Patents by Inventor Jeremy Gray
Jeremy Gray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250145982Abstract: The disclosure generally relates to systems, methods, and apparatuses for magnetic bead loading. An example embodiment of the disclosure relates to an apparatus including a vertically oriented plate having a first major surface and a second major surface opposite the first major surface; a magnet holder securing a magnet in proximity to the first major surface of the vertically oriented plate; a drive mechanism coupled to the magnet holder and operable to move the magnet holder and magnet in parallel to the first major surface of the vertically oriented plate; and a substrate holder to receive a substrate and hold the substrate in a vertical orientation against the surface of the vertically oriented plate.Type: ApplicationFiled: January 14, 2025Publication date: May 8, 2025Inventors: Hua Yu, Xiaoling Yang, Rui Zheng, Chiu Tai Andrew Wong, Jeremy Gray
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Patent number: 12226745Abstract: The present disclosure provides methods, compositions and kits as well as systems for manipulating nucleic acids, including implementing isothermal amplification, such as recombinase-polymerase amplification (RPA), of a nucleic acid template using a pre-seeded solid support. Provided are rapid and efficient methods for generating template nucleic acid molecules comprising specific nucleotide sequence bound to solid support. Such methods can be used, for example, in manipulating nucleic acids in preparation for analysis methods that utilize monoclonal populations of nucleic acids.Type: GrantFiled: May 3, 2019Date of Patent: February 18, 2025Assignee: Life Technologies CorporationInventors: Abraham Rosenbaum, Collyn Seeger, Jeremy Gray, Hua Yu
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Publication number: 20250043342Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.Type: ApplicationFiled: October 18, 2024Publication date: February 6, 2025Inventors: Philip WAGGONER, James A. BALL, Michael L. MINTO, David M. COX, Wolfgang HINZ, Alexander MASTROIANNI, Jeremy GRAY, Marc GLAZER, Scott PARKER, Kimberly GORRELL
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Patent number: 12139758Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.Type: GrantFiled: January 8, 2024Date of Patent: November 12, 2024Assignee: Life Technologies CorporationInventors: Philip Waggoner, James A. Ball, Michael L. Minto, David M. Cox, Wolfgang Hinz, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Scott Parker, Kimberly Gorrell
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Publication number: 20240309443Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.Type: ApplicationFiled: January 8, 2024Publication date: September 19, 2024Inventors: Philip WAGGONER, James A. BALL, Michael L. MINTO, David M. COX, Wolfgang HINZ, Alexander MASTROIANNI, Jeremy GRAY, Marc GLAZER, Scott PARKER, Kimberly GORRELL
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Publication number: 20240125733Abstract: A sensor component includes a sensor including a sensor surface and a reaction site in cooperation with the sensor and exposing the sensor surface. The reaction site including a reaction site surface. A surface agent is bound to the reaction site surface or the sensor surface. The surface agent includes a surface active functional group reactive with Bronsted base or Lewis acid functionality on the reaction site surface or the sensor surface and including distal functionality that does not have a donor electron pair.Type: ApplicationFiled: September 27, 2023Publication date: April 18, 2024Inventors: Ronald L. CICERO, James A. BALL, Alexander MASTROIANN1, Christina E. INMAN, Jeremy GRAY, Marc GLAZER, Yufang WANG, Joseph KOSCINSKI, Phil WAGGONER
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Patent number: 11879156Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.Type: GrantFiled: August 10, 2022Date of Patent: January 23, 2024Assignee: Life Technologies CorporationInventors: Phil Waggoner, James A. Ball, Wolfgang Hinz, Michael L. Minto, Scott Parker, David M. Cox, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Kimberly Gorrell
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Patent number: 11782019Abstract: A sensor component includes a sensor including a sensor surface and a reaction site in cooperation with the sensor and exposing the sensor surface. The reaction site including a reaction site surface. A surface agent is bound to the reaction site surface or the sensor surface. The surface agent includes a surface active functional group reactive with Bronsted base or Lewis acid functionality on the reaction site surface or the sensor surface and including distal functionality that does not have a donor electron pair.Type: GrantFiled: October 1, 2020Date of Patent: October 10, 2023Assignee: Life Technologies CorporationInventors: Ronald L. Cicero, Marc Glazer, Yufang Wang, Christina E Inman, Jeremy Gray, Joseph Koscinski, James A. Ball, Phil Waggoner, Alexander Mastroianni
