Abstract: A method of forming a polymer matrix array includes applying an aqueous solution into wells of a well array. The aqueous solution includes polymer precursors. The method further includes applying an immiscible fluid over the well array to isolate the aqueous solution within the wells of the well array and polymerizing the polymer precursors isolated in the wells of the well array to form the polymer matrix array. An apparatus includes a sensor array, a well array corresponding to the sensor array, and an array of polymer matrices disposed in the well array.

Abstract: Under the present disclosure, a chat interface and computer program product for comparing free time between instant message chat members in order to schedule an upcoming event are provided. One approach includes: storing individual calendars corresponding to each member of the chat; initiating a free time comparison; and combining the individual calendars corresponding to each member of the chat into a free time summary calendar, wherein the free time summary calendar indicates at least one of free time periods that are simultaneously available to all of the members of the chat and conflict time periods during which at least two chat members simultaneously have an event scheduled. The free time summary calendar may be viewed in day, week, and month view formats.

Abstract: The application relates to methods of forming arrays of solid state nanopores. A substrate is provided having an array of apertures extending through the substrate. The substrate is oxidized so that an oxide layer is formed on the substrate. The formation of the oxide layer reduces the cross-sectional dimensions of the apertures. This method is useful for producing arrays of nanopores having controlled dimensions.

Abstract: Disclosed are compositions, devices, and methods for loading molecules of interest onto a substrate by contacting beads having molecules of interest attached to them with the substrate, for example by providing a field that brings the beads into proximity or contact with the substrate and moves the beads with respect to the substrate. Such molecules of interest can be deposited onto substrates for single-molecule analysis.

Abstract: The application relates to methods of manufacture of improved optical containment structures. The invention relates to arrays of zero-mode waveguide structures comprising nanoscale apertures having non-reflective coatings on their walls. The methods provide for selectively coating the walls of the zero mode waveguides, allowing for selective functionalization of the bases.

Abstract: A method for providing an activity management tool includes receiving a user request for an activity overview, and identifying installed applications and open windows of the installed applications. The method further includes presenting an activity overview graphical user interface (GUI) having a first area and a second area. The first area includes visual indicators of the installed applications. The second area includes the open windows of the installed applications, where the open windows are resized and positioned in such a way as to be simultaneously viewable by the user.

Abstract: A method for providing an activity management tool includes receiving a user request for an activity overview, identifying currently running applications, applications that are likely to be run in the future, and open windows of the currently running applications. The method further includes presenting an activity overview graphical user interface (GUI) having a first area and a second area. The first area includes visual indicators of the currently running applications and the applications likely to be run in the future. The second area includes the open windows of the currently running applications, where the open windows are resized and positioned in such a way as to be simultaneously viewable by the user.

Abstract: A method for providing a workspace management tool includes presenting a workspace overview graphical user interface (GUI) having a first area and a second area. The first area includes visual indicators of favorite applications of a user, and the second area includes multiple regions, each region representing a different work space. The method further includes receiving, via the workspace overview GUI, a user request to open a new window for one of the favorite applications in a first work space, adding the new window to the first work space, and presenting the new window in a reduced form in a region representing the first work space without overlapping other open windows of the first work space.

Abstract: Under the present disclosure, a chat interface and computer program product for comparing free time between instant message chat members in order to schedule an upcoming event are provided. One approach includes: storing individual calendars corresponding to each member of the chat; initiating a free time comparison; and combining the individual calendars corresponding to each member of the chat into a free time summary calendar, wherein the free time summary calendar indicates at least one of free time periods that are simultaneously available to all of the members of the chat and conflict time periods during which at least two chat members simultaneously have an event scheduled. The free time summary calendar may be viewed in day, week, and month view formats.

Abstract: The application relates to improved optical containment structures, methods of manufacture and use, and systems for employing same. The optical containment structures generally comprise zero-mode waveguide structures having non-reflective walls. The non-reflective walls allow the preparation of optical containment regions in which the optical containment dimensions can be decoupled from the solution containment dimensions. The application also relates to methods for producing islands of functionality within nanoscale apertures.

Abstract: Methods for non-random loading of single analyte molecules into array structures are provided. The methods allow for distribution of a population of target molecules into a plurality of size confined regions such as wells. Sizing moieties are linked to individual target molecules. The sizing moieties are of sufficient size, relative to the size-confined reaction or observation regions, such that only a selected number of sizing moieties will fit into the size confined regions. The confined regions and the sizing moieties or target molecules comprise a selected charge that allow for controlling the loading of the sizing moities.

Abstract: Disclosed are compositions, devices, and methods for loading molecules of interest onto a substrate by contacting beads having molecules of interest attached to them with the substrate, for example by providing a field that brings the beads into proximity or contact with the substrate and moves the beads with respect to the substrate. Such molecules of interest can be deposited onto substrates for single-molecule analysis.

Abstract: The application relates to methods of manufacture of improved optical containment structures. The invention relates to arrays of zero-mode waveguide structures comprising nanoscale apertures having non-reflective coatings on their walls. The methods provide for selectively coating the walls of the zero mode waveguides, allowing for selective functionalization of the bases.

Abstract: Disclosed are compositions, devices, and methods for loading molecules of interest onto a substrate by contacting beads having molecules of interest attached to them with the substrate, for example by providing a field that brings the beads into proximity or contact with the substrate and moves the beads with respect to the substrate. Such molecules of interest can be deposited onto substrates for single-molecule analysis.

Abstract: A method and apparatus for providing a cloud computing graphical user interface is described. In one embodiment, the method includes receiving a request to display an aggregate of cloud computing system resources of different cloud computing systems. The method may also include rendering a visual summary of aggregated cloud computing system resources, wherein the aggregated cloud computing system resources include at least one cloud computing system pool.

Abstract: Methods, substrates, and devices related to arrays of optical confinements having surfaces with high levels of bias. Substrates having transparent or silica based portions and opaque or reflective portions are treated with 1) a selective passivating agent, that selectively coats the opaque or reflective regions, 2) a functionalizing agent such as a coupling agent, and 3) a selective removal agent, which selectively removes functionalizing agent from the passivated opaque or reflective surfaces.

Abstract: Methods, substrates, and devices related to arrays of optical confinements having surfaces with high levels of bias. Substrates having transparent or silica based portions and opaque or reflective portions are treated with 1) a selective passivating agent, that selectively coats the opaque or reflective regions, 2) a functionalizing agent such as a coupling agent, and 3) a selective removal agent, which selectively removes functionalizing agent from the passivated opaque or reflective surfaces.

Abstract: The application relates to methods for producing islands of functionality within nanoscale apertures. Islands of functionality can be produced by growing an aperture constriction layer from the walls, functionalizing the exposed base of the aperture, then removing the aperture constriction layer. The aperture constriction layer can be produced, for example, by anodically growing an oxide layer onto a cladding through which the aperture extends. The islands of functionality can be used to bind a single molecule of interest, such as an enzyme within the nanoscale aperture.

Abstract: Disclosed are compositions, devices, and methods for loading molecules of interest onto a substrate by contacting beads having molecules of interest attached to them with the substrate, for example by providing a field that brings the beads into proximity or contact with the substrate and moves the beads with respect to the substrate. Such molecules of interest can be deposited onto substrates for single-molecule analysis.

Abstract: A method and apparatus for providing a cloud computing graphical user interface is described. In one embodiment, the method includes receiving a request to display an aggregate of cloud computing system resources of different cloud computing systems. The method may also include rendering a visual summary of aggregated cloud computing system resources, wherein the aggregated cloud computing system resources include at least one cloud computing system pool.