Patents by Inventor Jeremy Gray

Jeremy Gray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250145982
    Abstract: The disclosure generally relates to systems, methods, and apparatuses for magnetic bead loading. An example embodiment of the disclosure relates to an apparatus including a vertically oriented plate having a first major surface and a second major surface opposite the first major surface; a magnet holder securing a magnet in proximity to the first major surface of the vertically oriented plate; a drive mechanism coupled to the magnet holder and operable to move the magnet holder and magnet in parallel to the first major surface of the vertically oriented plate; and a substrate holder to receive a substrate and hold the substrate in a vertical orientation against the surface of the vertically oriented plate.
    Type: Application
    Filed: January 14, 2025
    Publication date: May 8, 2025
    Inventors: Hua Yu, Xiaoling Yang, Rui Zheng, Chiu Tai Andrew Wong, Jeremy Gray
  • Patent number: 12226745
    Abstract: The present disclosure provides methods, compositions and kits as well as systems for manipulating nucleic acids, including implementing isothermal amplification, such as recombinase-polymerase amplification (RPA), of a nucleic acid template using a pre-seeded solid support. Provided are rapid and efficient methods for generating template nucleic acid molecules comprising specific nucleotide sequence bound to solid support. Such methods can be used, for example, in manipulating nucleic acids in preparation for analysis methods that utilize monoclonal populations of nucleic acids.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: February 18, 2025
    Assignee: Life Technologies Corporation
    Inventors: Abraham Rosenbaum, Collyn Seeger, Jeremy Gray, Hua Yu
  • Publication number: 20250043342
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Application
    Filed: October 18, 2024
    Publication date: February 6, 2025
    Inventors: Philip WAGGONER, James A. BALL, Michael L. MINTO, David M. COX, Wolfgang HINZ, Alexander MASTROIANNI, Jeremy GRAY, Marc GLAZER, Scott PARKER, Kimberly GORRELL
  • Patent number: 12139758
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Grant
    Filed: January 8, 2024
    Date of Patent: November 12, 2024
    Assignee: Life Technologies Corporation
    Inventors: Philip Waggoner, James A. Ball, Michael L. Minto, David M. Cox, Wolfgang Hinz, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Scott Parker, Kimberly Gorrell
  • Publication number: 20240309443
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Application
    Filed: January 8, 2024
    Publication date: September 19, 2024
    Inventors: Philip WAGGONER, James A. BALL, Michael L. MINTO, David M. COX, Wolfgang HINZ, Alexander MASTROIANNI, Jeremy GRAY, Marc GLAZER, Scott PARKER, Kimberly GORRELL
  • Publication number: 20240125733
    Abstract: A sensor component includes a sensor including a sensor surface and a reaction site in cooperation with the sensor and exposing the sensor surface. The reaction site including a reaction site surface. A surface agent is bound to the reaction site surface or the sensor surface. The surface agent includes a surface active functional group reactive with Bronsted base or Lewis acid functionality on the reaction site surface or the sensor surface and including distal functionality that does not have a donor electron pair.
    Type: Application
    Filed: September 27, 2023
    Publication date: April 18, 2024
    Inventors: Ronald L. CICERO, James A. BALL, Alexander MASTROIANN1, Christina E. INMAN, Jeremy GRAY, Marc GLAZER, Yufang WANG, Joseph KOSCINSKI, Phil WAGGONER
  • Patent number: 11879156
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Grant
    Filed: August 10, 2022
    Date of Patent: January 23, 2024
    Assignee: Life Technologies Corporation
    Inventors: Phil Waggoner, James A. Ball, Wolfgang Hinz, Michael L. Minto, Scott Parker, David M. Cox, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Kimberly Gorrell
  • Patent number: 11782019
    Abstract: A sensor component includes a sensor including a sensor surface and a reaction site in cooperation with the sensor and exposing the sensor surface. The reaction site including a reaction site surface. A surface agent is bound to the reaction site surface or the sensor surface. The surface agent includes a surface active functional group reactive with Bronsted base or Lewis acid functionality on the reaction site surface or the sensor surface and including distal functionality that does not have a donor electron pair.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: October 10, 2023
    Assignee: Life Technologies Corporation
    Inventors: Ronald L. Cicero, Marc Glazer, Yufang Wang, Christina E Inman, Jeremy Gray, Joseph Koscinski, James A. Ball, Phil Waggoner, Alexander Mastroianni
  • Publication number: 20230175046
    Abstract: A method of forming a polymer matrix array includes applying an aqueous solution into wells of a well array. The aqueous solution includes polymer precursors. The method further includes applying an immiscible fluid over the well array to isolate the aqueous solution within the wells of the well array and polymerizing the polymer precursors isolated in the wells of the well array to form the polymer matrix array. An apparatus includes a sensor array, a well array corresponding to the sensor array, and an array of polymer matrices disposed in the well array.
