Abstract: A method for treating a gluten-induced disease, such as celiac disease, in a subject in need thereof is provided. The method comprises administering to the subject at least one agent that activates aryl hydrocarbon receptor such as AhR agonists, bacterial probiotics with AhR agonist activity, and IL-22 agonists, polypeptides and nucleic acid.

Abstract: The present technology relates to respirator devices including source control features. In some embodiments, a source control mask device can include a shield that substantially covers the mouth and nose of a user and a mechanism that can actively extract air as it is exhaled by the user. The extracted exhaled air can then be sanitized before the mask device discharges it into the atmosphere. The mask device may selectively form a seal to the user's face dependent on air flow conditions.

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

Abstract: The present technology relates to respirator devices including source control features. In some embodiments, a source control mask device can include a shield that substantially covers the mouth and nose of a user and a mechanism that can actively extract air as it is exhaled by the user. The extracted exhaled air can then be sanitized before the mask device discharges it into the atmosphere. The mask device may selectively form a seal to the user's face dependent on air flow conditions.

Abstract: Disclosed are systems and methods for conducting an open conversation user interface and more particularly, to a channel-agnostic user interface experience which can utilize automated background intelligence to simplify the exchange between a software system or member service representative (MSR) and a member, and avoids the need for web-based free form inputs.

Abstract: This invention relates to methods and compositions for treating Angelman syndrome, including administering to a subject an effective amount of a clustered regularly interspersed short palindromic repeat (CRISPR)-associated endonuclease and one or more than one guide RNA molecules having complementarity to a target nucleotide sequence in UBE3A-ATS in cells of the subject.

Abstract: An oral cleaning system includes a toothbrush body with a first stem. The first stem has a rigid configuration and a first head with a first plurality of bristles. A channel is defined within the first stem and at least one fluid outlet is defined in the first head. The at least one fluid outlet is in fluid communication with the channel and is configured to facilitate irrigation of a mouth or teeth via the first head. A second stem is connected to the first stem and extends upwardly and outwardly from a distal portion of the first stem. The second stem includes a second plurality of bristles and is generally opposed and spaced from the first head. The second stem has a semi-flexible configuration such that the second head is resiliently movable inwardly or outwardly relative to the first head without substantially bending the first stem.

Abstract: Embodiments of the present disclosure relate to a mask or shield adapted to generate a flow of positive pressure air directed through substantially opposing jets that creates a stream of laminar flow filtered air to create a turbulent air pocket therein for supplying filtered breathable air to a wearer's face.

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

Abstract: A mask or shield comprising a flow of positive pressure air directed through substantially opposing jets that creates a stream of laminar flow filtered air to create a turbulent air pocket therein for supplying filtered breathing air to a wearer's face and to exclude outside unpurified air. Also a mask or shield comprising a flow of positive pressure air directed via a powered impeller unit that is configured to distribute positively pressurised filtered breathable air inside the face mask in a substantially 360° plane or arc substantially parallel to the internal surface of the face mask and to exclude external unpurified air. The mask is separated from and does not form a seal around a wearer's face unless required such as in a deadly environment or malfunction.

Abstract: Provided herein are compounds that form covalent bonds with peptidases, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SPase), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

Abstract: The following disclosure discusses systems and methods of detecting and analyzing cutaneous conditions. According to one embodiment, a 2D image of the cutaneous condition and a set of 3D point clouds associated with the 2D image are captured using an image capturing device. The 2D image and the set of 3D point clouds are sent to a computing device. The computing device generates a 3D surface according to the set of 3D point clouds. Subsequently, the computing device receives a depth map for the 2D image based upon the 3D surface from another computing device such that the depth map comprises depth data for each pixel of the 2D image. The cutaneous condition may then be measured and analyzed based upon the depth map using the computing device.

Abstract: An oral irrigator has a separate high pressure water system and low pressure mouth rinse system to deliver two different fluids to a pick or other accessories. The water system and mouth rinse system are combined in a handle. The pick is connected to the handle. The water system has a blocking valve located in the handle and the mouth rinse system has a hand pump located in the handle. The hand pump sits next to a valve button for closing the blocking valve. When the hand pump is pressed, it presses against the valve button of the blocking valve to shut off the source of high pressure water to the pick. The pressure in the pick drops so that the hand pump can then introduce mouth rinse into the pick. When the hand pump is released, the blocking valve opens up and high pressure water returns to the pick.

Abstract: An oral cleaning system includes a toothbrush body with a first stem. The first stem has a rigid configuration and a first head with a first plurality of bristles. A channel is defined within the first stem and at least one fluid outlet is defined in the first head. The at least one fluid outlet is in fluid communication with the channel and is configured to facilitate irrigation of a mouth or teeth via the first head. A second stem is connected to the first stem and extends upwardly and outwardly from a distal portion of the first stem. The second stem includes a second plurality of bristles and is generally opposed and spaced from the first head. The second stem has a semi-flexible configuration such that the second head is resiliently movable inwardly or outwardly relative to the first head without substantially bending the first stem.

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.