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Publication number: 20230175046Abstract: A method of forming a polymer matrix array includes applying an aqueous solution into wells of a well array. The aqueous solution includes polymer precursors. The method further includes applying an immiscible fluid over the well array to isolate the aqueous solution within the wells of the well array and polymerizing the polymer precursors isolated in the wells of the well array to form the polymer matrix array. An apparatus includes a sensor array, a well array corresponding to the sensor array, and an array of polymer matrices disposed in the well array.Type: ApplicationFiled: February 1, 2023Publication date: June 8, 2023Inventors: David LIGHT, Wolfgang HINZ, Ronald CICERO, Christina INMAN, Paul KENNEY, Alexander MASTROIANNI, Roman ROZHKOV, Yufang WANG, Jeremy GRAY, Marc GLAZER, Dmitriy GREMYACHINSKIY
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Patent number: 11578356Abstract: A method of forming a polymer matrix array includes treating a surface within a well of a well array with a surface compound including a surface reactive functional group and a radical-forming distal group; applying an aqueous solution including polymer precursors to the well of the well array; and activating the radical-forming distal group of the surface coupling compound with an initiator and atom transfer radical polymerization (ATRP) catalyst to initiate radical polymerization of the polymer precursors within the well of the well array to form the polymer matrix array.Type: GrantFiled: July 24, 2020Date of Patent: February 14, 2023Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: David Light, Wolfgang Hinz, Ronald Cicero, Christina Inman, Paul Kenney, Alexander Mastroianni, Roman Rozhkov, Yufang Wang, Jeremy Gray, Marc Glazer, Dmitriy Gremyachinskiy
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Publication number: 20230037531Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.Type: ApplicationFiled: August 10, 2022Publication date: February 9, 2023Inventors: Phil Waggoner, James A. Ball, Wolfgang Hinz, Michael L. Minto, Scott Parker, David M. Cox, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Kimberly Gorrell
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Publication number: 20220361683Abstract: A body pillow with attachable tail apparatus for wrinkle prevention and comfortable side sleeping includes a pillow body having a body front side, a body back side, a body top side, and a body bottom side. The body bottom side is planar and the body top side is arcuate to rest against the user's back. A cover is coupled to the pillow body. The cover is selectively engageable with the pillow body to cover the body front side, the body back side, the body top side, and the body bottom side. A first attachment member is coupled to the cover adjacent the body back side. A tail has a tail proximal end and a tail distal end and is configured to rest between the user's knees. A second attachment member is coupled to the tail proximal end and is selectively engageable with the first attachment member.Type: ApplicationFiled: May 12, 2021Publication date: November 17, 2022Inventors: Jeremy Gray, Renee Gray
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Patent number: 11441178Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.Type: GrantFiled: March 20, 2020Date of Patent: September 13, 2022Assignee: Life Technologies CorporationInventors: Phil Waggoner, James A. Ball, Wolfgang Hinz, Michael L. Minto, Scott Parker, David M. Cox, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Kimberly Gorrell
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Publication number: 20220220534Abstract: The present disclosure provides methods, compositions and kits as well as systems for manipulating nucleic acids, including implementing isothermal amplification, such as recombinase-polymerase amplification (RPA), of a nucleic acid template using a pre-seeded solid support. Provided are rapid and efficient methods for generating template nucleic acid molecules comprising specific nucleotide sequence bound to solid support. Such methods can be used, for example, in manipulating nucleic acids in preparation for analysis methods that utilize monoclonal populations of nucleic acids.Type: ApplicationFiled: March 30, 2022Publication date: July 14, 2022Inventors: Abraham ROSENBAUM, Collyn SEEGER, Jeremy GRAY, Hua YU