    Type: Application
    Filed: February 1, 2023
    Publication date: June 8, 2023
    Inventors: David LIGHT, Wolfgang HINZ, Ronald CICERO, Christina INMAN, Paul KENNEY, Alexander MASTROIANNI, Roman ROZHKOV, Yufang WANG, Jeremy GRAY, Marc GLAZER, Dmitriy GREMYACHINSKIY
  • Patent number: 11578356
    Abstract: A method of forming a polymer matrix array includes treating a surface within a well of a well array with a surface compound including a surface reactive functional group and a radical-forming distal group; applying an aqueous solution including polymer precursors to the well of the well array; and activating the radical-forming distal group of the surface coupling compound with an initiator and atom transfer radical polymerization (ATRP) catalyst to initiate radical polymerization of the polymer precursors within the well of the well array to form the polymer matrix array.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: February 14, 2023
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: David Light, Wolfgang Hinz, Ronald Cicero, Christina Inman, Paul Kenney, Alexander Mastroianni, Roman Rozhkov, Yufang Wang, Jeremy Gray, Marc Glazer, Dmitriy Gremyachinskiy
  • Publication number: 20230037531
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Application
    Filed: August 10, 2022
    Publication date: February 9, 2023
    Inventors: Phil Waggoner, James A. Ball, Wolfgang Hinz, Michael L. Minto, Scott Parker, David M. Cox, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Kimberly Gorrell
  • Publication number: 20220361683
    Abstract: A body pillow with attachable tail apparatus for wrinkle prevention and comfortable side sleeping includes a pillow body having a body front side, a body back side, a body top side, and a body bottom side. The body bottom side is planar and the body top side is arcuate to rest against the user's back. A cover is coupled to the pillow body. The cover is selectively engageable with the pillow body to cover the body front side, the body back side, the body top side, and the body bottom side. A first attachment member is coupled to the cover adjacent the body back side. A tail has a tail proximal end and a tail distal end and is configured to rest between the user's knees. A second attachment member is coupled to the tail proximal end and is selectively engageable with the first attachment member.
    Type: Application
    Filed: May 12, 2021
    Publication date: November 17, 2022
    Inventors: Jeremy Gray, Renee Gray
  • Patent number: 11441178
    Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: September 13, 2022
    Assignee: Life Technologies Corporation
    Inventors: Phil Waggoner, James A. Ball, Wolfgang Hinz, Michael L. Minto, Scott Parker, David M. Cox, Alexander Mastroianni, Jeremy Gray, Marc Glazer, Kimberly Gorrell
  • Publication number: 20220220534
    Abstract: The present disclosure provides methods, compositions and kits as well as systems for manipulating nucleic acids, including implementing isothermal amplification, such as recombinase-polymerase amplification (RPA), of a nucleic acid template using a pre-seeded solid support. Provided are rapid and efficient methods for generating template nucleic acid molecules comprising specific nucleotide sequence bound to solid support. Such methods can be used, for example, in manipulating nucleic acids in preparation for analysis methods that utilize monoclonal populations of nucleic acids.
