Patents by Inventor Jeremy I. Levin

Jeremy I. Levin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Beta-sulfonamide hydroxamic acid inhibitors of tace/matrix metalloproteinase
    Patent number: 7595327
    Abstract: This invention provides compounds of Formula I, having the structure: that are useful in treating diseases or disorders mediated by TNF-?, such as arthritis (rheumatoid arthritis (RA), juvenile RA, psoriatic arthritis, osteoarthritis etc), tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection, ankylosing spondylitis, psoriasis, sepsis, multiple sclerosis, Crohn's disease, degenerative cartilage loss, asthma, idiopathic pulmonary fibrosis, vasculitis, systemic lupus erythematosus, irritable bowel syndrome, acute coronary syndrome, hepatitis C, cachexia, COPD, stroke or type 2 diabetes, and for alleviation of symptoms thereof. The invention further provides methods for use of the compounds.
    Type: Grant
    Filed: March 16, 2006
    Date of Patent: September 29, 2009
    Assignee: Wyeth
    Inventors: Jeremy I. Levin, Zhong Li, George Diamantidis, Frank E. Lovering, Weiheng Wang, Jeffrey S. Condon, Yang-I Lin, Jerauld S. Skotnicki, Kaapjoo Park
  • Alkynyl-containing tryptophan derivative inhibitors of TACE/matrix metalloproteinase
    Patent number: 7576222
    Abstract: This invention provides compounds of Formula I, having the structure: that are useful in treating diseases or disorders mediated by TNF-?. The invention further provides methods for use of the compounds for treating such a disease or disorder or for alleviating symptoms thereof.
    Type: Grant
    Filed: December 27, 2005
    Date of Patent: August 18, 2009
    Assignee: Wyeth
    Inventors: Kaapjoo Park, Jeremy I. Levin, Ariamala Gopalsamy
  • Method for the treatment of polycystic kidney disease
    Patent number: 7488754
    Abstract: The present invention provides a method for treating, inhibiting the progression of, or eradicating polycystic kidney disease of in a patient in need thereof which comprises providing to said patient an effective amount of a TACE inhibitor compound alone or in combination with an effective amount of an EGF receptor kinase inhibitor.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: February 10, 2009
    Assignee: Wyeth
    Inventors: Philip Frost, Jeremy I. Levin
  • Method for preparing hydroxamic acids
    Patent number: 7179911
    Abstract: Processes for using a compound of formula III: to make compounds of formulae I and II: and processes for making the compound of formula III, where R1-5 and J are as defined herein.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: February 20, 2007
    Assignee: Wyeth
    Inventors: Ting-Zhong Wang, Lalitha Krishnan, Joseph Zeldis, Jeremy I. Levin, Jean Schmid, Mellard Jennings, Huan-Qiu Li, Zhixin Wen
  • Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors
    Patent number: 6946473
    Abstract: Compounds of the formula which are useful in disease conditions mediated by TNF-?, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: September 20, 2005
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, James M. Chen, Xue-Mei Du, Jay D. Albright, Arie Zask
  • Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and TACE inhibitors
    Patent number: 6825354
    Abstract: Compounds of the formula are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: November 30, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, Aranapakam M. Venkatesan, Derek C. Cole, James M. Chen, Jamie M. Davis, George T. Grosu
  • Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/TACE inhibitors
    Publication number: 20040229924
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: June 17, 2004
    Publication date: November 18, 2004
    Applicant: WYETH
    Inventors: Jeremy I. Levin, Aranapakam M. Venkatesan, James M. Chen, Arie Zask, Vincent P. Sandanayaka, Mila T. Du, Jannie L. Baker
  • Acetylenic &agr;-amino acid-based sulfonamide hydroxamic acid tace inhibitors
    Patent number: 6812227
    Abstract: Compounds of the formula: are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: November 2, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, James M. Chen, Derek C. Cole, Mila T. Du, Leif M. Laakso
  • Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
    Patent number: 6762178
    Abstract: Hydroxamic acids having the formula are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: July 13, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, James M. Chen
  • Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
    Patent number: 6753337
    Abstract: Compounds of the formula: useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: June 22, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, Aranapakam M. Venkatesan, James M. Chen, Arie Zask, Vincent P. Sandanayaka, Mila T. Du, Jannie L. Baker
  • Acetylenic &agr;-amino acid-based sulfonamide hydroxamic acid tace inhibitors
    Patent number: 6716833
    Abstract: Compounds of the formula: are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: April 6, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Jeremy I. Levin, James M. Chen, Derek C. Cole, Mila T. Du, Leif M. Laakso
  • Method for the treatment of polycystic kidney disease
    Publication number: 20040063672
    Abstract: The present invention provides a method for treating, inhibiting the progression of, or eradicating polycystic kidney disease of in a patient in need thereof which comprises providing to said patient an effective amount of a TACE inhibitor compound alone or in combination with an effective amount of an EDF receptor kinase inhibitor.
    Type: Application
    Filed: October 2, 2003
    Publication date: April 1, 2004
    Inventors: Philip Frost, Jeremy I. Levin
  • Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors
    Publication number: 20040033988
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: February 27, 2003
    Publication date: February 19, 2004
    Applicant: Wyeth
    Inventors: Jeremy I. Levin, James M. Chen, Derek C. Cole, Mila T. Du, Leif M. Laakso
  • Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors
    Publication number: 20030212049
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: February 27, 2003
    Publication date: November 13, 2003
    Applicant: Wyeth
    Inventors: Jeremy I. Levin, James Ming Chen, Derek C. Cole, Mila T. Du, Leif M. Laakso
  • Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors
    Publication number: 20030208066
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: March 17, 2003
    Publication date: November 6, 2003
    Applicant: American Cyanamid Company
    Inventors: Jeremy I.. Levin, James Ming Chen, Xue-Mei Du, Jay D. Albright, Arie Zask
  • Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors
    Patent number: 6548524
    Abstract: This invention provides, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-&agr; converting enzyme (TACE. tumor necrosis factor-&agr; converting enzyme) which arc useful for the treatment of diseases in which these enzymes are implicated.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: April 15, 2003
    Assignee: American Cyanamid Company
    Inventors: Jeremy I. Levin, Arie Zask, Yansong Gu, Jay D. Albright, Xuemei Du
  • Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
    Patent number: 6534491
    Abstract: This invention provides, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stroinelysins and collagenases) and TNF-&agr; converting enzyme (TACE, tumor necrosis factor-&agr;converting enzyme) which are useful for the treatment of diseases in which these enzymes are implicated.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: March 18, 2003
    Assignee: American Cyanamid Company
    Inventors: Jeremy I. Levin, Arie Zask, Yansong Gu, Jay D. Albright, Xuemei Du
  • Acetylenic alpha -amino acid-based sulfonamide hydroxamic acid tace inhibitors
    Publication number: 20030008849
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: December 27, 2000
    Publication date: January 9, 2003
    Inventors: Jeremy I. Levin, James M. Chen, Derek C. Cole, Mila T. Du, Leif M. Laakso
  • Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
    Patent number: 6498167
    Abstract: This invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases and TNF-&agr; converting enzyme (TACE, tumor necrosis factor-&agr; converting enzyme) of formula (B) as shown herein or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: December 24, 2002
    Assignee: American Cyanamid Company
    Inventors: Jeremy I. Levin, Arie Zask, Yansong Gu, Jay D. Albright, Xuemei Du
  • Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
    Publication number: 20020188132
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: December 4, 2000
    Publication date: December 12, 2002
    Inventors: Jeremy I. Levin, James M. Chen, Frances C. Nelson