for artificial control of the redox potential. The present disclosure provides a new-concept biomemory device as an information storage device based on the principle of electron transfer of a naturally occurring biomolecule.

Abstract: The present invention relates to a sensor for detecting hydrogen peroxide, comprising: (a) a gold (Au) nanoparticle conjugated with a conducting oxide substrate comprising a conduction oxide; (b) a cytochrome c immobilized on the gold nanoparticle. In the performance of the present sensor, current values are increased in parallel with increased hydrogen peroxide concentration. Such performance enables to easily analyze the presence or concentration of hydrogen peroxide.