    Type: Application
    Filed: March 30, 2022
    Publication date: July 14, 2022
    Inventors: Abraham ROSENBAUM, Collyn SEEGER, Jeremy GRAY, Hua YU
  • Patent number: 11293056
    Abstract: The present disclosure provides methods, compositions and kits as well as systems for manipulating nucleic acids, including implementing isothermal amplification, such as recombinase-polymerase amplification (RPA), of a nucleic acid template using a pre-seeded solid support. Provided are rapid and efficient methods for generating template nucleic acid molecules comprising specific nucleotide sequence bound to solid support. Such methods can be used, for example, in manipulating nucleic acids in preparation for analysis methods that utilize monoclonal populations of nucleic acids.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: April 5, 2022
    Assignee: Life Technologies Corporation
    Inventors: Abraham Rosenbaum, Collyn Seeger, Jeremy Gray, Hua Yu
  • Publication number: 20210102917
    Abstract: An apparatus includes a substrate; a gate structure disposed over the substrate and having an upper surface; a well structure disposed over the substrate and defining a well over the upper surface of the gate structure; a conductive layer disposed on the upper surface of the gate structure and at least partially extending along a wall of the well in the well structure; and a dielectric structure disposed over the well structure and defining an opening to the well.
    Type: Application
    Filed: November 3, 2020
    Publication date: April 8, 2021
    Applicant: Life Technologies Corporation
    Inventors: Jeremy GRAY, Jordan OWENS, James BUSTILLO
  • Publication number: 20210102916
    Abstract: A sensor component includes a sensor including a sensor surface and a reaction site in cooperation with the sensor and exposing the sensor surface. The reaction site including a reaction site surface. A surface agent is bound to the reaction site surface or the sensor surface. The surface agent includes a surface active functional group reactive with Bronsted base or Lewis acid functionality on the reaction site surface or the sensor surface and including distal functionality that does not have a donor electron pair.
    Type: Application
    Filed: October 1, 2020
    Publication date: April 8, 2021
    Applicant: Life Technologies Corporation
    Inventors: Ronald L. Cicero, Marc Glazer, Yufang Wang, Christina E. Inman, Jeremy Gray, Joseph Koscinski, James A. Ball, Phil Waggoner, Alexander Mastroianni
  • Patent number: 10901145
    Abstract: The application relates to methods of analyzing luminescent species. A substrate is provided that has a plurality of zero mode waveguides having apertures that extend through an upper non-reflective layer that is disposed on a lower transparent layer of a substrate. The apertures have non-reflective oxide layers on the reflective side walls of the apertures, the side walls having a thickness of greater than 10 nm, and the oxide layer is formed by oxidizing the non-reflective layer. The volume within the oxide layer defines a solution volume, and the volume within the reflective walls defines a ZMW volume. Having such non-reflective layers on the walls of the ZMW usefully decouples the solution volume from the ZMW volume.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: January 26, 2021
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Jeremy Gray, Lei Sun
  • Publication number: 20200354780
    Abstract: A method of forming a polymer matrix array includes applying an aqueous solution into wells of a well array. The aqueous solution includes polymer precursors. The method further includes applying an immiscible fluid over the well array to isolate the aqueous solution within the wells of the well array and polymerizing the polymer precursors isolated in the wells of the well array to form the polymer matrix array. An apparatus includes a sensor array, a well array corresponding to the sensor array, and an array of polymer matrices disposed in the well array.
    Type: Application
    Filed: July 24, 2020
    Publication date: November 12, 2020
    Inventors: David LIGHT, Wolfgang HINZ, Ronald CICERO, Christina INMAN, Paul KENNEY, Alexander MASTROIANNI, Roman ROZHKOV, Yufang WANG, Jeremy GRAY, Marc GLAZER, Dmitriy GREMYACHINSKIY
  • Patent number: 10809225
    Abstract: A sensor component includes a sensor including a sensor surface and a reaction site in cooperation with the sensor and exposing the sensor surface. The reaction site including a reaction site surface. A surface agent is bound to the reaction site surface or the sensor surface. The surface agent includes a surface active functional group reactive with Bronsted base or Lewis acid functionality on the reaction site surface or the sensor surface and including distal functionality that does not have a donor electron pair.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: October 20, 2020
    Assignee: Life Technologies Corporation
    Inventors: Ronald L. Cicero, Marc Glazer, Yufang Wang, Christina E. Inman, Jeremy Gray, Joseph Koscinski, James A. Ball, Phil Waggoner, Alexander Mastroianni