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Patent number: 11293056Abstract: The present disclosure provides methods, compositions and kits as well as systems for manipulating nucleic acids, including implementing isothermal amplification, such as recombinase-polymerase amplification (RPA), of a nucleic acid template using a pre-seeded solid support. Provided are rapid and efficient methods for generating template nucleic acid molecules comprising specific nucleotide sequence bound to solid support. Such methods can be used, for example, in manipulating nucleic acids in preparation for analysis methods that utilize monoclonal populations of nucleic acids.Type: GrantFiled: November 7, 2018Date of Patent: April 5, 2022Assignee: Life Technologies CorporationInventors: Abraham Rosenbaum, Collyn Seeger, Jeremy Gray, Hua Yu
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Publication number: 20210102917Abstract: An apparatus includes a substrate; a gate structure disposed over the substrate and having an upper surface; a well structure disposed over the substrate and defining a well over the upper surface of the gate structure; a conductive layer disposed on the upper surface of the gate structure and at least partially extending along a wall of the well in the well structure; and a dielectric structure disposed over the well structure and defining an opening to the well.Type: ApplicationFiled: November 3, 2020Publication date: April 8, 2021Applicant: Life Technologies CorporationInventors: Jeremy GRAY, Jordan OWENS, James BUSTILLO
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Publication number: 20210102916Abstract: A sensor component includes a sensor including a sensor surface and a reaction site in cooperation with the sensor and exposing the sensor surface. The reaction site including a reaction site surface. A surface agent is bound to the reaction site surface or the sensor surface. The surface agent includes a surface active functional group reactive with Bronsted base or Lewis acid functionality on the reaction site surface or the sensor surface and including distal functionality that does not have a donor electron pair.Type: ApplicationFiled: October 1, 2020Publication date: April 8, 2021Applicant: Life Technologies CorporationInventors: Ronald L. Cicero, Marc Glazer, Yufang Wang, Christina E. Inman, Jeremy Gray, Joseph Koscinski, James A. Ball, Phil Waggoner, Alexander Mastroianni
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Patent number: 10901145Abstract: The application relates to methods of analyzing luminescent species. A substrate is provided that has a plurality of zero mode waveguides having apertures that extend through an upper non-reflective layer that is disposed on a lower transparent layer of a substrate. The apertures have non-reflective oxide layers on the reflective side walls of the apertures, the side walls having a thickness of greater than 10 nm, and the oxide layer is formed by oxidizing the non-reflective layer. The volume within the oxide layer defines a solution volume, and the volume within the reflective walls defines a ZMW volume. Having such non-reflective layers on the walls of the ZMW usefully decouples the solution volume from the ZMW volume.Type: GrantFiled: November 27, 2018Date of Patent: January 26, 2021Assignee: Pacific Biosciences of California, Inc.Inventors: Jeremy Gray, Lei Sun
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Publication number: 20200354780Abstract: A method of forming a polymer matrix array includes applying an aqueous solution into wells of a well array. The aqueous solution includes polymer precursors. The method further includes applying an immiscible fluid over the well array to isolate the aqueous solution within the wells of the well array and polymerizing the polymer precursors isolated in the wells of the well array to form the polymer matrix array. An apparatus includes a sensor array, a well array corresponding to the sensor array, and an array of polymer matrices disposed in the well array.Type: ApplicationFiled: July 24, 2020Publication date: November 12, 2020Inventors: David LIGHT, Wolfgang HINZ, Ronald CICERO, Christina INMAN, Paul KENNEY, Alexander MASTROIANNI, Roman ROZHKOV, Yufang WANG, Jeremy GRAY, Marc GLAZER, Dmitriy GREMYACHINSKIY
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Patent number: 10809225Abstract: A sensor component includes a sensor including a sensor surface and a reaction site in cooperation with the sensor and exposing the sensor surface. The reaction site including a reaction site surface. A surface agent is bound to the reaction site surface or the sensor surface. The surface agent includes a surface active functional group reactive with Bronsted base or Lewis acid functionality on the reaction site surface or the sensor surface and including distal functionality that does not have a donor electron pair.Type: GrantFiled: July 1, 2015Date of Patent: October 20, 2020Assignee: Life Technologies CorporationInventors: Ronald L. Cicero, Marc Glazer, Yufang Wang, Christina E. Inman, Jeremy Gray, Joseph Koscinski, James A. Ball, Phil Waggoner, Alexander Mastroianni